A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Theoretical Biology

• Publication date

  2006-07-21

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1016/J.JTBI.2005.11.036PMID 16457852
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-wide association studies: theoretical and practical concerns

  2005cited by this paper
• An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray

  2005cited by this paper
• Genome-wide strategies for detecting multiple loci that influence complex diseases

  2005cited by this paper
• Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease.

  2005cited by this paper
• The Interaction of Four Genes in the Inflammation Pathway Significantly Predicts Prostate Cancer Risk

  2005cited by this paper
• A global view of epistasis

  2005cited by this paper
• Microarray data mining with visual programming

  2005cited by this paper
• Genome-wide association studies for common diseases and complex traits

  2005cited by this paper
• Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage

  2005cited by this paper
• Modular epistasis in yeast metabolism

  2005cited by this paper
• Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis.

  2005influential reference
• Combinatorial Pharmacogenetics

  2005cited by this paper
• Data mining in bioinformatics using Weka

  2004influential reference
• Multilocus Analysis of Hypertension: A Hierarchical Approach

  2004cited by this paper
• Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation

  2004influential reference
• Epistasis, complex traits, and mapping genes

  2004cited by this paper
• Genetic Programming Neural Networks as a Bioinformatics Tool for Human Genetics

  2004cited by this paper
• Linkage of calpain 10 to type 2 diabetes: the biological rationale.

  2004cited by this paper
• Genetic dissection of diseases: design and methods.

  2004cited by this paper
• Computational analysis of gene-gene interactions using multifactor dimensionality reduction

  2004cited by this paper
• Genetics, statistics and human disease: analytical retooling for complexity.

  2004cited by this paper
• STUDENTJAMA. The challenges of whole-genome approaches to common diseases.

  2004influential reference
• Ideal Discrimination of Discrete Clinical Endpoints Using Multilocus Genotypes

  2004influential reference
• The Opportunity for Canalization and the Evolution of Genetic Networks

  2004influential reference
• Human genetics, animal models and computer simulations for studying hypertension.

  2004cited by this paper
• The Elements of Statistical Learning: Data Mining, Inference, and Prediction

  2004cited by this paper
• Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus

  2004cited by this paper
• "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits.

  2003cited by this paper
• Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases

  2003cited by this paper
• Theoretical and Empirical Analysis of ReliefF and RReliefF

  2003influential reference
• Power of multifactor dimensionality reduction for detecting gene‐gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity

  2003influential reference
• Genes, Environment, and Cardiovascular Disease

  2003cited by this paper
• The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

  2003cited by this paper
• Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions

  2003influential reference
• Attribute Interactions in Medical Data Analysis

  2003influential reference
• The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases

  2003cited by this paper
• Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system.

  2003cited by this paper
• Connecting the dots between genes, biochemistry, and disease susceptibility: systems biology modeling in human genetics.

  2003cited by this paper
• New strategies for identifying gene-gene interactions in hypertension

  2002cited by this paper
• Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.

  2001influential reference
• Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes.

  2001cited by this paper
• How to Solve It: Modern Heuristics

  2000cited by this paper
• Canalization in evolutionary genetics: a stabilizing theory?

  2000influential reference
• Epistasis and the Evolutionary Process

  2000cited by this paper
• Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

  1999cited by this paper
• A Complete Enumeration and Classification of Two-Locus Disease Models

  1999cited by this paper
• Feature Extraction, Construction and Selection: A Data Mining Perspective

  1998cited by this paper
• Feature Transformation by Function Decomposition

  1998cited by this paper
• The language of gene interaction.

  1998cited by this paper
• Constructive Induction: Covering Attribute Spectrum

  1998cited by this paper
• Data-Driven Constructive Induction

  1998cited by this paper
• Data mining

  1997influential reference
• Permutation Tests: A Practical Guide to Resampling Methods for Testing Hypotheses

  1995cited by this paper
• Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.

