The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biochemical Journal

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BJ20070766PMID 17627608PMCID PMC2275072
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitamin C

  2007cited by this paper
• Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole

  2006cited by this paper
• Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L‐gulono‐1,4‐lactone dehydrogenase

  2006cited by this paper
• Infection-induced respiratory burst in BALB/c macrophages kills Leishmania guyanensis amastigotes through apoptosis: possible involvement in resistance to cutaneous leishmaniasis.

  2006cited by this paper
• The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

  2005cited by this paper
• Vitamin C biosynthesis in trypanosomes: a role for the glycosome.

  2005cited by this paper
• Oxidative stress and antioxidant defenses: a target for the treatment of diseases caused by parasitic protozoa.

  2004cited by this paper
• Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi.

  2004cited by this paper
• The trypanosomiases.

  2003cited by this paper
• Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium.

  2003cited by this paper
• TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.

  2002cited by this paper
• Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum

  2002cited by this paper
• The Trypanosoma cruzi Enzyme TcGPXI Is a Glycosomal Peroxidase and Can Be Linked to Trypanothione Reduction by Glutathione or Tryparedoxin*

  2002cited by this paper
• BIOSYNTHESIS OF ASCORBIC ACID IN PLANTS: A Renaissance.

  2001cited by this paper
• Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi

  2001cited by this paper
• Structural Analysis of Flavinylation in Vanillyl-Alcohol Oxidase*

  2000cited by this paper
• Distinct Mitochondrial and Cytosolic Enzymes Mediate Trypanothione-dependent Peroxide Metabolism in Trypanosoma cruzi *

  2000cited by this paper
• MioC Is an FMN-binding Protein That Is Essential forEscherichia coli Biotin Synthase Activity in Vitro *

  2000cited by this paper
• Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans.

  1999cited by this paper
• Criteria and recommendations for vitamin C intake.

  1999cited by this paper
• Criteria and recommendations for vitamin C intake.

  1999cited by this paper
• Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: The current state of affairs

  1998cited by this paper
• Isolation of a cDNA coding for L-galactono-gamma-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast.

  1997cited by this paper
• D-arabinose dehydrogenase and biosynthesis of erythroascorbic acid in Candida albicans.

  1996cited by this paper
• Reduction of dehydroascorbate by trypanothione.

  1996cited by this paper
• Vitamin C: antioxidant or pro-oxidant in vivo?

  1996cited by this paper
• Isolation and Characterization of a New Vitamin C Producing Enzyme (L-Gulono-γ-lactone Dehydrogenase) of Bacterial Origin

  1995cited by this paper
• Oxidative mechanisms in the toxicity of metal ions.

  1995cited by this paper
• Purification and properties of L-galactono-gamma-lactone dehydrogenase, a key enzyme for ascorbic acid biosynthesis, from sweet potato roots.

  1995cited by this paper
• Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231.

  1994cited by this paper
• Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes.

  1994cited by this paper
• Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man.

  1994cited by this paper
• The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.

  1993cited by this paper
• Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages.

  1993cited by this paper
• Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid

  1993cited by this paper
• Trypanosoma cruzi glycosomal glyceraldehyde‐3‐phosphate dehydrogenase does not conform to the ‘hotspot’ topogenic signal model.

  1990cited by this paper
• Development of a trichloroacetic acid precipitation assay for covalent adducts of thymidylate synthase.

  1990cited by this paper
• Ascorbate is an outstanding antioxidant in human blood plasma.

  1989cited by this paper
• The karyotype and ploidy of Trypanosoma cruzi.

  1986cited by this paper
• Resistance to cutaneous leishmaniasis in genetically susceptible BALB/c mice.

  1981cited by this paper
• Evolution and the need for ascorbic acid.

  1970cited by this paper
• A kinetic study of the mechanism of action of L-gulonolactone oxidase.

  1966cited by this paper
• Biological synthesis of ascorbic acid: L-galactono-gamma-lactone dehydrogenase.

