Oxidative Stress-induced liver damage and remodeling of the liver vasculature.

As an organ critically important for targeting and clearing viruses, bacteria, and other foreign material, the liver operates via immune-tolerant, anti-inflammatory mechanisms indispensable to the immune response. Stress and stress-induced factors disrupt the homeostatic balance in the liver, inflicting tissue damage, injury, and remodeling. These factors include oxidative stress induced by viral infections, environmental toxins, drugs, alcohol, and diet. A recurrent theme seen amongst stressors common to multiple liver disease is the induction of mitochondrial dysfunction, increased ROS expression and depletion of ATP. Inflammatory signaling additionally exacerbates the condition, generating a pro-inflammatory, immunosuppressive microenvironment and activation of apoptotic and necrotic mechanisms that disrupt the integrity of liver morphology. These pathways initiate signaling pathways that significantly contribute to the development of liver steatosis, inflammation, fibrosis, cirrhosis, and liver cancers. In addition, hypoxia and oxidative stress directly enhance angiogenesis and lymphangiogenesis in chronic liver diseases. Late-stage consequences of these conditions often narrow the outcomes for liver transplantation or result in death. This review provides a detailed perspective on various stress-induced factors and the specific focus on role of oxidative stress in different liver diseases with special emphasis on different molecular mechanisms. It also highlights how resultant changes in the liver vasculature corelates with pathogenesis.

• Publication year

  2023

• Venue

  American Journal of Pathology

• Publication date

  2023-06-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.ajpath.2023.06.002PMID 37355037
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats.

  2023cited by this paper
• Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis

  2023cited by this paper
• Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species–p90RSK–Vascular Endothelial Growth Factor Receptor 3 Pathway

  2023cited by this paper
• The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease

  2023cited by this paper
• Ginger (Zingiber officinale Roscoe), Lemon (Citrus limon L.) Juices as Preventive Agents from Chronic Liver Damage Induced by CCl4: A Biochemical and Histological Study

  2022cited by this paper
• Endoplasmic Reticulum Stress and Metabolism in Hepatocellular Carcinoma.

  2022cited by this paper
• Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries

  2022cited by this paper
• Drug-Induced Liver Injury From Sacubitril-Valsartan Versus a Single Dose of Acarbose

  2022cited by this paper
• Updates in Cholangiocarcinoma

  2022cited by this paper
• Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients

  2022cited by this paper
• Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

  2022cited by this paper
• Trovafloxacin drives inflammation-associated drug-induced adverse hepatic reaction through changing macrophage polarization.

  2022cited by this paper
• Updates in Cholangiocarcinoma

  2022cited by this paper
• Targeting lymphangiogenesis and lymph node metastasis in liver cancer.

  2021cited by this paper
• Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer

  2021cited by this paper
• Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target

  2021cited by this paper
• Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

  2021cited by this paper
• Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

  2021cited by this paper
• Immune cell - produced ROS and their impact on tumor growth and metastasis

  2021cited by this paper
• Dietary Cocoa Ameliorates Non-Alcoholic Fatty Liver Disease and Increases Markers of Antioxidant Response and Mitochondrial Biogenesis in High Fat-Fed Mice.

  2021cited by this paper
• Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice

  2021cited by this paper
• Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration

  2021cited by this paper
• The roles and mechanisms of hypoxia in liver fibrosis

  2021cited by this paper
• Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

  2021cited by this paper
• Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC

  2021cited by this paper
• The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer

  2021cited by this paper
• Mitochondrial Management of Reactive Oxygen Species

  2021cited by this paper
• Tumor Lymphatic Interactions Induce CXCR2-CXCL5 Axis and Alter Cellular Metabolism and Lymphangiogenic Pathways to Promote Cholangiocarcinoma

  2021cited by this paper
• Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

  2021cited by this paper
• Mechanism of Hydrophobic Bile Acid-Induced Hepatocyte Injury and Drug Discovery

  2020cited by this paper
• Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway.

  2020cited by this paper
• Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver

  2020cited by this paper
• A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway.

