Impaired replication of protease inhibitor-resistant HIV-1 in human thymus

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature Medicine

• Publication date

  2001-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/89090PMID 11385509
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protease inhibitor-resistant HIV-1 from patients with preserved CD4 cell counts is cytopathic in activated CD4 T lymphocytes

  2001cited by this paper
• Primary and Recombinant HIV Type 1 Strains Resistant to Protease Inhibitors Are Pathogenic in Mature Human Lymphoid Tissues

  2001cited by this paper
• Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.

  2001cited by this paper
• Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: role of changes in thymic output and T cell death.

  2001cited by this paper
• Factors influencing T-cell turnover in HIV-1-seropositive patients.

  2000cited by this paper
• Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy.

  2000cited by this paper
• Antiviral Activity of 2′-Deoxy-3′-Oxa-4′-Thiocytidine (BCH-10652) against Lamivudine-Resistant Human Immunodeficiency Virus Type 1 in SCID-hu Thy/Liv Mice

  2000cited by this paper
• Effect of recent thymic emigrants on progression of HIV-1 disease.

  2000cited by this paper
• Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.

  2000cited by this paper
• Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1

  1999cited by this paper
• Measuring Recent Thymic Emigrants in Blood of Normal and HIV-1–Infected Individuals before and after Effective Therapy

  1999cited by this paper
• Determinants of paradoxical CD4 cell reconstitution after protease inhibitor-containing antiretroviral regimen.

  1999cited by this paper
• Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study.

  1999cited by this paper
• The SCID-hu Thy/Liv Mouse

  1999cited by this paper
• Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease.

  1999cited by this paper
• A randomized, controlled trial of indinavir, zidovudine, and lamivudine in adults with advanced human immunodeficiency virus type 1 infection and prior antiretroviral therapy.

  1999cited by this paper
• Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients : a prospective cohort study

  1999cited by this paper
• Loss of Viral Fitness Associated with Multiple Gag and Gag-Pol Processing Defects in Human Immunodeficiency Virus Type 1 Variants Selected for Resistance to Protease Inhibitors In Vivo

  1998cited by this paper
• Changes in thymic function with age and during the treatment of HIV infection

  1998cited by this paper
• Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease.

  1998cited by this paper
• Simian Immunodeficiency Virus Replicates to High Levels in Sooty Mangabeys without Inducing Disease

  1998cited by this paper
• Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up.

  1998cited by this paper
• Human Immunodeficiency Virus Type 1 Protease Genotypes and In Vitro Protease Inhibitor Susceptibilities of Isolates from Individuals Who Were Switched to Other Protease Inhibitors after Long-Term Saquinavir Treatment

  1998cited by this paper
• High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

  1998cited by this paper
• Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection.

  1998cited by this paper
• Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.

  1998cited by this paper
• CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART)

  1998cited by this paper
• Resistance-Associated Loss of Viral Fitness in Human Immunodeficiency Virus Type 1: Phenotypic Analysis of Protease andgag Coevolution in Protease Inhibitor-Treated Patients

  1998cited by this paper
• CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART). Swiss HIV Cohort Study.

  1998cited by this paper
• Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites

  1997cited by this paper
• Plasma Viral Load and CD4+ Lymphocytes as Prognostic Markers of HIV-1 Infection

  1997cited by this paper
• Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors

  1997cited by this paper
• Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease.

  1997cited by this paper
• Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy.

  1997cited by this paper
• A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team.

  1997cited by this paper
• Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds

  1996cited by this paper
• Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

  1996cited by this paper
• Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

  1996cited by this paper
• In vivo selection of HIV-1 variants with reduced susceptibility to the protease inhibitor L-735,524 and related compounds.

  1996cited by this paper
• Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors.

  1996cited by this paper
• Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug.

  1996cited by this paper
• Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure.

  1995cited by this paper
• In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

  1995cited by this paper
• Long-term human hematopoiesis in the SCID-hu mouse

  1990cited by this paper

• Management of Antiretroviral Therapy with Boosted Protease Inhibitors—Darunavir/Ritonavir or Darunavir/Cobicistat

  2021cites this paper
• Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort

  2018cites this paper
• The Association between Detected drug Resistance Mutations and CD4+ T-Cell Decline in HIV-Positive Individuals Maintained on a Failing Treatment Regimen

  2018cites this paper
• Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

  2018cites this paper
• Effectiveness and cost-effectiveness of potential responses to future high levels of transmitted HIV drug resistance in antiretroviral drug-naive populations initiating therapy : modelling study and economic analysis

  2018cites this paper
• Studies of retroviral infection in humanized mice.

  2015cites this paper
• Effectiveness and cost-effectiveness of potential responses to future high levels of transmitted HIV drug resistance in antiretroviral drug-naive populations beginning treatment: modelling study and economic analysis.

  2014cites this paper
• Significant changes in integrase-associated HIV-1 replication capacity between early and late isolates.

  2013cites this paper
• Impaired Surfactant Production by Alveolar Epithelial Cells in a SCID-hu Lung Mouse Model of Congenital Human Cytomegalovirus Infection

  2012cites this paper
• Evolution of the human immunodeficiency virus type 1 protease: effects on viral replication capacity and protease robustness.

