WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Tumor Biology

• Publication date

  2015-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13277-014-2696-0PMID 25293520
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• miR‐181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway

  2014cited by this paper
• Controversies in colorectal cancer: First line treatment with epidermal growth factor inhibitors and RAS in 2014

  2014cited by this paper
• MicroRNA-200c inhibits apoptosis in pituitary adenoma cells by targeting the PTEN/Akt signaling pathway.

  2014cited by this paper
• Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53.

  2014cited by this paper
• SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

  2014cited by this paper
• WWP1 gene is a potential molecular target of human oral cancer.

  2013cited by this paper
• Decreased Expression of Transcription Elongation Factor A-Like 7 Is Associated with Gastric Adenocarcinoma Prognosis

  2013cited by this paper
• WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer Cells

  2013cited by this paper
• Target protein for Xklp2 (TPX2), a microtubule-related protein, contributes to malignant phenotype in bladder carcinoma

  2013cited by this paper
• Gastric cancer epidemiology and risk factors

  2013cited by this paper
• Increased levels of SLP-2 correlate with poor prognosis in gastric cancer

  2013cited by this paper
• Gastric carcinogenesis.

  2012cited by this paper
• Clinical Implication of Elevated Human Cervical Cancer Oncogene-1 Expression in Esophageal Squamous Cell Carcinoma

  2012cited by this paper
• WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27Kip1 Degradation in Human Diploid Fibroblasts*

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• WWP1: a versatile ubiquitin E3 ligase in signaling and diseases

  2011cited by this paper
• Gastric Cancer: Epidemiology and Risk Factors

  2010cited by this paper
• The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages.

  2010cited by this paper
• Overexpression of Pim‐1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma

  2010cited by this paper
• WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

  2009cited by this paper
• Targeting Gastric Cancer with Trastuzumab: New Clinical Practice and Innovative Developments to Overcome Resistance

  2009cited by this paper
• An activated Notch1 signaling pathway inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma cell line EC9706.

  2008cited by this paper
• WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis

  2008cited by this paper
• Editorial [Hot Topic: Akt Pathway in Oncogenesis and as a Target for Anti-Cancer Therapy (Guest Editor: Jin Q. Cheng) ]

  2008cited by this paper
• Tumour‐promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator

  2008cited by this paper
• Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery.

  2008cited by this paper
• The HECT family of E3 ubiquitin ligases: multiple players in cancer development.

  2008cited by this paper
• The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

  2008cited by this paper
• Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas

  2007cited by this paper
• Ubiquitination regulates PTEN nuclear import and tumor suppression.

  2007cited by this paper
• NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

  2007cited by this paper
• Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer

  2007cited by this paper
• The Nedd4-like family of E3 ubiquitin ligases and cancer

  2007cited by this paper
• The amplified WWP1 gene is a potential molecular target in breast cancer

  2007cited by this paper
• Gene Expression Profiles Identify Epithelial-to-Mesenchymal Transition and Activation of Nuclear Factor-κB Signaling as Characteristics of a High-risk Head and Neck Squamous Cell Carcinoma

  2006cited by this paper
• Proteomic signatures corresponding to histological classification and grading of soft‐tissue sarcomas

  2006cited by this paper
• Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma.

  2006cited by this paper
• Global Cancer Statistics, 2002

  2005cited by this paper
• Explaining gastric cancer survival differences among European countries

  2004cited by this paper
• The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

  2004cited by this paper
• Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

  2004cited by this paper
• PI3K/PTEN/Akt Pathway

  2004cited by this paper
• Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

  2004cited by this paper
• Negative regulation of transforming growth factor-β (TGF-β) signaling by WW domain-containing protein 1 (WWP1)

  2004cited by this paper
• PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling.

  2003cited by this paper
• Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.

  2003cited by this paper
• Zinc-induced PTEN Protein Degradation through the Proteasome Pathway in Human Airway Epithelial Cells*

  2003cited by this paper
• Increased Expression of Interleukin‐9, Interleukin‐9 Receptor, and the Calcium‐Activated Chloride Channel hCLCA1 in the Upper Airways of Patients With Cystic Fibrosis

  2003cited by this paper
• Differential expression and localisation of WWP1, a Nedd4-like protein, in epithelia

  2003cited by this paper
• Amplification and Overexpression of Elongin C Gene Discovered in Prostate Cancer by cDNA Microarrays

  2002cited by this paper
• Time Trend Analysis of Gastric Cancer Incidence in Japan by Histological Types,1975-1989

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Time trend analysis of gastric cancer incidence in Japan by histological types, 1975-1989

  2001cited by this paper
• The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma

  2000cited by this paper
• A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

  1995cited by this paper

• WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer

  2025cites this paper
• A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins

  2025cites this paper
• Portrait of WWP1: the current state in human cancer

  2025cites this paper
• CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer

  2024cites this paper
• Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells

  2024cites this paper
• Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer

  2023cites this paper
• WWP1 E3 ligase at the crossroads of health and disease

  2023influential citation
• NEDD4 E3 ubiquitin ligases: promising biomarkers and therapeutic targets for cancer.

  2023cites this paper
• UPS: Opportunities and challenges for gastric cancer treatment

  2023cites this paper
• The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives

  2023cites this paper
• Ubiquitination/de-ubiquitination: A promising therapeutic target for PTEN reactivation in cancer.

  2022cites this paper
• E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression

  2021cites this paper
• High Expression of WWP1 Associates with Tumor Progression in Papillary Thyroid Cancer

  2021cites this paper
• The emerging role of WWP1 in cancer development and progression

  2021influential citation
• The HECT family of E3 ubiquitin ligases and PTEN.

  2021cites this paper
• Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance

  2021cites this paper
• WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.

  2020cites this paper
• Functional role of WW domain‐containing proteins in tumor biology and diseases: Insight into the role in ubiquitin‐proteasome system

  2020cites this paper
• Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer.

  2020cites this paper
• Functional roles of E3 ubiquitin ligases in gastric cancer

  2020cites this paper
• Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

  2020cites this paper
• WWP1在慢性淋巴细胞白血病中的异常表达及临床意义

  2020cites this paper
• Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers

  2020cites this paper
• The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

  2019cites this paper
• Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1

  2018cites this paper
• High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer.

  2018cites this paper
• The polycomb group protein EZH2 induces epithelial–mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter

  2018cites this paper
• miR‐129‐5p and ‐3p co‐target WWP1 to suppress gastric cancer proliferation and migration

  2018cites this paper
• WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway

  2018influential citation
• Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer

  2017cites this paper
• Cross‐Tissue Identification of Somatic Stem and Progenitor Cells Using a Single‐Cell RNA‐Sequencing Derived Gene Signature

  2017cites this paper
• The importance of regulatory ubiquitination in cancer and metastasis

  2017cites this paper
• E3 ubiquitin ligases in cancer and implications for therapies

  2017cites this paper
• The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia

  2017cites this paper
• Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer.

  2016cites this paper
• Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway.

  2016cites this paper
• Crosstalk between Meg 3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN / PI 3 K / AKT pathway

  2016cites this paper
• Overexpression of WWP1 Promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma

  2015cites this paper
• Molecular functions of NEDD4 E3 ubiquitin ligases in cancer.

  2015cites this paper
• Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.

  2015cites this paper
• FOXM1 and its Oncogenic Signaling in Gastric Cancer.

  2015cites this paper