Formation and growth of multicellular spheroids of human origin

No abstract is available for this paper.

• Publication year

  1983

• Venue

  International Journal of Cancer

• Publication date

  1983-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.2910310502PMID 6852971
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Determinants for the establishment of permanent tissue culture lines from human gliomas.

  2009cited by this paper
• Long term culture of normal and neoplastic human glia.

  2009cited by this paper
• Banding patterns in human glioma cell lines.

  2009cited by this paper
• Spheroids in Cancer Research

  1984cited by this paper
• Expression of epidermal and nerve growth factor receptors and soft agar growth factor production by human lung cancer cells.

  1981cited by this paper
• Anchorage-independent growth of normal human fibroblasts.

  1981cited by this paper
• Penetration of substances into tumor tissue—A methodological study on cellular spheroids

  1981cited by this paper
• Radiation effects on cultured human lymphoid cells. Analysis using the growth extrapolation method.

  1981cited by this paper
• AN ESTABLISHED HUMAN CELL LINE DERIVED FROM A MALIGNANT MEDIASTINAL TERATOMA

  1980cited by this paper
• Surface glycoproteins of normal and neoplastic glia cells in culture

  1980cited by this paper
• Isolation and growth characteristics of continuous cell lines from small‐cell carcinoma of the lung

  1980cited by this paper
• Detection of induced DNA strand breaks with improved sensitivity in human cells.

  1980cited by this paper
• Variable radiobiological responses of spheroids.

  1980cited by this paper
• Resistance to adriamycin in multicellular spheroids.

  1979cited by this paper
• The Nature of Lymphoid Cell Lines and Their Relationship to the Virus

  1979cited by this paper
• Proliferation and viability in cellular spheroids of human origin.

  1978cited by this paper
• Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones.

  1978cited by this paper
• Properties of human malignant glioma cells in vitro.

  1978cited by this paper
• Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human culturei endothelial and glial cells.

  1977cited by this paper
• A simplified method for production and growth of multicellular tumor spheroids.

  1977cited by this paper
• Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human cultured endothelial and glial cells

  1977cited by this paper
• Cytochemical Profile of Human Haematopoietic Biopsy Cells and Derived Cell Lines

  1977cited by this paper
• A proliferation gradient in three‐dimensional colonies of cultured human glioma cells

  1977cited by this paper
• Cell Proliferation Kinetics and Radiation Therapy

  1977cited by this paper
• Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

  1976cited by this paper
• Radiation response of multicell spheroids--an in vitro tumour model.

  1976cited by this paper
• In vitro cultivation of human renal cell cancer

  1976cited by this paper
• Subdivision of the G1 phase of human glia cells in culture.

  1976cited by this paper
• In vitro cultivation of human renal cell cancer

  1976cited by this paper
• Serum stimulation of stationary human glia and glioma cells in culture.

  1975cited by this paper
• Establishment and characteristics of two unique cell lines from patients with lymphosarcoma

  1974cited by this paper
• IN VITRO AND IN VIVO LABELLING OF ANIMAL TUMOURS WITH TRITIATED THYMIDINE

  1973cited by this paper
• SELF-REGULATION OF GROWTH IN THREE DIMENSIONS

  1973cited by this paper
• Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

  1973cited by this paper
• The deficient density‐dependent growth control of human malignant glioma cells and virus‐transformed glia‐like cells in culture

  1973cited by this paper
• The relationship between growth rate, labelling index and histological type of human solid tumours.

  1973cited by this paper
• Soft Agar Techniques

  1973cited by this paper
• Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

  1973influential reference
• High‐frequency establishment of human immunoglobulin‐producing lymphoblastoid lines from normal and malignant lymphoid tissue and peripheral blood

  1971cited by this paper
• Relation between the pathological nature and the growth rate of human tumors.

  1971cited by this paper
• The Early Interaction of Coxsackievirus B3 with HeLa Cells

  1971cited by this paper
• Definition of a continuous human cell line derived from neuroblastoma.

  1970cited by this paper
• Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.

