A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex that can be carried out by the cellular stress responsive kinases; GCN2, PERK, PKR, and HRI. eIF2α phosphorylation downregulates mRNA translation initiation en masse, however ATF4 translation is upregulated. The integrated stress response can output two contradicting outcomes in cells; pro-survival or apoptosis. The mechanism for choice between these outcomes is unknown, however combinations of ATF4 heterodimerisation partners and post-translational modifications have been linked to this regulation. This semi-systematic review article covers ATF4 target genes, heterodimerisation partners and post-translational modifications. Together, this review aims to be a useful resource to elucidate the mechanisms controlling the effects of the integrated stress response. Additional putative roles of the ATF4 protein in cell division and synaptic plasticity are outlined.

• Publication year

  2023

• Venue

  Frontiers in Molecular Neuroscience

• Publication date

  2023-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fnmol.2023.1112253PMID 36825279PMCID 9941348
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intricate coupling between the transactivation and basic-leucine zipper domains governs phosphorylation of transcription factor ATF4 by casein kinase 2.

  2023cited by this paper
• Intricate coupling between the transactivation and basic-leucine zipper domains governs phosphorylation of transcription factor ATF4 by casein kinase 2

  2022cited by this paper
• The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

  2022cited by this paper
• The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases

  2022cited by this paper
• ATF4 promotes brain vascular smooth muscle cells proliferation, invasion and migration by targeting miR-552-SKI axis

  2022cited by this paper
• Activating transcription factor 4 aggravates angiotensin II-induced cell dysfunction in human vascular aortic smooth muscle cells via transcriptionally activating fibroblast growth factor 21

  2022cited by this paper
• Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells

  2022cited by this paper
• The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

  2022cited by this paper
• Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

  2021cited by this paper
• Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

  2021cited by this paper
• ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/β-catenin signaling

  2021cited by this paper
• FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

  2021cited by this paper
• Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation

  2021cited by this paper
• ATF4-mediated GDF15 suppresses LPS-induced inflammation and MUC5AC in human nasal epithelial cells through the PI3K/Akt pathway.

  2021cited by this paper
• High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

  2021cited by this paper
• Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia

  2021cited by this paper
• PERK signaling activation restores nucleus pulposus degeneration by activating autophagy under hypoxia environment.

  2021cited by this paper
• A maternal low-protein diet during gestation induces hepatic autophagy-related gene expression in a sex-specific manner in Sprague-Dawley rats

  2021cited by this paper
• Targeting synaptic plasticity in schizophrenia: insights from genomic studies.

  2021cited by this paper
• Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex

  2021cited by this paper
• Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition

  2021cited by this paper
• Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

  2020cited by this paper
• The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4

  2020cited by this paper
• The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

  2020cited by this paper
• Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

  2020cited by this paper
• JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis

  2020cited by this paper
• Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

  2020cited by this paper
• A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation

  2020cited by this paper
• Ionizing radiation regulates vascular endothelial growth factor-A transcription in cultured human vascular endothelial cells via the PERK/eIF2α/ATF4 pathway.

  2020cited by this paper
• A reference map of the human binary protein interactome

  2020cited by this paper
• Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response

  2020cited by this paper
• UniProt: the universal protein knowledgebase in 2021

  2020cited by this paper
• The integrated stress response: From mechanism to disease

  2020cited by this paper
• C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes.

  2019cited by this paper
• eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

  2019cited by this paper
• ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

  2019cited by this paper
• Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells.

  2019cited by this paper
• Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing.

  2019cited by this paper
• Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate.

  2019cited by this paper
• Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress.

  2018cited by this paper
• Structural basis for eIF2B inhibition in integrated stress response

  2018cited by this paper
• Structural basis for the inhibition of translation through eIF2α phosphorylation

  2018cited by this paper
• A PDX1-ATF transcriptional complex governs β cell survival during stress

  2018cited by this paper
• GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress

  2018cited by this paper
• Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells

  2018cited by this paper
• The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation

  2018cited by this paper
• Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABABR Trafficking

  2018cited by this paper
• The structural basis of translational control by eIF2 phosphorylation

  2018cited by this paper
• Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress–Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer

  2018cited by this paper
• ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS

  2018cited by this paper
• TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter.

