Mixed brain pathologies account for most dementia cases in community-dwelling older persons

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Neurology

• Publication date

  2007-12-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1212/01.wnl.0000271090.28148.24PMID 17568013
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuropathological evaluation of mixed dementia.

  2007cited by this paper
• Neuropathology of older persons without cognitive impairment from two community-based studies

  2006cited by this paper
• Recent Clinical-Pathologic Research on the Causes of Dementia in Late Life: Update From the Honolulu-Asia Aging Study

  2005cited by this paper
• Early and late life cognitive activity and cognitive systems in old age

  2005cited by this paper
• The Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study Cohort

  2005cited by this paper
• Classification of vascular dementia in the Cardiovascular Health Study Cognition Study

  2005cited by this paper
• AD lesions and infarcts in demented and non‐demented Japanese‐American men

  2005cited by this paper
• Diagnosis and management of dementia with Lewy bodies

  2005cited by this paper
• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• Mixed dementia: emerging concepts and therapeutic implications.

  2004cited by this paper
• Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology

  2004cited by this paper
• Vascular pathologies and cognition in a population-based cohort of elderly people.

  2004cited by this paper
• The age gap between patients in clinical studies and in the general population: a pitfall for dementia research.

  2004cited by this paper
• Efficacy and Tolerability of Donepezil in Vascular Dementia: Positive Results of a 24-Week, Multicenter, International, Randomized, Placebo-Controlled Clinical Trial

  2003cited by this paper
• Vascular dementia in a population-based autopsy study.

  2003cited by this paper
• Donepezil in vascular dementia

  2003cited by this paper
• Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study

  2003cited by this paper
• Incidence, Manifestations, and Predictors of Brain Infarcts Defined by Serial Cranial Magnetic Resonance Imaging in the Elderly: The Cardiovascular Health Study

  2002cited by this paper
• The prevalence of frontotemporal dementia

  2002cited by this paper
• Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial.

  2002cited by this paper
• Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

  2002cited by this paper
• Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales

  2001cited by this paper
• α‐Synuclein pathology is highly dependent on the case selection

  2001cited by this paper
• Neuropathologic Substrates of Ischemic Vascular Dementia

  2000cited by this paper
• Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease.

  1999cited by this paper
• Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study.

  1998cited by this paper
• Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease.

  1997cited by this paper
• Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.

  1997cited by this paper
• Clinical-neuropathologic findings in multi-infarct dementia

  1997cited by this paper
• The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology Confirmation of the Clinical Diagnosis of Alzheimer's Disease

  1995cited by this paper
• The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery

  1994cited by this paper
• Opportunities and Challenges in International Collaborative Epidemiologic Research of Dementia and Its Subtypes: Studies Between Japan and the U.S.

  1994cited by this paper
• Frontal lobe degeneration of non‐Alzheimer type

  1992cited by this paper
• The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

  1991cited by this paper
• Clinical diagnosis of Alzheimer's disease

  1984cited by this paper

• Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

  2026cites this paper
• Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and hippocampal neuron loss.

  2026cites this paper
• Decoding Alzheimer's Disease One Cell Class at a Time

  2026cites this paper
• Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort

  2026cites this paper
• Value of Diet and Nutraceuticals in the Prevention and Treatment of Mixed Alzheimer’s Disease and Vascular Dementia

  2026cites this paper
• Subtyping Alzheimer's disease and Parkinson's disease using longitudinal electronic health records.

  2026cites this paper
• The 2024 NIA-AA biological definition of Alzheimer's disease: linking biomarkers to clinical practice.

  2026influential citation
• Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

  2026cites this paper
• Associations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study

  2026cites this paper
• Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias.

  2026cites this paper
• Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample.

  2026cites this paper
• Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults

  2026cites this paper
• Microglial, astrocytic, oligodendrocyte, B-/T-cell and neutrophil dysregulation in neuroinflammation of Alzheimer's disease and related dementias.

  2026cites this paper
• Associations of Lifetime Cognitive Enrichment With Incident Alzheimer Disease Dementia, Cognitive Aging, and Cognitive Resilience.

  2026cites this paper
• Heterogeneous patterns of cognitive decline in Alzheimer's disease across three domains of cognition

  2026cites this paper
• ReCOGnAIze app to detect vascular cognitive impairment and mild cognitive impairment

  2026cites this paper
• Neuropsychiatric Symptoms in Patients With Pathologically Confirmed Comorbid Alzheimer Disease and Frontotemporal Lobar Degeneration.

