Epithelial-mesenchymal interactions in the pathogenesis of asthma

ABSTRACT Asthma is regarded as an inflammatory disorder of the conducting airways characterized by a mast cell, eosinophil and T lymphocyte inflammatory response that is responsive to anti-inflammatory therapy, such as corticosteroids. In more severe and chronic disease, corticosteroids become less effective. As in other chronic inflammatory diseases, the tissue in which the cellular and mediator processes occur plays a major role in maintaining the response and creating a basis for disease persistence. Herein, we describe evidence that the airway epithelium interacting with the underlying mesenchymal cells recapitulates branching morphogenesis, as observed in the developing lung, to create airway wall remodeling. The reciprocal signaling between the susceptible epithelium and responsive mesenchyme (epithelial mesenchymal trophic unit) offers a new paradigm for asthma and creates new opportunities for developing therapeutics based on reversing the 'chronic wound' phenotype of asthmatic airways.

• Publication year

  2003

• Venue

  Allergology International

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/J.1440-1592.2003.00274.X
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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