Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood.v90.12.4789PMID 9389695
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

  1996cited by this paper
• Protein-Tyrosine Phosphorylation and p72 syk Activation in Human Platelets Stimulated with Collagen Is Dependent upon Glycoprotein Ia/IIa and Actin Polymerization

  1996cited by this paper
• Complete Amino Acid Sequence and Identification of the Platelet Glycoprotein Ib-binding Site of Jararaca GPIb-BP, a Snake Venom Protein Isolated from Bothrops jararaca(*)

  1996cited by this paper
• Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptide.

  1996cited by this paper
• Integrin alpha IIb beta 3-mediated translocation of CDC42Hs to the cytoskeleton in stimulated human platelets.

  1995cited by this paper
• Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

  1995cited by this paper
• Protein Tyrosine Phosphorylation in Human Platelets during Shear Stress-Induced Platelet Aggregation (SIPA) Is Regulated by Glycoprotein (GP) Ib/IX as well as GP IIb/IIIa and Requires Intact Cytoskeleton and Endogenous ADP

  1995cited by this paper
• Cytosolic Phospholipase A2 Is Phosphorylated in Collagen- and Thrombin-stimulated Human Platelets Independent of Protein Kinase C and Mitogen-activated Protein Kinase (*)

  1995cited by this paper
• Isolation and Characterization of jararaca GPIb-BP, a Snake Venom Antagonist Specific to Platelet Glycoprotein lb

  1995cited by this paper
• Anti-CD9 Monoclonal Antibody Activates p72syk in Human Platelets (*)

  1995cited by this paper
• Ristocetin-induced Platelet Agglutination Stimulates GPIIb/IIIa-dependent Calcium Influx

  1995cited by this paper
• Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor.

  1995cited by this paper
• Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2 (*)

  1995cited by this paper
• Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets.

  1995cited by this paper
• Thrombin Induces Activation of p38 MAP Kinase in Human Platelets (*)

  1995cited by this paper
• Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.

  1994cited by this paper
• Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s).

  1994cited by this paper
• Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.

  1994cited by this paper
• Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers.

  1994cited by this paper
• Translocation of p72syk to the cytoskeleton in thrombin-stimulated platelets.

  1994cited by this paper
• Tyrosine kinases Lyn and Syk regulate B cell receptor‐coupled Ca2+ mobilization through distinct pathways.

  1994cited by this paper
• Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.

  1994cited by this paper
• Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.

  1993cited by this paper
• von Willebrand factor

  1993cited by this paper
• On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

  1993cited by this paper
• Protein kinase C is activated in platelets subjected to pathological shear stress.

  1993cited by this paper
• Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets

  1993cited by this paper
• Association with B-cell-antigen receptor with protein-tyrosine kinase p72syk and activation by engagement of membrane IgM.

  1993cited by this paper
• Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets.

  1993cited by this paper
• von Willebrand factor: structure and function.

  1993cited by this paper
• Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets

  1992cited by this paper
• Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation.

  1992cited by this paper
• Translocation of pp60c‐src to the cytoskeleton during platelet aggregation.

  1992cited by this paper
• Protein-tyrosine kinase p72syk is activated by wheat germ agglutinin in platelets.

  1992cited by this paper
• Association of pp60src with Triton X-100-insoluble residue in human blood platelets requires platelet aggregation and actin polymerization.

  1992cited by this paper
• von Willebrand factor: structure and function.

  1991cited by this paper
• Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib.

  1991cited by this paper
• The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.

  1991cited by this paper
• Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca.

  1991cited by this paper
• von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

  1991cited by this paper
• Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

  1991cited by this paper
• High pp60c-src level in human platelet dense bodies.

  1989cited by this paper
• Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor.

  1989cited by this paper
• von Willebrand factor and von Willebrand disease.

  1987cited by this paper
• The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments.

  1986cited by this paper
• von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.

  1986cited by this paper
• Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

  1986cited by this paper
• Defective ristocetin-induced platelet aggregation in von Willebrand's disease and its correction by factor VIII.

  1973cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Molecular mechanisms driving the interactions between platelet and gastric cancer cells during peritoneal dissemination

  2024cites this paper
• Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets

  2023cites this paper
• Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets

  2022cites this paper
• Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy

  2020cites this paper
• Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling

  2017cites this paper
• Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.

