Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Pharmacy and Science

• Publication date

  2001-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/JPS.1119PMID 11745727
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies

  2004cited by this paper
• Induction of Astrocyte Differentiation by Endothelial Cells

  2001cited by this paper
• Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

  2001cited by this paper
• VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly.

  2001cited by this paper
• Astrocytes Increase the Functional Expression of P-Glycoprotein in an In Vitro Model of The Blood-Brain Barrier

  2000cited by this paper
• Blood—Brain Barrier Is Involved in the Efflux Transport of a Neuroactive Steroid, Dehydroepiandrosterone Sulfate, via Organic Anion Transporting Polypeptide 2

  2000cited by this paper
• Neurons and ECM regulate occludin localization in brain endothelial cells

  2000cited by this paper
• Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug.

  2000cited by this paper
• Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro.

  2000cited by this paper
• Blood-brain barrier controls carnitine level in the brain: a study on a model system with RBE4 cells.

  2000cited by this paper
• Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

  2000cited by this paper
• Neural Induction of the Blood–Brain Barrier: Still an Enigma

  2000cited by this paper
• Blood-brain barrier formation of grafted human umbilical vein endothelial cells in athymic mouse brain.

  2000cited by this paper
• Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT.

  2000cited by this paper
• Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells.

  2000cited by this paper
• Enhancement of Transport of D-Melphalan Analogue by Conjugation with L-Glutamate across Bovine Brain Microvessel Endothelial Cell Monolayers

  2000cited by this paper
• Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells.

  2000cited by this paper
• Xenobiotic transport across isolated brain microvessels studied by confocal microscopy.

  2000cited by this paper
• Carrier-Mediated Delivery of Metabotropic Glutamate Receptor Ligands to the Central Nervous System: Structural Tolerance and Potential of the l-system Amino Acid Transporter at the Blood-Brain Barrier

  2000cited by this paper
• Functional Expression of the Serotonin Transporter in Immortalized Rat Brain Microvessel Endothelial Cells

  2000cited by this paper
• Active transport of fentanyl by the blood-brain barrier.

  1999cited by this paper
• Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier*

  1999cited by this paper
• Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier.

  1999cited by this paper
• Active Transport of Fentanyl by the Blood-Brain Barrier 1

  1999cited by this paper
• Non-invasive drug delivery to the human brain using endogenous blood-brain barrier transport systems.

  1999cited by this paper
• Blood-brain barrier biology and methodology.

  1999cited by this paper
• Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium.

  1999cited by this paper
• The cell biology of the blood-brain barrier.

  1999cited by this paper
• Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.

  1999cited by this paper
• GSH Transport in Immortalized Mouse Brain Endothelial Cells

  1999cited by this paper
• High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).

  1999cited by this paper
• Dexamethasone Regulation of P‐Glycoprotein Activity in an Immortalized Rat Brain Endothelial Cell Line, GPNT

  1999cited by this paper
• Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier.

  1999cited by this paper
• Evaluation of an in vitro coculture model for the blood-brain barrier: Comparison of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources

  1999cited by this paper
• Transport of Cationized Anti‐Tetanus Fab'2 Fragments Across an In Vitro Blood‐Brain Barrier Model: Involvement of the Transcytosis Pathway

  1999cited by this paper
• HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.

  1999cited by this paper
• Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: influence of astrocyte contact.

  1999cited by this paper
• Butyric acid mediated induction of enhanced transendothelial resistance in an in vitro model blood-brain barrier system.

  1999cited by this paper
• Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro.

  1999cited by this paper
• An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol.

  1999cited by this paper
• Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors.

  1999cited by this paper
• Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-alpha exposure.

  1999cited by this paper
• L-DOPA transport properties in an immortalised cell line of rat capillary cerebral endothelial cells, RBE 4.

  1999cited by this paper
• Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

  1999cited by this paper
• P-Glycoprotein, a gatekeeper in the blood-brain barrier.

