New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Natural product reports (Print)

• Publication date

  2014-09-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1039/c4np00046cPMID 25156669
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HC-toxin.

  2020cited by this paper
• Norine: A powerful resource for novel nonribosomal peptide discovery

  2015cited by this paper
• Biosynthesis of fungal indole alkaloids.

  2014cited by this paper
• Discovering the secondary metabolite potential encoded within entomopathogenic fungi.

  2014cited by this paper
• A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum

  2014cited by this paper
• Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study.

  2014cited by this paper
• Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci

  2013cited by this paper
• Screening the Biosphere: The Fungicolous Fungus Trichoderma phellinicola, a Prolific Source of Hypophellins, New 17-, 18-, 19-, and 20-Residue Peptaibiotics

  2013cited by this paper
• A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus.

  2013cited by this paper
• The Sequences of the Eleven‐Residue Peptaibiotics: Suzukacillins‐B

  2013cited by this paper
• The Genome and Development-Dependent Transcriptomes of Pyronema confluens: A Window into Fungal Evolution

  2013cited by this paper
• Isolation and Characterisation of a Ferrirhodin Synthetase Gene from the Sugarcane Pathogen Fusarium sacchari

  2013cited by this paper
• Unprecedented 17‐Residue Peptaibiotics Produced by Marine‐Derived Trichoderma atroviride

  2013cited by this paper
• antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

  2013cited by this paper
• The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

  2013cited by this paper
• Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites

  2013cited by this paper
• Fungal peptide synthetases: an update on functions and specificity signatures

  2013cited by this paper
• Induced production of depsipeptides by co-culturing Fusarium tricinctum and Fusarium begoniae

  2013cited by this paper
• Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae

  2013cited by this paper
• One pathway, many compounds: heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity

  2013cited by this paper
• The Comprehensive Peptaibiotics Database

  2013cited by this paper
• Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV.

  2013cited by this paper
• Phytotoxic secondary metabolites and peptides produced by plant pathogenic Dothideomycete fungi.

  2013cited by this paper
• Echinocandins: production and applications

  2013cited by this paper
• Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.

  2013cited by this paper
• An Extracellular Siderophore Is Required to Maintain the Mutualistic Interaction of Epichloë festucae with Lolium perenne

  2013cited by this paper
• Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis

  2013cited by this paper
• Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata.

  2013cited by this paper
• EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold.

  2013cited by this paper
• Isolation, structure, and biological activity of Phaeofungin, a cyclic lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test.

  2013cited by this paper
• A nonribosomal peptide synthetase mediates siderophore production and virulence in the citrus fungal pathogen Alternaria alternata.

  2013cited by this paper
• Molecular Diversity Sculpted by Fungal PKS–NRPS Hybrids

  2013cited by this paper
• Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.

  2013cited by this paper
• Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens.

  2012cited by this paper
• Overexpression of NRPS4 leads to increased surface hydrophobicity in Fusarium graminearum.

  2012cited by this paper
• Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis

  2012cited by this paper
• Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology.

  2012cited by this paper
• Characterization of the Suillus grevillei Quinone Synthetase GreA Supports a Nonribosomal Code for Aromatic α‐Keto Acids

  2012cited by this paper
• Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus

  2012cited by this paper
• Chemical and Physical Modulation of Antibiotic Activity in Emericella Species

  2012cited by this paper
• New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679

  2012cited by this paper
• Cyclization of Fungal Nonribosomal Peptides by a Terminal Condensation-Like Domain

  2012cited by this paper
• Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities

  2012cited by this paper
• Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.

  2012cited by this paper
• Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris

  2012cited by this paper
• The Production of Multiple Small Peptaibol Families by Single 14‐Module Peptide Synthetases in Trichoderma/Hypocrea

  2012cited by this paper
• Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne

  2012cited by this paper
• Unveiling the biosynthetic puzzle of destruxins in Metarhizium species

  2012cited by this paper
• Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.

  2012cited by this paper
• Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.

