Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2

No abstract is available for this paper.

• Publication year

  2003

• Venue

  International Journal of Cancer

• Publication date

  2003-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.10845PMID 12478664
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.

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• The Leukemia-Lymphoma Cell Line Facts Book

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• Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

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• Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances.

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• The BCL11 gene family: involvement of BCL11A in lymphoid malignancies.

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• Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells.

  2000cited by this paper
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• Classical and Molecular Cytogenetics of Tumor Cells

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• Genetic analysis of sorted Hodgkin and Reed‐Sternberg cells using comparative genomic hybridization

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• Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia

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• Cytogenetics of Hodgkin’s disease

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• An optimized, fully automated system for fast and accurate identification of chromosomal rearrangements by multiplex-FISH (M-FISH)

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• Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.

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• Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

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• Frequent jumping translocations of chromosomal segments involving the ABL oncogene alone or in combination with CD3-MLL genes in secondary leukemias.

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• Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene.

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• A phase II study of the oral JAK1/JAK2 inhibitor ruxolitinib in advanced relapsed/refractory Hodgkin lymphoma

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  2017cites this paper
• Recurrent Genetic Mutations in Lymphoid Malignancies

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• Cytogenetic analysis of hematologic malignant diseases

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• Recurrent genetic defects in classical Hodgkin lymphoma cell lines

  2016influential citation
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