TRIM8/GERP RING Finger Protein Interacts with SOCS-1*

Members of the suppressor of cytokine signaling (SOCS) family of signaling molecules regulate the activation of cytokine signaling. Experimental evidence indicates that SOCS expression is induced by cytokines and pro-inflammatory stimuli and is controlled at both the transcriptional and post-transcriptional levels. SOCS proteins are unstable and seem to be rapidly degraded by proteasomal pathways. However, the mechanisms by which SOCS protein levels are regulated remain unclear. Here, we show that TRIM8/GERP, a RING finger protein, interacts with SOCS-1 in vitro andin vivo. TRIM8/GERP, previously identified as a new member of the family of proteins containing a tripartite motif (TRIM), is a 551-amino acid RING finger protein conserved across species. TRIM8/GERP expression can be induced by interferon-γ in epithelial and lymphoid cells. Coexpression of TRIM8/GERP with SOCS-1 decreases SOCS-1 protein stability and levels. Functionally, expression of TRIM8/GERP decreases the repression of interferon-γ signaling mediated by SOCS-1. These data suggest that TRIM8/GERP may be a regulator of SOCS-1 function.

• Publication year

  2002

• Venue

  Journal of Biological Chemistry

• Publication date

  2002-10-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M205900200PMID 12163497
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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• IL-4/IL-13 signaling beyond JAK/STAT.

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• Regulation of SOCS-1 Expression by Translational Repression*

  2000cited by this paper
• Leukemia-inhibitory factor-neuroimmune modulator of endocrine function.

  2000cited by this paper
• Negative regulation of cytokine signaling pathways.

  2000cited by this paper
• The Janus Kinase Inhibitor, JAB/SOCS-1, Is an Interferon-γ Inducible Gene and Determines the Sensitivity to Interferons

  2000cited by this paper
• A novel RING finger-B box-coiled-coil protein, GERP.

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• Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.

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• Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame.

  2000cited by this paper
• Differential inhibition of IL‐6‐type cytokine‐induced STAT activation by PMA

  2000cited by this paper
• Signaling and transcription in T helper development.

  2000cited by this paper
• SOCS proteins, regulators of intracellular signaling.

  2000cited by this paper
• The janus kinase inhibitor, Jab/SOCS-1, is an interferon-gamma inducible gene and determines the sensitivity to interferons.

  2000cited by this paper
• SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.

  1999cited by this paper
• SOCS3 is essential in the regulation of fetal liver erythropoiesis.

  1999cited by this paper
• Negative regulation of cytokine signaling: STAT-induced STAT inhibitor.

  1999cited by this paper
• Shp-2 tyrosine phosphatase: signaling one cell or many.

  1999cited by this paper
• Janus kinases and their role in growth and disease.

  1999cited by this paper
• One Ring to Rule a Superfamily of E3 Ubiquitin Ligases

  1999cited by this paper
• The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.

  1999cited by this paper
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  1999cited by this paper
• The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling.

  1999cited by this paper
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• The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

  1999cited by this paper
• The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

  1998cited by this paper
• Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.

  1998cited by this paper
• The SOCS proteins: a new family of negative regulators of signal transduction

  1998cited by this paper
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  1996cited by this paper
• The RING finger domain: a recent example of a sequence-structure family.

  1996cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1988cited by this paper
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• Human TRIM Gene Expression in Response to Interferons

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• Clinical characteristics and pathophysiologic features of growth restriction, insulin resistance and tumour development

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