The role of selected non-coding RNAs in the biology of non-small cell lung cancer.

Lung cancer is the second most frequently diagnosed cancer worldwide and a leading cause of cancer-related deaths. Non-small cell lung carcinoma (NSCLC) represents 85% of all cases. Accumulating evidence highlights the outstanding role of non-coding RNA (ncRNA) in regulating the tumorigenesis process by modulating crucial signaling pathways. Micro RNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA) are either up- or downregulated in lung cancer patients and can promote or suppress the progression of the disease. These molecules interact with messenger RNA (mRNA) and with each other to regulate gene expression and stimulate proto-oncogenes or silence tumor suppressors. NcRNAs provide a new strategy to diagnose or treat lung cancer patients and multiple molecules have already been identified as potential biomarkers or therapeutic targets. The aim of this review is to summarize the current evidence on the roles of miRNA, lncRNA and circRNA in NSCLC biology and present their clinical potential.

• Publication year

  2023

• Venue

  Advances in Medical Sciences

• Publication date

  2023-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.advms.2023.02.004PMID 36933328
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• miR-596-3p suppresses brain metastasis of non-small cell lung cancer by modulating YAP1 and IL-8

  2022cited by this paper
• Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation

  2022cited by this paper
• Interplay between K-RAS and miRNAs.

  2022cited by this paper
• Circ_0001955 promotes the progression of non-small cell lung cancer via miR-769-5p/EGFR axis

  2022cited by this paper
• Activation of circ_0072088/miR‐1261/PIK3CA pathway accelerates lung adenocarcinoma progression

  2022cited by this paper
• Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy

  2022cited by this paper
• Clinical impact of STK11 mutation in advanced-stage non-small cell lung cancer.

  2022cited by this paper
• Cancer statistics, 2022

  2022cited by this paper
• Validation and analysis of expression, prognosis and immune infiltration of WNT gene family in non-small cell lung cancer

  2022cited by this paper
• Circular RNA hsa_circ_0000317 inhibits non-small cell lung cancer progression through regulating microRNA-494-3p/phosphatase and tensin homolog deleted on chromosome 10 axis

  2022cited by this paper
• Synthetic Circular miR-21 Sponge as Tool for Lung Cancer Treatment

  2022cited by this paper
• Tumor specificity of WNT ligands and receptors reveals universal squamous cell carcinoma oncogenes

  2022cited by this paper
• The long noncoding RNA MIR122HG is a precursor for miR-122-5p and negatively regulates the TAK1-induced innate immune response in teleost fish

  2022cited by this paper
• Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145

  2022cited by this paper
• Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

  2022cited by this paper
• Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly

  2022cited by this paper
• PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?

  2022cited by this paper
• The Landscape of Actionable Genomic Alterations by Next-Generation Sequencing in Tumor Tissue Versus Circulating Tumor DNA in Chinese Patients With Non-Small Cell Lung Cancer

  2022cited by this paper
• Methyltransferase-like 3 facilitates lung cancer progression by accelerating m6A methylation-mediated primary miR-663 processing and impeding SOCS6 expression

  2022cited by this paper
• Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma

  2022cited by this paper
• Functions of long non-coding RNA LNC11649 in non-small cell lung cancer cells as a reprocessed form of MALAT1.

  2022cited by this paper
• PCAT19 Regulates the Proliferation and Apoptosis of Lung Cancer Cells by Inhibiting miR-25-3p via Targeting the MAP2K4 Signal Axis

  2022cited by this paper
• Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer

  2022cited by this paper
• miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1

  2022cited by this paper
• Long Non-coding RNA LINC01426 Contributes to the Malignant Behaviors of NSCLC Via Acting As a Sponge for miR-143-3p

  2022cited by this paper
• Circular RNA circENTPD7 suppresses the accumulation of PTEN to promote cell proliferation in non-small cell lung cancer

  2022cited by this paper
• LKB1: Can We Target an Hidden Target? Focus on NSCLC

  2022cited by this paper
• MicroRNA-20a promotes non-small cell lung cancer proliferation by upregulating PD-L1 by targeting PTEN

