Roles of Noncoding RNAs in Regulation of Mitochondrial Electron Transport Chain and Oxidative Phosphorylation

The mitochondrial electron transport chain (ETC) plays an essential role in energy production by inducing oxidative phosphorylation (OXPHOS) to drive numerous biochemical processes in eukaryotic cells. Disorders of ETC and OXPHOS systems are associated with mitochondria- and metabolism-related diseases, including cancers; thus, a comprehensive understanding of the regulatory mechanisms of ETC and OXPHOS systems is required. Recent studies have indicated that noncoding RNAs (ncRNAs) play key roles in mitochondrial functions; in particular, some ncRNAs have been shown to modulate ETC and OXPHOS systems. In this review, we introduce the emerging roles of ncRNAs, including microRNAs (miRNAs), transfer-RNA-derived fragments (tRFs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the mitochondrial ETC and OXPHOS regulation.

• Publication year

  2023

• Venue

  International Journal of Molecular Sciences

• Publication date

  2023-05-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms24119414PMID 37298366PMCID 10253563
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs

  2023cited by this paper
• Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)

  2023cited by this paper
• A FRET-based respirasome assembly screen identifies spleen tyrosine kinase as a target to improve muscle mitochondrial respiration and exercise performance in mice

  2023cited by this paper
• Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma

  2022cited by this paper
• Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells.

  2022influential reference
• Manipulation of the MiR-378a/mt-ATP6 Regulatory Axis Rescues ATP Synthase in the Diabetic Heart and Offers a Novel Role for LncRNA Kcnq1ot1.

  2022influential reference
• tModBase: deciphering the landscape of tRNA modifications and their dynamic changes from epitranscriptome data

  2022cited by this paper
• miR-181c level predicts response to exercise training in patients with heart failure and preserved ejection fraction: an analysis of the OptimEx-Clin trial.

  2021cited by this paper
• Mitochondrial noncoding RNAs: new wine in an old bottle

  2021cited by this paper
• Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4

  2021influential reference
• Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer

  2021cited by this paper
• The Long Non-Coding RNA SAMMSON Is a Regulator of Chemosensitivity and Metabolic Orientation in MCF-7 Doxorubicin-Resistant Breast Cancer Cells

  2021cited by this paper
• The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

  2021cited by this paper
• Biogenesis and Functions of Circular RNAs Come into Focus.

  2020cited by this paper
• OXPHOS genes expression and control in mitochondrial disorders

  2020cited by this paper
• Mitochondrial disorders of the OXPHOS system

  2020cited by this paper
• Contribution of miRNAs, tRNAs and tRFs to Aberrant Signaling and Translation Deregulation in Lung Cancer

  2020cited by this paper
• Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway

  2020influential reference
• Long Non-coding RNAs Involved in Metabolic Alterations in Breast and Prostate Cancers

  2020cited by this paper
• Mycobacterium tuberculosis infection drives mitochondria-biased dysregulation of host tRNA-derived fragments.

  2020cited by this paper
• Mechanisms Underlying the Regulation of Mitochondrial Respiratory Chain Complexes by Nuclear Steroid Receptors

  2020cited by this paper
• Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output.

  2020influential reference
• Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer

  2020cited by this paper
• Mitochondrial Genome-Derived circRNA mc-COX2 Functions as an Oncogene in Chronic Lymphocytic Leukemia

  2020cited by this paper
• The expanding regulatory mechanisms and cellular functions of circular RNAs

  2020cited by this paper
• Mitochondrial Epigenetics: Non-Coding RNAs as a Novel Layer of Complexity

  2020cited by this paper
• Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

  2020cited by this paper
• tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression

  2020cited by this paper
• Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription.

  2019cited by this paper
• Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance

  2019cited by this paper
• The Role of Non-coding RNAs in Oncology.

  2019cited by this paper
• The biogenesis, biology and characterization of circular RNAs

  2019cited by this paper
• Pathways to disease from natural variations in human cytoplasmic tRNAs

  2019cited by this paper
• Mitochondrial DNA: the overlooked oncogenome?

  2019cited by this paper
• Mitochondrial miR-762 regulates apoptosis and myocardial infarction by impairing ND2

  2019cited by this paper
• The MELAS mutation m.3243A>G alters the expression of mitochondrial tRNA fragments.

  2019influential reference
• The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

  2019cited by this paper
• Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches

  2019cited by this paper
• Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation

  2019cited by this paper
• Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs

  2018cited by this paper
• The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.

  2018cited by this paper
• Publisher Correction: Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

  2018cited by this paper
• Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

  2018cited by this paper
• The role of RNA modifications in the regulation of tRNA cleavage

  2018cited by this paper
• Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

  2018cited by this paper
• Prostate cancer-associated lncRNAs.

  2018cited by this paper
• Mitochondrial DNA transcription and translation: clinical syndromes

  2018cited by this paper
• Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer

  2018cited by this paper
• Mitochondrial complex III Rieske Fe-S protein processing and assembly

  2018cited by this paper
• Modifications and functional genomics of human transfer RNA

  2018cited by this paper
• A 360° view of circular RNAs: From biogenesis to functions

  2018cited by this paper
• Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

  2018cited by this paper
• Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase).

