Mice deficient in the X‐linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus‐68 and hypo‐gammaglobulinemia

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Medical Virology

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jmv.10504PMID 12966553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SAP is required for generating long-term humoral immunity

  2003cited by this paper
• Dual Functional Roles for the X-linked Lymphoproliferative Syndrome Gene Product SAP/SH2D1A in Signaling through the Signaling Lymphocyte Activation Molecule (SLAM) Family of Immune Receptors*

  2003cited by this paper
• A Spectrum of Mutations in SH2D1A That Causes X-linked Lymphoproliferative Disease and Other Epstein-Barr Virus-associated Illnesses

  2002cited by this paper
• Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family

  2002cited by this paper
• A mouse model for infectious mononucleosis

  2002cited by this paper
• "Decisions, decisions.": beta-catenin-mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells.

  2001cited by this paper
• NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease.

  2001cited by this paper
• Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

  2001influential reference
• Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.

  2001cited by this paper
• Natural history of murine gamma-herpesvirus infection.

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• SAP controls T cell responses to virus and terminal differentiation of TH2 cells

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• Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

  2001cited by this paper
• Dissecting the host response to a gamma-herpesvirus.

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• Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients*

  2001cited by this paper
• Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected B Cells in X-Linked Lymphoproliferative Disease

  2001cited by this paper
• The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B.

  2000cited by this paper
• Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome1

  2000cited by this paper
• Correlation of mutations of the SH2D1A gene and epstein-barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease.

  2000cited by this paper
• Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease1

  2000cited by this paper
• X-Linked Lymphoproliferative Disease

  2000cited by this paper
• Analysis of the Virus-Specific and Nonspecific B Cell Response to a Persistent B-Lymphotropic Gammaherpesvirus1

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• Inhibition of IgG1 and IgE Production by Stimulation of the B Cell CTLA-4 Receptor1

  2000cited by this paper
• SH2D1A mutation analysis for diagnosis of XLP in typical and atypical patients

  1999cited by this paper
• Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.

  1999cited by this paper
• Non-Antigen-Specific B-Cell Activation following Murine Gammaherpesvirus Infection Is CD4 Independent In Vitro but CD4 Dependent In Vivo

  1999cited by this paper
• Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP).

  1999cited by this paper
• Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

  1998cited by this paper
• The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

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• Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiency

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• CD2 and its ligands are involved in development and activation of MAIT cells.

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• Murine Models of Familial Cytokine Storm Syndromes.

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• Unmutated but T cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance

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• The hyperinflammatory spectrum: from defects in cytotoxicity to cytokine control

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• Epstein–Barr Virus in Inborn Immunodeficiency—More Than Infection

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• EBV Infection and Human Primary Immune Deficiencies

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• Murine Models of Familial Cytokine Storm Syndromes

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• Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?

  2018cites this paper
• X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective

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• Elevated SAP/SLAM expression in hepatitis B vaccine responders, but not in non-responders among chronic hepatitis C patients.

  2018cites this paper
• Responses to Microbial Challenges by SLAMF Receptors

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• The Role of Glucocorticoid Receptor in the Racial/Ethnic Disparity of Aggressive Breast Cancer

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• Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders.

  2015cites this paper
• Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.

  2015cites this paper
• Enhanced Response of T Cells from Murine Gammaherpesvirus 68-Infected Mice Lacking the Suppressor of T Cell Receptor Signaling Molecules Sts-1 and Sts-2

  2014cites this paper
• Murine Gammaherpesvirus 68 Reactivation from B Cells Requires IRF4 but Not XBP-1

  2014cites this paper
• Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular Help

  2014cites this paper
• lymphoproliferative disease gene sap Impaired Ig class switch in mice deficient for the X-linked

  2013cites this paper
• lymphoproliferative disease patients cells: IgM+IgD+ CD27+ B cells harbour the virus in X-linked Epstein-Barr virus persistence in the absence of conventional memory B

  2013cites this paper
• Memory CD8+ T Cells in Latent IL-15-Independent Proliferative Renewal of

  2013cites this paper
• Evolving role of 2B4/CD244 in T and NK cell responses during virus infection

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• Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment

  2012cites this paper
• NKT Cell Activation During (Microbial) Infection

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• Development and regulation of natural T helper 17 cells

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• The role of SAP and SLAM family molecules in the humoral immune response

  2011cites this paper
• The requirements for natural Th 17 cell development are distinct from those of conventional Th 17 cells

  2011cites this paper
• SLAM family receptors and SAP adaptors in immunity.