  2018cited by this paper
• The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition

  2018cited by this paper
• The GABAergic System: An Overview of Physiology, Physiopathology and Therapeutics

  2018cited by this paper
• Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes

  2017cited by this paper
• Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

  2017cited by this paper
• PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

  2017cited by this paper
• NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

  2017cited by this paper
• Neurodegeneration: Keeping ATF4 on a Tight Leash

  2017cited by this paper
• Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells.

  2017influential reference
• Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation

  2017cited by this paper
• Mammalian Pseudokinase TRIB3 in Normal Physiology and Disease: Charting the Progress in Old and New Avenues.

  2017influential reference
• Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation

  2017cited by this paper
• The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation

  2016cited by this paper
• ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation

  2016influential reference
• Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response*

  2016influential reference
• The integrated stress response

  2016cited by this paper
• The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress

  2016cited by this paper
• A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis*

  2015influential reference
• p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.

  2015influential reference
• GABA receptors in brain development, function, and injury

  2015cited by this paper
• Lower expression of activating transcription factors 3 and 4 correlates with shorter progression-free survival in multiple myeloma patients receiving bortezomib plus dexamethasone therapy

  2015cited by this paper
• C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

  2015cited by this paper
• Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element*

  2015cited by this paper
• The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells.

  2015cited by this paper
• ChIP bias as a function of cross-linking time

  2015cited by this paper
• ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

  2015cited by this paper
• Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response*

  2015cited by this paper
• Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory.

  2015cited by this paper
• ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells

  2015cited by this paper
• Phosphoinositide 3-Kinases Upregulate System xc − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

  2014influential reference
• The scanning mechanism of eukaryotic translation initiation.

  2014cited by this paper
• PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

  2014cited by this paper
• A proteome-scale map of the human interactome network.

  2014cited by this paper
• Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.

  2013cited by this paper
• Networks of bZIP Protein-Protein Interactions Diversified Over a Billion Years of Evolution

  2013cited by this paper
• eIF2B promotes eIF5 dissociation from eIF2•GDP to facilitate guanine nucleotide exchange for translation initiation

  2013cited by this paper
• ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

  2013cited by this paper
• Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.

  2013influential reference
• Implication of eIF2α kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress‐responsive genes by sodium salicylate

  2013cited by this paper
• 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.

  2013cited by this paper
• The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

  2013cited by this paper
• FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress.

  2013cited by this paper
• CG methylated microarrays identify a novel methylated sequence bound by the CEBPB|ATF4 heterodimer that is active in vivo

  2013cited by this paper
• The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway.

  2012cited by this paper
• UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.

  2011cited by this paper
• Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications.

  2011cited by this paper
• New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform

  2011cited by this paper
• Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation*♦

  2011influential reference
• Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling

  2011cited by this paper
• Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress

  2011cited by this paper

• Sodium aescinate induces renal cell ferroptosis through the ATF4/CTH/SQOR axis.

  2026cites this paper
• Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation

  2026cites this paper
• Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury

  2026cites this paper
• ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis

  2026cites this paper
• Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling

  2026cites this paper
• Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature

  2026influential citation
• The dual role of activating transcription factor 4: from cellular stress sentinel to cardiovascular disease intervention

  2026cites this paper
• tRF-3021a, a tRNA-Ala-TGC derived 3’ fragment, promotes glioblastoma cell invasion, suppresses apoptosis, and is required for normal levels of protein synthesis

  2026cites this paper
• ATF4 in cardiovascular diseases: an emerging therapeutic target.

  2026cites this paper
• The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells

  2026cites this paper
• Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate.

