Rho GTPases and Nox dependent ROS production in skin. Is there a connection?

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Histology and Histopathology

• Publication date

  2012-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.14670/HH-27.1395PMID 23018239
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.

  2015cited by this paper
• Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species

  2011cited by this paper
• RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

  2011cited by this paper
• The 'invisible hand': regulation of RHO GTPases by RHOGDIs

  2011cited by this paper
• Inhibition effect of Gynura procumbens extract on UV-B-induced matrix-metalloproteinase expression in human dermal fibroblasts.

  2011cited by this paper
• Rhinovirus-Induced Barrier Dysfunction in Polarized Airway Epithelial Cells Is Mediated by NADPH Oxidase 1

  2011cited by this paper
• Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases.

  2011cited by this paper
• Redox Control of GTPases: From Molecular Mechanisms to Functional Significance in Health and Disease

  2011cited by this paper
• The role of oxidative stress in the pathogenesis and treatment of asthma

  2010cited by this paper
• Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1–Independent Pathways in Human Endothelial Cells

  2010cited by this paper
• Anti-photoaging and Photoprotective Compounds Derived from Marine Organisms

  2010cited by this paper
• 5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase

  2010cited by this paper
• The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing

  2010cited by this paper
• Precursor of Advanced Glycation End Products Mediates ER-Stress-Induced Caspase-3 Activation of Human Dermal Fibroblasts through NAD(P)H Oxidase 4

  2010cited by this paper
• Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

  2010cited by this paper
• Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.

  2010cited by this paper
• Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts

  2010cited by this paper
• Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.

  2010cited by this paper
• Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells

  2010cited by this paper
• Reactive oxygen species in cancer

  2010cited by this paper
• Prolonged Hypoxia Increases ROS Signaling and RhoA Activation in Pulmonary Artery Smooth Muscle and Endothelial Cells

  2010cited by this paper
• Rho GTPase function in tumorigenesis.

  2009cited by this paper
• Scleroderma--pathophysiology.

  2009cited by this paper
• Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

  2009cited by this paper
• Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1.

  2009cited by this paper
• Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

  2009cited by this paper
• Oxidative stress in cardiovascular disease.

  2009cited by this paper
• Induction of cellular senescence by secretory phospholipase A2 in human dermal fibroblasts through an ROS-mediated p53 pathway.

  2009cited by this paper
• NADPH Oxidase 1 Controls the Persistence of Directed Cell Migration by a Rho-Dependent Switch of α2/α3 Integrins

  2009cited by this paper
• Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin

  2009cited by this paper
• Involvement of Reactive Oxygen Species in TGF‐β1‐induced Tropoelastin Expression by Human Dermal Fibroblasts

  2009cited by this paper
• The role of oxidative stress in atherosclerosis.

  2009cited by this paper
• Rac1 expression by fibroblasts is required for tissue repair in vivo.

  2009cited by this paper
• Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice.

  2008cited by this paper
• IL-8 production and AP-1 transactivation induced by UVA in human keratinocytes: roles of D-alpha-tocopherol.

  2008cited by this paper
• The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation

  2008cited by this paper
• Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.

  2008cited by this paper
• RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells.

  2008cited by this paper
• Activation of NADPH oxidase 1 in tumour colon epithelial cells.

  2008cited by this paper
• Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium‐derived contracting factor

  2007cited by this paper
• Innate host defense: Nox and Duox on phox's tail.

  2007cited by this paper
• GEFs and GAPs: critical elements in the control of small G proteins.

  2007cited by this paper
• The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.

  2007cited by this paper
• Inhibition of the myosin light chain kinase prevents hypoxia‐induced blood–brain barrier disruption

  2007cited by this paper
• Redox Regulation of Ephrin/Integrin Cross-Talk

  2007cited by this paper
• Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1

  2007cited by this paper
• HIV-1 Tat Activates Dual Nox Pathways Leading to Independent Activation of ERK and JNK MAP Kinases*

  2007cited by this paper
• Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells

  2007cited by this paper
• Epidermal deletion of Rac1 causes stem cell depletion, irrespective of whether deletion occurs during embryogenesis or adulthood.

  2007cited by this paper
• Oxidative stress in the pathogenesis of skin disease.

  2006cited by this paper
• The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction.

  2006cited by this paper
• Dermal wound healing is subject to redox control.

  2006cited by this paper
• NADPH oxidases: new kids on the block.

  2006cited by this paper
• Rac1 Is Crucial for Hair Follicle Integrity but Is Not Essential for Maintenance of the Epidermis

  2006cited by this paper
• Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.

