FIZZ2/RELM-β Induction and Role in Pulmonary Fibrosis

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Immunology

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.4049/jimmunol.1000964PMID 21602491PMCID PMC4030639
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased contractility of isolated lung parenchyma in an animal model of pulmonary fibrosis induced by bleomycin.

  2015cited by this paper
• Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

  2010cited by this paper
• A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice?

  2010cited by this paper
• Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis

  2010cited by this paper
• In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.

  2009cited by this paper
• Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis.

  2009cited by this paper
• Increased Bronchoalveolar Lavage Fluid CD1c Expressing Dendritic Cells in Idiopathic Pulmonary Fibrosis

  2009cited by this paper
• The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis

  2009cited by this paper
• Notch1 signaling in FIZZ1 induction of myofibroblast differentiation.

  2009cited by this paper
• Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension.

  2009cited by this paper
• Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis.

  2008cited by this paper
• Dendritic cells accumulate in human fibrotic interstitial lung disease.

  2007cited by this paper
• Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung.

  2007influential reference
• New Insights into the Pathogenesis and Treatment of Idiopathic Pulmonary Fibrosis: A Potential Role for Stem Cells in the Lung Parenchyma and Implications for Therapy

  2007cited by this paper
• Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts

  2007cited by this paper
• Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.

  2007cited by this paper
• Airway remodeling and RELM-beta.

  2007cited by this paper
• Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice.

  2007cited by this paper
• Airway remodeling and RELM-β

  2007cited by this paper
• Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2.

  2006cited by this paper
• BMC Bioinformatics BioMed Central Methodology article Empirical array quality weights in the analysis of microarray data

  2006influential reference
• Human RELMβ is a mitogenic factor in lung cells and induced in hypoxia

  2006influential reference
• Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.

  2006cited by this paper
• Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.

  2006cited by this paper
• Resistin-like Molecule β Activates MAPKs, Suppresses Insulin Signaling in Hepatocytes, and Induces Diabetes, Hyperlipidemia, and Fatty Liver in Transgenic Mice on a High Fat Diet*

  2005cited by this paper
• Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.

  2005cited by this paper
• Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases

  2005cited by this paper
• Serum concentrations of resistin-like molecules β and γ are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow

  2005cited by this paper
• Bone marrow-derived progenitor cells in pulmonary fibrosis.

  2004cited by this paper
• Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

  2004cited by this paper
• Regulation of Found in Inflammatory Zone 1 Expression in Bleomycin-Induced Lung Fibrosis: Role of IL-4/IL-13 and Mediation via STAT-61

  2004cited by this paper
• Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.

  2004cited by this paper
• RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract.

  2004cited by this paper
• IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

  2004cited by this paper
• FIZZ1 stimulation of myofibroblast differentiation.

  2004cited by this paper
• Targeting the mitogen-activated protein kinase cascade to treat cancer

  2004cited by this paper
• Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts.

  2003cited by this paper
• [Airway remodeling in asthma].

  2003cited by this paper
• Role of interferon-gamma in the evolution of murine bleomycin lung fibrosis.

  2003cited by this paper
• Role of interferon-γ in the evolution of murine bleomycin lung fibrosis

  2003cited by this paper
• Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells 1

  2003cited by this paper
• Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern.

  2003cited by this paper
• Exploration, normalization, and summaries of high density oligonucleotide array probe level data.

  2003cited by this paper
• The myofibroblast in pulmonary fibrosis.

  2002cited by this paper
• Phosphatidylinositol 3-kinases in tumor progression.

  2001cited by this paper
• Role of cytokines and cytokine therapy in wound healing and fibrotic diseases.

  2001cited by this paper
• Idiopathic pulmonary fibrosis.

  2001cited by this paper
• A family of tissue-specific resistin-like molecules.

  2001cited by this paper
• Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

  2001cited by this paper
• AMERICAN THORACIC SOCIETY; EUROPEAN RESPIRATORY SOCIETY; AMERICAN COLLEGE OF CHEST PHYSICIANS. IDIOPATHIC PULMONARY FIBROSIS: PREVAILING AND EVOLVING HYPOTHESES ABOUT ITS PATHOGENESIS AND IMPLICATIONS FOR THERAPY

  2001cited by this paper
• FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family

  2000cited by this paper
• Airway remodeling in asthma.

