Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Annals of Oncology

• Publication date

  2014-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/annonc/mdu191PMID 24915873
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial.

  2014cited by this paper
• Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis

  2013cited by this paper
• Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98.

  2013cited by this paper
• CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer

  2012cited by this paper
• Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis.

  2012cited by this paper
• Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

  2012cited by this paper
• Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials

  2012cited by this paper
• Tumour-infiltrating FOXP3+ lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer

  2012cited by this paper
• Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade

  2011cited by this paper
• Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer.

  2011cited by this paper
• Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer

  2011cited by this paper
• Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance

  2011cited by this paper
• An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer

  2011cited by this paper
• Immune parameters affecting the efficacy of chemotherapeutic regimens

  2011cited by this paper
• CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

  2011cited by this paper
• The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity.

  2010cited by this paper
• Missing covariate data in medical research: to impute is better than to ignore.

  2010cited by this paper
• Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer.

  2010cited by this paper
• Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

  2010cited by this paper
• Epitope landscape in breast and colorectal cancer.

  2008cited by this paper
• Immunosenescence of ageing

  2007cited by this paper
• Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.

  2006cited by this paper
• Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

  2006cited by this paper
• REporting recommendations for tumor MARKer prognostic studies (REMARK)

  2005cited by this paper
• Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

  2003cited by this paper
• Potential for selection bias with tumor tissue retrieval in molecular epidemiology studies.

  2002cited by this paper
• Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.

  1999cited by this paper
• The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects.

  1994cited by this paper

• Prominent protumoral cellular compartments of the tumor microenvironment in triple-negative breast cancer

  2026cites this paper
• Comprehensive analysis of mitophagy-related genes reveals prognostic signatures in breast cancer: based on immune landscapes and treatment target predict.

  2026cites this paper
• Unraveling TIME: CD8+ T cell– and CXCL11-driven endocrine resistance in breast cancer

  2026cites this paper
• Programmable local immunochemotherapy for triple-negative breast cancer via spatiotemporally controlled release of CpG oligodeoxynucleotides, gemcitabine, and paclitaxel.

  2026cites this paper
• IL3RA identified as novel biomarker and therapeutic target for ER+ breast cancer through plasma proteome-wide mendelian randomization and TCGA database analysis.

  2026cites this paper
• Research Progress on Immunotherapeutics for Triple-Negative Breast Cancer from a Single-cell Perspective.

  2026cites this paper
• Genetically engineered ErbB2 overexpression sensitizes organoid-derived tumors to checkpoint inhibition in a syngeneic model of gastric cancer.

  2026cites this paper
• DABSP: Integrating histologic and transcriptomic data for pan-cancer survival outcome prediction through a dual-directional attention based multimodal data fusion framework

  2026cites this paper
• Transcriptomics analysis unveils the complex interplay between diabetes and hypertension in regulating renal cell carcinoma pathway followed by pancreatic metastasis

  2025cites this paper
• The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes

  2025cites this paper
• Prognostic significance of CD8+ T cell Spatial Biomarkers in ER+ and ER− breast cancer: A retrospective cohort study

  2025cites this paper
• Leveraging a chromosomal instability-based signature to predict the prognosis and immune landscape of breast cancer

  2025cites this paper
• Subtype-specific genetic drivers of immune evasion in breast cancer

  2025cites this paper
• Kontextual reframes analysis of spatial omics data and reveals consistent cell relationships across images

  2025cites this paper
• Regulatory T Cells in Invasive Breast Cancer: Prognosis, Mechanisms and Therapy

  2025cites this paper
• Dynamic predictive power of TP53 signatures in breast cancer prognosis: Pre- and post-neoadjuvant chemotherapy insights

  2025cites this paper
• Tumor Infiltrating Lymphocytes in Breast Cancer: A Narrative Review with Focus on Analytic Validity, Clinical Validity, and Clinical Utility.

  2025cites this paper
• Cross-Talk Between Cancer and Its Cellular Environment—A Role in Cancer Progression

  2025cites this paper
• Quantitative analysis of T cell subsets in a population of Black women with invasive breast cancer

  2025cites this paper
• Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy.

  2025cites this paper
• Ferroptosis in tumor associated immune cells: a double-edged sword against tumors.

  2025cites this paper
• Prognostic significance of CD8 + tumor-infiltrating lymphocytes in operable breast cancer: a meta-analysis

  2025influential citation
• Inflammation in cancer: therapeutic opportunities from new insights

  2025cites this paper
• Breast carcinoma tumour-infiltrating lymphocytes in pre- and post-systemic therapy in HIV-positive and HIV-negative women

  2025cites this paper
• Inside the Tumor: Decoding the Feline Mammary Tumor Microenvironment and Its Prognostic Value—A Review

  2025cites this paper
• Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence

  2025cites this paper
• Unraveling the microbiome's role in breast cancer progression and treatment response.