  2012cites this paper
• Developmental regulation of P‐glycoprotein activity within thymocytes results in increased anti‐HIV protease inhibitor activity

  2011cites this paper
• Editorial: Developmental regulation of P‐glycoprotein and HIV therapy: spare the thymus but spoil the child?

  2011cites this paper
• Impaired Infectivity of Ritonavir-resistant HIV Is Rescued by Heat Shock Protein 90AB1

  2011cites this paper
• The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

  2011cites this paper
• Estimated average annual rate of change of CD4+ T-cell counts in patients on combination antiretroviral therapy

  2010cites this paper
• Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy

  2010cites this paper
• In Vivo Validation of a Bioinformatics Based Tool to Identify Reduced Replication Capacity in HIV-1

  2010cites this paper
• Both CD31(+) and CD31⁻ naive CD4(+) T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapy.

  2010cites this paper
• HIV Replication Capacity Is an Independent Predictor of Disease Progression in Persons With Untreated Chronic HIV Infection

  2010cites this paper
• IFN-α-Induced Upregulation of CCR5 Leads to Expanded HIV Tropism In Vivo

  2010cites this paper
• Continue Antiretroviral Therapy during Virologic Failure?

  2010cites this paper
• Patients with Discordant Responses to Antiretroviral Therapy Have Impaired Killing of HIV-Infected T Cells

  2010cites this paper
• Placental remodeling of the uterine vasculature

  2010cites this paper
• HIV protease inhibitors: recent clinical trials and recommendations on use

  2009cites this paper
• A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals.

  2008cites this paper
• Viral drug resistance and fitness.

  2008cites this paper
• HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.

  2008cites this paper
• Drug-associated changes in amino acid residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response.

  2008cites this paper
• CHAPTER 15 – Clinical Implications of HIV Fitness and Virulence

  2008cites this paper
• Dinamica virale e risposta immune HIV-1-specifica in neonati sottoposti a terapia antiretrovirale ed immunoricostituzione in bambini infettati da HIV-1 con differente risposta virologica alla terapia

  2008cites this paper
• A new strategy based on recombinant viruses for assessing the replication capacity of HIV‐1

  2008cites this paper
• The role of the thymus in HIV infection: a 10 year perspective

  2008cites this paper
• Apoptosis and HIV infection: about molecules and genes.

  2008cites this paper
• Chapter 12. Placental remodeling of the uterine vasculature.

  2008cites this paper
• Clinical implications of discordant viral and immune outcomes following protease inhibitor containing antiretroviral therapy for HIV-infected children

  2008influential citation
• Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study

  2008cites this paper
• Genetic and catalytic efficiency structure of an HCV protease quasispecies

  2007cites this paper
• Demeter Fitness ReplicationImmunodeficiency Virus Type 1 Clinical Significance of Human

  2007cites this paper
• Partial treatment interruptions.

  2007cites this paper
• Estudio de carcterísticas fenotípicas del VIH mediante la generación y desarrollo de virus recombinantes: aplicación al estudio de la capacidad replicativa de virus multirresistentes

  2007cites this paper
• Estudio de la influencia de estímulos inmunológicos repetidos en forma de un calendario vacunal en pacientes adultos infectados por el virus de la inmunodeficiencia humana en estadios tempranos de la infección (con tratamiento antirretroviral y tras su suspensión).

  2007cites this paper
• Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen

  2007cites this paper
• Clinical Significance of Human Immunodeficiency Virus Type 1 Replication Fitness

  2007cites this paper
• Drug resistance mutations and the cellular immune response: a valuable synergy for the development of novel immune therapies

  2007cites this paper
• Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice

  2007cites this paper
• Target Cell APOBEC3C Can Induce Limited G-to-A Mutation in HIV-1

  2007cites this paper
• Immune reconstitution in human immunodeficiency virus type 1‐infected children with different virological responses to anti‐retroviral therapy

  2007cites this paper
• HIV‐1 viral fitness estimation using exchangeable on subsets priors and prior model selection

  2007cites this paper
• Human Immunodeficiency Virus Persistence and Production in T-Cell Development

  2006cites this paper
• Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.

  2006cites this paper
• Models of HIV-1 disease: A review of current status

  2006cites this paper
• Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity

  2006cites this paper
• Is Moderate HIV Viremia Associated With a Higher Risk of Clinical Progression in HIV-Infected People Treated With Highly Active Antiretroviral Therapy: Evidence From the Italian Cohort of Antiretroviral-Naive Patients Study

  2006cites this paper
• Genotypic Resistance and Immunologic Outcomes Among HIV-1-Infected Women With Viral Failure

  2006cites this paper
• Access to adequate nutrition is a major potential obstacle to antiretroviral adherence among HIV-infected individuals in Rwanda

  2006cites this paper
• Emergence of Drug Resistance Is Associated with an Increased Risk of Death among Patients First Starting HAART

  2006cites this paper
• On the comparison of artificial network and interpretation systems based on genotype resistance mutations in HIV-1-infected patients

  2006cites this paper
• High HIV prevalence among injecting drug users in Estonia: implications for understanding the risk environment

  2006cites this paper
• Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

  2006cites this paper
• Apoptosis in Organ Culture and Animal Models of HIV Disease

  2005cites this paper
• The role of viral fitness in HIV pathogenesis

  2005cites this paper
• Genetic evolution of HIV in patients remaining on a stable HAART regimen despite insufficient viral suppression

  2005cites this paper
• Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time

  2005cites this paper
• Increased thymic output in HIV-negative patients after antiretroviral therapy

  2005cites this paper
• Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection.