  1970cited by this paper
• Regulation of proliferation and movement of human glialike cells in culture.

  1969cited by this paper
• The mitotic apparatus of a giant ameba: solubility properties and induction of elongation.

  1969cited by this paper
• Minimum clone size for estimating normal reproductive capacity of cultured cells.

  1968cited by this paper
• The radiobiology of human cancer radiotherapy

  1968cited by this paper
• The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour.

  1968cited by this paper
• Cloning of Immunoglobulin-Producing Human Leukemic and Lymphoma Cells in Long-Term Cultures.∗

  1967cited by this paper
• Two established in vitro cell lines from human mesenchymal tumours

  1967cited by this paper
• Spontaneous lymphoblastoid transformation of long‐term cell cultures from human malignant lymphoma

  1967cited by this paper
• Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia

  1965cited by this paper
• AScites Tumours From BHK.21 Cells Transformed in Vitro by Polyoma Virus

  1964cited by this paper
• AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS.

  1964cited by this paper
• The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

  1955cited by this paper

• Comparative Viability Analysis of Monolayer Cell Suspension and Multicellular Tumor Spheroids as an In-vitro Tumor Model

  2025cites this paper
• From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research

  2025cites this paper
• The cost-efficient techniques to evaluate the age-based structural heterogeneity and morphological analysis of multicellular tumor spheroids.

  2025cites this paper
• Relaxin-2 is a novel biomarker for differentiated thyroid carcinoma in humans.

  2024cites this paper
• Robust formation of optimal single spheroids towards cost‐effective in vitro three‐dimensional tumor models

  2023cites this paper
• Spinal Cord Organoids to Study Motor Neuron Development and Disease

  2023cites this paper
• Generation of a 3D melanoma model and visualization of doxorubicin uptake by fluorescence imaging

  2022cites this paper
• Multi-cellular aggregates, a model for living matter

  2021cites this paper
• Swift Formation of Optimal Single Spheroids towards In-Vitro 3-Dimensional Tumour Models

  2021cites this paper
• Confocal Microscopy in Conjunction With Haemocytometry to Evaluate the Imperative Physical Characteristics of Multicellular Tumor Spheroids

  2021cites this paper
• Predicting the results of competition between two breast cancer lines grown in 3-D spheroid culture.

  2021cites this paper
• Potent antitumor activity of cepharanthine against triple-negative breast cancer spheroids compared with tetrandrine

  2020cites this paper
• Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation

  2020influential citation
• On a 2D Model of Avascular Tumor with Weak Allee Effect

  2019cites this paper
• Spheroid-3D and Monolayer-2D Intestinal Electrochemical Biosensor for Toxicity/Viability Testing: Applications in Drug Screening, Food Safety, and Environmental Pollutant Analysis.

  2019cites this paper
• Transport of trans‐activator of transcription (TAT) peptide in tumour tissue model: evaluation of factors affecting the transport of TAT evidenced by flow cytometry

  2019cites this paper
• Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs

  2018cites this paper
• Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles.

  2018cites this paper
• Predictive Modeling of Neuroblastoma Growth Dynamics in Xenograft Model After Bevacizumab Anti-VEGF Therapy

  2018cites this paper
• Development of a three-dimensional haematopoietic stem cell-permissive bone marrow niche model using magnetic levitation

  2018cites this paper
• Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts

  2018cites this paper
• Spheroids Formation on Non‐Adhesive Surfaces by Liquid Overlay Technique: Considerations and Practical Approaches

  2018cites this paper
• Preparation and analysis of cutaneous primary myofibroblast three-dimensional culture: an experimental system for myofibroblast deactivation studies.

  2017cites this paper
• Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence

  2017cites this paper
• Integration and automation of a micro-tissue and microsphere based tissue engineering system and its application in cartilage regeneration and cancer models

  2017cites this paper
• Coadministration of a tumor‐penetrating peptide improves the therapeutic efficacy of paclitaxel in a novel air‐grown lung cancer 3D spheroid model

  2017cites this paper
• A multiscale agent-based framework integrated with a constraint-based metabolic network model of cancer for simulating avascular tumor growth.

