Impaired NADPH oxidase activity in Rac2‐deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Leukocyte Biology

• Publication date

  2006-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1189/jlb.0705371PMID 16275890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rac GTPase Isoform-specific Regulation of NADPH Oxidase and Chemotaxis in Murine Neutrophils in Vivo

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• The arachidonic acid‐binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac‐2

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• Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles1

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• Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass.

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• Anionic amphiphile and phospholipid-induced conformational changes in human neutrophil flavocytochrome b observed by fluorescence resonance energy transfer.

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• Reconstitution of Chemotactic Peptide-Induced Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase Activation in Transgenic COS-phox Cells1

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• Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathways.

  2003cited by this paper
• A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase.

  2003cited by this paper
• Properties of phagocyte NADPH oxidase p47-phox mutants with unmasked SH3 (Src homology 3) domains: full reconstitution of oxidase activity in a semi-recombinant cell-free system lacking arachidonic acid.

  2003cited by this paper
• Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement

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• The Hemopoietic Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates N-Formyl-Methionyl-Leucyl-Phenylalanine-Activated Neutrophil Functions 1

  2003cited by this paper
• Regulation of neutrophil function by Rac GTPases

  2003cited by this paper
• Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions1

  2003cited by this paper
• Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes

  2003cited by this paper
• Phospholipase C and phosphatidylinositol 3‐kinase signaling are involved in the exogenous arachidonic acid‐stimulated respiratory burst in human neutrophils

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  2002cited by this paper
• The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization.

  2002cited by this paper
• Cytosolic Phospholipase A2 (cPLA2) Regulation of Human Monocyte NADPH Oxidase Activity

  2002cited by this paper
• Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions1

  2002cited by this paper
• Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.

  2002cited by this paper
• Rac Activation Induces NADPH Oxidase Activity in Transgenic COS phox Cells, and the Level of Superoxide Production Is Exchange Factor-dependent*

  2002cited by this paper
• Protein Kinase C ζ Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47phox and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst

  2001cited by this paper
• Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways1

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• Differential Localization of Rho Gtpases in Live Cells

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• Essential Requirement of Cytosolic Phospholipase A2for Stimulation of NADPH Oxidase-associated Diaphorase Activity in Granulocyte-like Cells*

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• Protein Kinases C Translocation Responses to Low Concentrations of Arachidonic Acid*

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• Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

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• Activation of the Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B Signaling Pathway in Arachidonic Acid-stimulated Human Myeloid and Endothelial Cells

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• Genetic and Biochemical Evidence That Haploinsufficiency of the Nf1 Tumor Suppressor Gene Modulates Melanocyte and Mast Cell Fates in Vivo

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• Structure of the TPR domain of p67phox in complex with Rac.GTP.

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• Cytosolic Phospholipase A2 Is Required for Macrophage Arachidonic Acid Release by Agonists That Do and Do Not Mobilize Calcium

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• fMLP-induced arachidonic acid release in db-cAMP-differentiated HL-60 cells is independent of phosphatidylinositol-4, 5-bisphosphate-specific phospholipase C activation and cytosolic phospholipase A(2) activation.

  2000cited by this paper
• Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

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• Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils.

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• The effects of aliphatic (n-nonane), naphtenic (1,2, 4-trimethylcyclohexane), and aromatic (1,2,4-trimethylbenzene) hydrocarbons on respiratory burst in human neutrophil granulocytes.

  2000cited by this paper
• Arachidonic Acid and Phosphorylation Synergistically Induce a Conformational Change of p47 phox to Activate the Phagocyte NADPH Oxidase*

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  1999cited by this paper
• Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.

  1999cited by this paper
• Tetratricopeptide Repeat (TPR) Motifs of p67 phox Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase*

  1999cited by this paper
• Essential Requirement of Cytosolic Phospholipase A2for Activation of the Phagocyte NADPH Oxidase*

  1998cited by this paper
• Stimulation of p38 Phosphorylation and Activity by Arachidonic Acid in HeLa Cells, HL60 Promyelocytic Leukemic Cells, and Human Neutrophils

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• Evidence of ζ Protein Kinase C Involvement in Polymorphonuclear Neutrophil Integrin-dependent Adhesion and Chemotaxis*

  1998cited by this paper
• Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells.

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Arachidonic acid increases activation of NADPH oxidase in monocytic U937 cells by accelerated translocation of p47-phox and co-stimulation of protein kinase C.

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  1996cited by this paper
• The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1 (*)

  1996cited by this paper
• Differential Activation of Cytosolic Phospholipase A2 (cPLA2) by Thrombin and Thrombin Receptor Agonist Peptide in Human Platelets. EVIDENCE FOR ACTIVATION OF cPLA2 INDEPENDENT OF THE MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2 (*)

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  1994influential reference
• Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

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