A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

No abstract is available for this paper.

• Publication year

  1997

• Venue

  The FASEB Journal

• Publication date

  1997-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fasebj.11.10.9271366PMID 9271366
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antioxidant and redox regulation of genes

  1999cited by this paper
• Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

  1997influential reference
• Mitochondrial function is involved in LDL oxidation mediated by human cultured endothelial cells.

  1997cited by this paper
• Evidence for numerous brown adipocytes lacking functional beta 3-adrenoceptors in fat pads from nonhuman primates.

  1996cited by this paper
• Antioxidant and redox regulation of gene transcription

  1996cited by this paper
• Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

  1996cited by this paper
• PUMPing plants

  1995cited by this paper
• The biochemistry of programmed cell death

  1995cited by this paper
• Causes of differences in respiration rate of hepatocytes from mammals of different body mass.

  1995cited by this paper
• A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein.

  1994cited by this paper
• Function and activation of NF-kappa B in the immune system.

  1994cited by this paper
• The development of mitochondrial medicine.

  1994cited by this paper
• Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate

  1993cited by this paper
• A role for oxygen radicals as second messengers.

  1991cited by this paper
• Molecular studies of the uncoupling protein

  1991cited by this paper
• Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile.

  1991cited by this paper
• Brown adipose tissue thermogenesis: interdisciplinary studies

  1990cited by this paper
• Mechanism and evolution of the uncoupling protein of brown adipose tissue.

  1990cited by this paper
• The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

  1990cited by this paper
• Oxidants and human disease: some new concepts

  1987cited by this paper
• Oxidants and human disease: some new concepts 1

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Thermogenic mechanisms in brown fat.

  1984cited by this paper
• CHAPTER 3 – Superoxide Radical and Hydrogen Peroxide in Mitochondria

  1982cited by this paper
• Localization of mitochondria in living cells with rhodamine 123.

  1980cited by this paper
• Postnatal development of rat liver mitochondria: state 3 respiration, adenine nucleotide translocase activity, and the net accumulation of adenine nucleotides.

  1980influential reference
• Mediation of the antilipolytic and lipogenic effects of insulin in adipocytes by intracellular accumulation of hydrogen peroxide.

  1980cited by this paper
• Preparation of isolated rat liver cells.

  1976cited by this paper
• Superoxide radicals as precursors of mitochondrial hydrogen peroxide

  1974cited by this paper
• Mitochondrial H2O2 formation: Relationship with energy conservation

  1973cited by this paper
• The cellular production of hydrogen peroxide.

  1972cited by this paper
• Respiratory chain linked H2O2 production in pigeon heart mitochondria

  1971cited by this paper
• [45] Cytochrome oxidase from beef heart mitochondria

  1967cited by this paper

• Effects of vitamin D on maturation and fatty acid metabolism in bone marrow-derived dendritic cells from atherosclerotic mice.

  2026cites this paper
• The pivotal role of mitochondria in the pathogenesis and treatment of liver failure: a comprehensive review.

  2026cites this paper
• Mitochondrial dysfunction and mitophagy as a driver of chronic kidney disease; an area for future exploration in feline chronic kidney disease?

  2025cites this paper
• Balb/c mice are protected from glucose and acute cold intolerance.

  2025cites this paper
• Therapeutic strategies to ameliorate mitochondrial oxidative stress in ischaemia-reperfusion injury: A narrative review

  2025cites this paper
• PGC-1α role in rescuing ferroptosis in cerebral ischemia/reperfusion injury through promoting mitochondrial biogenesis and UCP2 expression.

  2025cites this paper
• Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer

  2025cites this paper
• Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

  2025cites this paper
• USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts

  2024cites this paper
• Mitochondrial Physiology of Cellular Redox Regulations.

  2024cites this paper
• RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells

  2024cites this paper
• Catalpolaglycone disrupts mitochondrial thermogenesis by specifically binding to a conserved lysine residue of UCP2 on the proton leak tunnel.