  1995cited by this paper
• Hypothesis-Driven Constructive Induction in AQ17-HCI: A Method and Experiments

  1994influential reference
• Genetic Algorithms in Search Optimization and Machine Learning

  1988cited by this paper
• A Theory and Methodology of Inductive Learning

  1983cited by this paper
• Optimization by Simulated Annealing

  1983cited by this paper
• An introduction to information theory: symbols, signals & noise

  1980cited by this paper
• The Strategy of the Genes

  1958influential reference
• EPISTASIS AND HYPOSTASIS

  1955cited by this paper
• Multivariate information transmission

  1954cited by this paper
• Canalization of Development and the Inheritance of Acquired Characters

  1942influential reference
• Mendel's Principles of Heredity

  1910cited by this paper
• THE CORRELATION BETWEEN RELATIVES ON THE SUPPOSITION OF MENDELIAN INHERITANCE

  year unknowncited by this paper
• Article in Press

  year unknowncited by this paper
• XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.

  year unknowncited by this paper
• Série Scientifique Scientific Series Inference for the Generalization Error

  year unknowninfluential reference

• Contribution of PNPLA3, GCKR, MBOAT7, NCAN, and TM6SF2 Genetic Variants to Hepatocellular Carcinoma Development in Mexican Patients

  2025cites this paper
• The allelic regulatory network of PtobHLH125 regulates secondary cell wall formation by affecting lignin biosynthesis in Populus tomentosa

  2025cites this paper
• DNA-based prediction of external ear morphology in the Chinese population: an exploratory study

  2025cites this paper
• A Quantitative Approach to Modeling the Overconsumption of Energy in Healthcare Buildings

  2025cites this paper
• Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk

  2025cites this paper
• Gene Polymorphisms Determining Sex Hormone-Binding Globulin Levels and Endometriosis Risk

  2025cites this paper
• Synergistic Epistasis and Systems Biology Approaches to Uncover a Pharmacogenomic Map Linked to Pain, Anti-Inflammatory and Immunomodulating Agents (PAIma) in a Healthy Cohort

  2024cites this paper
• Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer Risk in Caucasian Women of Russia

  2024cites this paper
• The PtoKNAT1-PtomiR6438a-PtoPOD38 axis controls lignin accumulation in Populus tomentosa

  2024cites this paper
• Association Between CYP2D7 and TCF20 Polymorphisms and Coronary Heart Disease

  2024influential citation
• COMT and SCN9A gene variants do not contribute to chronic low back pain in Mexican-Mestizo patients

  2024influential citation
• Polymorphic variants of the hOGG1, APEX1, XPD, SOD2, and CAT genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk

  2024cites this paper
• Metabotropic glutamate receptor genetic variants and peripheral receptor expression affects trait scores of autistic probands

  2024cites this paper
• Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk

  2024influential citation
• Nearest-Neighbours Estimators for Conditional Mutual Information

  2024cites this paper
• Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity

  2024influential citation
• The rs6576457 G > A variant in the MKRN3 gene promoter significantly increases the risk of central precocious puberty and lung cancer in Hubei Chinese population.

  2024cites this paper
• Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight

  2023influential citation
• SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer

  2023cites this paper
• Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis

  2023cites this paper
• Glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of Indian ADHD probands

  2023cites this paper
• Interaction between maintenance variables of medical ultrasound scanners through multifactor dimensionality reduction

  2023cites this paper
• The effect of epistatic interactions between genetic variants located in microRNA and silencing complex genes on prostate cancer progression risk

  2023cites this paper
• A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility

  2023cites this paper
• Epigenetic Evaluation of the TBX20 Gene and Environmental Risk Factors in Mexican Paediatric Patients with Congenital Septal Defects

  2023cites this paper
• Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis

  2023cites this paper
• Cartography of Genomic Interactions Enables Deep Analysis of Single-Cell Expression Data

  2023cites this paper
• Effects of genetic polymorphisms of LINC-PINT gene on liver cancer susceptibility in the Chinese Han population.

