Regulation of loop extrusion on the interphase genome

Abstract In the human cell nucleus, dynamically organized chromatin is the substrate for gene regulation, DNA replication, and repair. A central mechanism of DNA loop formation is an ATPase motor cohesin-mediated loop extrusion. The cohesin complexes load and unload onto the chromosome under the control of other regulators that physically interact and affect motor activity. Regulation of the dynamic loading cycle of cohesin influences not only the chromatin structure but also genome-associated human disorders and aging. This review focuses on the recently spotlighted genome organizing factors and the mechanism by which their dynamic interactions shape the genome architecture in interphase.

• Publication year

  2023

• Venue

  Critical reviews in biochemistry and molecular biology

• Publication date

  2023-01-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/10409238.2023.2182273PMID 36921088
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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