Applications of MXene and its modified materials in skin wound repair

The rapid healing and repair of skin wounds has been receiving much clinical attention. Covering the wound with wound dressing to promote wound healing is currently the main treatment for skin wound repair. However, the performance of wound dressing prepared by a single material is limited and cannot meet the requirements of complex conditions for wound healing. MXene is a new two-dimensional material with electrical conductivity, antibacterial and photothermal properties and other physical and biological properties, which has a wide range of applications in the field of biomedicine. Based on the pathophysiological process of wound healing and the properties of ideal wound dressing, this review will introduce the preparation and modification methods of MXene, systematically summarize and review the application status and mechanism of MXene in skin wound healing, and provide guidance for subsequent researchers to further apply MXene in the design of skin wound dressing.

• Publication year

  2023

• Venue

  Frontiers in Bioengineering and Biotechnology

• Publication date

  2023-03-13

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.3389/fbioe.2023.1154301PMID 36994359PMCID 10042448
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fabrication and Performance Evaluation of Gelatin/Sodium Alginate Hydrogel-Based Macrophage and MSC Cell-Encapsulated Paracrine System with Potential Application in Wound Healing

  2023cited by this paper
• Recent Advances in the Synthesis of MXene Quantum Dots

  2023cited by this paper
• Bio-interface Engineering of MXene Nanosheets with Immobilized Lysozyme for Light Enhanced Enzymatic Inactivation of Methicillin-Resistant Staphylococcus aureus

  2022cited by this paper
• Polysaccharide Electrospun Nanofibers for Wound Healing Applications

  2022cited by this paper
• MXene-Chitosan Composites and Their Biomedical Potentials

  2022cited by this paper
• Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials

  2022cited by this paper
• Sponge‐Like Macroporous Hydrogel with Antibacterial and ROS Scavenging Capabilities for Diabetic Wound Regeneration

  2022cited by this paper
• Generation of cost-effective MXene@polydopamine-decorated chitosan nanofibrous wound dressing for promoting wound healing.

  2022cited by this paper
• Vitamin A in Skin and Hair: An Update

  2022cited by this paper
• Dual photothermal nanocomposites for drug-resistant infectious wound management.

  2022cited by this paper
• ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus–infected chronic skin wound healing

  2022cited by this paper
• Advances of MXenes; Perspectives on Biomedical Research

  2022cited by this paper
• An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing

  2022cited by this paper
• MXene-based hydrogels towards the photothermal applications

  2022cited by this paper
• Tailored Hydrogel Delivering Niobium Carbide Boosts ROS-Scavenging and Antimicrobial Activities for Diabetic Wound Healing.

  2022cited by this paper
• MXenes: state-of-the-art synthesis, composites and bioapplications.

  2022cited by this paper
• Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties.

  2022cited by this paper
• Flexible, high-strength and multifunctional polyvinyl alcohol/MXene/polyaniline hydrogel enhancing skin wound healing.

  2022cited by this paper
• Challenges in the diagnosis and management of wound infection

  2022cited by this paper
• Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing.

  2022cited by this paper
• Studies on stratum corneum metabolism: function, molecular mechanism and influencing factors

  2022cited by this paper
• Advances in preparation, mechanism and applications of various carbon materials in environmental applications: A review.

  2022cited by this paper
• Supramolecular Thermo‐Contracting Adhesive Hydrogel with Self‐Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA‐Infected Wound Healing

  2022cited by this paper
• Status and challenges of electrical stimulation use in chronic wound healing.

  2022cited by this paper
• Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications

  2022cited by this paper
• MXene‐Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing

  2022cited by this paper
• Microvascular remodeling following skin injury

  2022cited by this paper
• Chitosan for constructing stable polymer-inorganic suspensions and multifunctional membranes for wound healing.

  2022cited by this paper
• Photo-Activated Nanofibrous Membrane with Self-Rechargeable Antibacterial Function for Stubborn Infected Cutaneous Regeneration.

  2022cited by this paper
• Muscle-inspired MXene/PVA hydrogel with high toughness and photothermal therapy for promoting bacteria-infected wound healing.

  2022cited by this paper
• Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing

  2022cited by this paper
• The initiation of oxidative stress and therapeutic strategies in wound healing.

  2022cited by this paper
• Electroactive Oxidized Alginate/Gelatin/MXene (Ti3C2Tx) Composite Hydrogel with Improved Biocompatibility and Self-Healing Property

  2022cited by this paper
• Nanomaterials for NIR‐II Photoacoustic Imaging

  2022cited by this paper
• A Nanozyme‐Immobilized Hydrogel with Endogenous ROS‐Scavenging and Oxygen Generation Abilities for Significantly Promoting Oxidative Diabetic Wound Healing

  2022cited by this paper
• Interfacial engineering of Bi2S3/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing

  2021cited by this paper
• MXenes for Solar Cells

  2021cited by this paper
• Conductive Antibacterial Hemostatic Multifunctional Scaffolds Based on Ti3C2Tx MXene Nanosheets for Promoting Multidrug-Resistant Bacteria-Infected Wound Healing.