  2005cites this paper
• HIV-1 virulence, fitness and replication capacity

  2005cites this paper
• Evolution of Human Immunodeficiency Virus Type 1 Protease Genotypes and Phenotypes In Vivo under Selective Pressure of the Protease Inhibitor Ritonavir

  2005cites this paper
• Impact of drug resistance genotypes on CD4+ counts and plasma viremia in heavily antiretroviral‐experienced HIV‐infected patients

  2005cites this paper
• Thymic function in HIV infection

  2005cites this paper
• Confronting the Emergence of Drug-Resistant HIV Type 1: Impact of Antiretroviral Therapy on Individual and Population Resistance

  2005cites this paper
• Prevalence and factors involved in discordant responses to highly active antiretroviral treatment in a closely followed cohort of treatment-naïve HIV-infected patients.

  2005cites this paper
• Lamivudine and Indinavir/Ritonavir Maintenance Therapy in Highly Pretreated HIV-Infected Patients (Vista Anrs 109)

  2005cites this paper
• Enhanced Replicative Capacity and Pathogenicity of HIV-1 Isolated From Individuals Infected With Drug-Resistant Virus and Declining CD4+ T-Cell Counts

  2005cites this paper
• Three-Year Clinical Outcomes of Resistance Genotyping and Expert Advice: Extended follow-up of the Argenta Trial

  2005cites this paper
• Clinical outcome after 4 years follow‐up of HIV‐seropositive subjects with incomplete virologic or immunologic response to HAART

  2005cites this paper
• Consequences of HIV Infection on Thymus Function and T Cell Development

  2005cites this paper
• HIV Protease (PR) and Cell Death

  2005cites this paper
• Alteration of the Apoptotic Pathways in the Thymus during HIV Infection

  2005cites this paper
• Textbook of Pediatric HIV Care: The immunology of pediatric HIV disease

  2005cites this paper
• Variaciones en el "fitness" del VIH-1 durante la Terapia Antirretroviral

  2005cites this paper
• Viral load in tissues during the early and chronic phase of non‐pathogenic SIVagm infection

  2004influential citation
• The clinical implications of reduced viral fitness

  2004cites this paper
• Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection.

  2004cites this paper
• Is thymus redundant after adulthood?

  2004cites this paper
• Immune reconstitution in HIV-1 infected children with discordant response to antiretroviral therapies: patterns of HIV-1 env gene evolution driven by restoration of thymic function.

  2004cites this paper
• T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis

  2004cites this paper
• Chapter 34 – HIV Drug Susceptibility Testing

  2004cites this paper
• Hepatitis C virus infection in human liver tissue engrafted in mice with an infectious molecular clone

  2004cites this paper
• Two-Year Clinical and Immune Outcomes in Human Immunodeficiency Virus–Infected Children Who Reconstitute CD4 T Cells Without Control of Viral Replication After Combination Antiretroviral Therapy

  2004cites this paper
• Virological and immunological response to antiretroviral therapy in HIV-1 infected children: genotypic and phenotypic assays in monitoring virological failure.

  2004cites this paper
• Genotypic and Phenotypic Correlates of the HIV Type 1 env Gene Evolution in Infected Children with Discordant Response to Antiretroviral Therapy

  2004cites this paper
• Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.

  2004cites this paper
• Persistent HIV‐1 replication does not explain low levels of T‐cell interferon‐γ mRNA and elevated serum NO2–/NO3– in patients with stable CD4 T‐cell responses to HAART

  2004cites this paper
• Effects of IL-7 on Early Human Thymocyte Progenitor Cells In Vitro and in SCID-hu Thy/Liv Mice1

  2003cites this paper
• Jeroen Primary Infection Virus Type 1 Variants Isolated during Drug-Resistant Human Immunodeficiency Infectivity and Replication Capacity of

  2003cites this paper
• Discordant Outcomes following Failure of Antiretroviral Therapy Are Associated with Substantial Differences in Human Immunodeficiency Virus-Specific Cellular Immunity

  2003cites this paper
• Infectivity and Replication Capacity of Drug-Resistant Human Immunodeficiency Virus Type 1 Variants Isolated during Primary Infection

  2003cites this paper
• Brief summary of the legal proceeding

  2003cites this paper
• Positive Regulation of CXCR4 Expression and Signaling by Interleukin-7 in CD4+ Mature Thymocytes Correlates with Their Capacity To Favor Human Immunodeficiency X4 Virus Replication

  2003cites this paper
• Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumonia

  2003cites this paper