  2026cites this paper
• Roles of the integrated stress response in regulation of inflammatory reactions

  2026cites this paper
• Saturated Phosphatidic Acids Induce mTORC1-Driven Integrated Stress Response Contributing to Glucolipotoxicity in Hepatocytes.

  2025cites this paper
• Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunction-associated steatotic liver disease

  2025cites this paper
• Mitochondrial quality control and stress signaling pathways in the pathophysiology of cardio-renal diseases.

  2025cites this paper
• Role of ATF4 in fibroblast proliferation and apoptosis induced by mechanical trauma through the miR−93-3p/Smad7 axis

  2025cites this paper
• Loss of non-canonical translation initiation factors impairs perinatal cardiac function in mice

  2025cites this paper
• Ribosome association inhibits stress-induced gene mRNA localization to stress granules

  2025cites this paper
• Impact of proteostasis workload on sensitivity to proteasome inhibitors in multiple myeloma

  2025cites this paper
• Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapeutic efficacy for rheumatoid arthritis

  2025cites this paper
• The Dynamic UPR Rheostat Orchestrates Single-Cell Plasticity in Glioblastoma

  2025cites this paper
• Regulation of redox homeostasis by ATF4-MTHFD2 axis during white adipose tissue browning

  2025cites this paper
• Omega-3 Fatty Acid Synergy with Glucocorticoid in Lupus Macrophages: Targeting Pathogenic Pathways to Reduce Steroid Dependence

  2025cites this paper
• Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer's acute stress response.

  2025cites this paper
• MiR338-3p expression in extracellular vesicles after severe trauma with or without traumatic brain injury

  2025cites this paper
• Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors.

  2025cites this paper
• Emerging roles for integrated stress response signaling in homeostasis

  2025influential citation
• Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.

  2025cites this paper
• Mathematical modelling reveals compound-specific stress pathway activity.

  2025cites this paper
• The ATF4-glutamine axis: a central node in cancer metabolism, stress adaptation, and therapeutic targeting

  2025cites this paper
• CerS2 is a druggable target in triple-negative breast cancer

  2025cites this paper
• Transcriptional Readthrough at Atf4 Locus Suppresses Rps19bp1 and Impairs Heart Development

  2025cites this paper
• Mammalian mitohormesis: from mitochondrial stressors to organismal benefits

  2025cites this paper
• MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic ductal adenocarcinoma

  2025cites this paper
• E7386 Enhances Lenvatinib’s Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma

  2025cites this paper
• Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.

  2025cites this paper
• LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia

  2025cites this paper
• Translation regulation of ATF4 by the termination complex Hbs1-Pelo is required for visual system development and function

  2025cites this paper
• Differential analysis of translation efficiency and usage of open reading frames using DOTSeq

  2025cites this paper
• Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations

  2025cites this paper
• The GCN-2/eIF-2α/ATF-4 signaling pathway is involved in C. elegans defense against Salmonella enterica infection

  2025cites this paper
• AP-1 mediated chromatin changes govern alveolar type 2 cell transition in lung injury-repair

  2025cites this paper
• Omega-3 fatty acid synergy with glucocorticoid in mouse lupus macrophage model: targeting pathogenic pathways to reduce steroid dependence

  2025cites this paper
• Endoplasmic Reticulum Stress in Cancer Progression: A Comprehensive Review of Its Role and Mechanisms

  2025cites this paper
• RAF inhibitors activate the integrated stress response by direct activation of GCN2

  2025cites this paper
• Space radiation induces distinct senescent phenotypes: Implications for space travel

  2025cites this paper
• HER3 enhances ATF4 induction and survival in breast cancer cells during endoplasmic reticulum stress.

  2025cites this paper
• Understanding Endoplasmic Reticulum Stress as a Central Driver of Atherosclerosis

  2025cites this paper
• Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila.

