CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature Immunology

• Publication date

  2001-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/89810PMID 11429551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5

  2004cited by this paper
• Real-Time Quantitative PCR

  2002cited by this paper
• Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.

  2001cited by this paper
• Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter

  2000cited by this paper
• Acetylation by PCAF Enhances CIITA Nuclear Accumulation and Transactivation of Major Histocompatibility Complex Class II Genes

  2000cited by this paper
• The language of covalent histone modifications

  2000cited by this paper
• The Drosophila MSL Complex Acetylates Histone H4 at Lysine 16, a Chromatin Modification Linked to Dosage Compensation

  2000cited by this paper
• CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.

  2000cited by this paper
• Associations and Interactions between Bare Lymphocyte Syndrome Factors

  2000cited by this paper
• Novel Mutations Within the RFX-B Gene and Partial Rescue of MHC and Related Genes Through Exogenous Class II Transactivator in RFX-B-Deficient Cells1

  2000cited by this paper
• Acetylation of Histones and Transcription-Related Factors

  2000cited by this paper
• A common set of factors control the expression of the MHC class II, invariant chain, and HLA-DM genes.

  1999cited by this paper
• Overlapping but Distinct Patterns of Histone Acetylation by the Human Coactivators p300 and PCAF within Nucleosomal Substrates*

  1999cited by this paper
• A common set of factors control the expression of the MHC class II, invariant chain, and HLA-DM genes.

  1999cited by this paper
• The molecular basis of MHC class II deficiency and transcriptional control of MHC class II gene expression.

  1999cited by this paper
• CREB regulates MHC class II expression in a CIITA-dependent manner.

  1999cited by this paper
• Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction.

  1999cited by this paper
• RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency.

  1999cited by this paper
• Interactions between the Class II Transactivator and CREB Binding Protein Increase Transcription of Major Histocompatibility Complex Class II Genes

  1999cited by this paper
• A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity.

  1999cited by this paper
• NF-Y Is Associated with the Histone Acetyltransferases GCN5 and P/CAF*

  1998cited by this paper
• A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients

  1998cited by this paper
• Involvement of CREB Binding Protein in Expression of Major Histocompatibility Complex Class II Genes via Interaction with the Class II Transactivator

  1998cited by this paper
• CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo.

  1998cited by this paper
• The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes.

  1998cited by this paper
• Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

  1998cited by this paper
• The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element.

  1998cited by this paper
• Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.

  1998cited by this paper
• The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.

  1997cited by this paper
• Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein.

  1997cited by this paper
• Continuous fluorescence monitoring of rapid cycle DNA amplification.

  1997cited by this paper
• Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA.

  1997cited by this paper
• HLA-DMA and HLA-DMB gene expression functions through the conserved S-X-Y region.

  1997cited by this paper
• RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency

  1997cited by this paper
• Induction of MHC class I expression by the MHC class II transactivator CIITA.

  1997cited by this paper
• Site α Is Crucial for Two Routes of IFNγ-Induced MHC Class I Transactivation: The ISRE-Mediated Route and a Novel Pathway Involving CIITA

  1997cited by this paper
• Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation.

  1996cited by this paper
• A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

  1996cited by this paper
• Real time quantitative PCR.

  1996cited by this paper
• Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation.

  1996cited by this paper
• Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA).

  1995cited by this paper
• A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).

  1995cited by this paper
• Major Histocompatibility Complex Class II-associated Invariant Chain Gene Expression Is Up-regulated by Cooperative Interactions of Sp1 and NF-Y (*)

  1995cited by this paper
• Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.

  1994cited by this paper
• Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA

  1994cited by this paper
• Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes

  1994cited by this paper
• Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

  1994cited by this paper
• Two complementation groups account for most cases of inherited MHC class II deficiency.

  1994cited by this paper
• Class II MHC transcriptional mutants are defective in higher order complex formation.

  1993cited by this paper
• Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome).

  1993cited by this paper
• Phosphorylated CREB binds specifically to the nuclear protein CBP

  1993cited by this paper
• Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells

  1992cited by this paper
• In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma.

  1992cited by this paper
• Genetic complexity of regulatory mutants defective for HLA class II gene expression.

  1992cited by this paper
• Formaldehyde cross-linking and immunoprecipitation demonstrate developmental changes in H1 association with transcriptionally active genes

  1991cited by this paper
• Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.

  1991cited by this paper
• In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome.

  1991cited by this paper
• Current protocols in immunology

  1991cited by this paper
• Combined immunodeficiency with defective expression in MHC class II genes.

  1989cited by this paper
• HLA gene amplification and hybridization analysis of polymorphism. HLA matching for bone marrow transplantation of a patient with HLA-deficient severe combined immunodeficiency syndrome.

