Regulatory mechanisms to control tissue alpha-tocopherol.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Free Radical Biology & Medicine

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 17640571PMCID PMC2693716
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity.

  2006cited by this paper
• Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats.

  2006cited by this paper
• Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.

  2006cited by this paper
• Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.D400044-JLR200

  2005cited by this paper
• CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs.

  2005cited by this paper
• Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1.

  2005cited by this paper
• Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.

  2005cited by this paper
• Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review.

  2005cited by this paper
• Carcinogenic polycyclic aromatic hydrocarbon‐DNA adducts and mechanism of action

  2005cited by this paper
• Induction of phase I, II and III drug metabolism/transport by xenobiotics

  2005cited by this paper
• Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs.

  2005cited by this paper
• Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice.

  2005cited by this paper
• TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES

  2004cited by this paper
• Vitamin E Trafficking

  2004cited by this paper
• Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes

  2004cited by this paper
• Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier.

  2004cited by this paper
• Transport Proteins and Intestinal Metabolism: P-Glycoprotein and Cytochrome P4503A

  2004cited by this paper
• The ABC Transporters MDR1 and MRP2: Multiple Functions in Disposition of Xenobiotics and Drug Resistance

  2004cited by this paper
• The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

  2004cited by this paper
• Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.

  2003cited by this paper
• Constitutive Expression of P-Glycoprotein in Normal Lung Alveolar Epithelium and Functionality in Primary Alveolar Epithelial Cultures

  2003cited by this paper
• Vitamin E activates gene expression via the pregnane X receptor.

  2003cited by this paper
• Induction of Drug Metabolism: The Role of Nuclear Receptors

  2003cited by this paper
• The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

  2003cited by this paper
• Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status.

  2002cited by this paper
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  2002cited by this paper
• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

  2002cited by this paper
• Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats.

  2002cited by this paper
• Mammalian ABC transporters in health and disease.

  2002cited by this paper
• Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation.

  2001cited by this paper
• Effect of peroxisome proliferator-activated receptor alpha activation on leukotriene B4 metabolism in isolated rat hepatocytes.

  2001cited by this paper
• Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin.

  2000cited by this paper
• Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney

  2000cited by this paper
• St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4

  2000cited by this paper
• Induction of P‐glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction

  2000cited by this paper
• Dexamethasone modulation of multidrug transporters in normal tissues

  1999cited by this paper
• The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.

  1999cited by this paper
• Urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman is a major route of elimination of gamma-tocopherol in humans.

  1999cited by this paper
• Is the role of the small intestine in first-pass metabolism overemphasized?

  1999cited by this paper
• Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.

  1998cited by this paper
• Biliary secretion of alpha-tocopherol and the role of the mdr2 P-glycoprotein in rats and mice.

  1998cited by this paper
• Dose-response comparison of RRR-alpha-tocopherol and all-racemic alpha-tocopherol on LDL oxidation.

  1997cited by this paper
• MDR1-Pgp 170 expression in human bronchus.

  1997cited by this paper
• Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones.

  1996cited by this paper
• In vivo induction of liver P-glycoprotein expression by xenobiotics in monkeys.

  1995cited by this paper
• Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

  1995cited by this paper
• Enterohepatic circulation of newly administered alpha-tocopherol in the rat.

  1988cited by this paper

• Insights into the binding mechanism between α‐TOH and CYP4F2: A homology modeling, molecular docking, and molecular dynamics simulation study

  2023cites this paper
• Fabrication of Ethosomes Containing Tocopherol Acetate to Enhance Transdermal Permeation: In Vitro and Ex Vivo Characterizations

  2022cites this paper
• The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review

  2022cites this paper
• Vitamin E research: Past, now and future.

  2021cites this paper
• Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients

  2019cites this paper
• Effect of vitamin E supplementation on α-tocopherol status and tissue antioxidants in American minks ( Neovison vison )

  2018cites this paper
• Induction of VEGF Expression by Alpha‐Tocopherol and Alpha‐Tocopheryl Phosphate via PI3Kγ/PKB and hTAP1/SEC14L2‐Mediated Lipid Exchange

  2015cites this paper
• Vitamin E: A Role in Signal Transduction.

  2015cites this paper
• The effect of vitamin E supplementation on an experimental Haemonchus contortus infection in lambs.

  2014cites this paper
• A randomized placebo-controlled trial of an omega-3 fatty acid and vitamins E+C in schizophrenia

  2013cites this paper
• Mechanisms for the prevention of vitamin E excess

  2013cites this paper
• Urinary α-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the Energetics Study.

  2012cites this paper
• α-Tocopheryl phosphate--an activated form of vitamin E important for angiogenesis and vasculogenesis?

  2012cites this paper
• Antioxidant supplementation attenuates oxidative stress in chronic hepatitis C patients.

  2012cites this paper
• A comparative review of vitamin E and associated equine disorders.

  2012cites this paper
• Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.

  2012cites this paper
• Urinary a-carboxyethyl hydroxychroman can be used as a predictor of a-tocopherol adequacy , as demonstrated in the Energetics Study 1 – 3

  2012cites this paper
• Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

  2012influential citation
• Maternal dietary loads of α-tocopherol depress protein kinase C signaling and synaptic plasticity in rat postnatal developing hippocampus and promote permanent deficits in adult offspring.

  2011cites this paper
• α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes.

  2011cites this paper
• Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?

  2010cites this paper
• Present trends in vitamin E research

  2010cites this paper
• Analysis of vitamin E metabolites in biological specimen.

  2010cites this paper
• Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.

  2010cites this paper
• Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice.

  2009cites this paper
• How can a chemically well established antioxidant work differently when in the body?

  2009cites this paper
• Alpha‐tocopherol transport in the lung is affected by the apoE genotype—Studies in transgenic apoE3 and apoE4 mice

  2009cites this paper
• Vitamin E: the shrew waiting to be tamed.

  2009cites this paper
• Vitamin E in Human Health and Disease

  2008cites this paper
• Vitamin E revisited: do new data validate benefits for chronic disease prevention?

  2008cites this paper
• Evolution of oxidative stress parameters and response to oral vitamins E and C in streptozotocin‐induced diabetic rats

  2008cites this paper
• Vitamin E and K interactions--a 50-year-old problem.

  2008cites this paper