  2024cites this paper
• A New Strategy for Targeting UCP2 to Modulate Glycolytic Reprogramming as a Treatment for Sepsis A New Strategy for Targeting UCP2

  2024cites this paper
• Reduction of hyperglycemia in STZ-induced diabetic mice by prophylactic treatment with heat-killed Mycobacterium aurum: possible effects on glucose utilization, mitochondrial uncoupling, and oxidative stress in liver and skeletal muscle

  2024cites this paper
• Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases

  2024cites this paper
• UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles

  2024cites this paper
• Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue

  2024cites this paper
• UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect

  2024cites this paper
• Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage

  2024cites this paper
• Inside the Biology of the β3-Adrenoceptor

  2024cites this paper
• Effect of CB1 Receptor Deficiency on Mitochondrial Quality Control Pathways in Gastrocnemius Muscle

  2024cites this paper
• Multigenerational exposure to temperature influences mitochondrial oxygen fluxes in the Medaka fish (Oryzias latipes)

  2024cites this paper
• Repurposing Niclosamide as a Therapeutic Drug against Acute Liver Failure by Suppressing Ferroptosis

  2023cites this paper
• Acanthamoeba castellanii Uncoupling Protein: A Complete Sequence, Activity, and Role in Response to Oxidative Stress

  2023cites this paper
• Antioxidant potential of nanomaterials

  2023cites this paper
• ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure

  2023cites this paper
• Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia

  2023cites this paper
• A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury

  2023cites this paper
• The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism

  2022cites this paper
• RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance

  2022cites this paper
• Proteome changes of sheep rumen epithelium during postnatal development

  2022cites this paper
• UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control

  2022cites this paper
• Circadian Control of Mitochondria in Reactive Oxygen Species Homeostasis

  2022cites this paper
• Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart

  2022cites this paper
• Antioxidant defense mechanisms and fatty acid catabolism in Red-billed Leiothrix (Leiothrix lutea) exposed to high temperatures

  2022cites this paper
• Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia

  2022cites this paper
• Regulation of Aging and Longevity by Ion Channels and Transporters

  2022cites this paper
• Role of UCP2 in the Energy Metabolism of the Cancer Cell Line A549

  2022cites this paper
• Protective Role of Mitochondrial Uncoupling Proteins against Age-Related Oxidative Stress in Type 2 Diabetes Mellitus

  2022cites this paper
• The Uncoupling Proteins: A Systematic Review on the Mechanism Used in the Prevention of Oxidative Stress

  2022cites this paper
• Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis

  2021cites this paper
• Management of Oxidative Stress: Crosstalk Between Brown/Beige Adipose Tissues and Skeletal Muscles

  2021cites this paper
• Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin

  2021cites this paper
• Mitochondrial redox biology: Reactive species production and antioxidant defenses

  2021cites this paper
• Uncoupling proteins in the mitochondrial defense against oxidative stress.

  2021cites this paper
• Progression-Mediated Changes in Mitochondrial Morphology Promotes Adaptation to Hypoxic Peritoneal Conditions in Serous Ovarian Cancer

  2021cites this paper
• Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg

  2021cites this paper
• Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

  2021cites this paper
• Mitochondrial reactive oxygen species in physiology and disease.

  2021cites this paper
• Quantile-specific heritability of 8-isoprostane and the modulating effects of smoking, alcohol, cardiovascular disease and diabetes on 8-isoprostane-gene interactions.

  2021cites this paper
• Mitochondria: Ultrastructure, dynamics, biogenesis, and main functions

  2021cites this paper
• Mitochondrial Management of Reactive Oxygen Species

  2021cites this paper
• Mitochondrial proton leaks and uncoupling proteins.

  2021cites this paper
• The review of the relationship between UCP2 and obesity: Focusing on inflammatory-obesity

  2021cites this paper
• Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?

  2021cites this paper
• Role of reactive oxygen species in atherosclerosis: Lessons from murine genetic models.

  2020cites this paper
• Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism

  2020cites this paper
• Intracellular delivery of therapeutic antisense oligonucleotides targeting mRNA coding mitochondrial proteins by cell-penetrating peptides.