  1989cited by this paper
• Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

  1984cited by this paper
• Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets

  1983cited by this paper
• Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji).

  1966cited by this paper

• Biological mechanism and immune response of MHC-II expression in tumor cells

  2025cites this paper
• Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications

  2025cites this paper
• Targeting pattern recognition receptors for cancer therapy: Mechanisms and strategies

  2025cites this paper
• The epigenetic hallmarks of immune cells in cancer

  2025cites this paper
• Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma

  2025cites this paper
• Targeting epigenetic reprogramming in DLBCL and its interaction with the tumor microenvironment for novel therapeutic approaches.

  2025cites this paper
• Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception

  2024cites this paper
• SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2

  2024cites this paper
• Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells

  2024cites this paper
• The necessary role of an efficient tumor immunotherapy by MHC II expression on amateur APCs

  2024cites this paper
• SARS-COV-2 NSP5 Antagonizes MHC II Expresion by Subverting Histone Deacetylase 2

  2023cites this paper
• The role of NOD-like receptors in innate immunity

  2023cites this paper
• Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance

  2022cites this paper
• Mining the Immunopeptidome for Antigenic Peptides in Cancer

  2022cites this paper
• Distinct Molecular Mechanisms of Altered HLA Class II Expression in Malignant Melanoma

  2021cites this paper
• The Murine MHC Class II Super Enhancer IA/IE-SE Contains a Functionally Redundant CTCF-Binding Component and a Novel Element Critical for Maximal Expression

  2021cites this paper
• A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

  2021cites this paper
• IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis

  2021cites this paper
• The transcriptional cofactor IRF2BP2 plays a key role in T cell homeostasis and Treg cell expansion

  2021cites this paper
• A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

  2020influential citation
• A genome-wide screen in macrophages identifies new regulators of IFNg-inducible MHCII

  2020influential citation
• Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages

  2020cites this paper
• Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors

  2020cites this paper
• Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression

  2019cites this paper
• Role of Histone Acetylation and Acetyltransferases in Gene Regulation

  2019cites this paper
• Emerging role of histone deacetylase inhibitors in the treatment of diffuse large B-cell lymphoma

  2019cites this paper
• NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies.

  2019cites this paper
• A super enhancer controls expression and chromatin architecture within the MHC class II locus

  2019influential citation
• PD-1 Expression during Acute Infection Is Repressed through an LSD1–Blimp-1 Axis

  2019cites this paper
• Chemical and genetic control of IFNγ‐induced MHCII expression

  2018cites this paper
• The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

  2018cites this paper
• Characterization of genomic alterations in CIITA and their functional and clinical implications in malignant lymphomas

  2017cites this paper
• Histone Acetylation and the Regulation of Major Histocompatibility Class II Gene Expression.

  2017cites this paper
• Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance

  2017cites this paper
• A Phase II Exploratory Study of PXD-101 (Belinostat) Followed by Zevalin in Patients with Relapsed Aggressive High-Risk Lymphoma

  2017cites this paper
• Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5.

  2017cites this paper
• Chemical and genetic control of IFNγ-induced MHCII expression

  2017cites this paper
• NLRP7 contributes to in vitro decidualization of endometrial stromal cells

  2017cites this paper
• CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.

  2017cites this paper
• A phase II study of belinostat (PXD101) in relapsed and refractory aggressive B-cell lymphomas: SWOG S0520

  2016cites this paper
• The NOD-Like Receptors

  2016cites this paper
• The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription.

  2016cites this paper
• Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells

  2016cites this paper
• Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation

  2015cites this paper
• NF-κB Regulates PD-1 Expression in Macrophages

  2015cites this paper
• The Mechanistic Function of the NOD-like Receptor NLRX1 in Apoptosis and Cell Death in the Nervous System

  2015cites this paper
• A phase I/II trial of vorinostat (SAHA) in combination with rituximab‐CHOP in patients with newly diagnosed advanced stage diffuse large B‐cell lymphoma (DLBCL): SWOG S0806

  2015cites this paper
• Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas

  2015cites this paper
• Role of 26S Proteasome and Regulator of G-Protein Signaling 10 in Regulating Neuroinflammation in the Central Nervous System

  2015cites this paper
• Epigenetics and miRNA during bacteria-induced host immune responses.

  2015cites this paper
• Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment

  2015cites this paper
• This information is current as Macrophages B Regulates PD-1 Expression in κ

  2015cites this paper
• Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR.

