CD94/NKG2 Expression Does Not Inhibit Cytotoxic Function of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells1

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Immunology

• Publication date

  2002-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.169.2.693PMID 12097371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

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  2002influential reference
• CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter

  2001cited by this paper
• The non-classical MHC class I molecule Qa-1(b) inhibits classical MHC class I-restricted cytotoxicity of cytotoxic T lymphocytes.

  2001cited by this paper
• Evolution of the T Cell Repertoire During Primary, Memory, and Recall Responses to Viral Infection1

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  2000cited by this paper
• Molecular mimicry mediated by MHC class Ib molecules after infection with Gram-negative pathogens

  2000cited by this paper
• NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells1

  2000cited by this paper
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  2000influential reference
• Emergence of CD8+ T Cells Expressing NK Cell Receptors in Influenza A Virus-Infected Mice1

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

  1999cited by this paper
• In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production.

  1995cited by this paper
• Structural and Functional Characteristics of the Class Ib Molecule, Qa‐1

  1995cited by this paper
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  1994cited by this paper
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  1992cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1984cited by this paper
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