  1999cited by this paper
• In vivo and in vitro evidence of blood-brain barrier transport of a novel cationic arginine-vasopressin fragment 4-9 analog.

  1999cited by this paper
• Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier.

  1999cited by this paper
• Carrier-mediated or specialized transport of drugs across the blood-brain barrier.

  1999cited by this paper
• In vitro models of the blood-brain barrier to polar permeants: comparison of transmonolayer flux measurements and cell uptake kinetics using cultured cerebral capillary endothelial cells.

  1999cited by this paper
• Characterization of transferrin receptor in an immortalized cell line of rat brain endothelial cells, RBE4.

  1999cited by this paper
• Dynamic modeling of the blood-brain barrier: a novel tool for studies of drug delivery to the brain.

  1999cited by this paper
• Dynamic in vitro modeling of the blood–brain barrier: a novel tool for studies of drug delivery to the brain

  1999cited by this paper
• Introduction to the Blood–Brain Barrier: Blood–brain barrier methodology and biology

  1998cited by this paper
• In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents.

  1998cited by this paper
• Basement Membrane Proteins Influence Brain Capillary Endothelial Barrier Function In Vitro

  1998cited by this paper
• Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

  1998cited by this paper
• Immortalized mouse brain endothelial cells are ultrastructurally similar to endothelial cells and respond to astrocyte-conditioned medium

  1998cited by this paper
• Theoretical calculation and prediction of brain-blood partitioning of organic solutes using MolSurf parametrization and PLS statistics.

  1998cited by this paper
• Alterations in Transendothelial Electrical Resistance by Vasoactive Agonists and Cyclic AMP in a Blood-Brain Barrier Model System

  1998cited by this paper
• Role of the CNS microvascular pericyte in the blood‐brain barrier

  1998cited by this paper
• Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.

  1998cited by this paper
• Monoacylation of ribonuclease A enables its transport across an in vitro model of the blood-brain barrier.

  1998cited by this paper
• Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae*

  1998cited by this paper
• Receptor-mediated angiotensin II transcytosis by brain microvessel endothelial cells.

  1998cited by this paper
• Hydrocortisone reinforces the blood-brain barrier properties in a serum free cell culture system.

  1998cited by this paper
• Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

  1998cited by this paper
• Evaluation of the Role of P-Glycoprotein in Ivermectin Uptake by Primary Cultures of Bovine Brain Microvessel Endothelial Cells

  1998cited by this paper
• Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

  1998cited by this paper
• Preliminary Characterization of Glial-Secreted Factors Responsible for the Induction of High Electrical Resistances Across Endothelial Monolayers in a Blood-Brain Barrier Model

  1998cited by this paper
• Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier

  1997cited by this paper
• Modulation of P-glycoprotein activity by glial factors and retinoic acid in an immortalized rat brain microvessel endothelial cell line.

  1997cited by this paper
• Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: Development of an immortalized cell line to study pathophysiology of CNS disease

  1997cited by this paper
• F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors.

  1997cited by this paper
• A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

  1997cited by this paper
• Preparation of glial extracellular matrix: a novel method to analyze glial-endothelial cell interaction.

  1997cited by this paper
• Morphological and functional characterization of an in vitro blood-brain barrier model.

  1997cited by this paper
• Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line.

  1997cited by this paper
• Glucose transport in immortalized rat brain capillary endothelial cells in vitro: transport activity and GLUT1 expression.

  1997cited by this paper
• Effect of tumor necrosis factor-alpha on the permeability of bovine brain microvessel endothelial cell monolayers.

  1997cited by this paper
• Drug metabolizing enzyme activities and superoxide formation in primary and immortalized rat brain endothelial cells.

  1997cited by this paper
• The effect of beta-turn structure on the permeation of peptides across monolayers of bovine brain microvessel endothelial cells.

