Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells 1

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Immunology

• Publication date

  2003-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4049/jimmunol.171.5.2684PMID 12928422
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response

  2003cited by this paper
• Dual Roles of IL-4 in Lung Injury and Fibrosis1

  2003cited by this paper
• Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts.

  2003cited by this paper
• Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2

  2003cited by this paper
• Alternative activation of macrophages

  2003cited by this paper
• A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma.

  2002cited by this paper
• Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

  2002cited by this paper
• IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells.

  2002cited by this paper
• Interleukin-13 fusion cytotoxin arrests Schistosoma mansoni egg-induced pulmonary granuloma formation in mice.

  2002cited by this paper
• Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice.

  2002cited by this paper
• Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4‐/‐ mice

  2002cited by this paper
• Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis.

  2002cited by this paper
• Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma.

  2002cited by this paper
• Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

  2002cited by this paper
• Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.

  2002cited by this paper
• IL-13-Induced Chemokine Responses in the Lung: Role of CCR2 in the Pathogenesis of IL-13-Induced Inflammation and Remodeling1

  2002cited by this paper
• A Novel Mechanism by Which Interferon-γ Can Regulate Interleukin (IL)-13 Responses

  2002cited by this paper
• Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice

  2001cited by this paper
• Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

  2001influential reference
• Growth factors in idiopathic pulmonary fibrosis: relative roles

  2001cited by this paper
• A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

  2001influential reference
• IL-13 Fusion Cytotoxin Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice1

  2001cited by this paper
• Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma1

  2001cited by this paper
• Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer.

  2001cited by this paper
• In Vivo Overexpression of IL-13 Receptor α2 Chain Inhibits Tumorigenicity of Human Breast and Pancreatic Tumors in Immunodeficient Mice

  2001cited by this paper
• The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma.

  2001influential reference
• Gene transfer of interleukin 13 receptor α2 chain dramatically enhances the antitumor effect of IL-13 receptor–targeted cytotoxin in human prostate cancer xenografts

  2001cited by this paper
• Lung interleukin-4 gene expression in a murine model of bleomycin-induced pulmonary fibrosis.

  2001cited by this paper
• IL-12 attenuates bleomycin-induced pulmonary fibrosis.

  2001cited by this paper
• The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway.

  2001cited by this paper
• Type 1/type 2 cytokine paradigm and the progression of pulmonary fibrosis.

  2001cited by this paper
• Studies of murine schistosomiasis reveal interleukin‐13 blockade as a treatment for established and progressive liver fibrosis

  2001cited by this paper
• Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus.

  2000cited by this paper
• Regulation of T helper type 2 cell immunity by interleukin-4 and interleukin-13.

  2000cited by this paper
• Idiopathic pulmonary fibrosis: molecular mechanisms and possible therapeutic strategies.

  2000influential reference
• Pivotal Role of CCR1-Positive Leukocytes in Bleomycin- Induced Lung Fibrosis in Mice1

  2000cited by this paper
• Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts.

  2000cited by this paper
• Immunoreactive interleukin 4 and interferon‐γ expression by type II alveolar epithelial cells in interstitial lung disease

  1999cited by this paper
• Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models.

  1999cited by this paper
• IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis.

  1999cited by this paper
• Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

  1999cited by this paper
• T cell independence of bleomycin‐induced pulmonary fibrosis

  1999cited by this paper
• Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis.

  1999cited by this paper
• An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.

  1999cited by this paper
• Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice.

  1999cited by this paper
• Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

  1999cited by this paper
• The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.

  1998cited by this paper
• IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts.

  1998cited by this paper
• TNF and IL‐6 mediate MIP‐1α expression in bleomycin‐induced lung injury

  1998cited by this paper
• Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

  1998cited by this paper
• Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).

  1998cited by this paper
• TNF-alpha receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers.

  1998cited by this paper
• Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung.

  1998cited by this paper
• Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: enhanced IL-13 production by IL-4-primed human mast cells.

  1998cited by this paper
• Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.

  1998cited by this paper
• Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway.

  1998cited by this paper
• An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4*

  1997cited by this paper
• The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor.

  1997cited by this paper
• TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis.

  1997cited by this paper
• Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells.

  1997cited by this paper
• [Not Available].

  1997cited by this paper
• RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

  1997cited by this paper
• Receptor for Interleukin (IL) 13 Does Not Interact with IL4 but Receptor for IL4 Interacts with IL13 on Human Glioma Cells*

  1996cited by this paper
• Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR).

  1996cited by this paper
• A simplified method for the analysis of hydroxyproline in biological tissues.

  1996cited by this paper
• IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts.

  1996cited by this paper
• A role for C‐C chemokines in fibrotic lung disease

  1995cited by this paper
• A type 2 (Th2‐like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)

  1995cited by this paper
• A Novel Chimeric Protein Composed of Interleukin 13 and Pseudomonas Exotoxin Is Highly Cytotoxic to Human Carcinoma Cells Expressing Receptors for Interleukin 13 and Interleukin 4 (*)

  1995cited by this paper
• Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury.

