Voltage-gated Proton “Channels”

A battle is raging over the molecular identity of the voltage-gated, H+-selective conductance that has been recorded in activated and/or depolarized phagocytes. Having stepped out of this arena, we feel uncommitted to any particular viewpoint and hope to be able to provide below an unbiased opinion

• Publication year

  2002

• Venue

  The Journal of General Physiology

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1085/jgp.20028706PMID 12451046PMCID 2229572
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system.

  2002cited by this paper
• Absence of Proton Channels in COS-7 Cells Expressing Functional NADPH Oxidase Components

  2002cited by this paper
• Heme Histidine Ligands within gp91 phox Modulate Proton Conduction by the Phagocyte NADPH Oxidase*

  2001cited by this paper
• The gp91 phox Component of NADPH Oxidase Is Not the Voltage-gated Proton Channel in Phagocytes, but It Helps*

  2001cited by this paper
• A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes*

  2001cited by this paper
• Activation of NADPH oxidase‐related proton and electron currents in human eosinophils by arachidonic acid

  2001cited by this paper
• Inhibition of the neutrophil NADPH oxidase and associated H+ channel by diethyl pyrocarbonate (DEPC), a histidine-modifying agent: evidence for at least two target sites.

  2001cited by this paper
• Voltage-gated proton channels in microglia.

  2001cited by this paper
• Novel homologs of gp91phox.

  2000cited by this paper
• Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils.

  2000cited by this paper
• A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.

  2000cited by this paper
• A Novel H+ Conductance in Eosinophils

  1999influential reference
• Essential Requirement of Cytosolic Phospholipase A2for Activation of the H+ Channel in Phagocyte-like Cells*

  1999cited by this paper
• NADPH oxidase: an update.

  1999cited by this paper
• Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

  1998cited by this paper
• Role of Histidines Identified by Mutagenesis in the NADPH Oxidase-associated H+ Channel*

  1998influential reference
• Electron currents generated by the human phagocyte NADPH oxidase

  1998cited by this paper
• Proton and chloride currents in Chinese hamster ovary cells.

  1997cited by this paper
• The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox.

  1997cited by this paper
• Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2.

  1997cited by this paper
• Arachidonic acid activatable electrogenic H+ transport in the absence of cytochrome b 558 in human T lymphocytes

  1996cited by this paper
• The Arachidonate-activable, NADPH Oxidase-associated H Channel

  1995influential reference
• Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells.

  1994cited by this paper
• Arachidonic acid stimulates the plasma membrane H+ conductance of macrophages.

  1994cited by this paper
• The respiratory burst oxidase.

  1994cited by this paper
• Activation of multiple pH-regulatory pathways in granulocytes by a phosphotyrosine phosphatase antagonist.

  1994cited by this paper
• Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.

  1994cited by this paper
• Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

  1993cited by this paper
• Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils.

  1993cited by this paper
• Proton currents in human granulocytes: regulation by membrane potential and intracellular pH.

  1993cited by this paper
• The NADPH-oxidase-associated H+ channel is opened by arachidonate.

  1992cited by this paper
• Molecular basis of the autosomal recessive forms of chronic granulomatous disease.

  1992cited by this paper
• Molecular basis of the autosomal recessive forms of chronic granulomatous disease.

  1992cited by this paper
• Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

  1991cited by this paper
• Hydrogen ion currents in rat alveolar epithelial cells.

  1991cited by this paper
• Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase.

  1989cited by this paper
• The respiratory burst oxidase.

  1988cited by this paper
• The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel.

  1987cited by this paper
• Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

  1984cited by this paper
• A voltage‐gated hydrogen ion current in the oocyte membrane of the axolotl, Ambystoma.

  1984cited by this paper
• Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones

  1982cited by this paper

• H+ and Confined Water in Gating in Many Voltage-Gated Potassium Channels: Ion/Water/Counterion/Protein Networks and Protons Added to Gate the Channel

  2025cites this paper
• Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice

  2024cites this paper
• Research progress on ion channels and their molecular regulatory mechanisms in the human sperm flagellum

  2023cites this paper
• Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems

  2023cites this paper
• Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity

  2023cites this paper
• Endocannabinoid signaling in microglia

  2022cites this paper
• Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels

  2022cites this paper
• The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

  2022cites this paper
• The HVCN1 voltage‐gated proton channel contributes to pH regulation in canine ventricular myocytes

  2022influential citation
• Voltage‐gated proton channels in polyneopteran insects

  2022cites this paper
• Universal response pattern of phytoplankton growth rates to increasing CO₂

  2021cites this paper
• Cell glycosaminoglycans content modulates human voltage‐gated proton channel (HV1) gating

  2021cites this paper
• The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation.

