Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Science

• Publication date

  2008-12-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/science.1164390PMID 19095944
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemokines in hematopoiesis

  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Cytokines and hematopoietic stem cell mobilization

  2006cited by this paper
• The stem cell niches in bone.

  2006cited by this paper
• KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes.

  2006cited by this paper
• Stem cells and their niche: a matter of fate

  2006cited by this paper
• In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

  2005cited by this paper
• The bone marrow vascular niche: home of HSC differentiation and mobilization.

  2005cited by this paper
• Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.

  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Lack of KIT or FMS internal tandem duplications but co-expression with ligands in AML.

  2004cited by this paper
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  2003cited by this paper
• Identification of the haematopoietic stem cell niche and control of the niche size

  2003cited by this paper
• Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.

  2003cited by this paper
• Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts.

  2002cited by this paper
• The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice

  2002cited by this paper
• [Cytokine].

  2001cited by this paper
• Reports

  2001cited by this paper
• SCF, IL-1beta, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML patients.

  2000cited by this paper
• Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.

  1999cited by this paper
• The biology of stem cell factor and its receptor C-kit.

  1999cited by this paper
• Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells.

  1996cited by this paper
• Factors that influence collection and engraftment of autologous peripheral-blood stem cells.

  1995cited by this paper
• Br. J. Cancer

  1991cited by this paper
• Bone Marrow Transplant

  1990cited by this paper
• Blood.

  1989cited by this paper
• Leukemia

  1984cited by this paper

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