Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study

Nien-Chu Shih,N. Kurniawan,R. Cabeen,L. Korobkova,E. Wong,H. Chui,K. Clark,C. Miller,D. Hawes,Kymry T. Jones,F. Sepehrband

Published 2023 in NeuroImage: Clinical

ABSTRACT

Highlights • Layer specific quantitative MRI (qMRI) estimates of dentate gyrus in AD are reported.• T2, R2, and SWI values were significantly correlated with neurofilament.• T2, R2, and SWI values were significantly correlated with neurofibrillary tangle.• High-resolution qMRI has clinical utility given the pathological specificity.

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