Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Free Radical Biology & Medicine

• Publication date

  2006-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.FREERADBIOMED.2006.06.022PMID 16962932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice.

  2005cited by this paper
• α-Tocopherol modulates Cyp3a expression, increases γ-CEHC production, and limits tissue γ-tocopherol accumulation in mice fed high γ-tocopherol diets

  2005cited by this paper
• Modulation of Cyp3a11 mRNA expression by α-tocopherol but not γ-tocotrienol in mice

  2005cited by this paper
• Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.D400044-JLR200

  2005cited by this paper
• Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.

  2005cited by this paper
• TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES

  2004cited by this paper
• Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.

  2004cited by this paper
• Enrichment of rat hepatic organelles by vitamin E administered subcutaneously.

  2004cited by this paper
• Vitamin E delivery to human skin: studies using deuterated α-tocopherol measured by APCI LC-MS

  2004cited by this paper
• Vitamin E delivery to human skin: studies using deuterated alpha-tocopherol measured by APCI LC-MS.

  2004cited by this paper
• Vitamin E Trafficking

  2004cited by this paper
• Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

  2004cited by this paper
• The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

  2004cited by this paper
• Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats.

  2004cited by this paper
• Transport Proteins and Intestinal Metabolism: P-Glycoprotein and Cytochrome P4503A

  2004cited by this paper
• Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier.

  2004cited by this paper
• The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

  2003cited by this paper
• Cytochromes P450, drugs, and diseases.

  2003cited by this paper
• Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR

  2003cited by this paper
• Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.

  2003cited by this paper
• Vitamin E activates gene expression via the pregnane X receptor.

  2003cited by this paper
• Incorporation of deuterated RRR- or all-rac-α-tocopherol in plasma and tissues of α-tocopherol transfer protein–null mice

  2002cited by this paper
• Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol.

  2002cited by this paper
• Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells.

  2002cited by this paper
• Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice.

  2002cited by this paper
• Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6β-hydroxycortisol in healthy volunteers

  2002cited by this paper
• Mammalian ABC transporters in health and disease.

  2002cited by this paper
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  2002cited by this paper
• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

  2002cited by this paper
• Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats.

  2002cited by this paper
• Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status.

  2002cited by this paper
• Tocopherols are metabolized in HepG2 cells by side chain ω-oxidation and consecutive β-oxidation

  2001cited by this paper
• Alpha-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2 (2'-carboxyethyl)-6-hydroxychroman, gamma-tocopherol metabolite, in rats.

  2001cited by this paper
• Antioxidant Supplements Block the Response of HDL to Simvastatin-Niacin Therapy in Patients With Coronary Artery Disease and Low HDL

  2001cited by this paper
• Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.

  2001cited by this paper
• Effect of peroxisome proliferator-activated receptor alpha activation on leukotriene B4 metabolism in isolated rat hepatocytes.

  2001cited by this paper
• Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation.

  2001cited by this paper
• α-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2(2′-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats

  2001cited by this paper
• St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4

  2000cited by this paper
• Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin.

  2000cited by this paper
• Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.

  2000cited by this paper
• Vitamin E: function and metabolism

  1999cited by this paper
• Grapefruit juice-drug interactions.

  1998cited by this paper
• Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.

  1998cited by this paper
• Biliary Secretion of α-Tocopherol and the Role of the mdr2 P-Glycoprotein in Rats and Mice

  1998cited by this paper
• Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat.

  1998cited by this paper
• Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.

  1998cited by this paper
• Biliary secretion of alpha-tocopherol and the role of the mdr2 P-glycoprotein in rats and mice.

  1998cited by this paper
• Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones.

  1996cited by this paper
• Colchicine and vinblastine prevent the piperonyl butoxide-induced increase in rat biliary output of alpha-tocopherol.

  1996cited by this paper
• Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

  1995cited by this paper
• Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin E deficiency.

  1993cited by this paper
• In vitro and in vivo studies of the effect of vitamin E on microsomal cytochrome P450 in rat liver.

  1991cited by this paper
• Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver.

  1990cited by this paper
• Influence of vitamin E supplementation on antipyring clearance in the cebus monkey

  1990cited by this paper
• Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats.

  1986cited by this paper
• Vitamin E deficiency in adults with chronic liver disease.

  1985cited by this paper
• Novel urinary metabolite of d-delta-tocopherol in rats.

  1984cited by this paper
• Mechanism causing vitamin E deficiency during chronic childhood cholestasis.

  1983cited by this paper
• Principles and methods of toxicology

  1982cited by this paper
• Obligatory role of bile for the intestinal absorption of vitamin E

  1970cited by this paper
• The metabolism of vitamin E. II. Purification and characterization of urinary metabolites of alpha-tocopherol.

  1956cited by this paper

• Transporters in vitamin uptake and cellular metabolism: impacts on health and disease

  2025cites this paper
• Asthma, allergy and vitamin E: Current and future perspectives.

