Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  EMBO Journal

• Publication date

  1988-09-01

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1002/j.1460-2075.1988.tb03140.xPMID 2460345PMCID PMC457076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Construction of a chimaeric type 1/type 2 poliovirus by genetic recombination.

  1988cited by this paper
• Antigen chimaeras of poliovirus as potential new vaccines

  1988cited by this paper
• Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.

  1988cited by this paper
• The atomic structure of Mengo virus at 3.0 A resolution.

  1987cited by this paper
• Reduced mouse neurovirulence of poliovirus type 2 lansing antigenic variants selected with monoclonal antibodies

  1987cited by this paper
• Expression of the poliovirus genome from infectious cDNA is dependent upon arrangements of eukaryotic and prokaryotic sequences in recombinant plasmids.

  1987cited by this paper
• Identification and characterization of a continuous neutralization epitope (C3) present on type 1 poliovirus.

  1987cited by this paper
• A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans

  1987cited by this paper
• Mapping of sequences required for mouse neurovirulence of poliovirus type 2 Lansing

  1986cited by this paper
• Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site

  1986cited by this paper
• Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA sequence analysis: Kbm9 and Kbm6.

  1986cited by this paper
• Antigenic structure of polioviruses of serotypes 1, 2 and 3.

  1986cited by this paper
• Highly infectious plasmids carrying poliovirus cDNA are capable of replication in transfected simian cells

  1986cited by this paper
• Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody.

  1985cited by this paper
• Rapid and easy sequencing of large linear double-stranded DNA and supercoiled plasmid DNA

  1985cited by this paper
• Three-dimensional structure of poliovirus at 2.9 A resolution.

  1985cited by this paper
• Structure of a human common cold virus and functional relationship to other picornaviruses

  1985cited by this paper
• Complete nucleotide sequences of all three poliovirus serotype genomes. Implication for genetic relationship, gene function and antigenic determinants.

  1984cited by this paper
• Comparison of the complete nucleotide sequences of the genomes of the neurovirulent poliovirus P3/Leon/37 and its attenuated Sabin vaccine derivative P3/Leon 12a1b.

  1984cited by this paper
• Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals.

  1984cited by this paper
• A poliovirus type 1 neutralization epitope is located within amino acid residues 93 to 104 of viral capsid polypeptide VP1.

  1983cited by this paper
• A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

  1983cited by this paper
• Localization of a poliovirus type 1 neutralization epitope in viral capsid polypeptide VP1.

  1983cited by this paper
• Natural variation of poliovirus neutralization epitopes

  1983cited by this paper
• Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.

  1982cited by this paper
• Molecular cloning of the genome of poliovirus type 1.

  1981cited by this paper
• Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.

  1981cited by this paper
• Efficient infection of monkey cells with DNA of simian virus 40.

  1981cited by this paper
• Cloned poliovirus complementary DNA is infectious in mammalian cells.

  1981cited by this paper
• A simple method to recover intact high molecular weight RNA and DNA after electrophoretic separation in low gelling temperature agarose gels.

  1979cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

  1975cited by this paper

• Characterization of Plaque Variants and the Involvement of Quasi-Species in a Population of EV-A71

  2020cites this paper
• Viral chimeras decrypt the role of enterovirus capsid proteins in viral tropism, acid sensitivity and optimal growth temperature

  2018cites this paper
• Polioviruses that bind a chimeric Pvr–nectin-2 protein identify capsid residues involved in receptor interaction

  2017cites this paper
• Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease

  2015cites this paper
• Recombinant Encephalomyocarditis Viruses Elicit Neutralizing Antibodies against PRRSV and CSFV in Mice

  2015cites this paper
• Pathogenic mechanisms of foodborne viral disease

  2014cites this paper
• Crystal Structures of Enterovirus 71 (EV71) Recombinant Virus Particles Provide Insights into Vaccine Design*

  2014cites this paper
• Enterovirus/picornavirus infections.

  2014cites this paper
• Identification of Site-Specific Adaptations Conferring Increased Neural Cell Tropism during Human Enterovirus 71 Infection

  2012cites this paper
• A mouse muscle-adapted enterovirus 71 strain with increased virulence in mice.

  2011cites this paper
• Development of a reverse genetic system for human enterovirus 71 (HEV71) and the molecular basis of its growth phenotype and adaptation to mice

  2009cites this paper
• Two clusters of mutations map distinct receptor-binding sites of echovirus 11 for the decay-accelerating factor (CD55) and for canyon-binding receptors.

