Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Clinical Investigation

• Publication date

  2005-01-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI19229PMID 15630445PMCID PMC539188
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1990cited by this paper
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  1990cited by this paper
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  1988cited by this paper
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