  2021cites this paper
• Vitamin E research: Past, now and future.

  2021cites this paper
• A review on vitamin E natural analogues and on the design of synthetic vitamin E derivatives as cytoprotective agents.

  2020cites this paper
• Vitamin E: metabolism and molecular aspects

  2020cites this paper
• Negative association between antioxidant vitamin intake and non-alcoholic fatty liver disease in Chinese non-diabetic adults: mediation models involving superoxide dismutase

  2020cites this paper
• Vitamin E: nutritional aspects

  2020cites this paper
• Rifampicin, Not Vitamin E, Suppresses Parenteral Nutrition Associated Liver Disease Development through Pregnane X Receptor Pathway in Piglets.

  2019cites this paper
• Vitamin E in Human Health

  2019cites this paper
• Bioavailability and Metabolism of Vitamin E

  2019cites this paper
• The Impact of Vitamin E Isoforms on Asthma and Allergy

  2019cites this paper
• Interaction Between Vitamin E and Polyunsaturated Fatty Acids

  2019cites this paper
• Co-carcinogenic effects of vitamin E in prostate

  2019cites this paper
• Chapter 1 The Hepatic Fate of Vitamin E

  2019cites this paper
• Testosterone represses urinary excretion of the alpha-tocopherol metabolite alpha-carboxymethylhydroxychroman in rats.

  2018cites this paper
• Fat-Soluble Vitamins in Fish: A Transcriptional Tissue-Specific Crosstalk that Remains to be Unveiled and Characterized

  2018cites this paper
• Water-Soluble Vitamin E-Tocopheryl Phosphate.

  2018cites this paper
• The Hepatic Fate of Vitamin E The Hepatic Fate of Vitamin E

  2018cites this paper
• The Hepatic Fate of Vitamin E

  2018cites this paper
• Effect of Chronic Iron Overloading on Cardiovascular System in Adult Male Albino Rats = الحمل الزائد المزمن للحديد على جهاز القلب والأوعية الدموية في الجرذان البالغة

  2017cites this paper
• The long chain α–tocopherol metabolite α‐13’‐COOH and γ‐tocotrienol induce P‐glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180

  2017cites this paper
• Mechanisms of Pituitary Ovarian Axis Dysfunction and the Role of Vitamin E in Chronic Iron Over Load Rat Model

  2017cites this paper
• Vitamin E Isoform-Specific Functions in Allergic Inflammation and Asthma

  2017cites this paper
• Complexity of vitamin E metabolism.

  2016cites this paper
• Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs.

  2016cites this paper
• Vitamin E: A Role in Signal Transduction.

  2015cites this paper
• THE SENSITIVITY OF CELLS WITH THE VARIOUS LEVEL OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 TO CYTOTOXIC ACTION OF QUINONIMINES AND α-TOCOPHEROL SYNTHETIC DERIVATIVES.

  2015cites this paper
• Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman.

  2015cites this paper
• α-Tocopherol status and altered expression of α-tocopherol-related proteins in streptozotocin-induced type 1 diabetes in rat models.

  2014cites this paper
• Regulation of non-antioxidative and inflammatory pathways in macrophages by long-chain metabolites of α-tocopherol

  2014cites this paper
• Vitamin K metabolism: current knowledge and future research.

  2014cites this paper
• Regulation of sheep α-TTP by dietary vitamin E and preparation of monoclonal antibody for sheep α-TTP.

  2014cites this paper
• Vitamin E-gene interactions in aging and inflammatory age-related diseases: implications for treatment. A systematic review.

  2014cites this paper
• Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy.

  2014cites this paper
• The α-tocopherol status and expression of α-tocopherol-related proteins in methionine-choline deficient rats treated with vitamin E

  2014cites this paper
• Reply: Understanding the roles of the vitamin E isoforms α- and γ-tocopherol in allergic airway disease.

  2014cites this paper
• ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.

  2013cites this paper
• Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice

  2013cites this paper
• Activity of xenobiotic-metabolizing enzymes in the liver of rats with multi-vitamin deficiency.

  2013cites this paper
• Green Tea and Vitamin E Enhance Exercise-Induced Benefits in Body Composition, Glucose Homeostasis, and Antioxidant Status in Elderly Men and Women

  2013cites this paper
• Mechanisms for the prevention of vitamin E excess

  2013cites this paper
• Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

  2012influential citation
• Molecular cloning and characterization of the sheep α-TTP gene and its expression in response to different vitamin E status.

  2012cites this paper
• High dosing of α-tocopherol inhibits rat liver regeneration by modifying signal transducer and activator of transcription protein expression and its correlation with cell redox state and retinoid metabolism

  2012cites this paper
• Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice

  2012cites this paper
• Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.

  2012cites this paper
• Elevation of tissue α-tocopherol levels by conjugated linoleic acid in C57BL/6J mice is not associated with changes in vitamin E absorption or α-carboxyethyl hydroxychroman production.

