An Overview of Dietary Flavonoids as a Nutraceutical Nanoformulation Approach to Life-Threatening Diseases.

Obesity, heart disease, diabetes, and cancer are just a few chronic diseases for which proper nutrition has been demonstrated to be a crucial factor in preven-tion. Flavonoids, found in many fruits and vegetables, are a type of dietary polyphenol with potent antioxidant activity and anti-carcinogenic characteris-tics. Flavonoids and foods rich in flavonoids have been shown in recent years to have profound effects on cognitive function, aging, and neurodegenerative diseases like Alzheimer's. Foods high in flavonoids, such as green tea, choco-late, blueberries, and other fruits and vegetables, have ameliorated symptoms of cognitive impairment, Alzheimer's disease, and dementia in several animal models. As a result of their ability to prevent neuronal death generated by neu-rotoxic chemicals such as free radicals and β-amyloid proteins. Furthermore, flavonoids are also effective in slowing the evolution of clinical signs of neuro-degenerative illnesses. In addition, flavonoids can improve lipid profiles by preventing the oxidation of low-density lipoproteins, and these antioxidant ca-pabilities are responsible for their therapeutic impacts. Finally, the potential of flavonoids to induce vasodilation and control apoptotic processes in the endo-thelium is another way in which they benefit the cardiovascular system. This review aims to offer up-to-date information on categorizing these compounds, their primary methods of action in the human body, and their positive impacts on the management of neurodegenerative diseases, cardiovascular disorders, and other life-threatening diseases.

• Publication year

  2023

• Venue

  Current Pharmaceutical Biotechnology

• Publication date

  2023-03-14

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.2174/1389201024666230314101654PMID 36918792
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of Flavonoid Supplementation on Common Eye Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

  2021cited by this paper
• Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

  2020cited by this paper
• Plants Used as Antihypertensive

  2020cited by this paper
• Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease.

  2020cited by this paper
• The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

  2020cited by this paper
• Self-Emulsifying Drug Delivery System (SEDDS): An Emerging Dosage Form to Improve the Bioavailability of Poorly Absorbed Drugs.

  2020cited by this paper
• Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance.

  2020cited by this paper
• Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases

  2020cited by this paper
• Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?

  2020cited by this paper
• The Effects of Flavonoids in Cardiovascular Diseases

  2020cited by this paper
• Flavonoids as anticancer therapies: A systematic review of clinical trials

  2019cited by this paper
• Nano-encapsulation of catechin in starch nanoparticles: Characterization, release behavior and bioactivity retention during simulated in-vitro digestion.

  2019cited by this paper
• Estimation of daily intake of flavonoids and major food sources in middle-aged Australian men and women.

  2019cited by this paper
• Ethyl oleate food-grade O/W emulsions loaded with apigenin: Insights to their formulation characteristics and physico-chemical stability.

  2019cited by this paper
• Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling.

  2019cited by this paper
• Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

  2019cited by this paper
• Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

  2019cited by this paper
• Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy.

  2019cited by this paper
• Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient

  2019cited by this paper
• Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

  2018cited by this paper
• The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function

  2018cited by this paper
• Self‐assembled amphiphilic zein‐lactoferrin micelles for tumor targeted co‐delivery of rapamycin and wogonin to breast cancer

  2018cited by this paper
• Enhancement of Anti-Inflammatory Properties of Nobiletin in Macrophages by a Nano-Emulsion Preparation.

  2018cited by this paper
• pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line.

  2018cited by this paper
• Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia

  2018cited by this paper
• Novel targets in Alzheimer's disease: A special focus on microglia.

  2018cited by this paper
• Physical properties and antioxidant capacity of chitosan/epigallocatechin-3-gallate films reinforced with nano-bacterial cellulose.

  2018cited by this paper
• Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies.

  2017cited by this paper
• Natural lipids enriched self-nano-emulsifying systems for effective co-delivery of tamoxifen and naringenin: Systematic approach for improved breast cancer therapeutics.

  2017cited by this paper
• Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals-An in vitro and in vivo approach.

  2017cited by this paper
• Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity.

