Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  International journal of pharmaceutics

• Publication date

  1999-07-20

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/S0378-5173(99)00119-2PMID 10387948
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method.

  1999cited by this paper
• Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels.

  1998cited by this paper
• Diffusion studies of methotrexate in Carbopol and Poloxamer gels

  1998cited by this paper
• In vitro evaluation of pluronic F127-based controlled-release ocular delivery systems for pilocarpine.

  1998cited by this paper
• Rheological evaluation of poloxamer as an in situ gel for ophthalmic use.

  1998cited by this paper
• Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel

  1998cited by this paper
• Preparation and Characterization of Polylactic Acid Microspheres Containing Water-Soluble Anesthetics with Small Molecular Weight.

  1997cited by this paper
• Percutaneous absorption and histopathology of a poloxamer-based formulation of capsaicin analog

  1997cited by this paper
• Drug delivery matrix containing native protein precipitates suspended in a poloxamer gel.

  1997cited by this paper
• Pharmacokinetic and local tissue disposition studies of naproxen following topical and systemic administration in dogs and rats

  1997cited by this paper
• Pharmacokinetic Considerations of New Insulin Formulations and Routes of Administration

  1997cited by this paper
• Varying effects of cyclodextrin derivatives on aggregation and thermal behavior of insulin in aqueous solution.

  1997cited by this paper
• Controlled release of human growth hormone in rats following parenteral administration of poloxamer gels

  1997cited by this paper
• Controlled release of human growth hormone following subcutaneous administration in dogs

  1997cited by this paper
• Preparation and evaluation of insulin-loaded poly(dl-lactide) microspheres using an experimental design

  1996cited by this paper
• Loss of gelation ability of Pluronic® F127 in the presence of some salts

  1996cited by this paper
• Optimized preparation of poly d,l (lactic-glycolic) microspheres and nanoparticles for oral administration

  1996cited by this paper
• Sustained-release interleukin-2 following intramuscular injection in rats

  1995cited by this paper
• Controlled Release of Lidocaine from Injectable Gels and Efficacy in Rat Sciatic Nerve Block

  1995cited by this paper
• Percutaneous Absorption of Indomethacin from Pluronic F127 Gels in Rats

  1995cited by this paper
• Indomethacin-loaded poly (d,l-lactide) nanocapsules protection from gastrointestinal ulcerations and anti-inflammatory activity evaluation in rats

  1993cited by this paper
• Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in Mice

  1992cited by this paper
• Polyoxyethylene-polyoxypropylene block copolymer gels as sustained release vehicles for subcutaneous drug administration

  1992influential reference
• Biological activity of urease formulated in poloxamer 407 after intraperitoneal injection in the rat.

  1992cited by this paper
• Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

  1991cited by this paper
• The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution

  1990cited by this paper
• Enhancement of therapeutic effects of recombinant interleukin 2 on a transplantable rat fibrosarcoma by the use of a sustained release vehicle, pluronic gel.

  1987cited by this paper
• The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery

  1987cited by this paper
• Pluronic F-127 gels as a novel vehicle for rectal administration of indomethacin.

  1986cited by this paper
• Aggregation of Insulin, Containing Surfactants, in Contact with Different Materials

  1985cited by this paper
• Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits

  1982cited by this paper
• In vitro release of lidocaine from pluronic F-127 gels

  1981cited by this paper
• Artificial skin. I. Preparation and properties of pluronic F-127 gels for treatment of burns.

  1972cited by this paper

• Preparation of poloxamer-based CPV virus-like particle vaccine and its immunological evaluation in mice.

  2026cites this paper
• Engineering Extended Release Profiles for Biologic Formulations via Chemical Cross-Linking of Poloxamer 407 Hydrogels

  2025cites this paper
• Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes.

  2024cites this paper
• Thermo-Responsive Hydrogel Containing Microfluidic Chitosan Nanoparticles Loaded with Opuntia ficus-indica Extract for Periodontitis Treatment

  2024cites this paper
• Injectable Systems for Long-lasting Insulin Therapy.

  2023cites this paper
• Exploring drug repositioning for leishmaniasis treatment: Ivermectin plus polymeric micelles induce immunological response and protection against tegumentary leishmaniasis.

  2023cites this paper
• Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy

  2023cites this paper
• Contemporary Applications of thermogelling PEO-PPO-PEO triblock copolymers

  2022cites this paper
• Recent progress in polymeric non-invasive insulin delivery.

  2022cites this paper
• Parasitological and immunological evaluation of a quinoline derivative salt incorporated into a polymeric micelle formulation against Leishmania infantum infection

  2022cites this paper
• Micellar solubilization of Lavender oil in aqueous P85/P123 systems: Investigating the associated micellar structural transitions, therapeutic properties and existence of double cloud points

  2021cites this paper
• Flau-A, a naphthoquinone derivative, is a promising therapeutic candidate against visceral leishmaniasis: A preliminary study.