  2025cites this paper
• Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse

  2025cites this paper
• Prognostic and predictive capacity of tumor infiltrating lymphocytes in the MA.20 regional node radiotherapy trial

  2025cites this paper
• Genomic characterization of tumor mutational burden-high breast carcinomas

  2025cites this paper
• Correlation of HLA‐A and HLA‐B/C Expression With PD‐1 and PD‐L1 Expression in Patients With Metastatic Breast Cancer as a Potential Prognosticator of Favorable Survival

  2025cites this paper
• Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer

  2025cites this paper
• Spatial proximity of CD8+ T cells to tumor cells predicts neoadjuvant therapy efficacy in breast cancer

  2025cites this paper
• Younger Age Is Associated with Favorable Outcomes in Adult Dogs with Hemangiosarcoma Receiving Adjuvant Doxorubicin Chemotherapy: Results from the PRO-DOX Study

  2025cites this paper
• High prevalence of FAP+ cancer-associated fibroblasts predicts poor outcome in patients with high-grade serous ovarian cancer with high CD8 T-cell density.

  2025cites this paper
• Genomic Characteristics Related to Histology-based Immune Features in Breast Cancer.

  2025cites this paper
• Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer

  2025cites this paper
• Breast cancer scoring based on a multiplexed profiling of soluble and cell-associated (immune) markers facilitates the prediction of pembrolizumab therapy

  2025cites this paper
• Expression characterization of the guanylate-binding protein gene family in breast cancer and its association with the immune microenvironment

  2025cites this paper
• Network-based transfer of pan-cancer immunotherapy responses to guide breast cancer prognosis

  2025cites this paper
• Optimizing TIL therapy for uveal melanoma: lessons learned and unlearned from cutaneous melanoma

  2025cites this paper
• Prognostic Significance of CD8 T-cell Spatial Biomarkers in ER+ and ER− Breast Cancer

  2025cites this paper
• Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes

  2025cites this paper
• Role of Multiparametric Ultrasound in Determining the Presence of Tumor‐Infiltrating Lymphocytes in Invasive Breast Cancer

  2025cites this paper
• Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

  2025cites this paper
• Digital Profiling of Immune Biomarkers in Breast Cancer: Relation to Anthracycline Benefit.

  2025cites this paper
• Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction

  2024cites this paper
• The transcriptional landscape of cancer stem-like cell functionality in breast cancer

  2024cites this paper
• Clinical protocol phase II study of tumor infiltrating lymphocytes in advanced tumors with alterations in the SWI/SNF complex: the TILTS study.

  2024cites this paper
• Prognostic Factors Associated with Breast Cancer-Specific Survival from 1995 to 2022: A Systematic Review and Meta-Analysis of 1,386,663 Cases from 30 Countries

  2024cites this paper
• Association of clinicopathologic and sonographic features with stromal tumor-infiltrating lymphocytes in triple-negative breast cancer

  2024cites this paper
• Detailed Profiling of the Tumor Microenvironment in Ethnic Breast Cancer, Using Tissue Microarrays and Multiplex Immunofluorescence

  2024cites this paper
• Advancing drug-response prediction using multi-modal and -omics machine learning integration (MOMLIN): a case study on breast cancer clinical data

  2024cites this paper
• Optimizing Lymphocyte Detection in Breast Cancer Whole Slide Imaging Through Data-Centric Strategies

  2024cites this paper
• The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer

  2024cites this paper
• "Cyclophosphamide and analogues; a matter of dose and schedule for dual anticancer activities".

  2024cites this paper
• Stromal B Lymphocytes Affecting Prognosis in Triple-Negative Breast Cancer by Opal/TSA Multiplexed Immunofluorescence

  2024cites this paper
• Regulatory T cells subgroups in the tumor microenvironment cannot be overlooked: Their involvement in prognosis and treatment strategy in melanoma

  2024cites this paper
• CD163+ macrophages in the triple-negative breast tumor microenvironment are associated with improved survival in the Women’s Circle of Health Study and the Women’s Circle of Health Follow-Up Study

  2024cites this paper
• Clinical and radiomics integrated nomogram for preoperative prediction of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer

  2024cites this paper
• The cellular composition of the tumor microenvironment is an important marker for predicting therapeutic efficacy in breast cancer

  2024cites this paper
• Exploring the underlying correlation between microbiota, immune system, hormones, and inflammation with breast cancer and the role of probiotics, prebiotics and postbiotics

  2024cites this paper
• Busting Breast Cancer Myths: A Deep Dive into Epidemiology, Risk Factors and Effective Management

  2024cites this paper
• Exploring histological predictive biomarkers for immune checkpoint inhibitor therapy response in non–small cell lung cancer

  2024cites this paper
• Translational and oncologic significance of tertiary lymphoid structures in pancreatic adenocarcinoma

  2024cites this paper
• Hist2Cell: Deciphering Fine-grained Cellular Architectures from Histology Images

  2024cites this paper
• Extracellular Matrix‐Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity

  2024cites this paper
• Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy

  2024cites this paper
• Experimental and clinical evidence in favour of an effective immune stimulation in ER-positive, endocrine-dependent metastatic breast cancer

  2024cites this paper
• A review concerning the breast cancer-related tumour microenvironment.