  2020cites this paper
• Antileishmanial effect of the natural immunomodulator genipin through suppression of host negative regulatory protein UCP2.

  2020cites this paper
• JNK inhibition alleviates oxidative DNA damage, germ cell apoptosis, and mitochondrial dysfunction in testicular ischemia reperfusion injury.

  2020cites this paper
• Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

  2020cites this paper
• Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response.

  2020cites this paper
• Mitochondrial Protection by PARP Inhibition

  2020cites this paper
• AMPK, Mitochondrial Function, and Cardiovascular Disease

  2020cites this paper
• Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response

  2020cites this paper
• Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model

  2020cites this paper
• EFFECTS OF TRIMETHYLAMINE N-OXIDE ON MOUSE EMBRYONIC STEM CELL PROPERTIES

  2020cites this paper
• RND3/RhoE deficiency in preeclamptic women impairs placental mitochondrial function via regulation of the PPARgamma-UCP2 pathway

  2020cites this paper
• β3-Adrenoreceptor Activity Limits Apigenin Efficacy in Ewing Sarcoma Cells: A Dual Approach to Prevent Cell Survival

  2019cites this paper
• Mitochondria: Ultrastructure, Dynamics, Biogenesis and Main Functions

  2019cites this paper
• Omics Integration for Mitochondria Systems Biology

  2019cites this paper
• The Role of Phosphatidylethanolamine Adducts in Modification of the Activity of Membrane Proteins under Oxidative Stress

  2019cites this paper
• Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats

  2019cites this paper
• The Biological Impact of Oxidative Metabolism in Trypanosomatid Parasites: What Is the Perfect Balance Between Reactive Species Production and Antioxidant Defenses?

  2019cites this paper
• Hanging in the balance: mitochondrial uncoupling protein-2 and the tumor microenvironment

  2019cites this paper
• Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells

  2019cites this paper
• Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.

  2019cites this paper
• Exercise-Induced 4-Hydroxynonenal Alters Myotube Cellular Redox Homeostasis and Mitochondrial Metabolism

  2019cites this paper
• Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis

  2019cites this paper
• Oxidative Stress in Microbial Diseases

  2019cites this paper
• Les astrocytes réactifs, des partenaires anti-agrégants dans la maladie de Huntington : identification des mécanismes impliqués dans le dialogue neurone-astrocyte

  2019cites this paper
• Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

  2019cites this paper
• Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma

  2019cites this paper
• Mitochondrial uncoupling proteins UCP4 and UCP5 from the Pacific white shrimp Litopenaeus vannamei

  2019cites this paper
• Thyroid hormones mediate metabolic rate and oxidative, anti-oxidative balance at different temperatures in Mongolian gerbils (Meriones unguiculatus).

  2019cites this paper
• Protein S-glutathionylation: The linchpin for the transmission of regulatory information on redox buffering capacity in mitochondria.

  2019cites this paper
• Emerging Roles in the Biogenesis of Cytochrome c Oxidase for Members of the Mitochondrial Carrier Family

  2019cites this paper
• Molecular evolution of thermogenic uncoupling protein 1 and implications for medical intervention of human disease.

  2019cites this paper
• Mitochondrial Dynamics and Hypothalamic Regulation of Metabolism.

  2018cites this paper
• Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition.

  2018cites this paper
• Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

  2018influential citation
• Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling

  2018cites this paper
• Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen

  2018cites this paper
• The role of kisspeptin in energy balance

  2018cites this paper
• The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

  2018cites this paper
• Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins.

  2018cites this paper
• An Overview on the Role of Oligodendrocytes and Mitochondria in the Progression of Multiple Sclerosis

  2018cites this paper
• Uncoupling Protein 2 in Cardiovascular Health and Disease

  2018cites this paper
• Diverse roles of mitochondria in ischemic stroke

  2018cites this paper
• Mitochondrial uncoupling, ROS generation and cardioprotection.

  2018cites this paper