  1958cited by this paper
• Biological synthesis of ascorbic acid: l-galactono-γ-lactone dehydrogenase

  1958cited by this paper

• Peroxynitrite detoxification by Trypanosoma cruzi heme peroxidase supports parasite survival in macrophages

  2025cites this paper
• Structural modeling of L-galactonolactone dehydrogenase from Trypanosoma cruzi

  2025cites this paper
• L-gulono-γ-lactone Oxidase, the Key Enzyme for L-Ascorbic Acid Biosynthesis

  2024cites this paper
• Recombinant C-Terminal Catalytic Domain of Rat L-Gulono Lactone Oxidase Produced in Bacterial Cells Is Enzymatically Active

  2024cites this paper
• A proposed pathway from D-glucose to D-arabinose in eukaryotes

  2024cites this paper
• Structural insights into the Smirnoff-Wheeler pathway for vitamin C production in the Amazon fruit Camu-Camu.

  2024cites this paper
• Impact of Lipid Matrix Composition on Activity of Membranotropic Enzymes Galactonolactone Oxidase from Trypanosoma cruzi and L-Galactono-1,4-Lactone Dehydrogenase from Arabidopsis thaliana in the System of Reverse Micelles

  2023influential citation
• Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin

  2022cites this paper
• Mitochondrial Ca2+ and Reactive Oxygen Species in Trypanosomatids

  2021cites this paper
• Vitamins, omega-3, magnesium, manganese, and thyme can boost our immunity and protect against COVID-19

  2020cites this paper
• Suramin could block the activity of Arabinono-1, 4-lactone oxidase enzyme from Leishmania donovani: structure-based screening and molecular dynamics analyses.

  2020cites this paper
• Multiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal species

  2019cites this paper
• Mechanistic and biocatalytic enzymology of flavoprotein oxidases

  2018cites this paper
• Characterization of Two Arabidopsis L-Gulono-1,4-lactone Oxidases, AtGulLO3 and AtGulLO5, Involved in Ascorbate Biosynthesis.

  2017cites this paper
• Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in Trypanosoma cruzi

  2017cites this paper
• The VAO/PCMH flavoprotein family.

  2017cites this paper
• Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP)

  2017cites this paper
• Comparative Metabolism of Free‐living Bodo saltans and Parasitic Trypanosomatids

  2016cites this paper
• Recent progress on the characterization of aldonolactone oxidoreductases.

  2016influential citation
• Estudio de la interacción entre Trypanosoma cruzi y células de mamífero

  2016cites this paper
• Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes

  2015cites this paper
• The role of benznidazole with cyanocobalamin and ascorbic acid in treating the chronic phase of Chagas disease.

  2014cites this paper
• Aldonolactone oxidoreductases.

  2014cites this paper
• Flavins and flavoproteins: applications in medicine.

  2014cites this paper
• Combined use of ascorbic acid and cyanocobalamin in clearance of Trypanosoma cruzi

  2014cites this paper
• Strategies to increase vitamin C in plants: from plant defense perspective to food biofortification

  2013cites this paper
• Vitamin C effects in mice experimentally infected with Trypanosoma cruzi QM2 strain.

  2012cites this paper
• Low-Molecular-Mass Antioxidants in Parasites

  2012influential citation
• EFFECTS OF VITAMIN C SUPPLEMENTATION ON ACUTE PHASE CHAGAS DISEASE IN EXPERIMENTALLY INFECTED MICE WITH Trypanosoma cruzi QM 1 STRAIN

  2012cites this paper
• Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain.

  2012cites this paper
• Iron Metabolism in Pathogenic Trypanosomes

  2012cites this paper
• Glucose metabolism in Trypanosoma cruzi.

  2011cites this paper
• Galactonolactone oxidoreductase from Trypanosoma cruzi employs a FAD cofactor for the synthesis of vitamin C.

  2011cites this paper
• Leishmania donovani encodes a functional enzyme involved in vitamin C biosynthesis: arabino-1,4-lactone oxidase.

  2011cites this paper
• Biochemistry of Trypanosoma cruzi

  2010cites this paper
• Galactonolactone Dehydrogenase Requires a Redox-Sensitive Thiol for Optimal Production of Vitamin C1

  2009cites this paper
• Characterization and redesign of galactonolactone dehydrogenase, a flavoprotein producing vitamin C

  2009influential citation
• Fighting the oxidative assault: the Trypanosoma cruzi journey to infection.

  2009cites this paper
• l‐Galactono‐γ‐lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis

  2008cites this paper
• Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.

  2008cites this paper
• The growing VAO flavoprotein family.

  2008cites this paper
• Peroxidases of Trypanosomatids

  2008cites this paper