  2020cited by this paper
• Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation

  2020cited by this paper
• Liver lymphatic drainage patterns follow segmental anatomy in a murine model

  2020cited by this paper
• Vascular Heterogeneity With a Special Focus on the Hepatic Microenvironment

  2020cited by this paper
• Pathogenesis of Viral Hepatitis-Induced Chronic Liver Disease: Role of Extracellular Vesicles

  2020cited by this paper
• Molecular and cellular mechanisms of liver fibrosis and its regression

  2020cited by this paper
• Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

  2020cited by this paper
• Hypoxia and Non-alcoholic Fatty Liver Disease

  2020cited by this paper
• Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

  2020cited by this paper
• The liver, a functionalized vascular structure

  2020cited by this paper
• Drug-Induced Liver Injury: A Unique Presentation of Single-Dose Administration of Propylthiouracil

  2020cited by this paper
• The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review

  2020cited by this paper
• Identification of the first oomycete mating-type locus sequence in the grapevine downy mildew pathogen, Plasmopara viticola

  2020cited by this paper
• Nitrosative stress and lipid homeostasis as a mechanism for zileuton hepatotoxicity and resistance in genetically sensitive mice.

  2020cited by this paper
• Flexible functional interactions between G-protein subunits contribute to the specificity of plant responses.

  2020cited by this paper
• Nanocarrier-mediated antioxidant delivery for liver diseases

  2020cited by this paper
• Emerging Roles for Lymphatics in Chronic Liver Disease

  2020cited by this paper
• Mechanisms of liver fibrosis and its role in liver cancer

  2020cited by this paper
• Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34

  2020cited by this paper
• Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway.

  2019cited by this paper
• EASL Clinical Practice Guidelines: Drug-induced liver injury.

  2019cited by this paper
• Cholangiocyte pathobiology

  2019cited by this paper
• Hepatocellular carcinoma in the setting of alcohol-related liver disease.

  2019cited by this paper
• A literature review for the mechanisms of stress‐induced liver injury

  2019cited by this paper
• Inflammation and Progression of Cholangiocarcinoma: Role of Angiogenic and Lymphangiogenic Mechanisms

  2019cited by this paper
• The cell biology of the hepatocyte: A membrane trafficking machine

  2019cited by this paper
• A Bile Duct‐on‐a‐Chip With Organ‐Level Functions

  2019cited by this paper
• Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

  2019cited by this paper
• Alcoholic liver disease

  2018cited by this paper
• Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A‐catalysed hydroxylation by sulfaphenazole

  2018cited by this paper
• Lymphatics in the liver.

  2018cited by this paper
• Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement

  2018cited by this paper
• Lactobacillus crispatus BC5 Interferes With Chlamydia trachomatis Infectivity Through Integrin Modulation in Cervical Cells

  2018cited by this paper
• Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels

  2018cited by this paper
• Flutamide Induces Hepatic Cell Death and Mitochondrial Dysfunction via Inhibition of Nrf2-Mediated Heme Oxygenase-1

  2018cited by this paper
• Alcoholic liver disease

  2018cited by this paper
• Liver sinusoidal endothelial cells: Physiology and role in liver diseases.

  2017cited by this paper
• Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

  2017cited by this paper
• Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

  2017cited by this paper
• Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity.

  2016cited by this paper
• Establishment of a mouse model for amiodarone‐induced liver injury and analyses of its hepatotoxic mechanism

  2016cited by this paper
• The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis

  2016cited by this paper
• Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D

  2016cited by this paper
• HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3

  2016cited by this paper
• Role of Oxidative Stress in Liver Health and Disease

  2016cited by this paper
• Hepatic Steatosis: Etiology, Patterns, and Quantification.

  2016cited by this paper
• Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

  2016cited by this paper
• Liver immunology and its role in inflammation and homeostasis

  2016cited by this paper
• Does User Fee Removal Policy Provide Financial Protection from Catastrophic Health Care Payments? Evidence from Zambia

  2016cited by this paper
• Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes

  2016cited by this paper
• Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study

  2016cited by this paper
• Adverse Outcome Pathways and Drug-Induced Liver Injury Testing.

  2015cited by this paper
• Hepatocytes: a key cell type for innate immunity

  2015cited by this paper
• Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection.

  2015cited by this paper
• Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function.

  2015cited by this paper
• A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer.

  2015cited by this paper
• An overview on the proposed mechanisms of antithyroid drugs-induced liver injury.

  2015cited by this paper
• The Role of Oxidative Stress and Antioxidants in Liver Diseases

  2015cited by this paper
• Metformin aggravates immune-mediated liver injury in mice

  2015cited by this paper
• TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

  2015cited by this paper
• Extremely high mutation load of the mitochondrial 8993 T>G mutation in a newborn: implications for prognosis and family planning decisions

  2015cited by this paper
• Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

  2015cited by this paper
• Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up

  2015cited by this paper
• Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.

  2015cited by this paper
• Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.

