Signaling Lymphocyte Activation Molecule-Associated Protein Is a Negative Regulator of the CD8 T Cell Response in Mice1

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Immunology

• Publication date

  2005-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.175.4.2212PMID 16081788
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Defective B cell responses in the absence of SH2D1A.

  2005cited by this paper
• Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.

  2005cited by this paper
• Molecular and cellular pathogenesis of X‐linked lymphoproliferative disease

  2005cited by this paper
• SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease.

  2004cited by this paper
• Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.

  2004cited by this paper
• SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.

  2004cited by this paper
• SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

  2004cited by this paper
• Cutting Edge: Rapid In Vivo CTL Activity by Polyoma Virus-Specific Effector and Memory CD8+ T Cells1

  2003cited by this paper
• SAP is required for generating long-term humoral immunity

  2003cited by this paper
• Long-Term Latent Murine Gammaherpesvirus 68 Infection Is Preferentially Found within the Surface Immunoglobulin D-Negative Subset of Splenic B Cells In Vivo

  2003cited by this paper
• Mice deficient in the X‐linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus‐68 and hypo‐gammaglobulinemia

  2003cited by this paper
• SAP couples Fyn to SLAM immune receptors

  2003cited by this paper
• A mouse model for infectious mononucleosis

  2002cited by this paper
• Association of the X-linked Lymphoproliferative Disease Gene Product SAP/SH2D1A with 2B4, a Natural Killer Cell-activating Molecule, Is Dependent on Phosphoinositide 3-Kinase*

  2002cited by this paper
• Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine γ-herpesvirus-induced infectious mononucleosis

  2001cited by this paper
• Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

  2001cited by this paper
• Abnormal T Cell Receptor Signal Transduction of CD4 Th Cells in X-Linked Lymphoproliferative Syndrome1

  2001cited by this paper
• Murine gammaherpesvirus‐68‐induced interleukin‐10 increases viral burden, but limits virus‐induced splenomegaly and leukocytosis

  2001cited by this paper
• Factors Controlling Levels of CD8+ T-Cell Lymphocytosis Associated with Murine γ-Herpesvirus Infection

  2001cited by this paper
• SAP controls T cell responses to virus and terminal differentiation of TH2 cells

  2001cited by this paper
• Factors controlling levels of CD8+ T-cell lymphocytosis associated with murine gamma-herpesvirus infection.

  2001cited by this paper
• SH2D1A and slam protein expression in human lymphocytes and derived cell lines

  2000cited by this paper
• Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease

  2000cited by this paper
• Murine γ-herpesvirus infection causes Vβ4-specific CDR3-restricted clonal expansions within CD8+ peripheral blood T lymphocytes

  2000cited by this paper
• Murine gamma-herpesvirus infection causes V(beta)4-specific CDR3-restricted clonal expansions within CD8(+) peripheral blood T lymphocytes.

  2000cited by this paper
• B Cells Regulate Murine Gammaherpesvirus 68 Latency

  1999cited by this paper
• Macrophages Are the Major Reservoir of Latent Murine Gammaherpesvirus 68 in Peritoneal Cells

  1999cited by this paper
• Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine γ‐herpesvirus infection

  1999cited by this paper
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  1999cited by this paper
• A gamma-herpesvirus sneaks through a CD8(+) T cell response primed to a lytic-phase epitope.

  1999cited by this paper
• X-Linked Lymphoproliferative Disease: Pathology and Diagnosis

  1999cited by this paper
• In vivo models for Epstein–Barr virus (EBV)‐associated B cell lymphoproliferative disease (BLPD)

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• Lymphoproliferative disease induced by murine herpesvirus-68.

  1998cited by this paper
• Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

  1998cited by this paper
• The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

  1998cited by this paper
• Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice.

  1998cited by this paper
• Lung Epithelial Cells Are a Major Site of Murine Gammaherpesvirus Persistence

  1998cited by this paper
• Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine γ-Herpesvirus: Role for a Viral Superantigen?

  1997cited by this paper
• Tuning into immunological dissonance: an experimental model for infectious mononucleosis.

