A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Science

• Publication date

  2000-01-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.287.5450.138PMID 10615049
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell transformation by the superoxide-generating oxidase Mox1

  1999cited by this paper
• A Novel H+ Conductance in Eosinophils

  1999cited by this paper
• Evidence That the Product of the Human X-Linked Cgd Gene, Gp91-phox, Is a Voltage-Gated H+ Pathway

  1999cited by this paper
• In Vitro Repression of Brca1-associated RING Domain Gene, Bard1, Induces Phenotypic Changes in Mammary Epithelial Cells

  1998cited by this paper
• Role of Histidines Identified by Mutagenesis in the NADPH Oxidase-associated H+ Channel*

  1998cited by this paper
• Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase.

  1998cited by this paper
• A Highly Temperature-sensitive Proton Current in Mouse Bone Marrow–derived Mast Cells

  1997cited by this paper
• The NADPH Oxidase of Phagocytic Leukocytes a

  1997cited by this paper
• Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel.

  1997cited by this paper
• The Arachidonate-activable, NADPH Oxidase-associated H Channel

  1995cited by this paper
• The respiratory burst oxidase.

  1994cited by this paper
• Voltage-activated hydrogen ion currents

  1994cited by this paper
• Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes.

  1994cited by this paper
• Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils.

  1993cited by this paper
• Proton currents in human granulocytes: regulation by membrane potential and intracellular pH.

  1993cited by this paper
• A voltage‐dependent proton current in cultured human skeletal muscle myotubes.

  1993cited by this paper
• Phorbol 12-myristate 13-acetate activates an electrogenic H(+)-conducting pathway in the membrane of neutrophils.

  1992cited by this paper
• Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.

  1992cited by this paper
• Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

  1991cited by this paper
• Hydrogen ion currents in rat alveolar epithelial cells.

  1991cited by this paper
• The respiratory burst oxidase.

  1988cited by this paper
• The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel.

  1987cited by this paper
• Preparation and cryopreservation of cytoplasts from human phagocytes.

  1986cited by this paper
• Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones

  1982cited by this paper

• NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

  2025cites this paper
• NADPH Oxidase in Pancreatic β-Cell Function

  2024cites this paper
• Vascular NADPH Oxidases and Atherothrombotic Stroke

  2024cites this paper
• The Interplay Between Endoplasmic Reticulum Stress and Oxidative Stress in Chondrocyte Catabolism.

  2024cites this paper
• Delineating the NOX-Mediated Promising Therapeutic Strategies for the Management of Various Cardiovascular Disorders: A Comprehensive Review.

  2024cites this paper
• NADPH Oxidase 3: Beyond the Inner Ear

  2024cites this paper
• Perivascular Adipose Tissue Oxidative Stress in Obesity

  2023cites this paper
• The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback.

  2023cites this paper
• NADPH oxidases in GtoPdb v.2023.3

  2023cites this paper
• NOX Dependent ROS Generation and Cell Metabolism

  2023cites this paper
• The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis

  2022cites this paper
• Mechanism of Gene-Environment Interactions Driving Glial Activation in Parkinson’s Diseases

  2021cites this paper
• The double-edged roles of ROS in cancer prevention and therapy

  2021cites this paper
• NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology

  2021cites this paper
• Inhibiting the Activity of NADPH Oxidase in Cancer

  2020cites this paper
• NADPH oxidase 1 is highly expressed in human large and small bowel cancers

  2020influential citation
• NOX Inhibitors: From Bench to Naxibs to Bedside.

  2020cites this paper
• Intersecting Stories of the Phagocyte NADPH Oxidase and Chronic Granulomatous Disease.

  2019cites this paper
• Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms

  2019cites this paper
• The NADPH Oxidase Family and Its Inhibitors

  2019cites this paper
• NADPH oxidases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling.

  2019cites this paper
• NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

  2019cites this paper
• Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2

  2019cites this paper
• FUNCTIONAL ANALYSIS OF NEUTROPHIL CYTOSOLIC FACTOR 4 ( NCF4) IN THE PATHOGENESIS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE

  2018cites this paper
• Escherichia coli LF 82 Differentially Regulates ROS Production and Mucin Expression in Intestinal Epithelial T 84 Cells : Implication of NOX 1

  2018cites this paper
• NOX4, a new genetic target for anti‐cancer therapy in digestive system cancer

  2018cites this paper
• NADPH oxidases and ROS signaling in the gastrointestinal tract

  2018cites this paper
• The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

  2018cites this paper
• Redox signalling in myeloid leukaemia

  2018cites this paper
• University of Groningen Establishment of Protein Delivery Systems Targeting Podocytes

  2018influential citation
• The defense and signaling role of NADPH oxidases in eukaryotic cells

  2018cites this paper
• Molecular and functional characterization of a new X-linked chronic granulomatous disease variant ( X 91 + ) case with a double missense mutation in the cytosolic gp 91 phox C-terminal tail STASIA

  2017cites this paper
• NADPH oxidases in Parkinson’s disease: a systematic review

  2017cites this paper
• NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

  2017cites this paper
• Exercise and Reactive Oxygen Species

  2017cites this paper
• Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett’s Associated Esophageal Adenocarcinoma Cells

  2017influential citation
• A Mini-Review of Reactive Oxygen Species in Urological Cancer: Correlation with NADPH Oxidases, Angiogenesis, and Apoptosis

  2017cites this paper
• malignant melanoma cells B in κ oxidoreductase constitutively activate NF- Reactive oxygen species from NAD(P)H:quinone

  2016cites this paper
• Reactive Oxygen Species Modulation of Vascular Smooth Muscle Signaling by

  2016cites this paper
• Protein Thiol Redox Signaling in Monocytes and Macrophages

  2016cites this paper
• Diabetes and Kidney Disease: Role of Oxidative Stress

  2016cites this paper
• Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase NOX5-S Expression in Human Esophageal Adenocarcinoma Cells

  2016cites this paper
• Overexpression of p67phox in response to fluoropyrimidines in HCT116 cells

  2016cites this paper
• Voltage-Gated Proton Channels

  2016cites this paper
• Nox1 in cardiovascular diseases: regulation and pathophysiology.