  1999cited by this paper
• NHLBI Workshop Summary. Pharmacological therapy for idiopathic pulmonary fibrosis. Past, present, and future.

  1999cited by this paper
• Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

  1999cited by this paper
• Human Parainfluenza Virus Type 3 Up-Regulates Major Histocompatibility Complex Class I and II Expression on Respiratory Epithelial Cells: Involvement of a STAT1- and CIITA-Independent Pathway

  1999cited by this paper
• Pharmacological Therapy for Idiopathic Pulmonary Fibrosis

  1999cited by this paper
• Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor.

  1997cited by this paper
• Transforming growth factor β1 and interleukin 4 induced α smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor

  1997cited by this paper
• Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

  1996cited by this paper
• Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.

  1996cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

  1994cited by this paper
• Isolation and culture of alveolar type II cells.

  1990cited by this paper
• Subepithelial fibrosis in the bronchi of asthmatics.

  1989cited by this paper
• Rat lung fibroblast collagen metabolism in bleomycin-induced pulmonary fibrosis.

  1985cited by this paper
• The myofibroblast in pulmonary fibrosis.

  1983cited by this paper
• Modified assay for determination of hydroxyproline in a tissue hydrolyzate.

  1980cited by this paper

• Resistin‐Like Molecule Beta Participates in Calcium Regulation Via Direct Interaction With CaSR and a PLC‐IP3R‐Dependent Mechanism in Hypoxia‐Induced Pulmonary Hypertension

  2026cites this paper
• RELM-β Augmented Hypoxia-Induced Pulmonary Hypertension Through Interacting with GIPC1, OR1N1 and CLIC4.

  2025cites this paper
• The role of HDAC6 in fibrosis: a novel and effective therapy strategy

  2025cites this paper
• Regulation of cardiac fibrosis in mice with TAC/DOCA‐induced HFpEF by resistin‐like molecule gamma and adenylate cyclase 1

  2024cites this paper
• The soluble factor milieu in idiopathic pulmonary fibrosis dysregulates epithelial differentiation

  2024cites this paper
• Cigarette smoke extract contributes to the inception and aggravation of asthmatic inflammation by stimulating innate immunity

  2023cites this paper
• Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs

  2023cites this paper
• Resistin-like molecules: a marker, mediator and therapeutic target for multiple diseases

  2023influential citation
• Resistin Pathway as Novel Mechanism of Post-lung Transplantation Bronchial Stenosis

  2023cites this paper
• Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis

  2023cites this paper
• B7H3-dependent myeloid-derived suppressor cell recruitment and activation in pulmonary fibrosis

  2022cites this paper
• Transcriptomic analysis of choroidal neovascularization reveals dysregulation of immune and fibrosis pathways that are attenuated by a novel anti-fibrotic treatment

  2022cites this paper
• Resistin, a Novel Host Defense Peptide of Innate Immunity

  2021cites this paper
• Predictive and Prognostic Utility of the Serum Level of Resistin-Like Molecule Beta for Risk Stratification in Patients with Community-Acquired Pneumonia

  2021cites this paper
• B7H3 expression and significance in idiopathic pulmonary fibrosis

  2021cites this paper
• COPD_A_321877 2503..2513

  2021cites this paper
• FIZZ2 as a Biomarker for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

  2021cites this paper
• The Inflammatory Response Induced by RELMβ Upregulates IL-8 and IL-1β Expression in Bronchial Epithelial Cells in COPD

  2021cites this paper
• Inhibition of the Arp2/3 complex represses human lung myofibroblast differentiation and attenuates bleomycin‐induced pulmonary fibrosis

  2021cites this paper
• Resistin: A journey from metabolism to cancer

  2021cites this paper
• The dual distinct role of telomerase in repression of senescence and myofibroblast differentiation

  2021cites this paper
• The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury

  2021cites this paper
• 21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision-Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial-Induced Lung Fibrosis.

  2020cites this paper
• Resistin-like Molecule β Acts as a Mitogenic Factor in Hypoxic Pulmonary Hypertension via Ca2+ dependent PI3K/Akt/mTOR and PKC/MAPKs Signaling Pathway

  2020cites this paper
• Resistin-like molecule β acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

  2020cites this paper
• Resistin family proteins in pulmonary diseases.

