IL-17-producing CD4−CD8− T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Annals of the Rheumatic Diseases

• Publication date

  2012-08-17

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/annrheumdis-2012-201511PMID 22904262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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• Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus.

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Prednisone and piroxicam for treatment of primary Sjögren's syndrome.

  1993cited by this paper
• A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

  1992cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1968influential reference

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