  2009cites this paper
• Plant-produced microbial vaccines

  2009cites this paper
• Viable Polioviruses That Encode 2A Proteins with Fluorescent Protein Tags

  2009cites this paper
• Display of Peptides on the Surface of Tobacco Mosaic Virus Particles

  2009cites this paper
• Interactions between multiple genetic determinants in the 5' UTR and VP1 capsid control pathogenesis of chronic post-viral myopathy caused by coxsackievirus B1.

  2008cites this paper
• The molecular basis of mouse adaptation by human enterovirus 71.

  2008cites this paper
• C E : Common Structural Themes in Viral Cell Entry Pathways

  2008cites this paper
• Cooperative Effect of the Attenuation Determinants Derived from Poliovirus Sabin 1 Strain Is Essential for Attenuation of Enterovirus 71 in the NOD/SCID Mouse Infection Model

  2007cites this paper
• An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses

  2005cites this paper
• Selective cleavage by trypsin of the capsid protein VP1 of type 3 poliovirus results in improved sorting of cell bound virions

  2005cites this paper
• Cytotropism of Theiler's murine encephalomyelitis viruses in oligodendrocyte-enriched cultures

  2005cites this paper
• Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

  2005cites this paper
• A single amino acid substitution in the capsid protein VP1 of Coxsackievirus B3 (CVB3) alters plaque phenotype in Vero cells but not cardiovirulence in a mouse model

  2005cites this paper
• Poliovirus cell entry: common structural themes in viral cell entry pathways.

  2002cites this paper
• An overview of the evolution of enterovirus 71 and its clinical and public health significance.

  2002cites this paper
• Isolation of an Intertypic Poliovirus Capsid Recombinant from a Child with Vaccine-Associated Paralytic Poliomyelitis

  2002cites this paper
• Characterization of CHAT and Cox Type 1 Live-Attenuated Poliovirus Vaccine Strains

  2002cites this paper
• Molecular Genetic Analysis of Revertants from a Poliovirus Mutant That Is Specifically Adapted to the Mouse Spinal Cord

  2001cites this paper
• Phylogenetic Analysis of Enterovirus 71 Strains Isolated during Linked Epidemics in Malaysia, Singapore, and Western Australia

  2001cites this paper
• Coxsackievirus Expression of the Murine Secretory Protein Interleukin-4 Induces Increased Synthesis of Immunoglobulin G1 in Mice

  2000cites this paper
• Molecular Tectonic Model of Virus Structural Transitions: the Putative Cell Entry States of Poliovirus

  2000cites this paper
• Suppression of a Fusion Defect by Second Site Mutations in the Ecotropic Murine Leukemia Virus Surface Protein

  1999cites this paper
• Reverse genetics of picornaviruses.

  1999cites this paper
• Isolation and Molecular Characterization of a Poliovirus Type 1 Mutant That Replicates in the Spinal Cords of Mice

  1999cites this paper
• Molecular aspects of poliovirus biology with a special focus on the interactions with nerve cells.

  1998cites this paper
• Molecular epidemiology of enteroviruses with special reference to their potential role in the etiology of insulin-dependent diabetes mellitus (IDDM). A review.

  1998cites this paper
• An approach to understanding the mechanisms of poliovirus persistence in infected cells of neural or non-neural origin.

  1998cites this paper
• A New Internal Ribosomal Entry Site 5′ Boundary Is Required for Poliovirus Translation Initiation in a Mouse System

  1998cites this paper
• Characterization of mouse lines transgenic with the human poliovirus receptor gene.

  1998cites this paper
• Insect Cell Culture: Recent Advances, Bioengineering Challenges and Implications in Protein Production

  1998cites this paper
• Coxsackievirus B3-induced myocarditis. Characterization of stable attenuated variants that protect against infection with the cardiovirulent wild-type strain.

  1997cites this paper
• Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes.

  1997cites this paper
• Allele-specific adaptation of poliovirus VP1 B-C loop variants to mutant cell receptors

  1997cites this paper
• Structural studies of poliovirus mutants that overcome receptor defects

  1997cites this paper
• Host range phenotype induced by mutations in the internal ribosomal entry site of poliovirus RNA

  1997cites this paper
• Structure-based design of peptide presentation on a viral surface: the crystal structure of a plant/animal virus chimera at 2.8 A resolution.

  1996cites this paper
• The structure of a highly virulent Theiler's murine encephalomyelitis virus (GDVII) and implications for determinants of viral persistence.

  1996cites this paper
• The poliovirus receptor: a hook, or an unzipper?

  1996cites this paper
• A neutralization site of DA strain of Theiler's murine encephalomyelitis virus important for disease phenotype.

  1996cites this paper
• Poliovirus biology and pathogenesis.

  1996cites this paper
• Poliovirus neurovirulence correlates with the presence of a cryptic AUG upstream of the initiator codon.

