Opioids in chronic non‐cancer pain: systematic review of efficacy and safety

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Pain

• Publication date

  2004-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.pain.2004.09.019PMID 15561393
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Research

  2006cited by this paper
• Analgesic Effects of Intravenous Lidocaine and Morphine on Postamputation Pain: A Randomized Double-Blind, Active Placebo-Controlled, Crossover Trial

  2004influential reference
• Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: a systematic review.

  2003cited by this paper
• "Hillbilly heroin" arrives in Cape Breton.

  2003cited by this paper
• Opioid therapy for chronic pain.

  2003influential reference
• Opioids versus antidepressants in postherpetic neuralgia: A randomized, placebo-controlled trial

  2003influential reference
• Recommendations for using opioids in chronic non‐cancer pain

  2003cited by this paper
• Controlled‐release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy

  2003influential reference
• Much ballyhooed biohazard training yet to begin.

  2003cited by this paper
• Controlled-release oxycodone for pain in diabetic neuropathy

  2003influential reference
• Morphine responsiveness, efficacy and tolerability in patients with chronic non‐tumor associated pain – results of a double‐blind placebo‐controlled trial (MONTAS)

  2002cited by this paper
• Effects of IV morphine in central pain: A randomized placebo-controlled study

  2002influential reference
• Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice

  2002cited by this paper
• Opioids versus antidepressants in postherpetic neuralgia: A randomized, placebo-controlled trial

  2002cited by this paper
• Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial.

  2002influential reference
• Analgesic Effects of Intravenous Lidocaine and Morphine on Postamputation Pain: A Randomized Double-blind, Active placebo-controlled, Crossover Trial

  2002cited by this paper
• The effect of opioids on phantom limb pain and cortical reorganization

  2001influential reference
• Definitions related to the use of opioids for the treatment of pain.

  2001cited by this paper
• The Response of Neuropathic Pain and Pain in Complex Regional Pain Syndrome I to Carbamazepine and Sustained-Release Morphine in Patients Pretreated with Spinal Cord Stimulation: A Double-Blinded Randomized Study

  2001cited by this paper
• Defining the clinically important difference in pain outcome measures

  2000cited by this paper
• Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature.

  2000cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Endocrine Consequences of Long-Term Intrathecal Administration of Opioids

  2000influential reference
• Around-the-clock, controlled-release oxycodone therapy for osteoarthritis-related pain: placebo-controlled trial and long-term evaluation.

  2000influential reference
• Misleading funnel plot for detection of bias in meta-analysis.

  2000cited by this paper
• Teasing apart quality and validity in systematic reviews: an example from acupuncture trials in chronic neck and back pain

  2000cited by this paper
• An evaluation of homogeneity tests in meta‐analyses in pain using simulations of individual patient data

  2000cited by this paper
• Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses.

  1999cited by this paper
• Improving the Quality of Reports of Meta-Analyses of Randomised Controlled Trials: The QUOROM Statement

  1999cited by this paper
• Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.

  1999influential reference
• Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia.

  1998influential reference
• Prolonged treatment with transdermal fentanyl in neuropathic pain.

  1998influential reference
• Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain.

  1997cited by this paper
• Controlled‐release oxycodone and morphine in cancer related pain

  1997cited by this paper
• Randomised trial of oral morphine for chronic non-cancer pain.

  1996influential reference
• A Double‐blind, Placebo‐Controlled, Repeated Dose, Dose‐Response Evaluation of Controlled‐Release (CR) Oxycodone in Patients with Osteoarthritis

  1996cited by this paper
• Assessing the quality of reports of randomized clinical trials: is blinding necessary?

  1996cited by this paper
• Opioids for chronic pain of non-malignant origin—Caring or crippling

  1995cited by this paper
• The number needed to treat: a clinically useful measure of treatment effect

  1995cited by this paper
• Morphine differentially affects the sensory and affective pain ratings in neurogenic and idiopathic forms of pain

  1991cited by this paper
• Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia

  1991influential reference
• Statistics with confidence: Confidence intervals and statistical guidelines .

  1990cited by this paper
• Statistics in Medicine: Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates

  1988cited by this paper
• Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

  1988cited by this paper
• Meta-analysis in clinical research.