  2023cites this paper
• Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis

  2022cites this paper
• Dimensionality reduction approach for many-objective epistasis analysis

  2022cites this paper
• Biomarker interaction selection and disease detection based on multivariate gain ratio

  2022cites this paper
• The Enigmatic Etiology of Oculo-Auriculo-Vertebral Spectrum (OAVS): An Exploratory Gene Variant Interaction Approach in Candidate Genes

  2022influential citation
• CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene–Gene Interactions Are Associated with Restenosis after Coronary Stenting

  2022cites this paper
• ELSSI: parallel SNP-SNP interactions detection by ensemble multi-type detectors

  2022cites this paper
• Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma

  2022cites this paper
• Specific dopaminergic genetic variants influence impulsivity, cognitive deficit, and disease severity of Indian ADHD probands

  2022cites this paper
• RORA polymorphisms are risk factors for allergic rhinitis susceptibility in the Shaanxi Han population.

  2022cites this paper
• Network approaches for identification of human genetic disease genes

  2022cites this paper
• GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ

  2022cites this paper
• Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease

  2022cites this paper
• Polymorphisms in DNA Repair and Xenobiotic Biotransformation Enzyme Genes and Lung Cancer Risk in Coal Mine Workers

  2022cites this paper
• Searching for subgroup-specific associations while controlling the false discovery rate

  2022cites this paper
• A pharmacogenetic interaction analysis of bevacizumab with paclitaxel in advanced breast cancer patients

  2022cites this paper
• Post-treatment symptomatic improvement of the eastern Indian ADHD probands is influenced by CYP2D6 genetic variations

  2022cites this paper
• Gene variants previously associated with reduced soft-tissue injury risk: Part 2 – Polygenic associations with elite status in Rugby

  2022cites this paper
• Concussion-Associated Polygenic Profiles of Elite Male Rugby Athletes

  2022cites this paper
• Genetic interactions effects for cancer disease identification using computational models: a review

  2021cites this paper
• What makes a good prediction? Feature importance and beginning to open the black box of machine learning in genetics

  2021cites this paper
• Whole Exome Sequencing identifies the potential role of genes involved in p53 pathway in Nasopharyngeal Carcinoma from Northeast India.

  2021cites this paper
• Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

  2021cites this paper
• Complex Genetic Interactions/Data Mining/Dimensionality Reduction

  2021cites this paper
• An epistasis and heterogeneity analysis method based on maximum correlation and maximum consistence criteria.

  2021cites this paper
• Epistasis Between Two Gene Variants of Leptin and Vascular Endothelial Growth Factor Genes in the Development of Primary Knee Osteoarthritis.

  2021cites this paper
• Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy

  2021cites this paper
• Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands

  2021cites this paper
• Spatial rank-based multifactor dimensionality reduction to detect gene–gene interactions for multivariate phenotypes

  2021cites this paper
• Machine learning in geography–Past, present, and future

  2021cites this paper
• Genome-wide association studies reveal the coordinated regulatory networks underlying photosynthesis and wood formation in Populus.

  2021cites this paper
• Optimized permutation testing for information theoretic measures of multi-gene interactions

  2021cites this paper
• Brief Survey on Machine Learning in Epistasis.

  2021cites this paper
• Association of DNA repair gene XPC Ala499Val (rs2228000 C>T) and Lys939Gln (rs2228001 A>C) polymorphisms with the risk of chronic myeloid leukemia: A case–control study in a South Indian population

  2021cites this paper
• Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia

  2021cites this paper
• Multilevel thresholding based follicle detection and classification of polycystic ovary syndrome from the ultrasound images using machine learning

  2021cites this paper
• Determining dependency and redundancy for identifying gene-gene interaction associated with complex disease

  2020cites this paper
• Polymorphism of Proteasomal Genes Can Be a Risk Factor for Systemic Autoimmune Diseases in Children

  2020cites this paper
• Cytokine genes multi-locus analysis reveals synergistic influence on genetic susceptibility in Indian SLE - A multifactor-dimensionality reduction approach.