  1997cited by this paper
• Modulation of cellular adhesion in bovine brain microvessel endothelial cells by a decapeptide.

  1997cited by this paper
• Receptor-Mediated Transcytosis of Transferrin through Blood-Brain Barrier Endothelial Cells

  1996cited by this paper
• SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics.

  1996cited by this paper
• A dynamic model of the blood-brain barrier "in vitro".

  1996cited by this paper
• Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

  1996cited by this paper
• Brain microvessel endothelial cell culture systems.

  1996cited by this paper
• Functional Expression of P‐Glycoprotein in an Immortalised Cell Line of Rat Brain Endothelial Cells, RBE4

  1996cited by this paper
• Astrocytic contributions to blood-brain barrier (BBB) formation by endothelial cells: a possible use of aortic endothelial cell for in vitro BBB model.

  1996cited by this paper
• Plasmodium falciparum: involvement of additional receptors in the cytoadherence of infected erythrocytes to microvascular endothelial cells.

  1996cited by this paper
• Characterization of the MDCK cell line for screening neurotoxicants.

  1996cited by this paper
• Establishment of the permanent microvascular endothelial cell line PBMEC/C1-2 from porcine brains.

  1996cited by this paper
• Properties of an immortalised vascular endothelial/glioma cell co‐culture model of the blood‐brain barrier

  1996cited by this paper
• Computation of brain-blood partitioning of organic solutes via free energy calculations.

  1996cited by this paper
• Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro.

  1996cited by this paper
• Synergistic stimulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities by retinoic acid and astroglial factors in immortalized rat brain microvessel endothelial cells

  1996cited by this paper
• Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells.

  1996cited by this paper
• Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers.

  1996cited by this paper
• Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions.

  1996cited by this paper
• Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells.

  1996cited by this paper

• Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier.

  2025cites this paper
• Treating glioblastoma with dextrin-based polymers

  2025cites this paper
• Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood–Brain Barrier and Assess Target Site Disposition

  2024cites this paper
• Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability

  2024cites this paper
• An efficient injection protocol for Drosophila larvae

  2024cites this paper
• The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases

  2024cites this paper
• A guide for blood–brain barrier models

  2024cites this paper
• Unraveling brain diseases: the promise of brain-on-a-chip models.

  2024cites this paper
• From Cells to Organoids: The Evolution of Blood-Brain Barrier Technology for Modelling Drug Delivery in Brain Cancer.

  2023cites this paper
• A novel 4-cell in-vitro blood-brain barrier model and its characterization by confocal microscopy and TEER measurement.

  2023cites this paper
• Evaluation of bottom‐up modeling of the blood–brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling

  2023cites this paper
• Human BBB-on-a-chip reveals barrier disruption, endothelial inflammation, and T cell migration under neuroinflammatory conditions

  2023cites this paper
• Microfluidic models of the neurovascular unit: a translational view

  2023cites this paper
• TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation

  2023cites this paper
• Lysophospholipids transport across blood-brain barrier in an in vitro reconstruction model.

  2023cites this paper
• Disease modeling in organoid cultures: a new tool for studying viruses

  2022cites this paper
• Del laboratorio a la clínica en el ictus isquémico agudo. Modelos experimentales in vitro e in vivo

  2022cites this paper
• Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems

  2021cites this paper
• The Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint

  2021cites this paper
• Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders

  2021cites this paper
• Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

  2021cites this paper
• Drug delivery and targeting to brain tumors: considerations for crossing the blood-brain barrier

  2021cites this paper
• Blood–Brain Barrier Permeability of Methyl- 3,4-dihydroxybenzoate derivative NO.2 for Neurodegenerative Diseases Treatment

  2021cites this paper
• Modeling ischemic stroke in a triculture neurovascular unit on-a-chip

  2021cites this paper
• Comparative Study of Human Pluripotent Stem Cell-Derived Endothelial Cells in Hydrogel-Based Culture Systems

  2021cites this paper
• ADMET tools: Prediction and assessment of chemical ADMET properties of NCEs

  2021cites this paper
• Harnessing Preclinical Data as a Predictive Tool for Human Brain Tissue Targeting.