  2017cites this paper
• Metalloproteolytic receptor shedding…platelets “acting their age”

  2016cites this paper
• Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets*

  2015cites this paper
• Platelets: Still a Therapeutical Target for Haemostatic Disorders

  2014cites this paper
• Phosphoproteomic analysis of platelet signalling cascades by flow cytometry

  2014cites this paper
• Molecular cloning and characterization of rhesus monkey platelet glycoprotein Ibα, a major ligand-binding subunit of GPIb-IX-V complex.

  2014cites this paper
• Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb‐IX‐V, and CLEC‐2

  2013cites this paper
• Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains.

  2011cites this paper
• Historical perspective and future directions in platelet research

  2011cites this paper
• A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

  2010cites this paper
• Lasers and liposomes : a potentially efficacious combination for the non-invasive removal of pathological cutaneous vasculature

  2009cites this paper
• Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.

  2008cites this paper
• Transformation, genomic instability and senescence mediated by platelet/megakaryocyte glycoprotein Ibα

  2007cites this paper
• A role for glycosphingolipid‐enriched microdomains in platelet glycoprotein Ib‐mediated platelet activation

  2007cites this paper
• von Willebrand factor activates endothelial nitric oxide synthase in blood platelets by a glycoprotein Ib‐dependent mechanism

  2006cites this paper
• GPVI Potentiation of Platelet Activation by Thrombin and Adhesion Molecules Independent of Src Kinases and Syk

  2006cites this paper
• Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3.

  2006cites this paper
• Platelet GPIb‐IX‐V‐dependent signaling

  2005cites this paper
• Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib

  2005cites this paper
• Intracellular signaling in platelets

  2005cites this paper
• Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner.

  2005cites this paper
• A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications.

  2005cites this paper
• Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an (cid:1) IIb (cid:2) 3- and aggregation-independent manner

  2005cites this paper
• GPIb is involved in platelet aggregation induced by mucetin, a snake C-type lectin protein from Chinese habu (Trimeresurus mucrosquamatus) venom

  2004cites this paper
• Signalling through the platelet glycoprotein Ib-V-IX complex.

  2004cites this paper
• GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase.

  2004cites this paper
• Platelet adhesion signalling and the regulation of thrombus formation

  2004influential citation
• Cleavage of platelet endothelial cell adhesion molecule‐1 (PECAM‐1) in platelets exposed to high shear stress

  2004cites this paper
• Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors.

  2004cites this paper
• Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions

  2004cites this paper
• Role of the Pyk2–MAP Kinase–cPLA2 Signaling Pathway in Shear-Dependent Platelet Aggregation

  2004cites this paper
• Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase.

  2003cites this paper
• A palmitylated peptide derived from the glycoprotein Ibβ cytoplasmic tail inhibits platelet activation

  2003cites this paper
• von Willebrand factor (VWF)‐dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function

  2003cites this paper
• Signaling events underlying thrombus formation

  2003cites this paper
• Understanding platelet function through signal transduction.

  2003cites this paper
• A role for p38 MAP kinase in platelet activation by von Willebrand Factor

  2003cites this paper
• PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets.

  2003cites this paper
• Activation of pp125FAK by type 2B recombinant von Willebrand factor binding to platelet GPIb at a high shear rate occurs independently of alpha IIb beta 3 engagement.

  2003cites this paper
• Activation of pp125FAK by type 2B recombinant von Willebrand factor binding to platelet GPIb at a high shear rate occurs independently of αIIbβ3 engagement

  2003cites this paper
• Filamin A binding to the cytoplasmic tail of glycoprotein Ibalpha regulates von Willebrand factor-induced platelet activation.

  2003cites this paper
• Activation of pp125FAK by type 2B recombinant von Willebrand factor binding to platelet GPIb at a high shear rate occurs independently of (cid:1) IIb (cid:2) 3 engagement

  2003cites this paper
• Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

  2003cites this paper
• Proline-rich Tyrosine Kinase 2 and Focal Adhesion Kinase Are Involved in Different Phases of Platelet Activation by vWF

  2002influential citation
• Localization of the Adhesion Receptor Glycoprotein Ib-IX-V Complex to Lipid Rafts Is Required for Platelet Adhesion and Activation

  2002cites this paper
• Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions.