  2016cites this paper
• Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics

  2015cites this paper
• Role of Mitochondria and Other ROS Sources in Hyperthyroidism-Linked Oxidative Stress

  2015cites this paper
• Peripheral chemoreception and arterial pressure responses to intermittent hypoxia.

  2015cites this paper
• Managing the Respiratory Burst in Phagocytes Voltage-Gated Proton Channels Find Their Dream Job

  2015cites this paper
• Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology

  2015cites this paper
• Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.

  2015cites this paper
• Disease-Related Vascular Calcification Inflammatory Cytokines and Reactive Oxygen Species as Mediators of Chronic Kidney

  2015cites this paper
• Escherichia coli LF82 Differentially Regulates ROS Production and Mucin Expression in Intestinal Epithelial T84 Cells: Implication of NOX1

  2015cites this paper
• Biphasic Roles of a Small G-Protein, RAC1 in Pancreatic Β-Cell

  2015cites this paper
• NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinges on long-term proliferation

  2015cites this paper
• Nox-4 and progressive kidney disease

  2015cites this paper
• Molecular regulation of Nox1 NADPH oxidase in vascular smooth muscle cell activation

  2015cites this paper
• Rational Design and Therapeutic Potential of a Novel Nox1 Inhibitor for the Treatment of Pulmonary Hypertension: In Vitro and In Vivo Effects of Nox1 Inhibition

  2014cites this paper
• NADPH Oxidases as Novel Pharmacologic Targets against Influenza A Virus Infection

  2014cites this paper
• The interaction of UVA radiation with cultured human skin cells

  2014cites this paper
• Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver.

  2014cites this paper
• NADPH Oxidases in Vascular Pathology

  2014cites this paper
• NADPH oxidases: an overview from structure to innate immunity-associated pathologies

  2014cites this paper
• Balancing Reactive Oxygen Species in the Epigenome: NADPH Oxidases as Target and Perpetrator

  2013cites this paper
• Mitogen-Activated Protein Kinase Module

  2013cites this paper
• Cytosolic Protein Phosphatases

  2013cites this paper
• The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.

  2013cites this paper
• Other Major Types of Signaling Mediators

  2013cites this paper
• Guanosine Triphosphatases and Their Regulators

  2013cites this paper
• Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension.

  2013cites this paper
• Cytoplasmic Protein Serine/Threonine Kinases

  2013cites this paper
• NADPH Oxidase Biology and the Regulation of Tyrosine Kinase Receptor Signaling and Cancer Drug Cytotoxicity

  2013cites this paper
• Dual-Specificity Protein Kinases

  2013cites this paper
• NADPH Oxidases: Structure and Function

  2013cites this paper
• Cytoplasmic Protein Tyrosine Kinases

  2013cites this paper
• Study designs to investigate Nox1 acceleration of neoplastic progression in immortalized human epithelial cells by selection of differentiation resistant cells

  2013cites this paper
• Role of NADPH oxidase NOX5-S, NF-κB, and DNMT1 in acid-induced p16 hypermethylation in Barrett's cells.

  2013cites this paper
• The role of reactive oxygen species in cell death induced by thymidylate synthase inhibitors

  2013cites this paper
• Preamble to Cytoplasmic Protein Kinases

  2013cites this paper
• Apoptosis, Free Radicals and Antioxidant Defense in Antitumor Therapy

  2012cites this paper
• Red in Translation Pulmonary Endothelial Cell NOX

  2012cites this paper
• Voltage-gated proton channels.

  2012cites this paper
• NOX5 in Human Spermatozoa

  2012cites this paper
• Evaluation of pharmacological properties of Danshen compounds by computational and biochemical approaches

  2012cites this paper
• Do Hv1 proton channels regulate the ionic and redox homeostasis of phagosomes?

  2012cites this paper
• NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone.

  2012cites this paper
• Differential roles of NADPH oxidases in vascular physiology and pathophysiology.

  2012cites this paper
• NOX5: from basic biology to signaling and disease.

  2012cites this paper
• Apocynin-Treatment Reverses Hyperoxaluria Induced Changes in NADPH Oxidase System Expression in Rat Kidneys: A Transcriptional Study

  2012cites this paper
• Functions of proton channels in phagocytes

  2012cites this paper
• Pulmonary endothelial cell NOX.

  2012cites this paper
• The role and regulatory mechanisms of nox1 in vascular systems

  2012cites this paper
• Molecular structure and function of Hv1 channels

  2012cites this paper
• Rho GTPases and Nox dependent ROS production in skin. Is there a connection?

  2012cites this paper
• 6.8 Voltage Gated Proton Channels

  2012cites this paper
• Aiding and abetting roles of NOX oxidases in cellular transformation

  2012cites this paper
• Role of IRAK-1 in the Dynamic Regulation of Reactive Oxygen Species

  2011cites this paper
• Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi Fujii Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme

  2011cites this paper
• Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells

  2011cites this paper