  2015cited by this paper
• Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: an intricate pathway.

  2014cited by this paper
• The role of Kupffer cells in hepatitis B and hepatitis C virus infections.

  2014cited by this paper
• Hepatitis B virus infection.

  2014cited by this paper

• Inhibition of store-operated calcium entry mitigates lipopolysaccharide-induced hepatotoxicity via modulating inflammatory and oxidative stress responses.

  2026cites this paper
• Pesticides Drive Liver Diseases Through Non-Apoptotic Regulated Cell Death Pathways

  2026cites this paper
• When Atrial Fibrillation Meets Alcoholic Liver Cirrhosis: Can Direct Oral Anticoagulants Bridge the Therapeutic Gap?

  2026cites this paper
• High-Altitude Condition Induces Hepatic Magnetic Susceptibility Changes and Liver Injury

  2026cites this paper
• Bioactive polyphenols from Isodon serra with antioxidant and hepatoprotective activities in vitro and in vivo

  2026cites this paper
• Heat waves and health crises: The unseen threat of heat stress on multiple organ systems.

  2026cites this paper
• In vitro bioaccessibility and alcoholic injury-alleviation effect of Lycium barbarum leaf phenolics

  2026cites this paper
• Bioactive extract and component from fruit spikes of Prunella vulgaris L. induce apoptosis in non-small cell lung cancer: An integrative network pharmacology, molecular docking, and experimental validation approach

  2026cites this paper
• An in-silico studies of Solanum erianthum compounds as PPAR-α and TGF-βR1 modulators in oxidative stress induced liver injury

  2026cites this paper
• Lobation and vascularity of the liver in the red-eared slider (Trachemys scripta elegans).

  2026cites this paper
• Hepatoprotective potential of Dozliv Forte-P Ultra and Dozliv Forte-P against CCl₄-induced hepatotoxicity in rats

  2026cites this paper
• Antioxidative Biomolecular protective activity of Napoleonaea vogelii Against Cyclophosphamide-induced hepatotoxicity in Rats

  2025cites this paper
• Uncovering the bequeathing potential of apoptotic mesenchymal stem cells via small extracellular vesicles for its enhanced immunomodulatory and regenerative ability

  2025cites this paper
• Myocardial infarction model in rats: can crocin reverse myocardial infarction-induced cardiac hepatopathy in melatonin deficiency?

  2025cites this paper
• Quantification of microplastics in bottled water by Pyr-GC/MS, human exposure, and in vitro hepatotoxicity assessment

  2025cites this paper
• Protective effect of osmanthus water extract on liver dysfunction caused by DBP based on organoids and organ chips technologies.

  2025cites this paper
• Research progress in the role of gut microbiota in ethanol metabolism.

  2025cites this paper
• Enzymatic synthesis and mechanistic insights into the hepatoprotective effects of α-monoglucosyl rutin against cyclophosphamide-induced liver injury: a multi-omics approach.

  2025cites this paper
• Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review)

  2025cites this paper
• Efek Ekstrak Nigella sativa Terhadap Histopatologi Pankreas Dan Hepar Pada Tikus Model Diabetes Melitus

  2025cites this paper
• A Hepatic Function Score's Unlikely Second Act: Risk-Stratifying Contrast-Associated Kidney Injury After STEMI.

  2025cites this paper
• Targeting Lipophagy in Liver Diseases: Impact on Oxidative Stress and Steatohepatitis

  2025cites this paper
• NOX1 inhibition sensitizes HCC cells to sorafenib and radiotherapy by modulating ROS-mediated programmed cell death

  2025cites this paper
• The Characterization and Identification of Cyperus Protein: An In Vitro Study on Its Antioxidant and Anti-Inflammatory Potential

  2025cites this paper
• Sesquiterpenoids from Lindera aggregata with Keap1 binding affinity: Chemical diversity and bioactivity screening

  2025cites this paper
• Anti-hepatic fibrosis activity and mechanisms of natural polysaccharides: A comprehensive review.

  2025cites this paper
• Phocaeicola plebeius oral treatment improve fibrosis by reversing cirrhosis-related hepatic gene dysregulation.

  2025cites this paper
• Transcriptomic analysis reveals chronic PFBA exposure at environmental levels induces liver damage in zebrafish.

  2025cites this paper
• Cytoglobin suppresses oxidative damage and compensatory proliferation via inhibiting AKT/ERK1/2/CyclinD1 axis in hepatocellular carcinoma.