  2012cited by this paper
• Iron – A Key Nexus in the Virulence of Aspergillus fumigatus

  2012cited by this paper
• Identification of a Gene Involved in the Synthesis of a Dipeptidyl Peptidase IV Inhibitor in Aspergillus oryzae

  2012cited by this paper
• Hypopulvins, novel peptaibiotics from the polyporicolous fungus Hypocrea pulvinata, are produced during infection of its natural hosts.

  2012cited by this paper
• Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.

  2012cited by this paper
• Phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensis

  2011cited by this paper
• Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum

  2011cited by this paper
• A Cytotoxic Fellutamide Analogue from the Sponge-Derived Fungus Aspergillus versicolor.

  2011cited by this paper
• Isolation, structure, and biological activities of Fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test.

  2011cited by this paper
• Rock-inhabiting fungi originated during periods of dry climate in the late Devonian and middle Triassic.

  2011cited by this paper
• A new cyclic peptide from the marine fungal strain Aspergillus sp. AF119

  2011cited by this paper
• Fueling the future with fungal genomics

  2011cited by this paper
• Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus.

  2011cited by this paper
• Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36

  2011cited by this paper
• SidL, an Aspergillus fumigatus Transacetylase Involved in Biosynthesis of the Siderophores Ferricrocin and Hydroxyferricrocin

  2011cited by this paper
• Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.

  2011cited by this paper
• Characterisation of the ArmA adenylation domain implies a more diverse secondary metabolism in the genus Armillaria.

  2011cited by this paper
• A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.

  2011cited by this paper
• Isolation and structural elucidation of proline-containing cyclopentapeptides from an endolichenic Xylaria sp.

  2011cited by this paper
• Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).

  2011cited by this paper
• Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp.

  2011cited by this paper
• Systematics of Catenulifera (anamorphic Hyaloscyphaceae) with an assessment of the phylogenetic position of Phialophora hyalina.

  2010cited by this paper
• Characterization of pseudacyclins A-E, a suite of cyclic peptides produced by Pseudallescheria boydii.

  2010cited by this paper
• Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033

  2010cited by this paper
• Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships

  2010cited by this paper
• Penilumamide, a novel lumazine peptide isolated from the marine-derived fungus, Penicillium sp. CNL-338.

  2010cited by this paper
• Diversity of Monomers in Nonribosomal Peptides: towards the Prediction of Origin and Biological Activity

  2010cited by this paper
• Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452

  2010cited by this paper
• Functional characterization and manipulation of the apicidin biosynthetic pathway in Fusarium semitectum

  2010cited by this paper
• Two Classes of New Peptaibols Are Synthesized by a Single Non-ribosomal Peptide Synthetase of Trichoderma virens*

  2010cited by this paper
• Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae.

  2010cited by this paper
• Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis

  2010cited by this paper
• Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria.

  2010cited by this paper
• Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorum PT06-1.

  2010cited by this paper
• Cyclodepsipeptides - potential drugs and lead compounds in the drug development process.

  2009cited by this paper
• Micafungin: a sulfated echinocandin

  2009cited by this paper
• Alternaramide, a cyclic depsipeptide from the marine-derived fungus Alternaria sp. SF-5016.

  2009cited by this paper
• Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp.

  2009cited by this paper
• An Antifungal Tetrapeptide from the Culture of Penicillium canescens

  2009cited by this paper
• The Ascomycota tree of life: a phylum-wide phylogeny clarifies the origin and evolution of fundamental reproductive and ecological traits.

  2009cited by this paper
• Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis*

  2009cited by this paper
• Lipopeptides as anti-infectives: a practical perspective

  2009cited by this paper
• Occurrence and characterization of peptaibols from Trichoderma citrinoviride, an endophytic fungus of cork oak, using electrospray ionization quadrupole time-of-flight mass spectrometry.