  1987cited by this paper

• Senescence Associated Osteoarthritis: Emerging Therapeutics and Future Directions

  2026cites this paper
• Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

  2026cites this paper
• Balancing risk and reward with dual opioid therapy for neuropathic pain. When is the right time?

  2026cites this paper
• Pharmacological and rehabilitation strategies in opioid-induced constipation: an observational study

  2026cites this paper
• Down-regulation of M6A demethylase ALKBH5 facilitates morphine tolerance via SGK1 in mice.

  2026cites this paper
• A Metabolic Framework for Reward: Redefining Dopamine and Opioids as Physiological Agents.

  2026cites this paper
• Predictive Models for Identifying Adult Patients at High Risk of Developing Opioid-Related Harms: a Systematic Review

  2025cites this paper
• Excitatory projections from the nucleus reuniens to the medial prefrontal cortex modulate pain and depression-like behaviors in mice

  2025cites this paper
• Implementation interventions to promote healthcare professional uptake of evidence-based opioid deprescribing for adults with chronic non-cancer pain.

  2025cites this paper
• Prognostic Value of Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Profiles in Predicting Outcomes of Occipital Nerve Stimulation for Refractory Chronic Migraine: A Retrospective Bias-Corrected Multivariable Analysis

  2025cites this paper
• MECHANISMS, EFFICACY, AND SAFETY OF SUZETRIGINE COMPARED WITH OTHER ANALGESICS IN ACUTE PAIN MANAGEMENT

  2025cites this paper
• Exercise prescription for improving chronic low back pain in adults: a network meta-analysis

  2025cites this paper
• Pain Management in Cancer Patients With Artificial Intelligence: Narrative Review

  2025cites this paper
• Knowledge, mechanisms, and intervention of the polytrauma clinical triad in military pain medicine

  2025cites this paper
• Inhibitory modulation of gastrointestinal motility in mice by Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2, a novel cyclic hexapeptide with multifunctional opioid agonism.

  2025cites this paper
• Underutilized treatments for patients with refractory cancer pain: a qualitative study assessing the use of intrathecal drug delivery devices in the United Kingdom compared to alternative treatments in cancer pain management

  2025cites this paper
• Opioid deprescribing: rethinking policies to facilitate better patient outcomes

  2025cites this paper
• Postoperative pain and quality of life assessment after endodontic preparation with rotary and reciprocating endodontic instruments: randomized clinical trial

  2025cites this paper
• Enhanced Analgesic Efficacy and Reduced Side Effects of Morphine by Combination with PD-1 Agonist.

  2025cites this paper
• Opioid Enantiomers: Exploring the Complex Interplay of Stereochemistry, Pharmacodynamics, and Therapeutic Potential.

  2025cites this paper
• A brain-to-small intestine circuit mediates morphine-induced constipation in male mice

  2025cites this paper
• The Efficacy and Safety of Methylnaltrexone in Cancer patients with Opioid-induced Constipation: A Systematic Review and Meta-analysis

  2025cites this paper
• Opioids in the Brazilian Healthcare Landscape: Crucial Analysis through Anvisa VigiMed Data and Pharmacogenetic Aspects

  2025cites this paper
• Innovative nanocarriers in arthritis therapy: the role of herbal cubosomes

  2025cites this paper
• Prediction of opioid use disorder among patients with chronic non-cancer pain receiving long-term opioid therapy.

  2025cites this paper
• Prescription Pattern of Laxatives for Opioid-Induced Constipation in Japanese Patients With Chronic Non-cancer Pain: A Retrospective Cohort Study of a Health Insurance Claims Database

  2025cites this paper
• Emesis and Constipation Induced by Methadone and the Active Metabolite of Tramadol (M1) in Animals

  2025cites this paper
• Controlled transdermal delivery of oxycodone by pulsed iontophoresis: In vitro and in vivo evaluations.

  2025cites this paper
• Evidence-Based Opinions from Multidisciplinary Experts on Use of Naturopathic Herbal Remedies in Pain Management

  2024cites this paper
• Current reviews depicting therapeutic potential of novel drug delivery system in rheumatoid arthritis

  2024cites this paper
• [Appropriate use of strong opioids in medical units: Recommendations and action to be taken in daily practice].

  2024cites this paper
• The Complexity of Neuropathic Pain and Central Sensitization: Exploring Mechanisms and Therapeutic Prospects.

  2024cites this paper
• Risk of fall or fracture with concomitant use of prescription opioids and other medications in osteoarthritis patients

  2024influential citation
• Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults

  2024cites this paper
• Central control of opioid-induced mechanical hypersensitivity and tolerance in mice.

  2024cites this paper
• Safety and efficacy of long‐term use of a buprenorphine transdermal patch system in patients with osteoarthritis and low back pain refractory to non‐opioid analgesics: Post‐marketing surveillance of 3000 cases

  2024cites this paper
• Prevalence of problematic pharmaceutical opioid use in patients with chronic non-cancer pain: A systematic review and meta-analysis.

  2024cites this paper
• Exploring the Impact of Opioids on Serum Chemistry: Insights from FT-Raman Spectroscopy and Biochemical Analysis

  2024cites this paper
• Population Pharmacokinetics of Naloxegol in Pediatric Subjects Receiving Opioids

  2024cites this paper
• S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation

  2024cites this paper
• A New Application for Cenicriviroc, a Dual CCR2/CCR5 Antagonist, in the Treatment of Painful Diabetic Neuropathy in a Mouse Model

  2024cites this paper
• Chronic opioid prescription in veterans with spinal cord injury: Prevalence and associated factors

  2024cites this paper
• Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia.

  2024cites this paper
• The Association Between Employment in Coal Mining and History of Injury, Current Pain, and Prescription Opioid Use

  2024cites this paper
• Long-Term Efficacy and Safety of High-Frequency Spinal Stimulation for Chronic Pain

  2024cites this paper
• VULNERABILITY FACTORS, ADJUSTMENT, AND OPIOID MISUSE IN CHRONIC NON-CANCER PAIN INDIVIDUALS.

  2024cites this paper
• Effect of oral naloxone on opioid-induced constipation in methadone maintenance treatment patients, a double-blind, placebo-control, clinical trial

  2024influential citation
• Impacts of genetic polymorphisms and cancer cachexia on naldemedine pharmacokinetics and bowel movements in patients receiving opioid analgesics

  2024cites this paper
• Nociceptive pain assessed by the PainDETECT questionnaire may predict response to opioid treatment for chronic low back pain

  2024cites this paper
• Unveiling the link between chronic pain and misuse of opioids and cannabis

  2024cites this paper
• Home Ultrasound: A Contemporary and Valuable Tool for Palliative Medicine

  2024cites this paper
• Opioids and the Gastrointestinal Tract: The Role of Peripherally Active µ-Opioid Receptor Antagonists in Modulating Intestinal Permeability

  2024cites this paper
• Chronic pain after spine surgery: Insights into pathogenesis, new treatment, and preventive therapy

  2023cites this paper
• Opioid-free percutaneous nephrolithotomy: an initial experience

  2023cites this paper
• Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews.

  2023cites this paper
• Brain stimulation for chronic pain management: a narrative review of analgesic mechanisms and clinical evidence

  2023cites this paper
• Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations

  2023cites this paper
• ERAS and reducing opioid use in obstetrics and gynecology - Multiple choice questions - Answers

  2023cites this paper
• Cebranopadol for the Treatment of Chronic Pain

  2023influential citation
• Risk factors for opioid addiction in chronic non-cancer pain

  2023cites this paper
• The Effect of Genetic Variation on the Sensitivity to Opioid Analgesics in Patients With Postoperative Pain: An Updated Meta-analysis.

  2023cites this paper
• The E�cacy of PRISTINE: Revealing Concealed Opioid Crisis Trends via Reddit Examination

  2023cites this paper
• Association between opioid prescription profiles and adverse health outcomes in opioid users referred for sleep disorder assessment: a secondary analysis of health administrative data

  2023cites this paper
• N-substituted tetrahydro-beta-carboline as mu-opioid receptors ligands: in silico study; molecular docking, ADMET and molecular dynamics approach

  2023cites this paper
• Tapentadol: A Review of Experimental Pharmacology Studies, Clinical Trials, and Recent Findings

  2023cites this paper
• Risk factors for chronic prescription opioid use in Multiple Sclerosis.

  2023cites this paper
• Comparison of Different Modeling Approaches for Prescription Opioid Use and Its Association With Adverse Events

  2023cites this paper
• Ellagitannins and triterpenoids extracts of Anogeissus leiocarpus stem bark extracts: Protective effects against osteoarthritis

  2023cites this paper
• Balancing the evidence: An update on analgesic use in rheumatic and musculoskeletal diseases

  2023cites this paper
• Ketamine use for management of vaso‐occlusive pain in pediatric sickle cell disease

  2023cites this paper
• Predictors of Postoperative Nausea and Vomiting After Same-Day Surgery: A Retrospective Study.

  2023cites this paper
• Examining Racial/Ethnic Differences in Patterns of Opioid Prescribing: Results from an Urban Safety-Net Healthcare System

  2023cites this paper
• Problematic opioid use among osteoarthritis patients with chronic post-operative pain after joint replacement: analyses from the BISCUITS study

  2023cites this paper
• Prevalence and predictors of opioid use before orthopaedic surgery in an Australian setting: A multicentre, cross-sectional, observational study

  2023cites this paper
• Efeito do tapentadol de liberação prolongada no manejo da dor crônica de moderada a intensa em pacientes idosos. Relato de casos

  2023cites this paper
• An observational post‐authorization safety study (PASS) of naloxegol drug utilization in four European countries

  2023cites this paper
• The United States opioid crisis: Big pharma alone is not to blame."

  2023cites this paper
• Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis

  2023cites this paper
• Functional Constipation and Obstructed Defecation.

  2023cites this paper
• Summary of the 2023 report of the international consultation on incontinence interstitial cystitis/bladder pain syndrome (IC/BPS) committee

  2023cites this paper
• Causal Discovery with Unobserved Variables: A Proxy Variable Approach

  2023cites this paper
• A Review of Chronic Pain and Device Interventions: Benefits and Future Directions

  2022cites this paper
• Medicinal cannabis for Australian patients with chronic refractory pain including arthritis

  2022cites this paper
• Basics of Chronic Pain Management

  2022cites this paper
• Neurophysiology and neuroanatomy of spinal cord electrode stimulation for the treatment of chronic pain – State of art

  2022cites this paper
• Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia

  2022cites this paper
• Pharmacotherapy of Opioid Use Disorder-Update and Current Challenges.

  2022cites this paper
• Actual situation and prescribing patterns of opioids by pain physicians in South Korea

  2022cites this paper
• SHORT-TERM STRESS SIGNIFICANTLY DECREASES MORPHINE ANALGESIA IN TRIGEMINAL BUT NOT IN SPINAL INNERVATED AREAS IN RATS.

  2022cites this paper
• Incidence, pathophysiology, and implications of opioid‐induced constipation and suggestions for patient‐provider interactions

  2022cites this paper
• Opioid trends in Finland: a register-based nationwide follow-up study

  2022cites this paper
• [Efficacy Survey of Naldemedine in the Poor-performance Status Group].

  2022cites this paper
• Using prescription opioids throughout a traumatic injury recovery: A qualitative exploratory study of adolescents in a Midwestern state.

  2022cites this paper
• Update on the role of naldemedine in opioid-induced constipation in patients with chronic noncancer pain

  2022cites this paper
• Opioid use for a first-incident upper extremity fracture in 220,440 patients without recent prior use in Ontario, Canada: a retrospective cohort study

  2022cites this paper
• Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation

  2022cites this paper
• Blocking of Caveolin-1 Attenuates Morphine-Induced Inflammation, Hyperalgesia, and Analgesic Tolerance via Inhibiting NLRP3 Inflammasome and ERK/c-JUN Pathway

  2022cites this paper
• Global Cluster Analysis and Network Visualization in Musculoskeletal Pain Management: A Scientometric Mapping

  2022cites this paper
• Effects of Electroacupuncture on Opioid-Induced Constipation in Patients With Cancer: Study Protocol for a Multicenter Randomized Controlled Trial

  2022cites this paper
• Less Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review

  2022cites this paper