  2021cites this paper
• Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines

  2021cites this paper
• Methods to Optimize CNS Exposure of Drug Candidates.

  2020cites this paper
• Comparison of the rate of dedifferentiation with increasing passages among cell sources for an in vitro model of the blood–brain barrier

  2020cites this paper
• A Novel Human Placental Barrier Model Based on Trophoblast Stem Cells Derived from Human Induced Pluripotent Stem Cells

  2020cites this paper
• Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

  2020cites this paper
• Fast Estimation of the Blood–Brain Barrier Permeability by Pulling a Ligand through a Lipid Membrane

  2020cites this paper
• A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood–brain barrier models for drug transport studies

  2020cites this paper
• Preeclampsia and increased permeability over the blood brain barrier - a role of vascular endothelial growth receptor 2.

  2020cites this paper
• Surface engineered liposomal delivery of therapeutics across the blood brain barrier: recent advances, challenges and opportunities

  2019cites this paper
• In vitro and in vivo models of BBB to evaluate brain targeting drug delivery

  2019cites this paper
• Recent Expansions on Cellular Models to Uncover the Scientific Barriers Towards Drug Development for Alzheimer’s Disease

  2019cites this paper
• Permeability through Caco-2 cell monolayers as a model for BBB: implementation and preliminary evaluation using model compounds

  2019cites this paper
• The development of a rabies virus glycoprotein derivative for targeted nanoparticulate drug delivery across an in vitro blood brain barrier model

  2019cites this paper
• A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

  2018cites this paper
• Regulation of human brain vascular pericytes and human astrocytes in a blood–brain barrier model using human brain microvascular endothelial cells: Expression of TGF-β1, VEGF, MMP-9 and P-gp

  2018cites this paper
• Blood-brain barrier on a chip.

  2018cites this paper
• Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

  2018cites this paper
• Methods of Delivering Molecules Through the Blood-Brain Barrier for Brain Diagnostics and Therapeutics

  2018cites this paper
• An ECV304 monoculture model for permeability assessment of blood–brain barrier

  2018cites this paper
• A Scalable and Efficient Bioprocess for Manufacturing Human Pluripotent Stem Cell-Derived Endothelial Cells

  2018cites this paper
• Therapeutic nanosystems co-deliver anticancer drugs and oncogene SiRNA to achieve synergetic precise cancer chemo-gene therapy.

  2018cites this paper
• PROTECTION AGAINST BLOOD-BRAIN BARRIER DAMAGES IN PATHOLOGICAL CONDITIONS: IN VIVŐ AND IN VITRO STUDIES

  2018cites this paper
• Manufacturing human pluripotent stem cell derived endothelial cells in scalable and cell-friendly microenvironments.

  2018cites this paper
• Microfluidic platform for the real time measurement and observation of endothelial barrier function under shear stress.

  2018cites this paper
• Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties

  2018cites this paper
• Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

  2017cites this paper
• Impedance-Based Analysis of the Cellular Response to Microparticles: Theory, Assay Development and Model Study

  2017cites this paper
• Paving the way towards complex blood-brain barrier models using pluripotent stem cells

  2017cites this paper
• ECM Mechano-Sensing Regulates Cytoskeleton Assembly and Receptor-Mediated Endocytosis of Nanoparticles.

  2017cites this paper
• Use of biopartitioning micellar chromatography and RP-HPLC for the determination of blood–brain barrier penetration of α-adrenergic/imidazoline receptor ligands, and QSPR analysis

  2017cites this paper
• Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood–Brain Barrier Function

  2017cites this paper
• Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs

  2017cites this paper
• Cerebral biomarkers in women with preeclampsia

  2017cites this paper
• Glutathione-decorated dendrons as potential drug carrier systems in Multiple Sclerosis

  2017cites this paper
• Prédiction in silico de l'absorption intestinale et de la pénétration cérébrale des pesticides chez l'homme

  2017cites this paper
• Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells.