  2026cites this paper
• Chemokines CXCL9 and CCL2 in Relation to Cerebral White Matter Disease, Cognitive Decline, and Dementia: The Northern Manhattan Study.

  2026cites this paper
• Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain Injury

  2026cites this paper
• Clinical characterization of probable Dementia with Lewy Bodies based on the initial clinical presentation in a Latin American Low- and Middle- Income Country.

  2026cites this paper
• Vascular dementia: World Stroke Organization fact sheet 2026

  2026cites this paper
• Treating Hearing Loss With Hearing Aids for the Prevention of Cognitive Decline and Dementia.

  2026cites this paper
• Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneity

  2025cites this paper
• Understanding the Silent Threat: A Review to Neurodegenerative Disorders

  2025cites this paper
• Augmenting radiological assessment of imaging evident dementias with radiomic analysis

  2025cites this paper
• Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

  2025cites this paper
• Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s disease

  2025cites this paper
• Comparative cortical transcriptomic profiling of Alzheimer's disease, vascular dementia and mixed dementia

  2025cites this paper
• Differential dementia risks of motoric cognitive risk syndrome and mild cognitive impairment among older adults in China: a 7-year cohort study

  2025cites this paper
• The pathophysiology of mixed Alzheimer's disease and vascular dementia

  2025cites this paper
• MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults

  2025cites this paper
• Expanding the Biomarkers Toolbox for Diagnosis of Vascular Cognitive Impairment and Dementia.

  2025cites this paper
• Psychiatry meets neurodegeneration – A collaborative approach to dementia prevention

  2025cites this paper
• Ante-mortem cognitive trajectories associated with Aβ and tau biomarker profiles in older adults with cerebrovascular disease: a longitudinal cohort study

  2025cites this paper
• Integration of Neuroimaging and Molecular Biomarkers in the Diagnosis of Alzheimer's Disease and Frontotemporal Dementia: The Promise of fMRI.

  2025cites this paper
• Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization.

  2025cites this paper
• Expert Guidance on Cognitive Impairment in Alzheimer's Disease: A Practical Seven-Step Approach from the United Arab Emirates

  2025cites this paper
• Cytokine expression profile in the human brain of older adults

  2025cites this paper
• Warfarin treatment is associated with lower post-mortem brain vitamin K concentrations in older adults.

  2025cites this paper
• A Review on Modifiable Risk Factors and Preventive Measures in Alzheimer's Disease

  2025cites this paper
• Single‐cell landscape of sex‐specific drivers of Alzheimer's disease

  2025cites this paper
• Brain microRNAs differentially expressed in age-related cerebral pathologies.

  2025cites this paper
• Cerebrovascular Pathology and Cognitive Outcomes in Older Black Decedents.

  2025cites this paper
• Antiamyloid Monoclonal Antibodies in Alzheimer's Disease, Part 1: Patient Selection.

  2025cites this paper
• Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to Aβ deposition and lysyl oxidase

  2025cites this paper
• Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution

  2025cites this paper
• A Fast Screen System for Dementia Based on EEG Signals

  2025cites this paper
• Human brain vascular multi-omics elucidates disease-risk associations.

  2025cites this paper
• Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.

  2025cites this paper
• Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience

  2025cites this paper
• Identifying dementia neuropathology using low‐burden clinical data

  2025cites this paper
• Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies

  2025cites this paper
• Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association.

  2025cites this paper
• Mixed Pathologies and Cognitive Outcomes in Persons Considered for Anti-Amyloid Treatment Eligibility Assessment: A Community-Based Study.

  2025cites this paper
• Cardiovascular Disease as a Predictor of Dementia: A Cross‐National Ecological Study of 204 Countries

  2025cites this paper
• Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans

  2025cites this paper
• Cerebrovascular remodeling in aging and neurodegenerative disease progression

  2025cites this paper
• Plasma proteomic associations with Alzheimer’s disease endophenotypes

  2025cites this paper
• Aging, Alzheimer's disease, and stroke: A 25-year longitudinal analysis of U.S. mortality trends

  2025cites this paper
• The Interplay of Inflammation and Gut-Microbiota Dysbiosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential

  2025cites this paper
• Contribution of sleep disturbances to cognitive changes in vascular cognitive impairment.