  2017cited by this paper
• Wine Flavonoids in Health and Disease Prevention

  2017cited by this paper
• Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage

  2017cited by this paper
• In vitro study on anti-inflammatory effects of epigallocatechin-3-gallate-loaded nano- and microscale particles

  2017cited by this paper
• Endothelial and Smooth Muscle Cell Interactions in the Pathobiology of Pulmonary Hypertension.

  2016cited by this paper
• Flavonoids: an overview

  2016cited by this paper
• Blood pressure regulation in stress: focus on nitric oxide-dependent mechanisms.

  2016cited by this paper
• Chemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan

  2016cited by this paper
• Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124 086 US men and women followed for up to 24 years

  2016cited by this paper
• Synthesis and Characterization of Chrysin-loaded PCL-PEG-PCL nanoparticle and its effect on breast cancer cell line.

  2016cited by this paper
• Intake and major sources of dietary flavonoid in Korean adults: Korean National Health and Nutrition Examination Survey 2010-2012.

  2015cited by this paper
• Estimation of dietary flavonoid intake and major food sources of Korean adults

  2015cited by this paper
• Mitochondriotropic nanoemulsified genistein-loaded vehicles for cancer therapy.

  2015cited by this paper
• Flavonoid Intake in European Adults (18 to 64 Years)

  2015cited by this paper
• Preparation, characterization and in vivo evaluation of curcumin self-nano phospholipid dispersion as an approach to enhance oral bioavailability.

  2015cited by this paper
• Chondrogenic effect of cell-based scaffold of self-assembling peptides/PLGA-PLL loading the hTGFβ3 plasmid DNA

  2015cited by this paper
• Hesperetin inhibits rat coronary constriction by inhibiting Ca(2+) influx and enhancing voltage-gated K(+) channel currents of the myocytes.

  2014cited by this paper
• Effect of β-cyclodextrin on the molecular properties of myricetin upon nano-encapsulation: insight from optical spectroscopy and quantum chemical studies.

  2014cited by this paper
• Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer’s Disease

  2014cited by this paper
• Luteolin Nanoparticle in Chemoprevention: In Vitro and In Vivo Anticancer Activity

  2014cited by this paper
• Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells

  2014cited by this paper
• Using an FFQ to assess intakes of dietary flavonols and flavones among female adolescents in the Suihua area of northern China

  2014cited by this paper
• In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery.

  2014cited by this paper
• High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women

  2013cited by this paper
• Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3'-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities.

  2013cited by this paper
• Anti-Inflammatory Potency of Nano-Formulated Puerarin and Curcumin in Rats Subjected to the Lipopolysaccharide-Induced Inflammation

  2013cited by this paper
• TPGS emulsified zein nanoparticles enhanced oral bioavailability of daidzin: in vitro characteristics and in vivo performance.

  2013cited by this paper
• Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.

  2013cited by this paper
• Liposomes as carriers of the lipid soluble antioxidant resveratrol: evaluation of amelioration of oxidative stress by additional antioxidant vitamin.

  2013cited by this paper
• Function of BKCa Channels Is Reduced in Human Vascular Smooth Muscle Cells From Han Chinese Patients With Hypertension

  2013cited by this paper
• Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades.

  2013cited by this paper
• Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

  2012cited by this paper
• The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.

  2012cited by this paper
• Blueberries and Neuronal Aging

  2012cited by this paper
• The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP-PKA-dependent signaling pathway.

  2012cited by this paper
• In vivo efficacy studies of layer-by-layer nano-matrix bearing kaempferol for the conditions of osteoporosis: a study in ovariectomized rat model.

  2012cited by this paper
• The Use of Silymarin in the Treatment of Liver Diseases

  2012cited by this paper
• Polyphenols and neuroprotection against ischemia and neurodegeneration.

  2011cited by this paper
• Hepatoprotective Effect of Flavonoid Glycosides from Lespedeza cuneata against Oxidative Stress Induced by tert‐Butyl Hyperoxide

  2011cited by this paper
• Flavonoids and Isoflavonoids: From Plant Biology to Agriculture and Neuroscience

  2010cited by this paper
• Inhibition of neointimal formation by trans-resveratrol: role of phosphatidyl inositol 3-kinase-dependent Nrf2 activation in heme oxygenase-1 induction.