  2022cited by this paper
• CircVAPA exerts oncogenic property in non‐small cell lung cancer by the miR‐876‐5p/WNT5A axis

  2021cited by this paper
• Cotargeting of miR‐126‐3p and miR‐221‐3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling

  2021cited by this paper
• Association of FOXO3 Blood DNA Methylation with Cancer Risk, Cancer Survival, and Mortality

  2021cited by this paper
• LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC

  2021cited by this paper
• Circular RNA circFOXO3 facilitate non-small cell lung cancer progression through upregulating HMGB3 via sponging miR-545-3p/miR-506-3p.

  2021cited by this paper
• MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer

  2021cited by this paper
• Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression

  2021cited by this paper
• Circular RNA circβ‐catenin aggravates the malignant phenotype of non‐small‐cell lung cancer via encoding a peptide

  2021cited by this paper
• MicroRNA-106a-5p promotes the proliferation, autophagy and migration of lung adenocarcinoma cells by targeting LKB1/AMPK

  2021cited by this paper
• Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management

  2021cited by this paper
• miR-150-5p-Containing Extracellular Vesicles Are a New Immunoregulator That Favor the Progression of Lung Cancer in Hypoxic Microenvironments by Altering the Phenotype of NK Cells

  2021cited by this paper
• KRAS mutation: from undruggable to druggable in cancer

  2021cited by this paper
• LKB1 expression and the prognosis of lung cancer

  2021cited by this paper
• Extracellular circular RNA profiles in plasma and urine of healthy, male college athletes

  2021cited by this paper
• miR-342-3p Regulates the Proliferation and Apoptosis of NSCLC Cells by Targeting BCL-2

  2021cited by this paper
• LncRNA PCAT29 Up-Regulates the Expression of PTEN by Down-Regulating miR-494 in Non-Small-Cell Lung Cancer to Suppress Tumor Progression.

  2021cited by this paper
• Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer

  2021cited by this paper
• Delivery of miR-320a-3p by gold nanoparticles combined with photothermal therapy for directly targeting Sp1 in lung cancer.

  2021cited by this paper
• Ultrasound-targeted microbubble destruction enhances the anti-tumor action of miR-4284 inhibitor in non-small cell lung cancer cells

  2021cited by this paper
• Diminished efficacy of PD-(L)1 inhibition in STK11- and KEAP1-mutant lung adenocarcinoma is impacted by KRAS mutation status.

  2021cited by this paper
• miR-21-5p is a Biomarker for Predicting Prognosis of Lung Adenocarcinoma by Regulating PIK3R1 Expression

  2021cited by this paper
• The molecular structure and biological functions of RNA methylation, with special emphasis on the roles of RNA methylation in autoimmune diseases

  2021cited by this paper
• Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products

  2021cited by this paper
• Ultrasound-targeted microbubble destruction mediated miR-492 inhibitor suppresses the tumorigenesis in non-small cell lung cancer

  2021cited by this paper
• Deregulation of AKT-mTOR Signaling Contributes to Chemoradiation Resistance in Lung Squamous Cell Carcinoma.

  2021cited by this paper
• MicroRNA-25-3p promotes cisplatin resistance in Non-small-cell lung carcinoma (NSCLC) through adjusting PTEN/PI3K/AKT route

  2021cited by this paper
• MicroRNA-486-5p Suppresses Lung Cancer via Downregulating mTOR Signaling In Vitro and In Vivo

  2021cited by this paper
• MicroRNA-16 Restores Sensitivity to Tyrosine Kinase Inhibitors and Outperforms MEK Inhibitors in KRAS-Mutated Non-Small Cell Lung Cancer

  2021cited by this paper
• Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring

  2021cited by this paper
• Long non-coding RNA MEG3 inhibits cell migration and invasion of non-small cell lung cancer cells by regulating the miR-21-5p/PTEN axis

  2021cited by this paper
• Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX)