  2002cites this paper
• Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway.

  2002cites this paper
• A Dual Function Anti-leukemic Agent with Anti-thrombotic Activity

  2002cites this paper
• Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.

  2002cites this paper
• Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions.

  2002cites this paper
• Dynamic Aspects Of Platelet Adhesion Under Flow

  2001cites this paper
• Aggretin, a Heterodimeric C-type Lectin from Calloselasma rhodostoma (Malayan Pit Viper), Stimulates Platelets by Binding to α2β1 Integrin and Glycoprotein Ib, Activating Syk and Phospholipase Cγ2, but Does Not Involve the Glycoprotein VI/Fc Receptor γ Chain Collagen Receptor*

  2001cites this paper
• Fibroblast Lines Receptor-Associated Factor-6 in Nasal Through the Association of Syk with TNF IL-1 Induced Chemokine Production

  2001cites this paper
• Identification and Characterisation of a Platelet GPIb/V/IX‐like Complex on Human Breast Cancers: Implications for the Metastatic Process

  2001cites this paper
• A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.

  2001cites this paper
• Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMkappa responsible for platelet agglutination in plasma and inducing signal transduction.

  2001cites this paper
• Fc-receptor Dependent Platelet Aggregation Induced by Monoclonal Antibodies against Platelet Glycoprotein Ib or von Willebrand Factor

  2001influential citation
• IL-1 Induced Chemokine Production Through the Association of Syk with TNF Receptor-Associated Factor-6 in Nasal Fibroblast Lines1

  2001cites this paper
• Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling.

  2001cites this paper
• Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2.

  2001cites this paper
• Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor*

  2001cites this paper
• Immunoneutralization of glycoprotein Ibα attenuates endotoxin-induced interactions of platelets and leukocytes with rat venular endothelium in vivo

  2001cites this paper
• Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta.

  2000cites this paper
• Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn.

  2000cites this paper
• Structural determinants within platelet glycoprotein Ibα involved in its binding to von Willebrand factor

  2000cites this paper
• Activation of protein–tyrosine kinase pathways in human platelets stimulated with the A1 domain of von Willebrand factor

  2000influential citation
• Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates.

  2000cites this paper
• Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets: implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization.

  2000cites this paper
• Networks in signal transduction: the role of adaptor proteins in platelet activation

  2000cites this paper
• Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2.

  2000cites this paper
• Platelet activation mediated through membrane glycoproteins: involvement of tyrosine kinases.

  2000cites this paper
• Porcine von Willebrand factor and thrombin induce the activation of c‐Jun amino‐terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal‐related kinase 2 (ERK2) in human platelets

  2000cites this paper
• Activation of protein-tyrosine kinase pathways in human platelets stimulated with the A1 domain of von Willebrand factor.

  2000cites this paper
• Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.

  2000cites this paper
• Structural determinants within platelet glycoprotein Ibalpha involved in its binding to von Willebrand factor.

  2000cites this paper
• Immunoneutralization of glycoprotein Ibalpha attenuates endotoxin-induced interactions of platelets and leukocytes with rat venular endothelium in vivo.

  2000cites this paper
• Platelet GP Ib/IX/V complex: physiological role

  2000cites this paper
• The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity.

  2000cites this paper
• Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin αIIbβ3 Using a Reconstituted Mammalian Cell Expression Model

  1999cites this paper
• Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–mediated Activation of Integrin (cid:97) IIb (cid:98) 3 Using a Reconstituted Mammalian Cell Expression Model

  1999cites this paper
• Rap1B and Rap2B Translocation to the Cytoskeleton by von Willebrand Factor Involves FcγII Receptor-mediated Protein Tyrosine Phosphorylation*

  1999cites this paper
• The Glycoprotein Ib-IX-V Complex in Platelet Adhesion and Signaling

  1999cites this paper
• Suppression of protein kinase C is associated with inhibition of PYK2 tyrosine phosphorylation and enhancement of PYK2 interaction with Src in thrombin-activated platelets.

  1999cites this paper
• Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor gamma-chain, Fyn, and Lyn to activate human platelets.

  1999cites this paper
• Increased thrombin responsiveness in platelets from mice lacking glycoprotein V.

  1999cites this paper