  2021cites this paper
• Development of In Situ Gelling Meloxicam-Human Serum Albumin Nanoparticle Formulation for Nose-to-Brain Application

  2021cites this paper
• Unusual Growth and Hydration Characteristics of Oil Solubilized Micelles in Aqueous Pluronic Systems.

  2021cites this paper
• Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment

  2021cites this paper
• Insulin therapy development beyond 100 years.

  2021cites this paper
• (Macro)molecular self-assembly for hydrogel drug delivery.

  2021cites this paper
• Pluronic F127-tailored lecithin organogel of acyclovir: preclinical evidence of antiviral activity using BALB/c murine model of cutaneous HSV-1 infection

  2021cites this paper
• Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches

  2020influential citation
• A clioquinol-containing Pluronic® F127 polymeric micelle system is effective in the treatment of visceral leishmaniasis in a murine model

  2020cites this paper
• Motor and sensitive recovery after injection of a physically cross-linked PNIPAAm-g-PEG hydrogel in rat hemisectioned spinal cord.

  2020cites this paper
• Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo.

  2020cites this paper
• Structural and therapeutic properties of curcumin solubilized pluronic F127 micellar solutions and hydrogels

  2020cites this paper
• In situ Nasal Gel of Granisetron for Enhancement of Bioavailability over Oral Delivery: Formulation, Optimization, and In vivo Evaluation

  2020cites this paper
• Development and evaluation of a lyophilized product containing insulin

  2020cites this paper
• Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium

  2020cites this paper
• Pluronic® F127-mediated control of insulin release rates from NPH microcrystals and blood glucose depression in STZ-induced diabetic rats

  2020cites this paper
• Insulin Release from NPH Insulin-Loaded Pluronic® F127 Hydrogel in the Presence of Simulated Tissue Enzyme Activity

  2020cites this paper
• Injectable Systems for Long-Lasting Insulin Therapy

  2019cites this paper
• Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA/P407 hydrogel system for drug delivery

  2019cites this paper
• Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development.

  2019cites this paper
• Advances in Therapeutics and Delayed Drug Release.

  2019cites this paper
• Modifying the Properties of Thermogelling Poloxamer 407 Solutions through Covalent Modification and the Use of Polymer Additives

  2019cites this paper
• In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection.

  2019cites this paper
• Thermosensitive nanocomposite gel for intra‐tumoral two‐photon photodynamic therapy

  2019cites this paper
• Comparing the therapeutic efficacy of different amphotericin B-carrying delivery systems against visceral leishmaniasis.

  2018cites this paper
• Preparation and Characterization

  2018cites this paper
• Recent Progress in Smart Polymers: Behavior, Mechanistic Understanding and Application

  2018cites this paper
• Combination of coating and injectable hydrogel depot to improve the sustained delivery of insulin

  2018cites this paper
• Design, optimization and pharmacodynamic comparison of dorzolamide hydrochloride soluble ocular drug insert prepared by using 3 2 factorial design

  2018cites this paper
• Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis).

  2017cites this paper
• Stimuli-Responsive Materials

  2017cites this paper
• Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices

  2017cites this paper
• Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

  2017cites this paper
• In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent.

  2017cites this paper
• Advances in pH-Sensitive Polymers for Smart Insulin Delivery.

  2017cites this paper
• Formulation and characterization of intra nasal delivery of nortriptyline hydrochloride thermoreversible gelling system in treatment of depression

  2017cites this paper
• Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy

  2017cites this paper
• Preparation and evaluation of flutamide mucoadhesive microparticles loaded poloxamer suppositories

  2016cites this paper
• Effects of temperature-responsive hydrogel on viscosity of denture adhesives.

  2016cites this paper
• Intestinal permeation enhancers for oral peptide delivery.

  2016cites this paper
• Synthesis, characterisation, and diffusive properties of functionalised nanomaterials

  2016cites this paper
• A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

  2016cites this paper
• Nanobiomaterials: Novel nanoplatforms for protein and peptide delivery

  2016cites this paper
• Influence of hydroxypropylmethylcellulose and poloxamer composite on developed ophthalmic in situ gel: Ex vivo and in vivo characterization

  2016cites this paper
• Pharmacology and antinociception of a sustained-released butorphanol – poloxamer 407 formulation in Amazon parrots

  2016cites this paper
• Poloxamer 407 (Pluronic(®) F127)-based polymeric micelles for amphotericin B: In vitro biological activity, toxicity and in vivo therapeutic efficacy against murine tegumentary leishmaniasis.