  2017cites this paper
• Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

  2017cites this paper
• Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells

  2017cites this paper
• In Vitro CNS Models

  2017cites this paper
• Reality Check for Nanomaterial‐Mediated Therapy with 3D Biomimetic Culture Systems

  2016cites this paper
• Structure and Regulation of the Blood–Brain Barrier

  2016cites this paper
• Cell Culture Models for Drug Transport Studies

  2016cites this paper
• In vitro screening of nanomedicines through the blood brain barrier: A critical review.

  2016cites this paper
• Application of Cell Culture and Tissue Models for Assessing Drug Transport

  2016cites this paper
• Flavonoids in Neurodegeneration: Limitations and Strategies to Cross CNS Barriers.

  2016cites this paper
• Transcytosis-Targeting Peptide: A Conductor of Liposomal Nanoparticles through the Endothelial Cell Barrier.

  2016cites this paper
• In vitro blood-brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms.

  2016cites this paper
• Electroporation of Brain Endothelial Cells on Chip toward Permeabilizing the Blood-Brain Barrier.

  2016cites this paper
• Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier.

  2016cites this paper
• Modeling Ischemic Stroke In Vitro: Status Quo and Future Perspectives

  2016cites this paper
• Blood-brain barrier transport machineries and targeted therapy of brain diseases

  2016cites this paper
• Immortalized endothelial cell lines for in vitro blood-brain barrier models: A systematic review.

  2016cites this paper
• Sobetirome prodrug esters with enhanced blood-brain barrier permeability.

  2016cites this paper
• The Blood-Brain Barrier Permeability of Lignans and Malabaricones from the Seeds of Myristica fragrans in the MDCK-pHaMDR Cell Monolayer Model

  2016cites this paper
• Animal Surrogate Systems

  2016cites this paper
• Reduction in cardiolipin decreases mitochondrial spare respiratory capacity and increases glucose transport into and across human brain cerebral microvascular endothelial cells

  2016cites this paper
• Blood-Brain Barrier Methods

  2016cites this paper
• Selecting Good 'Drug-Like' Properties to Optimize Small Molecule Blood-Brain Barrier Penetration.

  2016cites this paper
• Membrane Transporters in Physiological Barriers of Pharmacological Importance.

  2016cites this paper
• 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.

  2016cites this paper
• Prediction of blood-brain barrier permeation of α-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis.

  2015cites this paper
• Endothelial -Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and CNS Homeostasis

  2015cites this paper
• Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models Towards Therapeutic Significance

  2015influential citation
• Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier.

  2015cites this paper
• Influence of puerarin, paeoniflorin, and menthol on structure and barrier function of tight junctions in MDCK and MDCK-MDR1 Cells

  2015cites this paper
• Blood-Brain Barrier Dysfunction and Repair after Blast-Induced Traumatic Brain Injury

  2015cites this paper
• In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches.

  2015cites this paper
• Exogenous arachidonic acid mediates permeability of human brain microvessel endothelial cells through prostaglandin E2 activation of EP3 and EP4 receptors

  2015cites this paper
• Endothelial &bgr;-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

  2015cites this paper
• Transport of treosulfan and temozolomide across an in-vitro blood–brain barrier model

  2015cites this paper
• Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model

  2015cites this paper
• Blood-brain barrier permeability mechanisms in view of quantitative structure-activity relationships (QSAR).

  2015cites this paper
• Fumaric Acid Esters Do Not Reduce Inflammatory NF-κB/p65 Nuclear Translocation, ICAM-1 Expression and T-Cell Adhesiveness of Human Brain Microvascular Endothelial Cells

  2015cites this paper