  2015cites this paper
• The Dual Role of Nod-Like Receptors in Mucosal Innate Immunity and Chronic Intestinal Inflammation

  2014cites this paper
• Transcriptional Regulation of YWHAZ, the Gene Encoding 14-3-3ζ

  2014cites this paper
• STAT3, STAT4, NFATc1, and CTCF Regulate PD-1 through Multiple Novel Regulatory Regions in Murine T Cells

  2014cites this paper
• Contributing factors in multiple sclerosis and the female sex bias.

  2014cites this paper
• Regulatory Regions in Murine T Cells Regulate PD-1 through Multiple Novel STAT 3 , STAT 4 , NFATc 1 , and CTCF

  2014cites this paper
• B Cell Differentiation Is Associated with Reprogramming the CCCTC Binding Factor–Dependent Chromatin Architecture of the Murine MHC Class II Locus

  2014cites this paper
• Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types

  2014cites this paper
• Epigenetics and periodontal disease: hope to tame the untameable.

  2014cites this paper
• The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

  2014cites this paper
• Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection

  2014cites this paper
• Chromatin Remodelling During Host-Bacterial Pathogen Interaction

  2013cites this paper
• Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat

  2013cites this paper
• Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR.

  2013cites this paper
• Vemurafenib enhances MHC induction in BRAFV600E homozygous melanoma cells

  2013cites this paper
• Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence

  2013cites this paper
• CIITAMHC Class II Expression via IRF4 and Cell Activation of CD4 T Cells by Promoting Tuberous Sclerosis Complex 1 in Dendritic Critical Role of the Tumor Suppressor

  2013cites this paper
• The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

  2013cites this paper
• This information is current as in Human THP-1 Monocytic Cells Histone Deacetylation at the Promoter Region HLA-DR Gene Expression by Up-Regulating Induced γ Mycobacteria Inhibition of IFN-

  2013cites this paper
• B-Dependent Enhancer κ Mechanism of Action of a Distal NF-

  2013cites this paper
• Functions of NOD-Like Receptors in Human Diseases

  2013cites this paper
• miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1

  2013cites this paper
• Critical Role of the Tumor Suppressor Tuberous Sclerosis Complex 1 in Dendritic Cell Activation of CD4 T Cells by Promoting MHC Class II Expression via IRF4 and CIITA

  2013cites this paper
• Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.

  2012cites this paper
• NLRC5 Cooperates with the RFX Transcription Factor Complex To Induce MHC Class I Gene Expression

  2012cites this paper
• This information is current as Cell Differentiation to Plasma Cells Band MHC Class II Gene Expression during Is an Early Repressor of the CIITA ZBTB 32 and

  2012cites this paper
• Dysregulated Recruitment of the Histone Methyltransferase EZH2 to the Class II Transactivator (CIITA) Promoter IV in Breast Cancer Cells

  2012cites this paper
• MHC Class I Gene Expression Transcription Factor Complex To Induce NLRC5 Cooperates with the RFX

  2012cites this paper
• The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity.

  2012cites this paper
• Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

  2012cites this paper
• Alternatively Spliced Forms of Tollip Regulate Inflammatory Signalling in Macrophages

  2012cites this paper
• I Transactivator Expression in Mice Deficient for Nlrc 5 / Class Cutting Edge : Impaired MHC Class

  2012cites this paper
• NLRC5: a newly discovered MHC class I transactivator (CITA).

  2012cites this paper
• Cell Differentiation to Plasma Cells B and MHC Class II Gene Expression during Is an Early Repressor of the CIITA ZBTB32

  2012cites this paper
• Multiple Histone Methyl and Acetyltransferase Complex Components Bind the HLA-DRA Gene

  2012cites this paper
• ZBTB32 Is an Early Repressor of the CIITA and MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells

  2012cites this paper
• This information is current as Insulators through Interactions with MHC Class II Genes MHC Class II Cohesin Regulates

  2011cites this paper
• Early epigenetic events regulate the adaptive immune response gene CIITA

  2011influential citation
• Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

  2011cites this paper
• Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators

  2011cites this paper
• The 26S Proteasome and Histone Modifying Enzymes Regulate

  2011influential citation
• Histone deacetylase inhibitor enhances the anti-tumor effect of gemcitabine: a special reference to gene-expression microarray analysis.

  2011cites this paper
• Regulation of major histocompatibility complex class II genes.

  2011cites this paper
• CTCF Controls Expression and Chromatin Architecture of the Human Major Histocompatibility Complex Class II Locus

  2010cites this paper
• PU.1 Binds to a Distal Regulatory Element That Is Necessary for B Cell-Specific Expression of CIITA

  2010cites this paper
• NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

  2010cites this paper
• Regulation of major histocompatibility complex class II gene expression, genetic variation and disease

  2010cites this paper
• The locus control region of the MHC class II promoter acts as a repressor element, the activity of which is inhibited by CIITA.

  2010cites this paper