Comparing the adult and pre‐pubertal testis: Metabolic transitions and the change in the spermatogonial stem cell metabolic microenvironment

Survivors of childhood cancer often suffer from infertility. While sperm cryopreservation is not feasible before puberty, the patient's own spermatogonial stem cells could serve as a germ cell reservoir, enabling these patients to father their own children in adulthood through the isolation, in vitro expansion, and subsequent transplantation of spermatogonial stem cells. However, this approach requires large numbers of stem cells, and methods for successfully propagating spermatogonial stem cells in the laboratory are yet to be established for higher mammals and humans. The improvement of spermatogonial stem cell culture requires deeper understanding of their metabolic requirements and the mechanisms that regulate metabolic homeostasis.

• Publication year

  2023

• Venue

  Andrology

• Publication date

  2023-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/andr.13397PMID 36690000PMCID PMC10363251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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