  1996cites this paper
• Early events in poliovirus infection: virus-receptor interactions.

  1996cites this paper
• Persistent poliovirus infection of human fetal brain cells

  1996cites this paper
• Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating

  1996cites this paper
• Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis

  1995cites this paper
• WIN51711-resistant mutants of poliovirus type 3: capsid residues important in uncoating functions.

  1995cites this paper
• Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine

  1995cites this paper
• Isolation of escape mutants of a hybrid poliovirus with the aid of insert-specific polyclonal antibodies.

  1995cites this paper
• Poliovirus variants selected on mutant receptor-expressing cells identify capsid residues that expand receptor recognition

  1995cites this paper
• Molecular determinants of rotavirus virulence

  1995cites this paper
• Biologie moléculaire du poliovirus

  1995cites this paper
• Early Events in Infection: Receptor Binding and Cell Entry

  1995cites this paper
• Enterovirus Structure and Assembly

  1995cites this paper
• Racaniello residues that expand receptor recognition . receptor-expressing cells identify capsid Poliovirus variants selected on mutant

  1995cites this paper
• Cell clones cured of persistent poliovirus infection display selective permissivity to the wild-type poliovirus strain Mahoney and partial resistance to the attenuated Sabin 1 strain and Mahoney mutants.

  1995cites this paper
• The Human Poliovirus Receptor

  1995cites this paper
• Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1

  1995cites this paper
• Coxsackieviral proteins functionally recognize the polioviral cloverleaf structure of the 5'-NTR of a chimeric enterovirus RNA: influence of species-specific host cell factors on virus growth.

  1995cites this paper
• Theiler's virus as a vector for foreign gene delivery

  1995cites this paper
• The use of picornaviruses as vectors for the engineering of live recombinant vaccines.

  1995cites this paper
• Canyon rim residues, including antigenic determinants, modulate serotype-specific binding of polioviruses to mutants of the poliovirus receptor.

  1995cites this paper
• Antibody recognition of picornaviruses and escape from neutralization: a structural view.

  1995cites this paper
• Expression of a foreign epitope on the surface of the adenovirus hexon.

  1994cites this paper
• The construction and characterization of poliovirus antigen chimeras presenting defined regions of the human T lymphocyte marker CD4.

  1994cites this paper
• Attenuated poliovirus strain as a live vector: expression of regions of rotavirus outer capsid protein VP7 by using recombinant Sabin 3 viruses

  1994cites this paper
• Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions

  1994cites this paper
• Characterization of the N-terminal part of the neutralizing antigenic site I of coxsackievirus B4 by mutation analysis of antigen chimeras.

  1994cites this paper
• Attenuated Mengo virus as a vector for immunogenic human immunodeficiency virus type 1 glycoprotein 120.

  1994cites this paper
• Polioviruses containing picornavirus type 1 and/or type 2 internal ribosomal entry site elements: genetic hybrids and the expression of a foreign gene.

  1994cites this paper
• Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro

  1994cites this paper
• Vaccines prepared from chimeras of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies and protective immunity to multiple serotypes of FMDV

  1994cites this paper
• Design and construction of rhinovirus chimeras incorporating immunogens from polio, influenza, and human immunodeficiency viruses.

  1994cites this paper
• Poliovirus Neurovirulence and its Attenuation

  1993cites this paper
• Potential use of poliovirus as a vector.

  1993cites this paper
• The structure of human rhinovirus 16.

  1993cites this paper
• Precise missense and silent point mutations are fixed in the genomes of poliovirus mutants from persistently infected cells

  1993cites this paper
• Identification of a region of the poliovirus genome involved in persistent infection of HEp-2 cells

  1993cites this paper
• Use of new vectors for the development of vaccines.

  1993cites this paper
• Comparison of surface properties of picornaviruses: strategies for hiding the receptor site from immune surveillance.

  1993cites this paper
• Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell

  1993influential citation
• Infectious cDNA, cell receptors and transgenic mice in the study of Sabin's poliovirus vaccines.

  1993cites this paper
• Regulation of Gene Expression in Animal Viruses

  1993cites this paper
• A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

  1993cites this paper
• Aspects of the Molecular Biology of Poliovirus Replication

  1993cites this paper
• Poliovirus antigenic hybrids simultaneously expressing antigenic determinants from all three serotypes.

  1992cites this paper
• Poliovirus vaccines.

  1992cites this paper
• Poliovirus chimeras expressing sequences from the principal neutralization domain of human immunodeficiency virus type 1

  1992cites this paper
• Mapping of the RD phenotype of the Nancy strain of coxsackievirus B3.

  1992cites this paper
• Interaction of Poliovirus with its Immunoglobulin-like Cell Receptor

  1992cites this paper