  2025cites this paper
• Integrated Network Analysis of Toxic Elements Co-exposure and Pathophysiological Changes Triggered by Oxidative Stress/Inflammation in Urban Sanitation Workers.

  2025cites this paper
• The Role of Ferroptosis on the Pathogenesis and Therapy of Hepatocellular Carcinoma

  2025cites this paper
• Association between liver function at hospital admission and mortality in pediatric patients receiving postcardiotomy venoarterial extracorporeal membrane oxygenation support.

  2025cites this paper
• Aqueous extract of Heliotropium indicum (scorpion tale) abrogates Pb-induced tissue damage in male Wistar rats through anti-inflammatory and histological restoration

  2025cites this paper
• Combined Effects of Environmental and Lifestyle Exposures on Liver Health: The Mediating Role of Allostatic Load

  2025cites this paper
• Evaluation of the Hepatoprotective Properties of Vitex Altissima Bark Extracts and Isolated Bioactive: In-vitro and In-vivo approach

  2025cites this paper
• Eksplorasi Potensi Tanaman Kipahit (Tithonia diversifolia) sebagai Terapi Alternatif Diabetes Mellitus

  2025cites this paper
• HBV reactivation drives cellular collapse and inhibits liver repair: a model of emergency hepatic crisis

  2025cites this paper
• Auramine O, a Synthetic Food Dye, Induces Hepatic Injury by Disrupting NOS2 Signaling, Inflammatory Cytokines, and Metabolic Pathways in an In Vivo Zebrafish Model.

  2025cites this paper
• Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway

  2025cites this paper
• Tannins: A Promising Antidote to Mitigate the Harmful Effects of Aflatoxin B1 to Animals

  2025cites this paper
• The Effect of Snakehead Fish on Superoxide Dismutase Levels and Gastric Histopathological Features in a Rat Model of Liver Cirrhosis

  2025cites this paper
• Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions

  2025cites this paper
• Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis

  2025cites this paper
• Hepatoprotective effect of the Sechium HD-Victor hybrid extract in a model of liver damage induced by carbon tetrachloride in mice.

  2025cites this paper
• Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review.

  2025cites this paper
• Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks.

  2025cites this paper
• Regular exercise alleviates metabolic dysfunction-associated steatohepatitis through rescuing mitochondrial oxidative stress and dysfunction in liver.

  2025cites this paper
• Evaluation of Cardiovascular and Hepatic Changes in Myocardial Infarction Patients Post-Covid-19 Vaccination.

  2025cites this paper
• Human umbilical cord-derived mesenchymal stem cells attenuate liver fibrosis by inhibiting hepatocyte ferroptosis through mitochondrial transfer.

  2025cites this paper
• Molecular Mechanism of Vine Tea Dihydromyricetin Extract on Alleviating Glucolipid Metabolism Disorder in db/db Mice: Based on Liver RNA-Seq and TLR4/MyD88/NF-κB Pathway

  2025cites this paper
• Inhibition of MALT1 Protease Attenuates Hepatic Sinusoidal Obstruction Syndrome by Modulating NRF2/HO1 and NF‐κB Pathway

  2025cites this paper
• Mangrove Against Invasive Snails: Aegiceras corniculatum Shows a Molluscicidal Effect on Exotic Apple Snails (Pomacea canaliculata) in Mangroves

  2025cites this paper
• Cell Membrane Vesicle Camouflaged Artificial Cells

  2025cites this paper
• Combined quercetin with phosphodiesterase inhibitors; sildenafil and pentoxifylline alleviated CCl4-induced chronic hepatic fibrosis: Role of redox-sensitive pathways.

  2025cites this paper
• Abdominal Aortic Aneurysm and Liver Fibrosis: Clinical Evidence and Molecular Pathomechanisms

  2025cites this paper
• Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights

  2025cites this paper
• Effect of high-altitude hypoxia on function and cytoarchitecture of rats’ liver

  2025influential citation
• The toxicological effects of perfluorooctanoic acid (PFOA) exposure in large yellow croaker (Larimichthys crocea): exploring the relationship between liver damage and gut microbiota dysbiosis.

  2025cites this paper
• Effect of Lipopolysaccharide (LPS) on Oxidative Stress and Apoptosis in Immune Tissues from Schizothorax prenanti

  2025cites this paper
• The evaluation and molecular mechanisms of hepatotoxicity induced by trans-emodin dianthrones isolated from Polygonum multiflorum Thunb. in Vitro.