  2020cites this paper
• Intracellular pH regulation: characterization and functional investigation of H+ transporters in Stylophora pistillata

  2020cites this paper
• pH dependence of the Slc4a11-mediated H conductance is influenced by intracellular lysine residues and modified by disease-linked mutations

  2020cites this paper
• Optical consequences of a genetically-encoded voltage indicator with a pH sensitive fluorescent protein.

  2019cites this paper
• Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice

  2019cites this paper
• Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals

  2019cites this paper
• Two-dimensional infrared (2D IR) spectroscopy for elucidating ion occupancies in the selectivity filter of ion channels

  2018cites this paper
• Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain

  2018cites this paper
• Exotic properties of a voltage-gated proton channel from the snail Helisoma trivolvis

  2018cites this paper
• Molecular and functional characterization of the voltage‐gated proton channel in zebrafish neutrophils

  2017influential citation
• The intimate and controversial relationship between voltage‐gated proton channels and the phagocyte NADPH oxidase

  2016cites this paper
• Insights into the structure and function of HV1 from a meta-analysis of mutation studies

  2016cites this paper
• The voltage‐gated proton channel Hv1/VSOP inhibits neutrophil granule release

  2016cites this paper
• Pharmacological Modulation of Proton Channel Hv1 in Cancer Therapy: Future Perspectives

  2016cites this paper
• INVITED MINI-REVIEW TITLE: Pharmacological modulation of proton channel Hv1 in cancer therapy: Future perspectives

  2016cites this paper
• Factors and pathways involved in capacitation: how are they regulated?

  2016cites this paper
• Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions

  2016cites this paper
• Ion channels in innate and adaptive immunity.

  2015cites this paper
• Acidification of the intimal fluid: the perfect storm for atherogenesis

  2015cites this paper
• Interaction of divalent metal ions with the carboxyl-terminal domain of human voltage-gated proton channel Hv1

  2014cites this paper
• Voltage Sensing Mechanism in the Voltage-gated and Proton (H+)-selective Ion Channel Hv1

  2014cites this paper
• Temperature-sensitive gating of voltage-gated proton channels.

  2014cites this paper
• Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: a study with PEGylation protection.

  2014cites this paper
• Proton channel models

  2014cites this paper
• The Concise Guide to Pharmacology 2013/14: Ion Channels

  2013cites this paper
• PROTEIN DESIGN - A VAST UNEXPLOITED RESOURCE

  2013cites this paper
• Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.

  2013cites this paper
• The control of male fertility by spermatozoan ion channels.

  2012cites this paper
• Biophysical properties of the voltage gated proton channel H(V)1.

  2012cites this paper
• Mechanism of Function of Viral Channel Proteins and Implications for Drug Development

  2012influential citation
• Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release

  2012cites this paper
• pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1.

  2011cites this paper
• A Voltage-Gated H+ Channel Underlying pH Homeostasis in Calcifying Coccolithophores

  2011cites this paper
• CO2 induced seawater acidification impacts sea urchin larval development II: gene expression patterns in pluteus larvae.

  2011cites this paper
• Rediscovering sperm ion channels with the patch-clamp technique.

  2011cites this paper
• Mechanismen der CO2 Toleranz bei Seeigeln des Genus Strongylocentrotus = Mechanisms of CO2 tolerance in sea urchins of the genus Strongylocentrotus

  2011cites this paper
• VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

  2009cites this paper
• Redox Signaling Across Cell Membranes

  2009cites this paper
• Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

  2009cites this paper
• The intimate and mysterious relationship between proton channels and NADPH oxidase

  2009cites this paper
• A Novel Amiloride-Sensitive H+ Transport Pathway Mediates Enhanced Superoxide Production in Thick Ascending Limb of Salt-Sensitive Rats, Not Na+/H+ Exchange

  2009cites this paper
• Voltage-gated proton channels

  2008cites this paper
• Voltage‐gated proton channels: what's next?

  2008cites this paper
• Nitric Oxide Reductase from Paracoccus denitrificans : A Proton Transfer Pathway from the “Wrong” Side

  2008cites this paper
• Pharmacology of voltage-gated proton channels.

  2007cites this paper
• [Phagocytosis and membrane potential].

  2007cites this paper
• Electron and proton transport by NADPH oxidases

  2005cites this paper
• Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes.

  2005cites this paper
• Consequences of the electrogenic function of the phagocytic NADPH oxidase

  2005cites this paper
• Analysis of mRNA Transcripts from the NAD(P)H Oxidase 1 (Nox1) Gene

  2004cites this paper
• Flow cytometric kinetic assay of the activity of Na+/H+ antiporter in mammalian cells

  2004cites this paper
• The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.

  2004cites this paper
• Interactions between Electron and Proton Currents in Excised Patches from Human Eosinophils

  2003cites this paper
• The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino-acid fragment of gp91phox.

  2003cites this paper