  2020cites this paper
• Molecular genetic markers of sensitivity to industrial environment factors at miners

  2020cites this paper
• Testing the Significance of Interactions in Genetic Studies Using Interaction Information and Resampling Technique

  2020cites this paper
• Cryptorchidism and Testicular Tumor: Comprehensive Analysis of Common Clinical Features and Search of SNVs in the KIT and AR Genes

  2020cites this paper
• Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

  2020cites this paper
• Fully Convolutional Variational Autoencoder For Feature Extraction Of Fire Detection System

  2020cites this paper
• Chromosomal Instability and Genetic Polymorphism in Miners and Workers of Coal Thermal Power Plants

  2020cites this paper
• Asymptotic Distributions of Empirical Interaction Information

  2020cites this paper
• Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study

  2020cites this paper
• A comparison of methods for interpreting random forest models of genetic association in the presence of non-additive interactions

  2020cites this paper
• Maize Carotenoid Gene Locus Mining Based on Conditional Gaussian Bayesian Network

  2020cites this paper
• Early Life Stress and Depression

  2020cites this paper
• Improving the interpretability of random forest models of genetic association in the presence of non-additive interactions

  2020cites this paper
• MIR17HG polymorphisms contribute to high-altitude pulmonary edema susceptibility in the Chinese population

  2020cites this paper
• Association of BLK and BANK1 Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population

  2020cites this paper
• Asymptotic Distributions of Empirical Interaction Information

  2020cites this paper
• Rad51 paralogs and the risk of unselected breast cancer: A case-control study

  2020cites this paper
• How to increase our belief in discovered statistical interactions via large-scale association studies?

  2019cites this paper
• Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients.

  2019cites this paper
• Multifactor dimensionality reduction analysis for detecting SNP-SNP, SNP-environment interactions associated with polycystic ovarian syndrome among South Indian women

  2019cites this paper
• HC-HDSD: A method of hypergraph construction and high-density subgraph detection for inferring high-order epistatic interactions

  2019cites this paper
• Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia

  2019cites this paper
• Gestión de volúmenes masivos de datos genéticos y análisis de la influencia de su interacción en el desarrollo de cáncer

  2019cites this paper
• Dopaminergic gene analysis indicates influence of inattention but not IQ in executive dysfunction of Indian ADHD probands

  2019cites this paper
• Genetic interaction analysis of VEGF-A rs3025039 and VEGFR-2 rs2071559 identifies a genetic profile at higher risk to develop nodular goiter

  2019cites this paper
• BLK and BANK1 polymorphisms and interactions are associated in Mexican patients with systemic lupus erythematosus

  2019cites this paper
• Vasoactive genes as molecular and genetic predictors of severe preeclampsia

  2019cites this paper
• RaSaR: a novel methodology for the detection of epistasis

  2019cites this paper
• Computational discovery of Genetic Markers for Type 2 diabetes

  2019influential citation
• Modelling the pathogenesis of cystic fibrosis and other monogenic conditions, and the occurrence of causative variants

  2019cites this paper
• TrioMDR: Detecting SNP interactions in trio families with model-based multifactor dimensionality reduction.

  2019cites this paper
• Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

  2019cites this paper
• Low bone mineral density and renal malformation in Mexican patients with Turner syndrome are associated with single nucleotide variants in vitamin D-metabolism genes

  2019cites this paper
• Selecting Optimal Subgroups for Treatment Using Many Covariates

  2018cites this paper
• Role of Gene-Gene Interactions in the Chromosomal Instability in Workers at Coal Thermal Power Plants

  2018cites this paper