  2017cites this paper
• A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ 2

  2016cites this paper
• The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells

  2016cites this paper
• Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3′-oxime (7BIO)

  2015cites this paper
• A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth.

  2015cites this paper
• Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status

  2015cites this paper
• Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells

  2015cites this paper
• Characterization and Clinical Implication of Th1/Th2/Th17 Cytokines Produced from Three-Dimensionally Cultured Tumor Tissues Resected from Breast Cancer Patients

  2015cites this paper
• Study of the cytotoxicity of asiaticoside on rats and tumour cells

  2014cites this paper
• Expression of the cAMP Binding Protein EPAC1 in Thyroid Tumors and Growth Regulation of Thyroid Cells and Thyroid Carcinoma Cells by EPAC Proteins

  2014cites this paper
• Predictive Models of Diffusive Nanoparticle Transport in 3-Dimensional Tumor Cell Spheroids

  2013cites this paper
• Effects of ellagic acid in human neuroblastoma cells

  2013cites this paper
• Imaging Herpes Simplex Virus Type 1 Amplicon Vector–Mediated Gene Expression in Human Glioma Spheroids

  2011cites this paper
• Efficient Derivation and Propagation of Glioblastoma Stem-Like Cells Under Serum-Free Conditions Using the Cambridge Protocol

  2011cites this paper
• SOLID TUMORS : A REVIEW Review Article

  2011cites this paper
• Construction of divalent anti-keratin 8 single-chain antibodies (sc(Fv)(2)), expression in Pichia pastoris and their reactivity with multicellular tumor spheroids.

  2011cites this paper
• Localization of Complexed Anticytokeratin 8 scFv TS1-218 to HeLa HEp-2 Multicellular Tumor Spheroids and Experimental Tumors

  2010cites this paper
• Potential Utility and Limitations of Thyroid Cancer Cell Lines as Models for Studying Thyroid Cancer

  2009cites this paper
• Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung.

  2009cites this paper
• MONOCLONAL ANTIBODIES TO GLIAL FIBRILLARY ACIDIC PROTEIN

  2009cites this paper
• Neuropotency of human mesenchymal stem cell cultures: clonal studies reveal the contribution of cell plasticity and cell contamination.

  2008cites this paper
• Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

  2008cites this paper
• The inhibition of proliferation and migration of glioma spheroids exposed to temozolomide is less than additive if combined with irradiation.

  2007cites this paper
• Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

  2007cites this paper
• Molecular Cytogenetic Profiles of Novel and Established Human Anaplastic Thyroid Carcinoma Models

  2007cites this paper
• Head and neck squamous cell carcinoma cell lines: Established models and rationale for selection

  2007cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 273 Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

  2007cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 147 Predictive Factors in Esophageal Carcinoma

  2006cites this paper
• THE EFFECTS OF HUMAN RECOMBINANT TUMOR NECROSIS FACTOR ON MORPHOLOGICAL AND RADIORECEPTOR STUDIES

  2006cites this paper
• Accumulation of 10 Bin the Central Degenerative Areas of Human Glioma and Colon Carcinoma Spheroids after Sulfhydryl Boron Hydride Administration 1

  2006cites this paper
• MODULATION OF GROWTH, DIFFERENTIATION AND GLYCOPROTEIN SPHEROID MODEL FOR SQUAMOUS CARCINOMA OF THE HEAD AND NECK SYNTHESIS BY P-ALL-TRANS RETINOIC ACID IN A MULTICELLULAR TUMOR

  2006cites this paper
• Telomerase activity is not a key determinant of sensitivity to standard cytotoxic drugs in human esophageal carcinoma cell lines

  2006cites this paper
• Predictive factors in esophageal carcinoma.

  2006cites this paper
• Combined modality therapy of gemcitabine and irradiation on human glioma spheroids derived from cell lines and biopsy tissue.