  2020cites this paper
• RELMα Is Induced in Airway Epithelial Cells by Oncostatin M without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo

  2020cites this paper
• The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria

  2020cites this paper
• Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline.

  2020cites this paper
• Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence

  2019cites this paper
• The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment

  2019cites this paper
• TGF-β1-induced SMAD2/3/4 activation promotes RELM-β transcription to modulate the endothelium-mesenchymal transition in human endothelial cells.

  2018cites this paper
• Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders.

  2018cites this paper
• Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta

  2018cites this paper
• Role of resistin in chronic periodontitis

  2018cites this paper
• An ST2‐dependent role of bone marrow‐derived group 2 innate lymphoid cells in pulmonary fibrosis

  2018cites this paper
• Localization of RELM‐β/FIZZ2 Is Associated with Cementum Formation

  2017cites this paper
• Application of bi-clustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

  2017cites this paper
• Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands

  2017cites this paper
• RELM‐&bgr; promotes human pulmonary artery smooth muscle cell proliferation via FAK‐stimulated surviving

  2017cites this paper
• NOGO-B promotes EMT in lung fibrosis via MMP14 mediates free TGF-beta1 formation

  2017cites this paper
• Tissue Remodeling and Repair During Type 2 Inflammation

  2016cites this paper
• Bone Marrow CD11c+ Cell–Derived Amphiregulin Promotes Pulmonary Fibrosis

  2016cites this paper
• Association of Resistin, Visfatin, and Osteoprotegerin in Diabetes Mellitus

  2016cites this paper
• Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations.

  2016cites this paper
• This information is current as Amphiregulin Promotes Pulmonary Fibrosis Derived − Cell + Bone Marrow CD 11 c

  2016cites this paper
• Hypoxia-Inducible Factor 1&agr; Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELM&agr;)–Induced Pulmonary Hypertension

  2016cites this paper
• Is Resistin A Biomarker for Periodontitis – An Insight

  2015cites this paper
• Resistin‐like molecule‐β (RELM‐β) targets airways fibroblasts to effect remodelling in asthma: from mouse to man

  2015cites this paper
• FIZZ1-induced myofibroblast transdifferentiation from adipocytes and its potential role in dermal fibrosis and lipoatrophy.

  2015cites this paper
• Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

  2015cites this paper
• CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.

  2015cites this paper
• Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

  2015cites this paper
• Resistin: A Potential Biomarker for Periodontitis Influenced Diabetes Mellitus and Diabetes Induced Periodontitis

  2014cites this paper
• The In Vivo Fibrotic Role of FIZZ1 in Pulmonary Fibrosis

  2014cites this paper
• Recent progress of RELMβ

  2014cites this paper
• Resistin-like Molecule α Promotes Pathogenic Th17 Cell Responses and Bacterial-Induced Intestinal Inflammation

  2013cites this paper
• Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-β and Associated Transcripts in Pulmonary Fibrosis

  2013cites this paper
• Identification of human CCR8 as a CCL18 receptor

  2013cites this paper
• Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis.

  2013cites this paper
• Intestinal Inflammation Th 17 Cell Responses and Bacterial-Induced Promotes Pathogenic α Resistin-like Molecule

  2013cites this paper
• Lung bone marrow-derived hematopoietic progenitor cells enhance pulmonary fibrosis.

  2013cites this paper
• Bacterial-Induced Intestinal Inflammation Pathogenic Th 17 Cell Responses and Promotes α Resistin-Like Molecule

  2013cites this paper
• Construction of a Computable Network Model of Tissue Repair and Angiogenesis in the Lung

  2013cites this paper
• Resistin-like molecule-α regulates IL-13-induced chemokine production but not allergen-induced airway responses.

  2012cites this paper
• Cellular Basis of Tissue Regeneration by Omentum

  2012cites this paper
• Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis

  2012cites this paper
• Effects of resistin-like molecule β over-expression on gastric cancer cells in vitro.

  2012cites this paper
• Resistin-like molecule-&bgr; is a human airway remodelling mediator

  2011cites this paper