The HOPS Proteins hVps41 and hVps39 Are Required for Homotypic and Heterotypic Late Endosome Fusion

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Traffic : the International Journal of Intracellular Transport

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/tra.12027PMID 23167963
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

  2011cited by this paper
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  2011cited by this paper
• Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

  2011cited by this paper
• Autophagosome Precursor Maturation Requires Homotypic Fusion

  2011cited by this paper
• Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

  2011cited by this paper
• Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion*

  2011cited by this paper
• Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

  2010cited by this paper
• VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

  2010cited by this paper
• Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling

  2010cited by this paper
• Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization

  2010cited by this paper
• Coiled‐coil interactions are required for post‐Golgi R‐SNARE trafficking

  2009cited by this paper
• Endosomal Fusion upon SNARE Knockdown is Maintained by Residual SNARE Activity and Enhanced Docking

  2009cited by this paper
• Assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using monodansylcadaverine (MDC) and DQ-BSA.

  2009cited by this paper
• Vps-C complexes: gatekeepers of endolysosomal traffic.

  2009cited by this paper
• SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.

  2009cited by this paper
• The Major Role of the Rab Ypt7p in Vacuole Fusion Is Supporting HOPS Membrane Association*♦

  2009cited by this paper
• Multiple roles of the vesicular‐SNARE TI‐VAMP in post‐Golgi and endosomal trafficking

  2009cited by this paper
• Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line.

  2008cited by this paper
• Lysosomes: fusion and function

  2007cited by this paper
• The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.

  2007influential reference
• Cryosectioning and immunolabeling

  2007cited by this paper
• New assay using fluorogenic substrates and immunofluorescence staining to measure cysteine cathepsin activity in live cell subpopulations

  2007cited by this paper
• Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells

  2006cited by this paper
• Combinatorial SNARE Complexes Modulate the Secretion of Cytoplasmic Granules in Human Neutrophils1

  2006cited by this paper
• An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility

  2006influential reference
• A critical role for vesicle‐associated membrane protein‐7 in exocytosis from human eosinophils and neutrophils

  2006cited by this paper
• Clinical and molecular genetic features of ARC syndrome

  2006cited by this paper
• Rab conversion as a mechanism of progression from early to late endosomes.

  2005influential reference
• The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex

  2005cited by this paper
• Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3

  2005cited by this paper
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

  2004cited by this paper
• Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events

  2004influential reference
• Identification of SNAREs Involved in Synaptotagmin VII-regulated Lysosomal Exocytosis*

  2004cited by this paper
• Synthesis of carotenoids by mutant strains of Streptomyces globisporus 1912

  2003cited by this paper
• A dual mechanism controlling the localization and function of exocytic v-SNAREs

  2003cited by this paper
• Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase.

  2003cited by this paper
• [Synthesis of carotenoids by mutant strains of Streptomyces globisporus 1912].

  2003cited by this paper
• Localization of Lysobisphosphatidic Acid-Rich Membrane Domains in Late Endosomes

  2001cited by this paper
• Human Vam6p promotes lysosome clustering and fusion in vivo

  2001influential reference
• Molecular Characterization of Mammalian Homologues of Class C Vps Proteins That Interact with Syntaxin-7*

  2001cited by this paper
• hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif.

  2001influential reference
• New Component of the Vacuolar Class C-Vps Complex Couples Nucleotide Exchange on the Ypt7 Gtpase to Snare-Dependent Docking and Fusion

  2000cited by this paper
• Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.

  2000cited by this paper
• Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes

  1999cited by this paper
• The diversity of Rab proteins in vesicle transport.

  1997cited by this paper
• Vam2/Vps41p and Vam6/Vps39p Are Components of a Protein Complex on the Vacuolar Membranes and Involved in the Vacuolar Assembly in the Yeast Saccharomyces cerevisiae*

  1997cited by this paper
• Improving structural integrity of cryosections for immunogold labeling

  1996cited by this paper
• Fine Structure Immunocytochemistry

  1993cited by this paper
• Practical methods for biological morphometry

  1979cited by this paper
• Stereological Methods. Practical methods for biological morphometry

  1979cited by this paper

• HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs.

  2026cites this paper
• Role of Lysosomal Morphology in Aging and Age-Related Diseases.

  2026cites this paper
• Trafficking to the lysosome: HOPS paves the way.