  2006cites this paper
• Role of intercellular communications in breast cancer multicellular tumor spheroids after chemotherapy.

  2006cites this paper
• Effects of irradiation and cisplatin on human glioma spheroids: inhibition of cell proliferation and cell migration

  2005cites this paper
• Differential effects of TGF-beta1 on telomerase activity in thyroid carcinoma cell lines.

  2005cites this paper
• Homogeneous penetration but heterogeneous binding of antibodies to carcinoembryonic antigen in human colon carcinoma HT-29 spheroids

  2005cites this paper
• Tumour fragment spheroids from human non-small-cell lung cancer maintained in organ culture

  2004cites this paper
• Effects of DFMO on glioma cell proliferation, migration and invasion in vitro

  2004cites this paper
• Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids

  2004cites this paper
• Cell–cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression

  2004cites this paper
• Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids

  2004cites this paper
• Beta‐glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation

  2004cites this paper
• The effect of elevated intraocular oxygen on organelle degradation in the embryonic chicken lens

  2003cites this paper
• Enhancement of effects of irradiation by gemcitabine in a glioblastoma cell line and cell line spheroids

  2003cites this paper
• A new method to prepare multicellular spheroids in cancer cell lines using a thermo-reversible gelation polymer.

  2003cites this paper
• Drug Delivery and Transport to Solid Tumors

  2003cites this paper
• Photodynamic Therapy with Photofrin Reduces Invasiveness of U87 Malignant Human Glioma Cells

  2002cites this paper
• p16ink4a and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG‐A astrocytoma cells

  2002cites this paper
• Photodynamic Therapy with Photofrin Reduces Invasiveness of Malignant Human Glioma Cells

  2002cites this paper
• Collagen type I expression in experimental anaplastic thyroid carcinoma: Regulation and relevance for tumorigenicity

  2002cites this paper
• In vitro preclinical models for a rational design of chemotherapy combinations in human tumors.

  2001cites this paper
• BMP-7-induced cell cycle arrest of anaplastic thyroid carcinoma cells via p21(CIP1) and p27(KIP1).

  2001cites this paper
• Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence.

  2000cites this paper
• Simulated brain tumor growth dynamics using a three-dimensional cellular automaton.

  2000cites this paper
• The influence of lipophilicity on binding of boronated DNA-intercalating compounds in human glioma spheroids.

  2000cites this paper
• Establishment and characterization of the follicular thyroid carcinoma cell line ML-1

  2000cites this paper
• Spheroids: relation between tumour and endothelial cells.

  2000cites this paper
• Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells.

  2000cites this paper
• Binding of 125I after administration of 125I-EGF-dextran, 125I-EGF or 125I to human bladder cancer spheroids.

  2000cites this paper
• Clinical Pharmacology

  2000cites this paper
• Fibrosis in undifferentiated (anaplastic) thyroid carcinomas: evidence for a dual action of tumour cells in collagen type I synthesis

  2000cites this paper
• Spheroids in radiobiology and photodynamic therapy.

  2000cites this paper
• Co‐expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells

  1999cites this paper
• Non-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture

  1999influential citation
• Lack of responsiveness to TGF-β1 in a thyroid carcinoma cell line with functional type I and type II TGF-β receptors and Smad proteins, suggests a novel mechanism for TGF-β insensitivity in carcinoma cells

  1999cites this paper
• Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells.

  1999cites this paper
• Culture of human main pancreatic duct epithelial cells

  1998cites this paper
• Cell culture as spheroids: an approach to multicellular resistance.

  1998cites this paper
• [Multicellular resistance: another mechanisms of pleiotropic resistance?].

  1998cites this paper
• Hypotonic Ca2+ signaling and volume regulation in proliferating and quiescent cells from multicellular spheroids

  1998cites this paper
• Characterization of glial filament-cytoskeletal interactions in human astrocytomas: an immuno-ultrastructural analysis.

  1998cites this paper
• Role of glial filaments in cells and tumors of glial origin: a review

  1997cites this paper