  2024cites this paper
• A non-inferiority, phase III trial of gemcitabine plus capecitabine versus gemcitabine plus carboplatin as first-line therapy and tumor-infiltrating lymphocytes as a prognostic biomarker in patients with advanced triple-negative breast cancer

  2024cites this paper
• Spatial distributions of CD8 and Ki67 cells in the tumor microenvironment independently predict breast cancer-specific survival in patients with ER+HER2– and triple-negative breast carcinoma

  2024cites this paper
• Identify critical genes of breast cancer and corresponding leading natural product compounds of potential therapeutic targets.

  2024cites this paper
• Integrating immunotherapy with conventional treatment regime for breast cancer patients- an amalgamation of armamentarium

  2024cites this paper
• Effect modification between HLA-F and CD56 markers reveals differences in survival for triple-negative breast cancer patients.

  2024cites this paper
• Prognostic Value of the Baseline Systemic Immune-Inflammation Index in HER2-Positive Metastatic Breast Cancer: Exploratory Analysis of Two Prospective Trials

  2024cites this paper
• Antitumor host immunity enhanced by near‐infrared photoimmunotherapy

  2024cites this paper
• Investigating the Correlation Between Long-Term Response in Patients with Metastatic HER2+ Breast Cancer and the Activity of Regulatory T Cells: A Retrospective Study

  2024cites this paper
• The conflicting prognostic role of the stroma-ratio in breast cancer molecular subtypes.

  2024cites this paper
• The Systemic Immune-Inflammation Index is a Predictor of Chemotherapy Sensitivity and Disease-Free Survival in Patients With Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.

  2024cites this paper
• Association between tumor-infiltrating lymphocytes and survival in patients with metastatic breast cancer receiving first-line chemotherapy: analysis of CALGB 40502

  2024cites this paper
• The Tumor Immune Microenvironment in Breast Cancer Progression

  2024cites this paper
• The breast cancer tumor microenvironment and precision medicine: immunogenicity and conditions favoring response to immunotherapy

  2024cites this paper
• Triple-Negative Breast Cancer Intrinsic FTSJ1 Favors Tumor Progression and Attenuates CD8+ T Cell Infiltration

  2024cites this paper
• Update on current and new potential immunotherapies in breast cancer, from bench to bedside

  2024cites this paper
• Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC

  2024cites this paper
• Estrogen Regulated Genes Compel Apoptosis in Breast Cancer Cells, Whilst Stimulate Antitumor Activity in Peritumoral Immune Cells in a Janus-Faced Manner

  2024cites this paper
• Integrated analysis reveals FLI1 regulates the tumor immune microenvironment via its cell-type-specific expression and transcriptional regulation of distinct target genes of immune cells in breast cancer

  2024cites this paper
• Tumor-infiltrating lymphocytes refine outcomes in triple-negative breast cancer treated with anthracycline-free neoadjuvant chemotherapy.

  2024cites this paper
• Molecular changes in breast cancer induced by radiation therapy.

  2024cites this paper
• Stratifying hepatocellular carcinoma based on immunophenotypes for immunotherapy response and prognosis

  2024cites this paper
• Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms

  2024cites this paper
• DNA Damage Responses in Tumors Are Not Proliferative Stimuli, but Rather They Are DNA Repair Actions Requiring Supportive Medical Care

  2024cites this paper
• Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer

  2024cites this paper
• Profiling Multiple CD8+ T-Cell Functional Dimensions Enhances Breast Cancer Immune Assessment.

  2024cites this paper
• Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer: a secondary analysis of a randomized clinical trial

  2023cites this paper
• Breast Cancer Immunity: It is TIME for the Next Chapter.

  2023cites this paper
• Clinical Meaning of Stromal Tumor Infiltrating Lymphocytes (sTIL) in Early Luminal B Breast Cancer

  2023cites this paper
• Survival in elderly patients with breast cancer with and without autoimmune disease

  2023cites this paper
• Analysis of immune subtypes in non-small-cell lung cancer based on TCGA database

  2023cites this paper