Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models

ABSTRACT Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an overview of the available human respiratory models and exposure systems for in vitro testing, advantages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.

• Publication year

  2023

• Venue

  Journal of Toxicology and Environmental Health. Part B, Critical Reviews

• Publication date

  2023-01-24

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1080/10937404.2023.2166638PMID 36692141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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