Orexin/hypocretin receptor signalling: a functional perspective

No abstract is available for this paper.

• Publication year

  2014

• Venue

  British Journal of Pharmacology

• Publication date

  2014-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/bph.12296PMID 23848055PMCID PMC3904253
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Discovery and development of orexin receptor antagonists as therapeutics for insomnia

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• OX1 Orexin/Hypocretin Receptor Signaling through Arachidonic Acid and Endocannabinoid Release

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• Mapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras.

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• Hypocretin/Orexin Receptor Functions in Mesopontine Systems Regulating Sleep, Arousal, and Cataplexy

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• Activation of central orexin/hypocretin neurons by dietary amino acids.

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• Activation of Orexin 1 Receptors in the Periaqueductal Gray of Male Rats Leads to Antinociception via Retrograde Endocannabinoid (2-Arachidonoylglycerol)-Induced Disinhibition

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• Cytosolic calcium elevation induced by orexin/hypocretin in granule cell domain cells of the rat cochlear nucleus in vitro.

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• Orexins Depolarize Rostral Ventrolateral Medulla Neurons and Increase Arterial Pressure and Heart Rate in Rats Mainly via Orexin 2 Receptors

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• Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors.

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• Acid-sensitive TASK-like K+ conductances contribute to resting membrane potential and to orexin-induced membrane depolarization in rat thalamic paraventricular nucleus neurons.

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• Orexin-A increases cell surface expression of AMPA receptors in the striatum.

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• Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

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• Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B.

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• Discovery of a functional immunoreceptor tyrosine‐ based switch motif in a 7‐transmembrane‐spanning receptor: role in the orexin receptor OX1R‐driven apoptosis

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• Involvement of TRPC3 channels in calcium oscillations mediated by OX(1) orexin receptors.

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• The brain hypocretins and their receptors: mediators of allostatic arousal.

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• Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells.

  2009influential reference
• Electrophysiological effects of orexins/hypocretins on pedunculopontine tegmental neurons in rats: an in vitro study.

  2009cited by this paper
• Properties of a T-type Ca2+channel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons.

  2009influential reference
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• Orexin receptor antagonists: medicinal chemistry and therapeutic potential.

  2008cited by this paper
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• SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons

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• Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway.

  2008influential reference
• The signalling profile of recombinant human orexin-2 receptor.

  2008influential reference
• Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.

  2008influential reference
• Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

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• Orexin peptides enhance median preoptic nucleus neuronal excitability via postsynaptic membrane depolarization and enhancement of glutamatergic afferents.

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• Multiple phospholipase activation by OX1 orexin/hypocretin receptors

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• Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells.

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• A hallmark of immunoreceptor, the tyrosine‐based inhibitory motif ITIM, is present in the G protein‐coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism

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• Orexin-induced modulation of state-dependent intrinsic properties in thalamic paraventricular nucleus neurons attenuates action potential patterning and frequency.

  2007cited by this paper
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  2007influential reference
• Role of leptin, ghrelin, angiotensin II and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism.

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• Neural substrates of awakening probed with optogenetic control of hypocretin neurons

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• IP3-independent signalling of OX1 orexin/hypocretin receptors to Ca2+ influx and ERK.

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• Electrical Inhibition of Identified Anorexigenic POMC Neurons by Orexin/Hypocretin

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• Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain.

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• Sodium/calcium exchanger: influence of metabolic regulation on ion carrier interactions.

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• Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B.

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• G-protein-coupled OX1 Orexin/hcrtr-1 Hypocretin Receptors Induce Caspase-dependent and -independent Cell Death through p38 Mitogen-/Stress-activated Protein Kinase*

  2006influential reference
• The Orexin OX1 Receptor Regulates Ca2+ Entry via Diacylglycerol-Activated Channels in Differentiated Neuroblastoma Cells

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• Modulation of thalamic neuron excitability by orexins.

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• Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function*

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• Excitatory action of hypocretin/orexin on neurons of the central medial amygdala.

  2006influential reference
• Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.

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• Narcolepsy and the hypocretin system—where motion meets emotion

  2006influential reference
• Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal.

  2006cited by this paper
• Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose.

  2006cited by this paper
• Properties of the Group IV phospholipase A2 family.

  2006cited by this paper
• Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1.

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• Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor.

  2006influential reference
• Orexin-A-induced Ca2+ Entry

  2005cited by this paper
• OX1 Orexin Receptors Couple to Adenylyl Cyclase Regulation via Multiple Mechanisms*

  2005cited by this paper
• Postsynaptic excitation of prefrontal cortical pyramidal neurons by hypocretin‐1/orexin a through the inhibition of potassium currents

  2005cited by this paper
• Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro.

  2005influential reference
• From waking to sleeping: neuronal and chemical substrates.

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