  1997cited by this paper
• Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68

  1996cited by this paper
• Progressive Loss of Cd8 + T Cell-mediated Control of a ~/-herpesvirus in the Absence of Cd4 + T Cells

  1996cited by this paper
• Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice.

  1996cited by this paper
• Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

  1996cited by this paper
• X-Linked Lymphoproliferative Disease: Twenty-Five Years after the Discovery

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• Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells

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• X-linked lymphoproliferative disease.

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  1990influential reference
• Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri.

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• Differential cellular susceptibility to Epstein‐Barr virus infection in a patient with X‐linked lymphoproliferative disease

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• Studies of EBV-lymphoid cell interactions in two patients with the X-linked lymphoproliferative syndrome: normal EBV-specific HLA-restricted cytotoxicity.

  1986cited by this paper
• Low Circulating Thymulin-like Activity in Children with Aids and Aids-related Complex

  1986cited by this paper
• Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome.

  1986cited by this paper
• Epstein-Barr virus (EBV) and X-linked lymphoproliferative syndrome (XLP).

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  1983cited by this paper
• Cell‐mediated immunity to Epstein‐Barr virus (EBV) and natural killer (NK)‐cell activity in the X‐linked lymphoproliferative syndrome

  1982cited by this paper
• Epstein-Barr virus-induced diseases in boys with the X-linked lymphoproliferative syndrome (XLP): update on studies of the registry.

  1982cited by this paper

• Serum metabolic profiles changes observed post COVID-19 – Case report

  2021cites this paper
• Epstein–Barr Virus in Inborn Immunodeficiency—More Than Infection

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• EBV Infection and Human Primary Immune Deficiencies

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• SLAMF6 in health and disease: Implications for therapeutic targeting.

  2019cites this paper
• Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?

  2018cites this paper
• 2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells

  2017cites this paper
• Neurotropic Coronavirus Infections

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• Responses to Microbial Challenges by SLAMF Receptors

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• Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular Help

  2014influential citation
• Cellular and Molecular Requirements for the Selection of In Vitro–Generated CD8 T Cells Reveal a Role for Notch

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  2013cites this paper
• Evolving role of 2B4/CD244 in T and NK cell responses during virus infection

  2012cites this paper
• Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

  2012cites this paper
• The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.

  2012cites this paper
• SLAM family receptors and SAP adaptors in immunity.

  2011cites this paper
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  2011cites this paper
• Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

  2011cites this paper
• Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency).

  2011cites this paper
• SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

  2010cites this paper
• SLAM-family receptors: immune regulators with or without SAP-family adaptors.

  2010cites this paper
• Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP).

  2009influential citation
• Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.

  2009cites this paper
• The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease

  2009cites this paper
• Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis

  2009cites this paper
• A gammaherpesvirus-secreted activator of V (cid:4) 4 + CD8 + T cells regulates chronic infection and immunopathology

  2008cites this paper
• A gammaherpesvirus-secreted activator of V (cid:4) 4 + CD8 + T cells regulates chronic infection and immunopathology

  2008cites this paper
• A gammaherpesvirus-secreted activator of Vβ4+ CD8+ T cells regulates chronic infection and immunopathology

  2008cites this paper
• The SLAM and SAP gene families control innate and adaptive immune responses.

  2008influential citation
• SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase1

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• Perturbation of B Cell Activation in SLAM-Associated Protein-Deficient Mice Is Associated with Changes in Gammaherpesvirus Latency Reservoirs1

  2007influential citation
• Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

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  2007influential citation
• Simultaneous Analysis of In Vivo CD8+ T Cell Cytotoxicity Against Multiple Epitopes using Multicolor Flow Cytometry

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• Increased proliferation of CD8+ T cells in SAP‐deficient mice is associated with impaired activation‐induced cell death

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• Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs

  2007influential citation
• Expression and function of the small immune adaptor protein SAP

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• The role of SAP and the SLAM family in autoimmunity.

  2006cites this paper
• Independent of SLAM and Fyn Kinase Cell Development and Humoral Immunity Is SAP Regulation of Follicular Helper CD4 T

  2006cites this paper
• Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease.

  2006cites this paper
• Immune regulation by SLAM family receptors and SAP-related adaptors

  2006cites this paper