NF-κB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent Mechanisms

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular and Cellular Biology

• Publication date

  2013-10-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00797-13PMID 24100018PMCID PMC3889551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2011cited by this paper
• Inflammatory bowel disease.

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  2008influential reference
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  1999cited by this paper
• Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.

  1998cited by this paper
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  1997cited by this paper

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  2022cites this paper
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  2021cites this paper
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