  2012cites this paper
• A Rethinking on the Benefits and Drawbacks of Common Antioxidants and a Proposal to Look for the Antioxidants in Allium Products as Ideal Agents: A Review

  2011cites this paper
• Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients.

  2011cites this paper
• α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes.

  2011cites this paper
• Supplemental and Highly Elevated Tocopherol Doses Differentially Regulate Allergic Inflammation: Reversibility of α-Tocopherol and γ-Tocopherol’s Effects

  2011cites this paper
• Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.

  2010cites this paper
• Reconvene and Reconnect the Antioxidant Hypothesis in Human Health and Disease

  2010cites this paper
• Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.

  2010influential citation
• Analysis of vitamin E metabolites in biological specimen.

  2010cites this paper
• Tocopheryl quinones and mitochondria.

  2010cites this paper
• Implications of apolipoprotein E genotype on inflammation and vitamin E status.

  2010cites this paper
• Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?

  2010cites this paper
• alpha-Tocopheryl phosphate--an active lipid mediator?

  2010cites this paper
• g-Tocotrienol and g-Tocopherol Are Primarily Metabolized to Conjugated 2-(b-carboxyethyl)- 6-Hydroxy-2,7,8-Trimethylchroman and Sulfated Long-Chain Carboxychromanols

  2009cites this paper
• g-Tocotrienol and g-Tocopherol Are Primarily Metabolized to Conjugated 2-(b-carboxyethyl)- 6-Hydroxychroman and Sulfated Long-Chain Carboxychromanols in Rats 1-3

  2009cites this paper
• Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment1

  2009influential citation
• Effects of pregnenolone-16α-carbonitrile on vitamin E status and protein levels of antioxidant enzymes in male rats fed a vitamin E-supplemented diet

  2009cites this paper
• Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats.

  2009cites this paper
• Vitamin E: the shrew waiting to be tamed.

  2009cites this paper
• Effects of Oxidized Frying Oil on Proteins Related to α-Tocopherol Metabolism in Rat Liver

  2009cites this paper
• RecruitmentInflammation by Regulating Leukocyte Immunoregulatory Functions during Isoforms of Vitamin E Have Opposing

  2009influential citation
• Plasma vitamin E metabolite concentrations in pregnant women and umbilcal cord blood pairs

  2009cites this paper
• Vitamin E in Disease Prevention – A Critical Appraisal of Vitamin E Supplementation Trials

  2009cites this paper
• Vitamin E Supplementation and Hepatic Drug Metabolism in Humans

  2009cites this paper
• Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice.

  2009cites this paper
• Vitamin E in Human Health and Disease

  2008cites this paper
• Lifelong α-Tocopherol Supplementation Increases the Median Life Span of C57BL/6 Mice in the Cold but Has Only Minor Effects on Oxidative Damage

  2008cites this paper
• Genetic polymorphisms as determinants for disease-preventive effects of vitamin E.

  2008cites this paper
• So many options but one choice: the human body prefers α-tocopherol. A matter of stereochemistry.

  2008cites this paper
• The Metabolism of Tocopherols and Tocotrienols and Novel Functions of Their Metabolites

  2008cites this paper
• Vitamin E and K interactions--a 50-year-old problem.

  2008cites this paper
• Vitamin E revisited: do new data validate benefits for chronic disease prevention?

  2008cites this paper
• Anti-inflammatory properties of alpha- and gamma-tocopherol.

  2007cites this paper
• AN ABSTRACT OF THE THESIS OF

  2007cites this paper
• Alpha-Tocopherol Transfer Protein (α-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice

  2007cites this paper
• Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women

  2007cites this paper
• Identification and quantitation of novel vitamin E metabolites, sulfated long-chain carboxychromanols, in human A549 cells and in rats Published, JLR Papers in Press, February 13, 2007.

  2007cites this paper
• Anti-inflammatory properties of aand c-tocopherol

  2007cites this paper
• Vitamin E regulatory mechanisms.

  2007cites this paper
• Pregnenolone and dexamethasone, modulators of cytochrome P450‐3A, not increase but reduce urinary α‐CEHC excretion in rats

  2007cites this paper
• Regulatory mechanisms to control tissue alpha-tocopherol.

  2007cites this paper
• PCR-verified microarray analysis and functional in vitro studies indicate a role of α-tocopherol in vesicular transport

  2007influential citation
• Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on "The relationship between dose of vitamin E and suppression of oxidative stress in humans".

  2007cites this paper
• Regulatory Mechanisms to Control Tissue α-Tocopherol

  2007influential citation
• Anti-inflammatory properties of a- and ?-tocopherol

  2007cites this paper
• Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins.

  2007cites this paper
• Vitamin E biotransformation in humans.

  2007cites this paper
• Adverse effects of vitamin E by induction of drug metabolism

  2007cites this paper
• Linus Pauling Institute The OREGON STATE UNIVERSITY From the Director

  2006cites this paper