Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbalip.2009.10.005PMID 19879375PMCID PMC2818386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.

  2008cited by this paper
• Defects of cholesterol biosynthesis

  2006cited by this paper
• Sterol Regulatory Element Binding Protein Is a Principal Regulator of Anaerobic Gene Expression in Fission Yeast

  2006cited by this paper
• A systematic study of yeast sterol biosynthetic protein-protein interactions using the split-ubiquitin system.

  2005cited by this paper
• Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.

  2005cited by this paper
• Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Tripanosoma cruzi, and Pneumocystis carinii

  2004cited by this paper
• In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity.

  2003cited by this paper
• Enhanced Synthesis of the Oxysterol 24(S),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase: A Novel Mechanism for the Attenuation of Foam Cell Formation

  2003cited by this paper
• Transcriptional Profiling Identifies Two Members of the ATP-binding Cassette Transporter Superfamily Required for Sterol Uptake in Yeast*

  2002cited by this paper
• Protein–protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis

  2002cited by this paper
• Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles*

  2002cited by this paper
• A novel gene conserved from yeast to humans is involved in sterol biosynthesis.

  2001cited by this paper
• Directed Evolution To Investigate Steric Control of Enzymatic Oxidosqualene Cyclization. An Isoleucine-to-Valine Mutation in Cycloartenol Synthase Allows Lanosterol and Parkeol Biosynthesis

  1999cited by this paper
• Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.

  1999cited by this paper
• Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles.

  1998cited by this paper
• Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues.

  1996cited by this paper
• A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae.

  1993cited by this paper
• Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase.

  1992cited by this paper
• Regulation of squalene epoxidase activity in rat liver.

  1990cited by this paper
• Regulation of the mevalonate pathway

  1990cited by this paper
• A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

  1989cited by this paper
• Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives.

  1988cited by this paper
• On the control of HMG-CoA reductase, a key regulatory enzyme of adrenal cholesterol synthesis.

  1986cited by this paper
• Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide.

  1981cited by this paper
• A simplification of the protein assay method of Lowry et al. which is more generally applicable.

  1977cited by this paper

• Analysis of the response mechanism in lipid degradation of key gene LDH1 knockout strains of Saccharomyces cerevisiae under levulinic acid stress

  2025cites this paper
• Ergosterol Biosynthesis and Regulation Impact the Antifungal Resistance and Virulence of Candida spp.

  2024cites this paper
• Efficient Plant Triterpenoids Synthesis in Saccharomyces cerevisiae: from Mechanisms to Engineering Strategies.

  2024cites this paper
• Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism

  2022cites this paper
• Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

  2019cites this paper
• DISCOVERING A NOVEL ANTIFUNGAL TARGET IN DOWNSTREAM STEROL BIOSYNTHESIS USING A SQUALENE SYNTHASE FUNCTIONAL MOTIF

  2017cites this paper
• 4-Methylzymosterone and Other Intermediates of Sterol Biosynthesis from Yeast Mutants Engineered in the ERG27 Gene Encoding 3-Ketosteroid Reductase

  2016influential citation
• Mapping a kingdom-specific functional domain of squalene synthase.

  2016cites this paper
• Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells.

  2016cites this paper
• A lipidomics approach to the viral-host dynamics of the unicellular, eukaryotic alga cChlorella variabilis and its viral pathogen, PBCV-1

  2015cites this paper
• Site‐directed mutagenesis of a fatty acid elongase ELO‐like condensing enzyme

  2013cites this paper
• Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.

  2013cites this paper
• Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts.

  2010influential citation
• Mitochondrial DNA

  2009cites this paper
• mitochondrial DNA

  year unknowncites this paper