  2021cited by this paper
• 2D Ti3C2Tx flakes prepared by in-situ HF etchant for simultaneous screening of carbamate pesticides.

  2021cited by this paper
• Living in Your Skin: Microbes, Molecules, and Mechanisms

  2021cited by this paper
• MXene/Polymer Nanocomposites: Preparation, Properties, and Applications

  2021cited by this paper
• CVD carbon-coated carbonized loofah sponge loaded with a directionally arrayed MXene aerogel for electromagnetic interference shielding

  2021cited by this paper
• Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

  2021cited by this paper
• Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

  2021cited by this paper
• Research progress on tantalum carbide coatings oncarbon materials

  2021cited by this paper
• Healing Mechanisms in Cutaneous Wounds: Tipping the Balance

  2021cited by this paper
• Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing.

  2021cited by this paper
• Nano-silver functionalized polysaccharides as a platform for wound dressings: A review.

  2021cited by this paper
• A systematic review and meta-analysis of the association between fluoride exposure and neurological disorders

  2021cited by this paper
• Involved

  2021cited by this paper
• Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance

  2021cited by this paper
• A mini-review of MXene porous films: Preparation, mechanism and application

  2021cited by this paper
• pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

  2021cited by this paper
• Two-dimensional biomaterials: material science, biological effect and biomedical engineering applications.

  2021cited by this paper
• A multifunctional green antibacterial rapid hemostasis composite wound dressing for wound healing.

  2021cited by this paper
• MXene/Carbon Nanotube Hybrids: Synthesis, Structures, Properties and Applications.

  2021cited by this paper
• Energy conversion and optical applications of MXene quantum dots

  2021cited by this paper
• Advances in the Synthesis of 2D MXenes

  2021cited by this paper
• Functional Hydrogels as Wound Dressing to Enhance Wound Healing.

  2021cited by this paper
• Facile single-step synthesis of MXene@CNTs hybrid nanocomposite by CVD method to remove hazardous pollutants.

  2021cited by this paper
• 2D MXene Nanomaterials for Versatile Biomedical Applications: Current Trends and Future Prospects.

  2021cited by this paper
• Methods of synthesis, characteristics, and environmental applications of MXene: A comprehensive review.

  2021cited by this paper
• A multimodal antimicrobial platform based on MXene for treatment of wound infection.

  2021cited by this paper
• Bioactive anti-inflammatory, antibacterial, conductive multifunctional scaffold based on MXene@CeO2 nanocomposites for infection-impaired skin multimodal therapy

  2021cited by this paper
• Fascinating MXene nanomaterials: emerging opportunities in the biomedical field.

  2021cited by this paper
• Preparation Strategies and Applications of MXene-Polymer Composites: A Review.

  2021cited by this paper
• Keratinocyte Growth Factor-Based Strategies for Wound Re-Epithelialization

  2021cited by this paper
• Wound Healing: From Passive to Smart Dressings

  2021cited by this paper
• Multifunctional 3D-Printed Wound Dressings.

  2021cited by this paper
• Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction

  2021cited by this paper
• MXene-Based Nanocomposite Sensors

  2021cited by this paper
• MXene polymer nanocomposites: a review

  2021cited by this paper
• Accelerated Skin Wound Healing by Electrical Stimulation

  2021cited by this paper
• MXene in the lens of biomedical engineering: synthesis, applications and future outlook

  2021cited by this paper
• NIR-responsive MXene nanobelts for wound healing

  2021cited by this paper
• Ultrafast, One-Step, Salt-Solution-Based Acoustic Synthesis of Ti3C2 MXene

  2021cited by this paper
• The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

  2021cited by this paper
• 2D and Heterostructure Nanomaterial Based Strategies for Combating Drug-Resistant Bacteria

  2020cited by this paper
• Synthesis, characterizations, and biocompatibility evaluation of polycaprolactone–MXene electrospun fibers

  2020cited by this paper
• On tuning the cytotoxicity of Ti3C2 (MXene) flakes to cancerous and benign cells by post-delamination surface modifications

  2020cited by this paper
• Engineering of 2D transition metal carbides and nitrides MXenes for cancer therapeutics and diagnostics.

  2020cited by this paper
• Two-dimensional MXene-based materials for photothermal therapy

  2020cited by this paper
• Insights into the Photothermal Conversion of 2D MXene Nanomaterials: Synthesis, Mechanism, and Applications

  2020cited by this paper
• Alginate hydrogel dressings for advanced wound management.

  2020cited by this paper
• Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis.

  2020cited by this paper
• Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation

  2020cited by this paper
• Wound healing: cellular mechanisms and pathological outcomes

  2020cited by this paper
• Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti3C2Tx MXene

  2020cited by this paper
• Biomimetic, biocompatible and robust silk Fibroin-MXene film with stable 3D cross-link structure for flexible pressure sensors

  2020cited by this paper
• A developmental basis for the anatomical diversity of dermis in homeostasis and wound repair

  2020cited by this paper
• The Cutaneous Wound Innate Immunological Microenvironment

  2020cited by this paper
• [Skin aging: Pathophysiology and innovative therapies].