  2010cited by this paper
• Current therapeutic targets for the treatment of Alzheimer’s disease

  2010cited by this paper
• Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment.

  2010cited by this paper
• Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort

  2010cited by this paper
• The Standard American Diet and its relationship to the health status of Americans.

  2010cited by this paper
• Regulation of vascular endothelial function by procyanidin-rich foods and beverages.

  2010cited by this paper
• Dietary Flavonol and Flavone Intakes and Their Major Food Sources in Chinese Adults

  2010cited by this paper
• Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain).

  2010cited by this paper
• Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects.

  2009cited by this paper
• (-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency.

  2009cited by this paper
• Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice.

  2008cited by this paper
• Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

  2008cited by this paper
• Enhanced wound healing by an epigallocatechin gallate‐incorporated collagen sponge in diabetic mice

  2008cited by this paper
• Grape-Derived Polyphenolics Prevent Aβ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

  2008cited by this paper
• Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

  2008cited by this paper
• Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease

  2008cited by this paper
• Flavonoids from Limnophila indica.

  2007cited by this paper
• Antibacterial pterocarpans from Erythrina subumbrans.

  2007cited by this paper
• Intake of specific flavonoids and risk of acute myocardial infarction in Italy

  2006cited by this paper
• Flavonoids Attenuate Cardiovascular Disease, Inhibit Phosphodiesterase, and Modulate Lipid Homeostasis in Adipose Tissue and Liver

  2006cited by this paper
• Age-related variations in flavonoid intake and sources in the Australian population

  2006cited by this paper
• Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia.

  2006cited by this paper
• Antioxidative flavanone glycosides from the branches and leaves of Viscum coloratum.

  2006cited by this paper
• Hepatoprotective effect of total flavonoids from Laggera alata against carbon tetrachloride-induced injury in primary cultured neonatal rat hepatocytes and in rats with hepatic damage.

  2006cited by this paper
• Isolation and in vitro antibacterial activity of astilbin, the bioactive flavanone from the leaves of Harungana madagascariensis Lam. ex Poir. (Hypericaceae).

  2006cited by this paper
• (+/−)‐Naringenin as large conductance Ca2+‐activated K+ (BKCa) channel opener in vascular smooth muscle cells

  2006cited by this paper
• Antioxidant activity with flavonoidal constituents fromAerva persica

  2006cited by this paper
• Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

  2005cited by this paper
• Antimicrobial and radical scavenging flavonoids from the stem wood of Erythrina latissima.

  2005cited by this paper
• Antioxidant constituents of the aerial parts of Globularia alypum growing in Morocco.

  2005cited by this paper

• Dual-Excited-State Intramolecular Proton Transfer Pathways Observed in Fisetin

  2026cites this paper
• Prunin: An Emerging Anticancer Flavonoid

  2025cites this paper
• Flavonoid glycosides of Stachys kurdica Boiss. & Hohen. against human lung cancer cells upon enzymatic docking paradigm

  2025cites this paper
• Integrated Experimental and Computational Investigation of Flavonoid–Nile Blue Interactions: Binding Mechanism, Antioxidant Activity, and PLS Modeling

  2025cites this paper
• Neuroprotective potential of Rhus coriaria: Insights into acetylcholinesterase inhibition and amyloid-β modulation

  2025cites this paper
• Impact of B-Ring Substitution on the Anti-Inflammatory Activity of Nitrochalcones

  2025cites this paper
• Exploring the biochemical potential of roselle seed (Hibiscus Sabdariffa L.) flour: Antioxidant and antinutrient responses to processing methods

  2024cites this paper
• Exploring the Therapeutic Potential of Flavonoids in the Management of Cancer.

  2024cites this paper
• Use of medicinal plants in the control of fish parasites and problems related to their use in ethnoveterinary treatment-A review

  2024cites this paper