Solid-phase capture and profiling of open chromatin by spatial ATAC

Current methods for epigenomic profiling are limited in their ability to obtain genome-wide information with spatial resolution. We introduce spatial ATAC, a method that integrates transposase-accessible chromatin profiling in tissue sections with barcoded solid-phase capture to perform spatially resolved epigenomics. We show that spatial ATAC enables the discovery of the regulatory programs underlying spatial gene expression during mouse organogenesis, lineage differentiation and in human pathology. Chromatin accessibility profiles are spatially resolved in tissue sections.

• Publication year

  2023

• Venue

  Nature Biotechnology

• Publication date

  2023-01-05

• Fields of study

  Biology, Medicine, Materials Science

• Identifiers
  DOI 10.1038/s41587-022-01603-9PMID 36604544PMCID 10421738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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