  2025cites this paper
• Ginger (Zingiber officinale) dietary supplementation in mice regulates liver antioxidant defense systems in a dose- and age-dependent

  2025cites this paper
• Nannochloropsis biomass alleviates high fat diet induced cardiac and hepatic metabolic disturbances in mice

  2025cites this paper
• Fatty Liver in Pregnancy: Bridging the Gap Between Diagnosis and Treatment

  2025cites this paper
• The protective role of vitamin C against linezolid-induced hepato-renal toxicity in a rat model

  2025cites this paper
• Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis

  2025cites this paper
• Natural products: A potential immunomodulators against inflammatory-related diseases

  2024cites this paper
• Oxidative stress–induced fibrinogen modifications in liver transplant recipients: unraveling a novel potential mechanism for cardiovascular risk

  2024cites this paper
• A systematic review of dietary and circulating carotenoids and liver disease.

  2024cites this paper
• BRUCE liver-deficiency potentiates MASLD/MASH in PTEN liver-deficient background by impairment of mitochondrial metabolism in hepatocytes and activation of STAT3 signaling in hepatic stellate cells

  2024cites this paper
• The role of quercetin in NLRP3-associated inflammation

  2024cites this paper
• Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk.

  2024cites this paper
• Effects of microbe-derived antioxidants on growth performance, hepatic oxidative stress, mitochondrial function and cell apoptosis in weaning piglets

  2024cites this paper
• Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities

  2024cites this paper
• Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

  2024cites this paper
• Oudemansiella radicata polysaccharides alleviated LPS-induced liver damage via regulating TLR4/NF-κB and Bax/Bcl-2 signaling pathways.

  2024cites this paper
• The Interaction of Apical Periodontitis, Cigarette Smoke, and Alcohol Consumption on Liver Antioxidant Status in Rats

  2024cites this paper
• Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF‐β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology

  2024cites this paper
• Sappanone A Ameliorates Concanavalin A-induced Immune-Mediated Liver Injury by Regulating M1 Macrophage Polarization

  2024cites this paper
• Unveiling the hepatoprotective mechanisms of Desmodium heterocarpon (L.) DC: Novel flavonoid identification and Keap1/Nrf2 pathway activation.

  2024cites this paper
• Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity.

  2024cites this paper
• Single and mixture exposure to atrazine and ciprofloxacin on Clarias gariepinus antioxidant defense status, hepatic condition and immune response.

  2024cites this paper
• Spatial Transcriptome Mapping of the Desmoplastic Growth Pattern of Colorectal Liver Metastases by In Situ Sequencing Reveals a Biologically Relevant Zonation of the Desmoplastic Rim

  2024cites this paper
• [Study on the protective effects of resveratrol on the liver of hindlimb-unloaded rats].

  2024cites this paper
• The Effect of Probiotic Supplementation in Cholestasis Liver Disease: A Systematic Review of Animal Studies

  2024cites this paper
• Association of multiple serum minerals and vitamins with metabolic dysfunction-associated fatty liver disease in US adults: National Health and Nutrition Examination Survey 2017–2018

  2024cites this paper
• Highly crystalline cellulose microparticles from dealginated seaweed waste ameliorate high fat-sugar diet-induced hyperlipidemia in mice by modulating gut microbiota.

  2024cites this paper
• Value of Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) in Assessing Liver Fibrosis in Metabolic Dysfunction-Associated Liver Disease: A Comprehensive Review of its Serum Biomarker Role.

  2024cites this paper
• Associations between chronic obstructive pulmonary disease and ten common cancers: novel insights from Mendelian randomization analyses

  2024cites this paper
• The Effect of Barley Bran Polyphenol-Rich Extracts on the Development of Nonalcoholic Steatohepatitis in Sprague–Dawley Rats Fed a High-Fat and High-Cholesterol Diet

  2024cites this paper
• Uncovering the bequeathing potential of Apoptotic Mesenchymal Stem Cells via small Extracellular Vesicles for its enhanced immunomodulatory ability

  2024cites this paper
• The Cellular, Molecular, and Pathological Consequences of Stress on the Liver.

  2023cites this paper
• Stress-induced immunosuppression inhibits immune response to infectious bursal disease virus vaccine partially by miR-27b-3p/SOCS3 regulatory gene network in chicken

  2023cites this paper
• Periploca forrestii Schltr. ameliorate liver injury caused by fluorosis in rat.

  2023cites this paper
• Oxidative Mechanisms and Cardiovascular Abnormalities of Cirrhosis and Portal Hypertension

  2023cites this paper