  2011cites this paper
• SLAM Family Receptors and Autoimmunity

  2011cites this paper
• Inherited defects causing hemophagocytic lymphohistiocytic syndrome

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• The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells

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• The power and the promise of restimulation‐induced cell death in human immune diseases

  2010cites this paper
• Role of SLAM-Associated Protein in the Pathogenesis of Autoimmune Diseases and Immunological Disorders

  2010cites this paper
• How do SAP family deficiencies compromise immunity?

  2010cites this paper
• SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

  2010cites this paper
• Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis.

  2010cites this paper
• Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

  2010influential citation
• Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis

  2009cites this paper
• Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

  2009cites this paper
• The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease

  2009cites this paper
• Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.

  2009cites this paper
• SAP expression in T cells, not in B cells, is required for humoral immunity

  2008cites this paper
• Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity*

  2008cites this paper
• A gammaherpesvirus-secreted activator of Vβ4+ CD8+ T cells regulates chronic infection and immunopathology

  2008cites this paper
• Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients.

  2008cites this paper
• A gammaherpesvirus-secreted activator of V (cid:4) 4 + CD8 + T cells regulates chronic infection and immunopathology

  2008cites this paper
• A gammaherpesvirus-secreted activator of V (cid:4) 4 + CD8 + T cells regulates chronic infection and immunopathology

  2008cites this paper
• The SLAM and SAP gene families control innate and adaptive immune responses.

  2008influential citation
• Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

  2007cites this paper
• SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses.

  2007cites this paper
• SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase1

  2007cites this paper
• Perturbation of B Cell Activation in SLAM-Associated Protein-Deficient Mice Is Associated with Changes in Gammaherpesvirus Latency Reservoirs1

  2007cites this paper
• SLAM‐Associated Protein Solves a Mystery of Autoimmunity

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• Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes.

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• The Roles of Major Histocompatibility Complex Class I and Foxk1 in Natural Killer Cell Development

  2007cites this paper
• Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs

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• NK cell regulation by SLAM family receptors and SAP‐related adapters

  2006cites this paper
• SLAM family receptors and SAP-related adaptors: matters arising.

  2006cites this paper
• Expression and function of the small immune adaptor protein SAP

  2006cites this paper
• SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells.

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• Immune regulation by SLAM family receptors and SAP-related adaptors

  2006cites this paper
• The CD2 family of natural killer cell receptors.

  2006cites this paper
• Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease.

  2006cites this paper
• Association between SAP and FynT: Inducible SH3 Domain-Mediated Interaction Controlled by Engagement of the SLAM Receptor

  2006cites this paper
• SAP Is Required for Th Cell Function and for Immunity to Influenza1

  2006cites this paper
• SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

  2006cites this paper
• Independent of SLAM and Fyn Kinase Cell Development and Humoral Immunity Is SAP Regulation of Follicular Helper CD4 T

  2006cites this paper
• Signaling Lymphocyte Activation Molecule-Associated Protein Is a Negative Regulator of the CD8 T Cell Response in Mice1

  2005cites this paper
• Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap.

  2005influential citation
• Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

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• Defective B cell responses in the absence of SH2D1A.

  2005cites this paper
• Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn

  2005cites this paper
• Molecular and cellular pathogenesis of X‐linked lymphoproliferative disease

  2005cites this paper
• Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.

  2005cites this paper
• Regulation of NKT cell development by SAP, the protein defective in XLP

  2005cites this paper
• Gammaherpesvirus Infection T Cells in Latent + Memory CD 8 IL-15-Independent Proliferative Renewal of J . Usherwood

  2004cites this paper
• X-linked immunodeficiencies

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• SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.

  2004cites this paper
• Wild-type p53 activates SAP expression in lymphoid cells

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• The SAP family of adaptors in immune regulation.

  2004cites this paper
• The X-linked lymphoproliferative syndrome: molecular and cellular basis of the disease

  2004cites this paper
• SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

  2004cites this paper
• Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.

  2004cites this paper