Mibefradil prevents neointima formation after vascular injury in rats. Possible role of the blockade of the T-type voltage-operated calcium channel.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  1995-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.ATV.15.8.1161PMID 7627710
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective inhibition of T-type Ca2+ channels by Ro 40-5967.

  1994cited by this paper
• T-type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts.

  1994cited by this paper
• T-type calcium current in latent pacemaker cells isolated from cat right atrium.

  1994cited by this paper
• Ca2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts.

  1993cited by this paper
• T-type Ca2+ current is expressed in hypertrophied adult feline left ventricular myocytes.

  1993cited by this paper
• Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats.

  1993cited by this paper
• Does the New Angiotensin Converting Enzyme Inhibitor Cilazapril Prevent Restenosis After Percutaneous Transluminal Coronary Angioplast?: Results of the MERCATOR Study A Multicenter, Randomized, Double‐Blind Placebo‐Controlled Trial

  1992cited by this paper
• Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Multicenter European Research Trial with Cilazapril after Angiopla

  1992cited by this paper
• Postnatal changes in T‐type calcium current density in rat atrial myocytes.

  1992cited by this paper
• Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes.

  1992cited by this paper
• L- and T-type Ca2+ channels in canine cardiac Purkinje cells. Single-channel demonstration of L-type Ca2+ window current.

  1992cited by this paper
• Hemodynamic and humoral effects of the novel calcium antagonist Ro 40‐5967 in patients with hypertension

  1992cited by this paper
• Differences of calcium channels in vascular muscle in hypertension.

  1991cited by this paper
• Ro 40–5967: A New Nondihydropyridine Calcium Antagonist

  1991cited by this paper
• Pharmacology of calcium channels in cardiac muscle, vascular muscle, and neurons.

  1991cited by this paper
• Characterization of ion channels seen in subconfluent human dermal fibroblasts.

  1991cited by this paper
• Ro 40–5967, in Contrast to Diltiazem, Does Not Reduce Left Ventricular Contractility in Rats with Chronic Myocardial Infarction

  1991cited by this paper
• The structurally novel Ca2+ channel blocker Ro 40-5967, which binds to the [3H] desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts

  1990cited by this paper
• In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action.

  1989cited by this paper
• Classes of calcium channels in vertebrate cells.

  1989cited by this paper
• Epidermal growth factor responsiveness in smooth muscle cells from hypertensive and normotensive rats.

  1989cited by this paper
• Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury.

  1989cited by this paper
• Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size.

  1988cited by this paper
• Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts.

  1988cited by this paper
• Multiple types of neuronal calcium channels and their selective modulation.

  1988cited by this paper
• Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.

  1983cited by this paper
• Myosin Isoenzymic Changes in Several Models of Rat Cardiac Hypertrophy

  1981cited by this paper
• The influence of hypertension on injury-induced myointimal thickening.

  1980cited by this paper
• The influence of hypertension on injury-induced myointimal thickening.

  1980cited by this paper
• Endothelial regeneration. II. Restitution of endothelial continuity.

  1979cited by this paper
• Measurement of blood pressure in unanaesthetized rats and mice.

  1968cited by this paper

• Therapeutic potential of carbon monoxide in hypertension-induced vascular smooth muscle cell damage revisited: from physiology and pharmacology.

  2022cites this paper
• Kv channels and vascular smooth muscle cell proliferation

  2018cites this paper
• Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca channels

  2017cites this paper
• Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca2+ channel

  2016cites this paper
• Regulation of T-Type Ca2+ Channels in Cancer Cell Cycle

  2015cites this paper
• Pharmacological Profiles of T-Type Calcium Channel Antagonists

  2015cites this paper
• T-type Calcium Channels in Basic and Clinical Science

  2015cites this paper
• Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice.

  2015cites this paper
• H2S does not regulate proliferation via T-type Ca2+ channels.

  2015cites this paper
• Arterial Chemoreceptors in Physiology and Pathophysiology

  2015cites this paper
• T-Type Ca2+ Channel Regulation by CO: A Mechanism for Control of Cell Proliferation.

  2015cites this paper
• Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels

  2014influential citation
• 2 – Calcium Channels in the Heart

  2014cites this paper
• Low-voltage-activated T-type Ca2+ channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin

  2014cites this paper
• Transcriptional regulation of α1H T-type calcium channel under hypoxia.

  2014cites this paper
• Mibefradil

  2012cites this paper
• The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.