  2009cited by this paper
• Acetylaszonalenin Biosynthesis in Neosartorya fischeri

  2009cited by this paper
• Alamethicin Aggregation in Lipid Membranes

  2009cited by this paper
• Structural pattern matching of nonribosomal peptides

  2009cited by this paper
• Siderophore synthesis in Magnaporthe grisea is essential for vegetative growth, conidiation and resistance to oxidative stress.

  2009cited by this paper
• Creating and screening Cochliobolus heterostrophus non-ribosomal peptide synthetase mutants.

  2008cited by this paper
• The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones.

  2008cited by this paper
• Natural Cyclopeptaibiotics and Related Cyclic Tetrapeptides: Structural Diversity and Future Prospects

  2008cited by this paper
• Siderophores in fungal physiology and virulence.

  2008cited by this paper

• Characteristics of fecal mycobiota and bacteriota in laying hens during different laying periods.

  2025cites this paper
• Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice

  2025cites this paper
• Biosynthetic Gene Cluster Diversity Across Native and Introduced Populations of an Ectomycorrhizal Fungus, Suillus luteus

  2024cites this paper
• Characterization of a methyltransferase for iterative N-methylation at the leucinostatin termini in Purpureocillium lilacinum

  2024cites this paper
• New Cyclic Pentapeptides from the Mangrove-Derived Aspergillus fumigatus GXIMD 03099

  2024cites this paper
• Streptomyces strains inhibit the growth of Fusarium kuroshium and Fusarium solani and promote the growth of Arabidopsis thaliana

  2024cites this paper
• Bacterial non-ribosomal peptides: a sustainable approach for combatting phytopathogenic fungi in agriculture

  2024cites this paper
• Chemistry and biology of marine-derived Trichoderma metabolites

  2024cites this paper
• Biosynthetic Characterization, Heterologous Production, and Genomics-Guided Discovery of GABA-Containing Fungal Heptapeptides.

  2023cites this paper
• The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides.

  2023cites this paper
• A Novel Zn2Cys6 Transcription Factor, TopC, Positively Regulates Trichodin A and Asperpyridone A Biosynthesis in Tolypocladium ophioglossoides

  2023cites this paper
• Recent advances on cyclodepsipeptides: biologically active compounds for drug research

  2023cites this paper
• Advances in the treatment of invasive fungal disease

  2023cites this paper
• Sources of Antifungal Drugs

  2023cites this paper
• Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri.

  2022cites this paper
• Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

  2022cites this paper
• Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

  2022cites this paper
• Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds

  2022cites this paper
• Cytotoxic Cyclodepsipeptides and Cyclopentane Derivatives from a Plant-Associated Fungus Fusarium sp.

  2022cites this paper
• Activation of mycelial defense mechanisms in the oyster mushroom Pleurotus ostreatus induced by Tyrophagus putrescentiae.

  2022cites this paper
• Engineering the biosynthesis of fungal nonribosomal peptides.

  2022cites this paper
• Halovirs I–K, antibacterial and cytotoxic lipopeptaibols from the plant pathogenic fungus Paramyrothecium roridum NRRL 2183

  2022cites this paper
• Deep learning approaches for natural product discovery from plant endophytic microbiomes

  2021cites this paper
• Understanding In-Silico Approaches to Design Synthetic Antifungal Peptides to Combat Fungal Infections like Mucormycosis

  2021cites this paper
• Understanding In-Silico Approaches to Design Synthetic Antifungal Peptides to Combat Fungal Infections like Mucormycosis

  2021cites this paper
• Genetic Relationships in the Toxin-Producing Fungal Endophyte, Alternaria oxytropis Using Polyketide Synthase and Non-Ribosomal Peptide Synthase Genes

  2021cites this paper
• Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea

  2021cites this paper
• Fungal Siderophores: Prospects and Applications

  2021cites this paper
• Bioinformatics Applications in Fungal Siderophores: Omics Implications

  2021cites this paper
• Emerimicins V-X, 15-Residue Peptaibols Discovered from an Acremonium sp. through Integrated Genomic and Chemical Approaches.