  2006cited by this paper
• Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha.

  2006cited by this paper
• Direct Involvement of the Small GTPase Rac in Activation of the Superoxide-producing NADPH Oxidase Nox1*

  2006cited by this paper
• Impaired NADPH oxidase activity in Rac2‐deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid

  2006cited by this paper
• Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.

  2006cited by this paper
• Regulation of NADPH Oxidases: The Role of Rac Proteins

  2006cited by this paper
• Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages

  2005cited by this paper
• Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.

  2005cited by this paper
• Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production.

  2005cited by this paper
• Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation.

  2005cited by this paper
• Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells.

  2005cited by this paper
• Platelet-derived Growth Factor and Reactive Oxygen Species (ROS) Regulate Ras Protein Levels in Primary Human Fibroblasts via ERK1/2

  2005cited by this paper
• Stem Cell Depletion Through Epidermal Deletion of Rac1

  2005cited by this paper
• Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.

  2005cited by this paper
• Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise.

  2005cited by this paper
• Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts

  2005cited by this paper
• NADPH oxidase and endothelial cell function.

  2005cited by this paper
• Activation and assembly of the NADPH oxidase: a structural perspective.

  2005cited by this paper
• Mechanism of Redox-mediated Guanine Nucleotide Exchange on Redox-active Rho GTPases*

  2005cited by this paper
• Rho GTPases: biochemistry and biology.

  2005cited by this paper
• GAP control: regulating the regulators of small GTPases.

  2004cited by this paper
• Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis

  2004cited by this paper
• Analysis of mRNA Transcripts from the NAD(P)H Oxidase 1 (Nox1) Gene

  2004cited by this paper
• NOX enzymes and the biology of reactive oxygen

  2004cited by this paper
• Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta.

  2004cited by this paper
• GTPases and reactive oxygen species: switches for killing and signaling

  2004cited by this paper
• Rho Is Involved in Superoxide Formation during Phagocytosis of Opsonized Zymosans*[boxs]

  2004cited by this paper
• A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes.

  2004cited by this paper
• Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.

  2004cited by this paper
• Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells

  2004cited by this paper
• Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells.

  2003cited by this paper
• Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1*

  2003cited by this paper
• Proteins Homologous to p47phox and p67phox Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells*

  2003cited by this paper
• Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

  2003cited by this paper
• NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91phox in the Regulated Production of Superoxide by Phagocytes

  2003cited by this paper
• Redox-dependent downregulation of Rho by Rac

  2003cited by this paper
• NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.

  2003cited by this paper
• Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis.

  2003cited by this paper
• Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events.

  2002cited by this paper
• Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin.

  2002cited by this paper
• Oxidant-induced Vascular Endothelial Growth Factor Expression in Human Keratinocytes and Cutaneous Wound Healing*

  2002cited by this paper
• An NAD(P)H oxidase regulates growth and transcription in melanoma cells.

  2002cited by this paper
• Current molecular models for NADPH oxidase regulation by Rac GTPase.

  2002cited by this paper
• Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.

  2002cited by this paper
• A Novel Superoxide-producing NAD(P)H Oxidase in Kidney*

  2001cited by this paper
• A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes*

  2001cited by this paper

• Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells.

  2022cites this paper
• Carbon Monoxide Releasing Molecule-2-Upregulated ROS-Dependent Heme Oxygenase-1 Axis Suppresses Lipopolysaccharide-Induced Airway Inflammation

  2019cites this paper
• CO-Releasing Molecule-2 Induces Nrf2/ARE-Dependent Heme Oxygenase-1 Expression Suppressing TNF-α-Induced Pulmonary Inflammation

  2019cites this paper
• NOX2 Expression Is Increased in Keratinocytes After Burn Injury

  2019cites this paper
• Wnt5a Signaling Promotes Host Defense against Leishmania donovani Infection

  2017cites this paper
• Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair

  2017cites this paper
• NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation.

  2016cites this paper
• Changes in dermal matrix in the absence of Rac1 in keratinocytes

  2016cites this paper
• Design of dual inhibitors of ROCK-I and NOX2 as potential leads for the treatment of neuroinflammation associated with various neurological diseases including autism spectrum disorder.

  2015cites this paper
• Analysis of the role of Rho GTPases in epithelial cells

  2014cites this paper
• NADPH Oxidase Complex-Derived Reactive Oxygen Species, the Actin Cytoskeleton, and Rho GTPases in Cell Migration

  2014influential citation
• RhoA/ROCK downregulates FPR2-mediated NADPH oxidase activation in mouse bone marrow granulocytes.

  2014cites this paper