  2017cited by this paper
• Identification of miRNA, lncRNA and mRNA-associated ceRNA networks and potential biomarker for MELAS with mitochondrial DNA A3243G mutation

  2017cited by this paper
• MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data

  2017cited by this paper
• Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies.

  2017cited by this paper
• Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression

  2017cited by this paper
• microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases

  2017cited by this paper
• MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects

  2017cited by this paper
• Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

  2017cited by this paper
• Comments on: “A comprehensive repertoire of tRNA-derived fragments in prostate cancer”

  2016cited by this paper
• tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers

  2016cited by this paper
• HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP

  2016cited by this paper
• Melanoma addiction to the long non-coding RNA SAMMSON

  2016cited by this paper
• Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

  2016cited by this paper
• MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation.

  2016cited by this paper
• A comprehensive repertoire of tRNA-derived fragments in prostate cancer

  2016cited by this paper
• The biogenesis and emerging roles of circular RNAs

  2016cited by this paper
• MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation

  2016cited by this paper
• Mitochondrial diseases

  2016cited by this paper
• miRNA-Dependent Activation of mRNA Translation.

  2016cited by this paper
• MINTbase: a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments

  2016cited by this paper
• Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies

  2015cited by this paper
• The Functions of MicroRNAs: mRNA Decay and Translational Repression.

  2015cited by this paper
• Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional?

  2015cited by this paper
• Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic Heart

  2015cited by this paper
• tRNA Biology in Mitochondria

  2015cited by this paper
• The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome.

  2015cited by this paper
• Detecting and characterizing circular RNAs

  2014cited by this paper
• Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

  2014cited by this paper
• Functional role of mitochondrial respiratory supercomplexes.

  2014cited by this paper
• miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo

  2014cited by this paper
• tRFdb: a database for transfer RNA fragments

  2014cited by this paper
• MicroRNA directly enhances mitochondrial translation during muscle differentiation.

  2014cited by this paper
• A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle

  2013cited by this paper
• Slicing tRNAs to boost functional ncRNA diversity

  2013cited by this paper
• Correction: Cell-Type Specific Features of Circular RNA Expression

  2013cited by this paper
• Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

  2013cited by this paper
• Identification and functional characterization of tRNA-derived RNA fragments (tRFs) in respiratory syncytial virus infection.

  2013cited by this paper
• Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

  2013cited by this paper
• Circular RNAs are abundant, conserved, and associated with ALU repeats.

  2013cited by this paper
• Cell-Type Specific Features of Circular RNA Expression

  2013cited by this paper
• The mitochondrial genome encodes abundant small noncoding RNAs

  2013cited by this paper
• The clinical maze of mitochondrial neurology

  2013cited by this paper
• MitomiRs delineating the intracellular localization of microRNAs at mitochondria.

  2013cited by this paper
• Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

  2012cited by this paper
• Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

  2012influential reference
• Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms

  2012cited by this paper
• Mitochondrial Diseases

  2012cited by this paper
• Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress*

  2012cited by this paper

• ZBTB16 Improves Myelin Damage in Diabetic Peripheral Neuropathy by Inhibiting Schwann Cell Dedifferentiation

  2026cites this paper
• NDUFA8 promotes cell viability and inhibits ferroptosis and cisplatin sensitivity by stabilizing Fe-S clusters in cervical cancer

  2025cites this paper
• Fasting the mitochondria to prevent neurodegeneration: the role of ceramides

  2025cites this paper
• Novel insights into the Leishmania infantum transcriptome diversity of protein-coding and non-coding sequences in both stages of parasite development using nanopore direct RNA sequencing

  2025cites this paper
• Human adipose-derived stem cell exosomes reduce mitochondrial DNA common deletion through PINK1/Parkin-mediated mitophagy to improve skin photoaging

  2025cites this paper
• Multiple factors based adaptive laboratory evolution strategy enhances DHA production in Aurantiochytrium sp. PKU#Mn16 by rewiring key metabolic pathways

  2025cites this paper
• Thermal priming mitigates the effects of lethal marine heatwaves on the Manila clam Ruditapes philippinarum

  2025cites this paper
• Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteostatic Collapse, and Network Failure Across the CNS

  2025cites this paper
• Mitochondrial Derived Peptides (MDPs) as Emerging Gero Protectors: Molecular Signaling, Systemic Effects, and Translational Perspectives

  2025influential citation
• Integrating mitoepigenetics into research in mood disorders: a state-of-the-art review

  2024cites this paper
• Long non-coding RNA variability in porcine skeletal muscle

  2024cites this paper
• From cells to power cells: harnessing bacterial electron transport for microbial fuel cells (MFCs)

  2024cites this paper
• Osthole Suppresses Cell Growth of Prostate Cancer by Disrupting Redox Homeostasis, Mitochondrial Function, and Regulation of tiRNAHisGTG

  2024cites this paper
• Guidelines for mitochondrial RNA analysis

  2024cites this paper
• tRNA‐derived fragment tRF‐30 propels diabetes‐induced retinal microvascular complications by regulating STAT3 signaling

  2024cites this paper
• Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous Oncology

  2024cites this paper
• LNC-ing Genetics in Mitochondrial Disease

  2024cites this paper
• New insights into the relationship of mitochondrial metabolism and atherosclerosis.

  2024cites this paper