  2021cited by this paper
• miR-582-5p Is a Tumor Suppressor microRNA Targeting the Hippo-YAP/TAZ Signaling Pathway in Non-Small Cell Lung Cancer

  2021cited by this paper
• LncRNA WT1-AS/miR-494-3p Regulates Cell Proliferation, Apoptosis, Migration and Invasion via PTEN/PI3K/AKT Signaling Pathway in Non-Small Cell Lung Cancer

  2021cited by this paper
• The Importance of STK11/LKB1 Assessment in Non-Small Cell Lung Carcinomas

  2021cited by this paper
• Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells

  2021cited by this paper
• YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer

  2021cited by this paper
• The role of miRNA-377 as a tumor suppressor in lung cancer by negative regulation of genes belonging to ErbB signaling pathway

  2021cited by this paper
• Elevated expression of miR-494-3p is associated with resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer

  2021cited by this paper
• Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p

  2021cited by this paper
• CircRNA WHSC1 promotes non‐small cell lung cancer progression via sponging microRNA‐296‐3p and up‐regulating expression of AKT serine/threonine kinase 3

  2021cited by this paper
• LINC00852 is associated with poor prognosis in non‐small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa‐miR‐145‐5p/KLF4 axis

  2021cited by this paper
• MEK inhibitors for the treatment of non-small cell lung cancer

  2021cited by this paper
• MicroRNA-4458 Regulates PD-L1 Expression to Enhance Anti-tumor Immunity in NSCLC via Targeting STAT3

  2021cited by this paper
• Oncogenic circRNA C190 Promotes Non–Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway

  2021cited by this paper
• UTMD-mediated delivery of miR-21-5p inhibitor suppresses the development of lung cancer.

  2021cited by this paper
• Phase I/Ib study with INT-1B3, a novel LNP-formulated micro-RNA (miR-193a-3p mimic) therapeutic for patients with advanced solid cancer.

  2021cited by this paper
• Circular RNA FOXO3 accelerates glycolysis and improves cisplatin sensitivity in lung cancer cells via the miR-543/Foxo3 axis

  2021cited by this paper
• MiR‐192/NKRF axis confers lung cancer cell chemoresistance to cisplatin via the NF‐κB pathway

  2021cited by this paper
• Circulating miRNAs in Serum as Biomarkers for Early Diagnosis of Non-small Cell Lung Cancer

  2021cited by this paper
• Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer

  2021cited by this paper
• Characterization of KRAS Mutation Subtypes in Non–small Cell Lung Cancer

  2021cited by this paper
• Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis

  2021cited by this paper
• Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

  2020cited by this paper
• CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145

  2020cited by this paper
• Circular RNA: metabolism, functions and interactions with proteins

  2020cited by this paper
• Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)

  2020cited by this paper
• Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

  2020cited by this paper
• Circular RNA circ-SLC7A6 acts as a tumor suppressor in non-small cell lung cancer through abundantly sponging miR-21

  2020cited by this paper
• A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

  2020cited by this paper
• A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

  2020cited by this paper
• The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population

  2020cited by this paper
• Liver kinase B1 correlates with prognosis and epithelial-mesenchymal transition of resectable early stage non-small cell lung cancer

  2020cited by this paper
• STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition

  2020cited by this paper
• Gene regulation by long non-coding RNAs and its biological functions

  2020cited by this paper
• Higher expression of miR-150-5p promotes tumorigenesis by suppressing LKB1 in non-small cell lung cancer.

  2020cited by this paper
• Effects and mechanism of microRNA-218 against lung cancer

  2020cited by this paper
• Emerging role of PTEN loss in evasion of the immune response to tumours

  2020cited by this paper
• RALY may cause an aggressive biological behavior and a dismal prognosis in non-small-cell lung cancer.

  2020cited by this paper
• Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration

  2020cited by this paper
• Depletion of circ-BIRC6, a circular RNA, suppresses non-small cell lung cancer progression by targeting miR-4491.