  1994cited by this paper
• Increased type I procollagen mRNA transcripts in the lungs of mice during the development of bleomycin-induced fibrosis.

  1994cited by this paper
• Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

  1994cited by this paper
• Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

  1994cited by this paper
• Enhanced type III collagen gene expression during bleomycin induced lung fibrosis.

  1993cited by this paper
• A sensitive ELISA for the detection of human monocyte chemoattractant protein-1 (MCP-1).

  1992cited by this paper
• Fibroblast chemotaxis induction by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122.

  1991cited by this paper
• Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis.

  1991cited by this paper
• Natural killer cell activity in a rat model of amiodarone-induced interstitial lung disease.

  1991cited by this paper
• Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.

  1990cited by this paper
• Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis.

  1987cited by this paper

• Reducing M2 macrophage in lung fibrosis by controlling anti-M1 agent

  2025cites this paper
• Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis

  2025cites this paper
• Clicktetrazine dECM-alginate hydrogels for injectable, mechanically mimetic, and biologically active vocal fold biomaterials.

  2025cites this paper
• Tissue regeneration: Unraveling strategies for resolving pathological fibrosis.

  2025cites this paper
• The CETSA-Luminex integrated platform for drug targets screening identifies IL-4-IN-1 as an anti-pulmonary fibrosis therapeutic candidate.

  2025cites this paper
• Depletion-restitution therapy of autoimmune rheumatic diseases. Part 2. Perspectives on bispecific antibodies

  2025cites this paper
• Modular assembly and evaluation of a TROP2-targeting immunotoxin for cancer therapy.

  2025cites this paper
• Epithelial–mesenchymal transition in chemoradiation‐induced lung damage: Mechanisms and potential treatment approaches

  2024cites this paper
• Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis

  2024cites this paper
• Single-cell transcriptomics reveals CD8+ T cell structure and developmental trajectories in idiopathic pulmonary fibrosis.

  2024cites this paper
• Th2 Cell Activation in Chronic Liver Disease Is Driven by Local IL33 and Contributes to IL13-Dependent Fibrogenesis

  2023cites this paper
• Exacerbation of pulmonary fibrosis following acute lung injury via activin-A production by recruited alveolar macrophages

  2023cites this paper
• The metformin immunoregulatory actions in tumor suppression and normal tissues protection.

  2023cites this paper
• Emerging role of immune cells as drivers of pulmonary fibrosis.

  2023cites this paper
• The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis

  2023cites this paper
• Immune Mechanisms of Pulmonary Fibrosis with Bleomycin

  2023cites this paper
• Multi-Platform Single-Cell Analysis Identifies Immune Cell Types Enhanced in Pulmonary Fibrosis.

  2022cites this paper
• Biology of lung macrophages in health and disease.

  2022cites this paper
• IL-33/regulatory T cell axis suppresses skin fibrosis.

  2022cites this paper
• Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis

  2021cites this paper
• Deleterious Role of Th9 Cells in Pulmonary Fibrosis

  2021cites this paper
• Vitamin D3 alleviates pulmonary fibrosis by regulating the MAPK pathway via targeting PSAT1 expression in vivo and in vitro.

  2021cites this paper
• Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases

  2021cites this paper
• A review on importance of bioactive compounds of medicinal plants in treating idiopathic pulmonary fibrosis (special emphasis on isoquinoline alkaloids)

  2021cites this paper
• Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

  2021cites this paper
• Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study

  2021cites this paper
• Emerging drugs for the treatment of idiopathic pulmonary fibrosis: 2020 phase II clinical trials

  2021cites this paper
• New promising drugs for the treatment of systemic sclerosis: pathogenic considerations, enhanced classifications, and personalized medicine

  2021cites this paper
• The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy

  2020cites this paper
• Antibody-based therapies for idiopathic pulmonary fibrosis

  2020cites this paper
• Pirfenidone modulates macrophage polarization and ameliorates radiation‐induced lung fibrosis by inhibiting the TGF‐β1/Smad3 pathway

  2020cites this paper
• CXCR3A regulates downstream IL-13 signaling and secretion of matricellular

  2020cites this paper
• Non-genetic Heterogeneity of Macrophages in Diseases—A Medical Perspective

  2020cites this paper
• CXCR3A promotes the secretion of the anti-fibrotic decoy receptor sIL-13Rα2 by pulmonary fibroblasts.

  2020cites this paper
• A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis

  2020cites this paper
• Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging

  2020cites this paper
• Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy

  2020cites this paper
• Fra-2-expressing macrophages promote lung fibrosis in mice.