  2020cited by this paper
• Intelligent Nanoparticle-Based Dressings for Bacterial Wound Infections

  2020cited by this paper
• Combinatorial Photothermal 3D‐Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis

  2020cited by this paper
• Recent development and prospects of surface modification and biomedical applications of MXenes.

  2019cited by this paper
• Multilayered stable 2D nano-sheets of Ti2NTx MXene: synthesis, characterization, and anticancer activity

  2019cited by this paper
• Cytotoxicity Assessment of Ti-Al-C Based MAX Phases and Ti3C2Tx MXenes on Human Fibroblasts and Cervical Cancer Cells.

  2019cited by this paper
• Inflammation and Its Role in Regeneration and Repair.

  2019cited by this paper
• Principles of Wound Dressings: A Review.

  2019cited by this paper
• Hydrogel Dressings for Advanced Wound Management.

  2019cited by this paper

• Graphene and Ti3C2T x MXene Nanomaterial-Infused Bioinks for Mechanical and Electrical Improvement of 3D Bioprinted Scaffolds

  2026cites this paper
• Antibacterial hydrogels for skin infected wounds: frontier approaches as antibiotic alternatives therapy

  2026cites this paper
• Design, synergistic mechanisms, and application of a MXene@CuS–CeO₂ photothermal–nanozyme multimodal antibacterial material in real water systems

  2026cites this paper
• Bioengineered MXene-Polymer-Metal Composites: From Synthesis and Structure to Multimodal Diagnostic and Therapeutic Applications.

  2026cites this paper
• Magneto-Responsive BC/MX Nanocomposite Membranes Promote Bone Regeneration through Electrical Stimulation

  2026cites this paper
• Smart Composite Hydrogels for Monitoring and Managing Chronic Wounds.

  2026cites this paper
• Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis

  2025cites this paper
• Research progress on MXenes in polysaccharide-based hemostasis and wound healing: A review.

  2025cites this paper
• Recent Advances in Biomedical Applications of MXene‐Integrated Electrospun Fibers: A Review

  2025cites this paper
• Chitosan and polyvinyl alcohol-based bilayer electrospun nanofibrous membrane incorporated with astaxanthin promotes diabetic wound healing by addressing multiple factors.

  2025cites this paper
• Carboxymethyl Chitosan Delaminated Ti3C2 MXenes as a Potential Therapeutic Nano Platform to Combat Chronic Wounds.

  2025cites this paper
• Chitosan-MXene-Silver nanocomposite film with improved physicochemical and biological functionalities to potentiate wound healing process

  2025cites this paper
• AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4

  2025cites this paper
• Review: 2D MXenes for biomedical applications—recent advances, challenges, and future perspectives

  2025cites this paper
• Conductive biomaterials for chronic wound healing

  2025cites this paper
• Hydrogel Microneedle Array-Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of Chronic Wounds.

  2025cites this paper
• Meta-analyses of the evolution of MXene synthesis for bioengineering and artificial intelligence-driven applications

  2025cites this paper
• Effect of tandem-type stabilization of Nb2CTx MXene on their colloidal and cytotoxic properties

  2025cites this paper
• 3D-Printed Auxetic Hydrogel Dressings Reinforced With MXene and Carbonized Polymer Dots for Cascaded Antibacterial and Pro-Regenerative Effects in Wound Healing.

  2025cites this paper
• Sustainable MXene-chitosan/chitin composites for Interdisciplinary applications in water purification, bio-medical, bio-sensing and electronic fields

  2024cites this paper
• Fabrication of a MXene-based shape-memory hydrogel and its application in the wound repair of skin.

  2024cites this paper
• Emerging trends in the application of hydrogel-based biomaterials for enhanced wound healing: A literature review.

  2024cites this paper
• Eco‐Friendly Production of 2D Ti3C2Tx MXene and Cytotoxicity Mitigation Toward Biomedical Applications

  2024cites this paper
• Advancements in employing two-dimensional nanomaterials for enhancing skin wound healing: a review of current practice

  2024cites this paper
• Mxene enhanced shape memory polymer composites: The rise of MXenes as fillers for stimuli-responsive materials

  2024cites this paper
• Antibacterial and wound healing activity of non-thermal plasma treated and MXene (Ti3C2TX)/ WO3 coated cotton fabrics

  2024cites this paper
• From stimuli-responsive polymers to nanosystems and electrocircuits: an update on the current state of polymeric hydrogel microneedles for wound healing

  2024cites this paper
• External Physical Field-Responsive Nanocomposite Hydrogels for Wound Healing Applications

  2024cites this paper
• Non-thermal plasma treated and MXene (Ti3C2Tx)/Chitosan/TiO2 nanocomposite coated cotton fabrics-Antibacterial and wound healing applications

  2024cites this paper
• Research Progress on Ti3C2Tx-Based Composite Materials in Antibacterial Field

  2024cites this paper
• MXene-based composites in smart wound healing and dressings

  2024cites this paper
• Green, pH-Sensitive, Highly Stretchable, and Hydrogen Bond-Dominated Ionogel for Wound Healing Activity.

  2023cites this paper
• MXene-Embedded Electrospun Polymeric Nanofibers for Biomedical Applications: Recent Advances

  2023cites this paper