  2021cites this paper
• Victorin, the host-selective cyclic peptide toxin from the oat pathogen Cochliobolus victoriae, is ribosomally encoded

  2020cites this paper
• The Desotamide Family of Antibiotics

  2020cites this paper
• Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations

  2020cites this paper
• Antimicrobial Peptides: a New Frontier in Antifungal Therapy

  2020cites this paper
• Combinatorial Biosynthesis of Sulfated Benzenediol Lactones with a Phenolic Sulfotransferase from Fusarium graminearum PH-1

  2020cites this paper
• Echinocandins: structural diversity, biosynthesis, and development of antimycotics

  2020cites this paper
• Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene.

  2019cites this paper
• Non-Ribosomal Peptide Synthetases: Nature's Indispensable Drug Factories

  2019cites this paper
• Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis

  2018influential citation
• Functional redundancy in Echinocandin B in-cluster transcription factor ecdB of Emericella rugulosa NRRL 11440

  2018cites this paper
• Trichodermides A-E: New Peptaibols Isolated from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16.

  2018cites this paper
• Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum.

  2018cites this paper
• How fungi defend themselves against microbial competitors and animal predators

  2018cites this paper
• Enantioselective Silver-Catalyzed Cascade Synthesis of Fused Lactone and Lactam Oxazolines.

  2018cites this paper
• Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids.

  2018cites this paper
• Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici.

  2017cites this paper
• ECHINOCANDINS VERSUS DATED ANTIFUNGALS IN COMBINATION AGAINST OPPORTUNISTIC MYCOTIC INFECTIONS

  2017cites this paper
• Antimicrobial potential of alkalophilic micromycetes Emericellopsis alkalina

  2017cites this paper
• 22-6 – Médicaments systémiques des dermatoses

  2017cites this paper
• Cyclic Peptoids as Mycotoxin Mimics: An Exploration of Their Structural and Biological Properties.

  2017cites this paper
• Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

  2017cites this paper
• Echinocandins in antifungal pharmacotherapy

  2017cites this paper
• The identification of fungi collected from the ceca of commercial poultry

  2017cites this paper
• Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus.

  2016cites this paper
• Fungal Metabolites for the Control of Biofilm Infections

  2016cites this paper
• Structural diversity in echinocandin biosynthesis: the impact of oxidation steps and approaches toward an evolutionary explanation

  2016cites this paper
• Genomic and transcriptomic analyses of the tangerine pathotype of Alternaria alternata in response to oxidative stress

  2016cites this paper
• Localization and Transcriptional Responses of Chrysoporthe austroafricana in Eucalyptus grandis Identify Putative Pathogenicity Factors

  2016cites this paper
• Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster

  2016cites this paper
• Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

  2016cites this paper
• Aspergillus section Nidulantes (formerly Emericella): Polyphasic taxonomy, chemistry and biology

  2016cites this paper
• Norine: A powerful resource for novel nonribosomal peptide discovery

  2015cites this paper
• Hitting the Sweet Spot: Glycans as Targets of Fungal Defense Effector Proteins

  2015cites this paper
• Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

  2015cites this paper
• Aspergillus mulundensis sp. nov., a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins

  2015cites this paper
• A novel family of cyclic oligopeptides derived from ribosomal peptide synthesis of an in planta-induced gene, gigA, in Epichloë endophytes of grasses.

  2015cites this paper
• Genetic Manipulation of the Pneumocandin Biosynthetic Pathway for Generation of Analogues and Evaluation of Their Antifungal Activity.

  2015cites this paper
• Evolution of Chemical Diversity in Echinocandin Lipopeptide Antifungal Metabolites

  2015cites this paper
• Improved Strategy for the Synthesis of the Anticancer Agent Culicinin D

  2015cites this paper
• Engineering of Glarea lozoyensis for Exclusive Production of the Pneumocandin B0 Precursor of the Antifungal Drug Caspofungin Acetate

  2014cites this paper