  2012cites this paper
• Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model

  2012cites this paper
• Functional expression of voltage‐gated calcium channels in human melanoma

  2012cites this paper
• Comparative cytotoxicity of gambierol versus other marine neurotoxins.

  2011cites this paper
• UvA-DARE ( Digital Academic Repository ) Venous and arterial coronary artery bypass grafts in a pharmacological perspective

  2011cites this paper
• Use of calcium channel blockers for glaucoma.

  2011cites this paper
• Differential regulation of low and high voltage-activated calcium channels in neonatal rat myocytes following chronic PKA modulation

  2011cites this paper
• T-type ca(2+) channel blockers increase smooth muscle progenitor cells and endothelial progenitor cells in bone marrow stromal cells in culture by suppression of cell death.

  2010cites this paper
• T-type calcium channel expression and function in the diseased heart

  2010cites this paper
• alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice.

  2009cites this paper
• T-type Ca2+ Channels Promote Oxygenation-induced Closure of the Rat Ductus Arteriosus Not Only by Vasoconstriction but Also by Neointima Formation*

  2009cites this paper
• Low-Dose Spironolactone: Effects on Artery-to-Artery Vein Grafts and Percutaneous Coronary Intervention Sites

  2009cites this paper
• The L-type Ca(2+) channel as a therapeutic target in heart disease.

  2009cites this paper
• Developmental change of T‐type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia

  2009cites this paper
• Inhibition of Human Mesangial Cell Proliferation by Targeting T-Type Calcium Channels

  2009cites this paper
• Calcium signaling and T-type calcium channels in cancer cell cycling.

  2008cites this paper
• Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation.

  2008cites this paper
• T-type Ca2+ channel blockers suppress the growth of human cancer cells.

  2008cites this paper
• Mutation of delta-sarcoglycan is associated with Ca(2+) -dependent vascular remodeling in the Syrian hamster.

  2007cites this paper
• Mutation of δ-Sarcoglycan Is Associated with Ca2+-Dependent Vascular Remodeling in the Syrian Hamster

  2007cites this paper
• Phenotype and Function of c‐kit+‐derived Amplifying Myocytes

  2007cites this paper
• Mutation of -Sarcoglycan Is Associated with Ca 2 -Dependent Vascular Remodeling in the

  2007cites this paper
• Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation

  2007cites this paper
• Chronic hypoxia up‐regulates α1H T‐type channels and low‐threshold catecholamine secretion in rat chromaffin cells

  2007cites this paper
• UvA-DARE (Digital Academic Repository) Interactions between calcium antagonists and the sympathetic nervous system in various pharmacological models

  2007cites this paper
• Lead discovery and optimization of T-type calcium channel blockers.

  2007cites this paper
• T‐type Ca2+ Channel Expression in Human Esophageal Carcinomas: A Functional Role in Proliferation

  2007cites this paper
• Ion Channels – Voltage Gated

  2007cites this paper
• Multiple transcripts of Ca2+ channel alpha1-subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus.

  2006cites this paper
• Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396.

  2006cites this paper
• Pharmacology and drug discovery for T-type calcium channels.

  2006cites this paper
• T-type calcium channels and tumor proliferation.

  2006cites this paper
• Mibefradil, a T-Type Ca2+ Channel Blocker, Protects Against Mesenteric Ischemia-Reperfusion-Induced Oxidative Injury and Histologic Alterations in Intestinal Mucosa in Rats

  2006cites this paper
• Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels.

  2006cites this paper
• T-type Ca2+ channels in vascular smooth muscle: multiple functions.

  2006cites this paper
• The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer.

  2006cites this paper
• EARLY ACTIVATION OF INTERNAL MEDIAL SMOOTH MUSCLE CELLS IN THE RABBIT AORTA AFTER MECHANICAL INJURY: RELATIONSHIP WITH INTIMAL THICKENING AND PHARMACOLOGICAL APPLICATIONS

  2006cites this paper
• Multiple transcripts of Ca2+ channel α1-subunits and a novel spliced variant of the α1C-subunit in rat ductus arteriosus

  2006cites this paper
• Régulation directe par les protéines G hétérotrimériques des canaux calciques neuronaux activés par le potentiel électrique de membrane

  2006cites this paper
• Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells.

  2005cites this paper
• International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels

  2005cites this paper
• Physical Forces and their Translation into Molecular Mechanisms

  2004cites this paper
• Calcineurin-NFAT Signaling in Cardiac Hypertrophy: In Sickness and In Health?