  2019cites this paper
• Akt1 regulates pulmonary fibrosis via modulating IL-13 expression in macrophages

  2019cites this paper
• Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis

  2019cites this paper
• Current advances in idiopathic pulmonary fibrosis: the pathogenesis, therapeutic strategies and candidate molecules.

  2019cites this paper
• Suppression of TRPM2 reduces renal fibrosis and inflammation through blocking TGF-β1-regulated JNK activation.

  2019cites this paper
• Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis.

  2019cites this paper
• Mechanisms of Fibrosis

  2019cites this paper
• Existing and emerging treatments for idiopathic pulmonary fibrosis

  2019cites this paper
• Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses

  2019cites this paper
• Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages

  2018cites this paper
• CCR10+ epithelial cells from idiopathic pulmonary fibrosis lungs drive remodeling.

  2018cites this paper
• Therapeutic targets and early stage clinical trials for pulmonary fibrosis

  2018cites this paper
• SAR156597 in idiopathic pulmonary fibrosis: a phase 2 placebo-controlled study (DRI11772)

  2018cites this paper
• Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes

  2018cites this paper
• PAI1 mediates fibroblast–mast cell interactions in skin fibrosis

  2018cites this paper
• Modeling Idiopathic Pulmonary Fibrosis in Humanized Severe Combined Immunodeficient Mice.

  2018cites this paper
• Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.

  2017cites this paper
• Type 2 immunity in tissue repair and fibrosis

  2017cites this paper
• Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis

  2017cites this paper
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  2017cites this paper
• Influence of the anti‐inflammatory cytokine interleukin‐4 on human joint capsule myofibroblasts

  2017cites this paper
• Therapeutic targets in idiopathic pulmonary fibrosis.

  2017cites this paper
• Interstitial lung disease in systemic sclerosis: current and future treatment

  2017cites this paper
• Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha

  2017cites this paper
• The good and bad of targeting cancer-associated extracellular matrix.

  2017cites this paper
• Fibrosis Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis

  2017cites this paper
• M2 macrophages induce EMT through the TGF‐β/Smad2 signaling pathway

  2017cites this paper
• Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis.

  2017cites this paper
• IL-13 is a therapeutic target in radiation lung injury

  2016cites this paper
• Immune Mechanisms in Pulmonary Fibrosis.

  2016cites this paper
• Mathematical modeling of liver fibrosis.

  2016cites this paper
• Novel drug targets for idiopathic pulmonary fibrosis

  2016cites this paper
• Lentivirus expressing soluble ST2 alleviates bleomycin-induced pulmonary fibrosis in mice.

  2016cites this paper
• Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases

  2016cites this paper
• Perspectives for the future

  2016cites this paper
• A Mathematical Model of Idiopathic Pulmonary Fibrosis

  2015cites this paper
• Bleomycin-Induced Lung Injury Activation and Fibroproliferation in IRAK-M Promotes Alternative Macrophage

  2015cites this paper
• Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

  2015cites this paper
• IL-13 Induces YY1 through the AKT Pathway in Lung Fibroblasts

  2015cites this paper
• miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

  2015cites this paper
• Local Modulation and Measurement of Macrophage-Derived Bioactive Proteins from Implanted Biomaterials in Rat

  2015cites this paper
• current as T Cells + the Induction of Profibrotic CD 8 IL-21 Promotes Pulmonary Fibrosis through

  2015cites this paper
• IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury

  2015cites this paper
• IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells

  2015cites this paper
• Therapeutic approach and molecular targets for novel treatments

  2015cites this paper
• From pathogenesis to therapy--Perspective on treatment strategies in fibrotic diseases.

  2015cites this paper
• Expression of suppressor of cytokine signaling 1 in the peripheral blood of patients with idiopathic pulmonary fibrosis

  2014cites this paper
• Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation

  2014influential citation
• STAT6 and lung inflammation

  2013cites this paper
• Silica Particles in Mice Lung Pathological Changes Triggered by IL-13 Immunotoxin Accelerates Resolution of

  2013cites this paper
• IL-13 signaling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis

  2013cites this paper
• IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

  2013cites this paper
• MicroRNA let-7c Regulates Macrophage Polarization

  2013cites this paper
• Leukotriene C4 aggravates bleomycin‐induced pulmonary fibrosis in mice

  2013cites this paper
• CD4+ T‐cell subsets and host defense in the lung

  2013cites this paper
• The role of thymic stromal lymphopoietin in pulmonary fibrosis

  2013cites this paper
• The evolving pharmacotherapy of pulmonary fibrosis

  2013influential citation
• New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research

  2013cites this paper
• Cytokines in chronic respiratory diseases

  2013cites this paper
• Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis

  2013influential citation
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  2013cites this paper
• Idiopathic pulmonary fibrosis: pathobiology of novel approaches to treatment.

  2012cites this paper
• CD4 T-Cell Immunity in the Lung

  2012cites this paper