  2020cited by this paper
• lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

  2020cited by this paper
• miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

  2020cited by this paper

• Scars That Speak: Unraveling the Oncogenic Aftermath of Pulmonary Tuberculosis—A Narrative Review

  2026cites this paper
• Silent Players, Loud Impact: The Influence of lncRNAs on Melanoma Progression

  2025cites this paper
• RNA-based mechanisms underlying oncogenicity and drug resistance in NRG1-rearranged non-small cell lung cancer.

  2025cites this paper
• Mitochondrial non-coding RNAs as novel biomarkers and therapeutic targets in lung cancer integration of traditional bioinformatics and machine learning approaches

  2025cites this paper
• CircCNKSR2 Facilitates NSCLC Tumorigenesis and Warburg Effect via miRNA-138-5p/PLEK2 Axis.

  2025cites this paper
• Long noncoding RNA TMPO-AS1 upregulates chromosomal passenger complex expression to promote cell proliferation in lung cancer via sponging microRNA let-7b-5p

  2025cites this paper
• circ-ZEB1 Enhances NSCLC Metastasis and Proliferation by Modulating the miR-491-5p/EIF5A Axis

  2025cites this paper
• The Role of Long Non-Coding RNA in the Pathogenesis of Psoriasis

  2025cites this paper
• NUTM2A-AS1 as a potential key regulator in cancer: unraveling its ceRNA networks and impact on tumor biology

  2025cites this paper
• MicroRNA155 in non-small cell lung cancer: a potential therapeutic target

  2025cites this paper
• MiRNAs and Microbiota in Non-Small Cell Lung Cancer (NSCLC): Implications in Pathogenesis and Potential Role in Predicting Response to ICI Treatment

  2024influential citation
• MicroRNAs and the Mediterranean diet: a nutri-omics perspective for lung cancer

  2024cites this paper
• Non-Coding RNA Involved in the Pathogenesis of Atherosclerosis—A Narrative Review

  2024cites this paper
• The Role of MicroRNA in the Pathogenesis of Acute Kidney Injury

  2024cites this paper
• Non-Coding RNA as a Biomarker in Lung Cancer

  2024cites this paper
• Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications

  2024cites this paper
• Ovine LncRSFD1 Mined from RNA-Seq: Identification, Expression Profile, Promotion of Preadipocyte Differentiation, Promoter Activity, and Its Polymorphisms Related to Phenotypic Traits

  2024cites this paper
• circRACGAP1 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through the miR-1296/CDK2 Pathway.

  2024cites this paper
• Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL

  2024cites this paper
• ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis

  2024cites this paper
• The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy

  2024cites this paper
• Time for micro-RNAs in steatotic liver disease: a case–control study

  2024cites this paper
• Elucidating the anti-cancer potential of Cinnamomum tamala essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations

  2024cites this paper
• miR-199a-5p targets DUSP14 to regulate cell proliferation, invasion and stemness in non-small cell lung cancer

  2024cites this paper
• circ_PPAPDC1A promotes Osimertinib resistance by sponging the miR-30a-3p/ IGF1R pathway in non-small cell lung cancer (NSCLC)

  2024cites this paper
• Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review

  2024cites this paper
• The Role of MicroRNA in the Pathogenesis of Duchenne Muscular Dystrophy

  2024cites this paper
• Abnormal expressions of PURPL, miR-363-3p and ADAM10 predicted poor prognosis for patients with ovarian serous cystadenocarcinoma

  2023cites this paper
• Non-Coding RNAs as Key Regulators in Lung Cancer

  2023cites this paper
• The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

  2023cites this paper
• Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer

  2023cites this paper
• Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

  2023cites this paper
• Various LncRNA Mechanisms in Gene Regulation Involving miRNAs or RNA-Binding Proteins in Non-Small-Cell Lung Cancer: Main Signaling Pathways and Networks

  2023cites this paper
• Expression Patterns, Clinical Associations, and Prognostic Significance of ADAMTS Gene-Derived circRNAs in Non-Small-Cell Lung Cancer

  2022cites this paper