  2004cites this paper
• NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-Benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A New Selective Inhibitor of T-Type Calcium Channels

  2004cites this paper
• Pharmacology of Cav3 (T-Type) Channels

  2004cites this paper
• AT2 Receptor of Angiotensin II and Cellular Differentiation

  2004cites this paper
• Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation

  2004cites this paper
• Low-Voltage-Activated (“T-Type”) Calcium Channels in Review

  2003cites this paper
• Molecular physiology of low-voltage-activated t-type calcium channels.

  2003cites this paper
• Modulation and Pharmacology of Low Voltage-Activated (“T-Type”) Calcium Channels

  2003cites this paper
• Induction of T-type Calcium Channel Gene Expression by Chronic Hypoxia*

  2003cites this paper
• Inhibition of collateral artery growth by mibefradil: possible role of volume-regulated chloride channels.

  2003cites this paper
• Restenosis after balloon angioplasty and/or stent insertion - origin and prevention: A review of the literature

  2002cites this paper
• Restenosis after balloon angioplasty and/or stent insertion - origin and prevention.

  2002cites this paper
• Impaired Mechanisms of Leukocyte Adhesion In Vitro by the Calcium Channel Antagonist Mibefradil

  2002cites this paper
• l-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblasts.

  2002cites this paper
• The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.

  2002influential citation
• Effect of T-Type Selective Calcium Antagonist on Renal Microcirculation: Studies in the Isolated Perfused Hydronephrotic Kidney

  2001cites this paper
• Comparison of L-type and mixed L- and T-type calcium channel blockers on kidney injury caused by deoxycorticosterone-salt hypertension in rats.

  2001cites this paper
• Evidence against an action of mibefradil at N-type voltage-operated calcium channels

  2001cites this paper
• Calcium currents and arrhythmias: insights from molecular biology.

  2001cites this paper
• T-Type calcium channel blockage ameliorates proteinuria and renal extracellular matrix accumulation in experimental diabetic rats

  2001cites this paper
• A mibefradil metabolite is a potent intracellular blocker of L-type Ca(2+) currents in pancreatic beta-cells.

  2000cites this paper
• Ion channels and the control of blood pressure.

  2000cites this paper
• A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca2+ Currents in Pancreatic β-Cells

  2000cites this paper
• Involvement of calcium-activated potassium channels in the regulation of DNA synthesis in cultured Müller glial cells.

  2000cites this paper
• Overexpression of T‐type calcium channels in HEK‐293 cells increases intracellular calcium without affecting cellular proliferation

  2000cites this paper
• Classification and Function of Voltage-Gated Calcium Channels

  2000cites this paper
• Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats.

  1999cites this paper
• Mibefradil-induced inhibition of proliferation of human peripheral blood mononuclear cells.

  1999cites this paper
• Comparative effects of mibefradil and other calcium antagonists on resistance arteries of different end organs

  1999cites this paper
• Kalziumantagonisten Resultate neuer Studien und ihre Bedeutung für die Praxis

  1999cites this paper
• Molecular Characterization of Two Members of the T‐Type Calcium Channel Family

  1999cites this paper
• Calcium-antagonist drugs.

  1999cites this paper
• Cytosolic calcium and lymphoproliferative response during calcium antagonism in men

  1999cites this paper
• Studies on the cardiovascular depressant effects of N-ethyl- and N-benzyl-1,2-diphenylethanolamines in the rat: elucidation of the mechanisms of action.

  1999cites this paper
• Effects of the calcium channel antagonist mibefradil on haemodynamic parameters and myocardial Ca(2+)-handling in infarct-induced heart failure in rats.

  1999cites this paper
• A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic beta-cell death.

  1999cites this paper
• Calcium antagonists. Results of recent studies and their significance for general practice.

  1999cites this paper
• Proliferation of human peripheral blood mononuclear cells during calcium entry blockade. Role of protein kinase C.

  1999cites this paper
• A Low Voltage-Activated Ca2+ Current Mediates Cytokine-Induced Pancreatic β-Cell Death.

  1999cites this paper
• 110499 Calcium-Antagonist Drugs

  1999cites this paper
• Differential effects of mibefradil, verapamil, and amlodipine on myocardial function and intracellular Ca(2+) handling in rats with chronic myocardial infarction.

  1999cites this paper
• L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil

  1999cites this paper