  2025cites this paper
• VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b

  2025cites this paper
• VPS16-Associated Dystonia: A Cohort-Based Clinical, Imaging and Genetic Profile

  2025cites this paper
• HOPS-dependent vesicle tethering lock inhibits endolysosomal fusions and autophagosome secretion upon the loss of Syntaxin17

  2025cites this paper
• Late endosome transport by RILP-RAB7A promotes dendrite arborization

  2025cites this paper
• MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

  2025cites this paper
• Triclabendazole suppresses cellular levels of glycosaminoglycan—A potential therapeutic agent for mucopolysaccharidoses and related diseases

  2025cites this paper
• Vacuole protein sorting 18 (Vps18) suppresses epithelial growth factor receptor (EGFR) expression and lung tumorigenesis

  2025cites this paper
• Lysosomal activity depends on TRPML1-mediated Ca2+ release coupled to incoming vesicle fusions

  2024cites this paper
• An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal

  2024cites this paper
• Insights into the Role of VPS39 and Its Interaction with CP204L and A137R in ASFV Infection

  2024cites this paper
• The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy

  2024cites this paper
• Loss of the HOPS complex disrupts early-to-late endosome transition, impairs endosomal recycling and induces accumulation of amphisomes

  2024influential citation
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  2023cites this paper
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• Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.

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• CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with the VPS39 Subunit of the Homotypic Fusion and Vacuole Protein Sorting Complex and Promotes Lysosome Clustering

  2023cites this paper
• Making bubbles: Targeting VPS41 induces vacuolization and methuosis.

  2023cites this paper
• Membrane tethers at a glance.

  2023cites this paper
• Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes

  2023cites this paper
• Multiple tethers of organelle contact sites are involved in α-synuclein toxicity in yeast

  2023cites this paper
• HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis

  2023cites this paper
• Structure of the endosomal CORVET tethering complex

  2023cites this paper
• Functional characterization of endo-lysosomal compartments by correlative live-cell and volume electron microscopy.

  2023cites this paper
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  2022cites this paper
• BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2

  2022cites this paper
• Endolysosomal cholesterol export: More than just NPC1

  2022cites this paper
• AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

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  2022cites this paper
• The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

  2022cites this paper
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  2021cites this paper
• Single-phagosome imaging reveals that homotypic fusion impairs phagosome degradative function.

  2021cites this paper
• Endomembrane remodeling and dynamics in Salmonella infection

  2021cites this paper
• Emerging and converging molecular mechanisms in dystonia

  2021cites this paper
• Phagosome maturation in macrophages: Eat, digest, adapt, and repeat.

  2021cites this paper
• Molecular mechanisms of mammalian autophagy.

  2021cites this paper
• Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

  2021cites this paper
• Bimodal endocytic probe for three-dimensional correlative light and electron microscopy

  2021cites this paper
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  2021cites this paper
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• Morpho-functional characterization of the endo-lysosomal system by high-throughput correlative light-electron microscopy

  2021cites this paper
• Identification of new interactions between endolysosomal tethering factors.

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• Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation

  2021cites this paper
• REGULATION OF CELLULAR DEGRADATION PATHWAYS BY VIRAL ONCOPROTEINS AND MICRORNAS

  2020cites this paper
• Autophagosome-lysosome fusion.

  2020cites this paper
• Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy

  2020cites this paper
• Loss‐of‐Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities

  2020cites this paper
• Proteomic identification of posttranslational modifications: cAMP-induced changes of phosphorylation and investigation of novel approaches detecting posttranslational modifications at lysine and arginine residues

  2020cites this paper
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  2020cites this paper
• ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• The Lysosome and Intracellular Signalling.

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• Molecular hypotheses to explain the shared pathways and underlying pathobiological causes in catatonia and in catatonic presentations in neuropsychiatric disorders.

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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• DQ-Red BSA Trafficking Assay in Cultured Cells to Assess Cargo Delivery to Lysosomes.

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  2017cites this paper
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  2017cites this paper
• Whole-cell scale dynamic organization of lysosomes revealed by spatial statistical analysis

  2017cites this paper
• Protein Interactions in the Last Steps of the Endosomal Degradative Pathway

  2017cites this paper
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  2017cites this paper
• JCB_201611027 1937..1948

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation

  2016influential citation
• Membrane dynamics in mammalian embryogenesis: Implication in signal regulation.

  2016cites this paper
• Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion

  2016cites this paper
• Phosphoinositides in Control of Membrane Dynamics.

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper