A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Molecular Endocrinology

• Publication date

  1997-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/MEND.11.3.9901PMID 9058373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Growth hormone binding to a circulating receptor fragment--the concept of receptor shedding and receptor splicing.

  2009cited by this paper
• The ubiquitin conjugation system is required for ligand‐induced endocytosis and degradation of the growth hormone receptor.

  1996cited by this paper
• Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein.

  1996cited by this paper
• Development of a constitutively active mutant form of the prolactin receptor, a member of the cytokine receptor family.

  1996cited by this paper
• Abnormal splicing of the leptin receptor in diabetic mice

  1996cited by this paper
• Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor.

  1996cited by this paper
• Molecular analysis of the granulocyte colony-stimulating factor receptor.

  1996cited by this paper
• Growth hormone receptor: structure and signal transduction.

  1995cited by this paper
• The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription.

  1995cited by this paper
• An alternatively spliced human insulin-like growth factor-I transcript with hepatic tissue expression that diverts away from the mitogenic IBE1 peptide.

  1995cited by this paper
• Identification of Phenylalanine 346 in the Rat Growth Hormone Receptor as Being Critical for Ligand-mediated Internalization and Down-regulation (*)

  1995cited by this paper
• Release of a soluble form of growth hormone receptors (growth hormone-binding proteins) from human IM-9 cells by proteolytic cleavage.

  1995cited by this paper
• Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor.

  1995cited by this paper
• Amino acids of the human growth hormone receptor that are required for proliferation and Jak-STAT signaling.

  1995cited by this paper
• Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction.

  1994cited by this paper
• Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.

  1994cited by this paper
• Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.

  1994cited by this paper
• Expression of two isoforms of the human growth hormone receptor in normal liver and hepatocarcinoma.

  1994cited by this paper
• Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor.

  1993cited by this paper
• Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits.

  1993cited by this paper
• Structural and functional aspects of the interaction between growth hormone and its receptor.

  1993cited by this paper
• Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript.

  1992cited by this paper
• Characterization of the short isoform of the growth hormone receptor synthesized by rat adipocytes.

  1992cited by this paper
• Characterization of putative growth hormone receptors in human choroid plexus.

  1991cited by this paper
• Expression of two forms of prolactin receptor in rat ovary and liver.

  1990cited by this paper
• Evaluation of the growth hormone-binding proteins in human plasma using high pressure liquid chromatography gel filtration.

  1990cited by this paper
• Soluble and membrane-bound forms of cytochrome b5 are the products of a single gene in chicken.

  1990cited by this paper
• Isolation and characterization of two novel rat ovarian lactogen receptor cDNA species.

  1990cited by this paper
• The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

  1989cited by this paper
• Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.

  1989cited by this paper
• The human liver growth hormone receptor.

  1989cited by this paper
• Release of growth hormone binding protein from IM-9 lymphocytes by endopeptidase is dependent on sulfhydryl group inactivation.

  1988cited by this paper
• Partial purification from human serum of a specific binding protein for human growth hormone.

  1987cited by this paper
• Growth hormone receptor and serum binding protein: purification, cloning and expression

  1987cited by this paper

• Analysis of truncated growth hormone receptor 1 in the differential growth of fine flounder Paralichthys adspersus

  2023cites this paper
• A Novel, Heterozygous, de novo Splicing Variant Affecting the Intracellular Domain of the Growth Hormone Receptor, and Causing a Mild Short Stature

  2023cites this paper
• Characterisation of dominant-negative GH receptor variants reveals a potential therapeutic target for short stature.

  2023cites this paper
• Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children

  2022cites this paper
• Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension

  2021influential citation
• Diet and Exercise Modulate GH-IGFs Axis, Proteolytic Markers and Myogenic Regulatory Factors in Juveniles of Gilthead Sea Bream (Sparus aurata)

  2021cites this paper
• A novel peptide antagonist of the human growth hormone receptor

  2021cites this paper
• Short stature explained by dimerization of human growth hormone induced by a p.C53S point mutation

  2020cites this paper
• Anterior Pituitary

  2020cites this paper
• Molecular modeling, docking and dynamic simulations of growth hormone receptor (GHR) of Labeo rohita

  2020cites this paper
• Expression of the growth hormone receptor isoforms and its correlation with the metabolic profile in morbidly obese subjects

  2018cites this paper
• Evolution of the receptors for growth hormone, prolactin, erythropoietin and thrombopoietin in relation to the vertebrate tetraploidizations.

  2017cites this paper
• Growth Hormone Resistance—Special Focus on Inflammatory Bowel Disease

  2017cites this paper
• Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children

  2016cites this paper
• Genetic Predictors of Response to Different Medical Therapies in Acromegaly.

  2016cites this paper
• Growth hormone receptors in the atherinid Odontesthes bonariensis: characterization and expression profile after fasting-refeeding and growth hormone administration.

  2016cites this paper
• Biological Determinants of Responsiveness to Growth Hormone: Pharmacogenomics and Personalized Medicine

  2016cites this paper
• Capítulo 9 – Farmacogenómica de la acromegalia

  2015cites this paper
• Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis.

  2015cites this paper
• Profile of pegvisomant in the management of acromegaly: an evidence based review of its place in therapy

  2015cites this paper
• Clinical and biochemical consequences of an intragenic growth hormone receptor (GHR) deletion in a large Chinese pedigree

  2015cites this paper
• Growth hormone binding protein - physiological and analytical aspects.

  2015cites this paper
• Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway

  2015cites this paper
• The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets

  2014influential citation
• Impact de la signalisation constitutive du récepteur de la prolactine sur la physiopathologie mammaire

  2014cites this paper
• Leptin signaling in the rainbow trout central nervous system is modulated by a truncated leptin receptor isoform.

  2014cites this paper
• Regulation of human growth hormone receptor expression by microRNAs.

  2014cites this paper
• The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma

  2014cites this paper
• Growth Hormone-Binding Proteins

  2014cites this paper
• Heterozygous GHR gene mutation in a child with idiopathic short stature

  2014cites this paper
• Normal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man

  2014cites this paper
• Evolutionary origin and divergence of the growth hormone receptor family: insight from studies on sea lamprey.

  2013cites this paper
• Ligand‐Receptor Fusion Dimers

  2013cites this paper
• Effect of zinc binding residues in growth hormone (GH) and altered intracellular zinc content on regulated GH secretion.

  2013cites this paper
• volutionary origin and divergence of the growth hormone receptor amily : Insight from studies on sea lamprey lizabeth

  2013influential citation
• The role of human growth hormone's C-terminal disulfide bridge.

  2013cites this paper
• Short stature in two siblings heterozygous for a novel bioinactive GH mutant (GH-P59S) suggesting that the mutant also affects secretion of the wild-type GH.

  2013cites this paper
• Lymphocyte GH-axis hormones in immunity.

  2013cites this paper
• Pathophysiology of human visceral obesity: an update.

  2013cites this paper
• Pharmacological Therapy for Acromegaly

  2012cites this paper
• Signal Transduction Mechanisms Underlying Growth Hormone ReceptorAction

  2012influential citation
• Molecular mechanisms of prolactin and its receptor.

  2012cites this paper
• Inherent growth hormone resistance in the skeletal muscle of the fine flounder is modulated by nutritional status and is characterized by high contents of truncated GHR, impairment in the JAK2/STAT5 signaling pathway, and low IGF-I expression.

  2012cites this paper
• Expression of a glycosylphosphatidylinositol-anchored ligand, growth hormone, blocks receptor signalling

  2012cites this paper
• Nonalcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF‐I levels

  2012cites this paper
• Long-Acting Growth Hormone Analogues

  2011cites this paper
• In vitro characterization of human growth hormone mutants

  2011cites this paper
• The roles of growth hormone and prolactin in the brain during development and recovery from hypoxic-ischemic injury

  2011influential citation
• A novel GH-1 gene mutation (GH-P59L) causes partial GH deficiency type II combined with bioinactive GH syndrome.

  2011cites this paper
• Normal and Aberrant Growth

  2011cites this paper
• Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women

  2011cites this paper
• Growth hormone and prolactin regulate human neural stem cell regenerative activity.

  2011cites this paper
• Genetics of GHRH, GHRH-receptor, GH and GH-receptor: its impact on pharmacogenetics.

  2011cites this paper
• The growth hormone receptor (GHR) c.899dupC mutation functions as a dominant negative: insights into the pathophysiology of intracellular GHR defects.

  2011cites this paper
• Genetic defects causing functional and structural isolated growth hormone deficiency

  2011cites this paper
• Growth Hormone Receptor in Growth

  2011cites this paper
• Growth hormone receptors in zebrafish (Danio rerio): adult and embryonic expression patterns.

  2010influential citation
• Studies of the role of growth hormone and its receptor in obesity

  2010influential citation
• A Short Receptor Downregulates JAK/STAT Signalling to Control the Drosophila Cellular Immune Response

  2010cites this paper
• Growth hormone (GH) deficiency type II: a novel GH-1 gene mutation (GH-R178H) affecting secretion and action.

  2010cites this paper
• Biochemical polymorphism of the growth hormone system proteins and its manifestations in human prostate cells

  2010cites this paper
• The big and small of it: how body size evolves.

  2010cites this paper
• A Novel Y332C Missense Mutation in the Intracellular Domain of The Human Growth Hormone Receptor Does Not Alter STAT5b Signaling: Redundancy of GHR Intracellular Tyrosines Involved in STAT5b Signaling

  2010cites this paper
• A role for growth hormone in neurorestoration and neurogenic processes in the brain

  2010influential citation
• Biological determinants of responsiveness to growth hormone: pharmacogenomics and personalized medicine.

  2010cites this paper
• Regulation of growth hormone receptors in human prostate cancer cell lines.

  2009cites this paper
• Expression of calsequestrin in atrial and ventricular muscle of thermally acclimated rainbow trout

  2009cites this paper
• Extreme Elevation of Serum Growth Hormone-Binding Protein Concentrations Resulting from a Novel Heterozygous Splice Site Mutation of the Growth Hormone Receptor Gene

  2009influential citation
• Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.

  2008cites this paper
• El receptor de la hormona de crecimiento humana (hGH) y la proteína de transporte de alta afinidad de la hGH

  2008influential citation
• ANALYSIS OF FUNCTIONAL GENETIC POLYMORPHISMS IN PROSTATE CANCER AND TYPE 2 DIABETES: GROWTH HORMONE RECEPTOR AND MUCIN 1

  2008influential citation
• Growth hormone (GH) insensitivity and insulin-like growth factor-I deficiency in Inuit subjects and an Ecuadorian cohort: functional studies of two codon 180 GH receptor gene mutations.

  2008cites this paper
• Developmental changes in the human GH receptor and its signal transduction pathways.

  2008cites this paper
• Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population.

  2008cites this paper
• Developmental changes in the hum an GH receptor and its signal transduction pathways

  2008cites this paper
• Cloning and characterization of dominant negative splice variants of the human histamine H 4 receptor

  2008cites this paper
• Caracterització molecular del gen GH1 en poblacions control i patològiques, patrons d'expressió en leucòcits de sang perifèrica i estudi funcional de proteïnes mutants detectades en pacients

  2007cites this paper
• Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options.

  2007cites this paper
• Membrane reinsertion of a myristoyl-peptidyl anchored extracellular domain growth hormone receptor.

  2007cites this paper
• A novel secretin receptor splice variant potentially useful for early diagnosis of pancreatic carcinoma.

  2007cites this paper
• Cloning of Atlantic halibut growth hormone receptor genes and quantitative gene expression during metamorphosis.

  2007cites this paper
• Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.

  2007cites this paper
• Molecular pharmacology of the human histamine H4 receptor

  2007cites this paper
• Growth hormone stimulates ad ipogenesis of 3 T 3L 1 cells through activation of the Stat 5 A / 5 B-PPAR g pathway

  2007cites this paper
• Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver.

  2007influential citation
• Molecular cloning, characterization and distribution of two types of growth hormone receptor in orange-spotted grouper (Epinephelus coioides).

  2007cites this paper
• A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist

  2007cites this paper
• Primary growth hormone (GH) insensitivity and insulin-like growth factor deficiency caused by novel compound heterozygous mutations of the GH receptor gene: genetic and functional studies of simple and compound heterozygous states.

  2007cites this paper
• Evaluation of the biological activity of a growth hormone (GH) mutant (R77C) and its impact on GH responsiveness and stature.

  2007cites this paper
• GROWTH HORMONE GENES AND PROSTATE CANCER RISK

  2007cites this paper
• The growth hormone receptor in growth.

  2007cites this paper
• GH mutant (R77C) in a pedigree presenting with the delay of growth and pubertal development: structural analysis of the mutant and evaluation of the biological activity.

  2007cites this paper
• Visualizing and Manipulating Growth Hormone (GH) Responses in Muscle and Other GH Target Tissues

  2007cites this paper
• Aspects of placental growth hormone physiology.

  2006cites this paper
• Subcellular shift of the hepatic growth hormone receptor with progression of hepatitis C virus‐related chronic liver disease

  2006cites this paper
• Physiology and pathophysiology of growth hormone-binding protein: methodological and clinical aspects.

  2006influential citation
• Interaction of Growth Hormone and Prolactin in Brain Circuits

  2006cites this paper
• Mechanisms of Signal Transduction Utilized by Growth Hormone

  2006cites this paper
• Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke

  2006cites this paper
• Growth Hormone Receptor Message in the Rat and Human Central Nervous System: Structure and Function

  2006cites this paper