  2016cites this paper
• Evaluation of buprenorphine hydrochloride Pluronic® gel formulation in male C57BL/6NCrl mice

  2016cites this paper
• Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo.

  2016cites this paper
• In vitro efficacy of anti-protozoal compounds against Tritrichomonas foetus

  2016cites this paper
• Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer

  2016cites this paper
• Treatment of murine visceral leishmaniasis using an 8-hydroxyquinoline-containing polymeric micelle system.

  2016cites this paper
• An 8-hydroxyquinoline-containing polymeric micelle system is effective for the treatment of murine tegumentary leishmaniasis

  2016cites this paper
• Relevant Aspects on Peptide Delivery from Nanostructured Therapeutic Systems

  2016cites this paper
• PLA micro- and nano-particles.

  2016cites this paper
• Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs

  2016cites this paper
• State-of-art on gel technologies for transdermal delivery of bacitracin

  2016cites this paper
• Inhalable nanocomposite microparticles: preparation, characterization and factors affecting formulation

  2016cites this paper
• Nod-Like Receptor Protein-3 Inflammasome Plays an Important Role during Early Stages of Wound Healing

  2015cites this paper
• Preparation of a Thermosensitive Gel Composed of a mPEG-PLGA-PLL-cRGD Nanodrug Delivery System for Pancreatic Tumor Therapy.

  2015cites this paper
• Three dimensional study of wounded plant roots recruiting entomopathogenic nematodes with Pluronic gel as a medium

  2015cites this paper
• Polymer Nanocomposites Based Thermo-Sensitive Gel for Paclitaxel and Temozolomide Co-Delivery to Glioblastoma Cells.

  2015cites this paper
• Synthesis of hybrid polymer blend nanoparticles and incorporation into in situ gel foam spray for controlled release therapy using a versatile synthetic purine nucleoside analogue antiviral drug

  2015cites this paper
• Chitosan and Pluronic® F-127: Pharmaceutical Applications

  2015cites this paper
• Natural and Synthetic Polymers as Drug Carriers for Delivery of Therapeutic Proteins

  2015cites this paper
• In situ-hardening hydrogels for the sustained release of protein pharmaceutics

  2015cites this paper
• Development and preclinical pharmacokinetics of a novel subcutaneous thermoresponsive system for prolonged delivery of heparin.

  2015cites this paper
• Prevention of Neointimal Hyperplasia by Local Application of Lentiviral Vectors Encoding Pin1 shRNA in Pluronic F127.

  2015cites this paper
• Development of an insect metalloproteinase inhibitor drug carrier system for application in chronic wound infections

  2015influential citation
• In‐Situ Gelling Thermosensitive Hydrogels for Protein Delivery Applications

  2015cites this paper
• Poloxamer-based in situ hydrogels for controlled delivery of hydrophilic macromolecules after intramuscular injection in rats

  2015influential citation
• Reduction of the in vivo burst release of insulin-loaded microparticles

  2015cites this paper
• An overview of injectable polymeric hydrogels for tissue engineering

  2015cites this paper
• Formulation and evaluation of novel reverse microemulsions containing salmon calcitonin in hydrofluoroalkane propellants.

  2014cites this paper
• Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist

  2014cites this paper
• Evolution of Antimicrobial Peptides to Self-Assembled Peptides for Biomaterial Applications

  2014cites this paper
• A novel approach of gastroretentive drug delivery : in situ gel

  2014cites this paper
• Application and progress in the materials for drug controlled release

  2014influential citation
• Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

  2014cites this paper
• Development and evaluation of in situ gelling system for treatment of periodontitis

  2014cites this paper
• Development and evaluation of pluronic- and methylcellulose-based thermoreversible drug delivery system for insulin

  2014cites this paper
• Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.

  2014influential citation
• Thermoresponsive polymers: insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications.

  2014cites this paper
• Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity.

  2014cites this paper
• Polyethylene glycol (PEG)-Poly(N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications.

  2014cites this paper
• Pluronic F127-Based Thermosensitive Gels for Delivery of Therapeutic Proteins and Peptides

  2014cites this paper
• A combined micelle and poly(serinol hexamethylene urea)-co-poly(N-isopropylacrylamide) reverse thermal gel as an injectable ocular drug delivery system.

  2014cites this paper
• Dual sustained release delivery system for multiple route therapy of an antiviral drug

  2014cites this paper
• A Review on Triggered Gel for Ocular Drug Delivery

  2014cites this paper
• Preparation and in vitro/in vivo evaluation of mucosal adjuvant in situ forming gels with diphtheria toxoid

  2014cites this paper