  2025cites this paper
• Expanding the landscape of the unfolded protein response: The roles of secondary transcription factors in development and disease

  2025cites this paper
• Research advances in epigenetic modifications and post-translational modifications in endothelial-mesenchymal transition

  2025cites this paper
• Bidirectional crosstalk between ER stress and lipid metabolism: From proteostasis to tumor adaptation

  2025cites this paper
• Basal level of ATF4 promotes T cell readiness for activation-induced proliferation

  2025cites this paper
• Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4

  2025cites this paper
• SLC7A5 is required for cancer cell growth under arginine-limited conditions.

  2025cites this paper
• eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress

  2025cites this paper
• Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis

  2025cites this paper
• Mcl‐1 is a Gatekeeper Molecule to Regulate the Crosstalk Between Ferroptotic Agent‐Induced ER Stress and TRAIL‐Induced Apoptosis

  2025cites this paper
• Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress

  2025cites this paper
• PERK-Olating Through Cancer: A Brew of Cellular Decisions

  2025cites this paper
• A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver disease

  2025cites this paper
• Pre-cachectic changes in amino acid homeostasis precede activation of eIF2α signaling in the liver at the onset of C26 cancer-induced cachexia

  2025cites this paper
• Farnesol Improves Endoplasmic Reticulum Stress and Hepatic Metabolic Dysfunction Induced by Tunicamycin in Mice

  2025cites this paper
• Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH

  2025cites this paper
• Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies

  2025cites this paper
• ISR Modulators in Neurological Diseases

  2025influential citation
• Virulent African swine fever virus infection of porcine monocytes causes SLA I subversion due to loss of proper ER structure/function.

  2025cites this paper
• Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell Model

  2025cites this paper
• Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress

  2025cites this paper
• L-Phenylalanine restriction amplifies boron neutron capture therapy efficacy through increased L-boronophenylalanine uptake and induces activating transcription factor 4 stress response in tumor cell lines

  2025cites this paper
• Diapause and Anoxia-Induced Quiescence Are Unique States in Embryos of the Annual Killifish, Austrofundulus limnaeus

  2025cites this paper
• Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation

  2025cites this paper
• Evolution of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness

  2025cites this paper
• Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish.

  2024cites this paper
• Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling

  2024influential citation
• The hormesis principle of neuroplasticity and neuroprotection.

  2024cites this paper
• Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response.

  2024cites this paper
• ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor

  2024influential citation
• Stem-loop-induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control

  2024cites this paper
• Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.

  2024cites this paper
• The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia

  2024cites this paper
• Gene Expression Profiling Reveals Fundamental Sex-Specific Differences in SIRT3-Mediated Redox and Metabolic Signaling in Mouse Embryonic Fibroblasts

  2024cites this paper
• Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway

  2024cites this paper
• Gene Expression Profiling to Unfolded Proteins Response as a Risk Modulator of Patients with Rheumatoid Arthritis

  2024cites this paper
• Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart.

  2024cites this paper
• eIF2α phosphorylation evokes dystonia-like movements with D2-receptor and cholinergic origin and abnormal neuronal connectivity

  2024cites this paper
• IGHMBP2 deletion suppresses translation and activates the integrated stress response

  2024cites this paper
• Novel insights into the activating transcription factor 4 in Alzheimer's disease and associated aging-related diseases: Mechanisms and therapeutic implications.

  2024cites this paper
• Soft extracellular matrix drives endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells.

  2024cites this paper
• Plant-derived bioactive compounds and their novel role in central nervous system disorder treatment via ATF4 targeting: A systematic literature review.

  2024cites this paper
• The high-affinity tryptophan uptake transport system in human cells

  2024cites this paper
• Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells

  2024cites this paper
• Large-Scale Comparative Transcriptomic Analysis of CHO Cell Functional Adaptation to Recombinant Monoclonal Antibody Production

  2024cites this paper
• Integrated transcriptomics identifies prognostic significance and therapeutic response of cancer-associated fibroblast subpopulations in ovarian cancer

  2024cites this paper
• Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay

  2024cites this paper
• Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis

  2024cites this paper
• GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

  2024cites this paper
• Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus

  2024cites this paper
• A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo

  2024cites this paper
• ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic

  2024cites this paper