  2025cites this paper
• Micro infarcts are associated with cognitive impairment in neurofibrillary tangle predominant decedents: evidence from the NACC autopsy cohort

  2025cites this paper
• Combining GWAS Summary Data and Proteomics Identified Potential Drug Targets in Dementia

  2025cites this paper
• Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community

  2025cites this paper
• The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center

  2025cites this paper
• Cut‐points and gray zones: The challenges of integrating Alzheimer's disease plasma biomarkers into clinical practice

  2025cites this paper
• Cardiovascular disease and dementia - from association to causality?

  2025cites this paper
• Phenotypes of white matter hyperintensities, mechanisms and aetiological differentiation: future targets pre-dementia—a systematic review

  2025cites this paper
• The Transdiagnostic Value of Plasma Biomarkers for Neurodegenerative and Cerebrovascular MRI Findings.

  2025cites this paper
• Sex differences in age-associated neurological diseases—A roadmap for reliable and high-yield research

  2025cites this paper
• Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases

  2025cites this paper
• Distinct Characteristics of Suspected Non-Alzheimer Pathophysiology in Relation to Cognitive Status and Cerebrovascular Burden

  2025cites this paper
• Effect Modifiers of the Association of Blood Pressure With Brain Amyloid and Tau Pathology

  2025cites this paper
• White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy.

  2025cites this paper
• Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome

  2025cites this paper
• Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification

  2025cites this paper
• Molecular and cellular signatures differentiate Parkinson’s disease from Parkinson’s disease with dementia

  2025cites this paper
• The night's watch: Exploring how sleep protects against neurodegeneration.

  2025cites this paper
• Global, Regional, and National Burden of Early‐Onset Alzheimer's Disease and Other Dementias in Young Adults Aged 40–64 Years, 1990–2021: A Population‐Based Study

  2025cites this paper
• How Low Can You Go? Flagging a Role for Hypotension in Cognitive Decline With Intensive Blood Pressure Therapy.

  2025cites this paper
• Interactive effects of APOE ɛ4 status and vascular burden on white matter microstructural integrity in aging with and without neurocognitive decline

  2025cites this paper
• Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults

  2025cites this paper
• Combination therapy targeting Alzheimer's disease risk factors is associated with a significant delay in Alzheimer's disease–related cognitive decline

  2025cites this paper
• Alpha‐Synuclein Demonstrates Varying Binding Affinities With Different Tau Isoforms

  2025cites this paper
• Neurodegenerative disease findings in Finnish neuropathologically examined medico-legal autopsy cases with acute head injuries.

  2025cites this paper
• Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groups

  2025cites this paper
• Dialysis and cognitive impairment

  2025cites this paper
• Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer’s disease

  2025cites this paper
• The temporal onset of associations of cortical proteins with cognitive resilience vary during late life

  2025cites this paper
• 2025 Alzheimer's disease facts and figures

  2025cites this paper
• Hippocampal subfields: volume, neuropathological vulnerability and cognitive decline in Alzheimer’s and Parkinson’s disease

  2025cites this paper
• High-Throughput Phenotyping of the Symptoms of Alzheimer Disease and Related Dementias Using Large Language Models: Cross-Sectional Study

  2025cites this paper
• LC‐MS/MS proteomics identifies plasma proteins related to cognition over 9‐year follow‐up

  2025cites this paper
• Neuropathologic correlates of distinct plasma biomarker profiles in community-living older adults.

  2025cites this paper
• Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study

  2025cites this paper
• Looking into Abnormal Co-Expressions of Tau and TDP-43 in the Realm of Mixed Dementia Types: A Double-Punch Scenario

  2025cites this paper
• 2988Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores.

  2025cites this paper
• Microinfarcts are Associated with Cognitive Impairment in Neurofibrillary Tangle Predominant Decedents: Evidence from the NACC Autopsy Cohort

  2025cites this paper
• Temporal sequence of amyloid and tau PET positivity: APOE-ϵ4 and sex effects, and implications for Alzheimer's disease progression

  2025cites this paper
• Role of tau versus TDP‐43 pathology on medial temporal lobe atrophy in aging and Alzheimer's disease

  2025cites this paper