Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  International journal of pharmaceutics

• Publication date

  2014-04-10

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1016/j.ijpharm.2014.01.010PMID 24440400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®

  2013cited by this paper
• Dose dependence of intratumoral perivascular distribution of monoclonal antibodies.

  2012cited by this paper
• Antitumor efficacy following the intracellular and interstitial release of liposomal doxorubicin.

  2012cited by this paper
• Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues.

  2012cited by this paper
• Block copolymer micelles target Auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells.

  2012cited by this paper
• Cancer stromal targeting (CAST) therapy.

  2012cited by this paper
• Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab.

  2012cited by this paper
• Quantitative immunohistochemistry for evaluating the distribution of Ki67 and other biomarkers in tumor sections and use of the method to study repopulation in xenografts after treatment with paclitaxel.

  2012cited by this paper
• Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles.

  2012cited by this paper
• Nanomedicine in cancer therapy: Innovative trends and prospects

  2011cited by this paper
• Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.

  2011cited by this paper
• Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures.

  2011cited by this paper
• Polymeric micelles for nano-scale drug delivery

  2011cited by this paper
• 3D tumour models: novel in vitro approaches to cancer studies

  2011cited by this paper
• Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.

  2011cited by this paper
• Tumor delivery of macromolecular drugs based on the EPR effect.

  2011cited by this paper
• New concept of cytotoxic immunoconjugate therapy targeting cancer‐induced fibrin clots

  2011cited by this paper
• A review of three-dimensional in vitro tissue models for drug discovery and transport studies.

  2011cited by this paper
• Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies.

  2010cited by this paper
• Nanoparticle technologies for cancer therapy.

  2010cited by this paper
• The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles.

  2010cited by this paper
• Polymeric micelles as a new drug carrier system and their required considerations for clinical trials

  2010cited by this paper
• The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles.

  2010cited by this paper
• The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors

  2010cited by this paper
• Multicellular tumor spheroids: an underestimated tool is catching up again.

  2010cited by this paper
• Poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles containing chemically conjugated and physically entrapped docetaxel: synthesis, characterization, and the influence of the drug on micelle morphology.

  2010cited by this paper
• Noninvasive monitoring of the fate of 111In-labeled block copolymer micelles by high resolution and high sensitivity microSPECT/CT imaging.

  2009cited by this paper
• Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels.

  2009cited by this paper
• Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect.

  2009cited by this paper
• Polymer therapeutics: clinical applications and challenges for development.

  2009cited by this paper
• Polymeric micellar delivery systems in oncology.

  2008cited by this paper
• Spatio‐temporal modeling of nanoparticle delivery to multicellular tumor spheroids

  2008cited by this paper
• In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration.

  2007cited by this paper
• Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)‐siRNA Conjugate Formulated in PEGylated Polyplexes

  2007cited by this paper
• Drug resistance and the solid tumor microenvironment.

  2007cited by this paper
• Drug penetration in solid tumours

  2006cited by this paper
• The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells.

  2006cited by this paper
• Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.

  2006cited by this paper
• Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery.

  2006cited by this paper
• Exploiting the enhanced permeability and retention effect for tumor targeting.

  2006cited by this paper
• The Distribution of the Anticancer Drug Doxorubicin in Relation to Blood Vessels in Solid Tumors

  2005cited by this paper
• Repopulation of cancer cells during therapy: an important cause of treatment failure

  2005cited by this paper
• Drug Delivery and Transport to Solid Tumors

  2003cited by this paper
• Rate of biodistribution of STEALTH liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity.

  2003cited by this paper
• Time-and concentration-dependent penetration of doxorubicin in prostate tumors

  2001cited by this paper
• Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.

  2000cited by this paper
• Forecasting the growth of multicell tumour spheroids: implications for the dynamic growth of solid tumours

  2000cited by this paper
• Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors.

  1999cited by this paper
• Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements

  1999cited by this paper
• Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

  1999cited by this paper
• Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

  1994cited by this paper
• Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors.

  1986cited by this paper
• Demonstration of an extracellular matrix in multicellular tumor spheroids.

  1984cited by this paper
• A simplified method for production and growth of multicellular tumor spheroids.

  1977cited by this paper
• © The Macmillan Press Ltd., SHORT COMMUNICATION

  year unknowncited by this paper

• Size-dependent penetration depth of colloidal nanoparticles into cell spheroids.

  2025cites this paper
• Polypeptide-based nanocarriers from aqueous ROPISA: Shape-dependent performance in colorectal and breast cancer models.

  2025cites this paper
• Advancements in mesoporous bioactive glasses for effective bone cancer therapy: Recent developments and future perspectives

  2025cites this paper
• Hydrogel Drug Delivery Systems for Minimally Invasive Local Immunotherapy of Cancer.

  2023cites this paper
• Changing Surface Polyethylene Glycol Architecture Affects Elongated Nanoparticle Penetration into Multicellular Tumor Spheroids.

  2022cites this paper
• Bioactive Glasses as Carriers of Cancer-Targeted Drugs: Challenges and Opportunities in Bone Cancer Treatment

  2022cites this paper
• The in vivo fate of polymeric micelles.

  2022cites this paper
• 3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles.

  2021cites this paper
• Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer.

  2021cites this paper
• Kinetics of Nanomedicine in Tumor Spheroid as an In Vitro Model System for Efficient Tumor-Targeted Drug Delivery With Insights From Mathematical Models

  2021cites this paper
• Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?

  2021cites this paper
• 3D cultures for modeling nanomaterial-based photothermal therapy.

  2020cites this paper
• Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model

  2020cites this paper
• Investigating the influence of block copolymer micelle length on cellular uptake and penetration in a multicellular tumor spheroid model.

  2020cites this paper
• Biofabrication of 3D tumor models in cancer research

  2020cites this paper
• Size-Controlled Preparation and Behavior Study of Phospholipid–Calcium Carbonate Hybrid Nanoparticles

  2020cites this paper
• Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis

  2020cites this paper
• Controlling the Stability of Colloidal Drug Aggregates for Chemotherapeutic Delivery

  2019cites this paper
• Biological barriers to cancer drug delivery, efficacy and cancer models

  2019cites this paper
• Anti-Cancerous Potential of Polyphenol-Loaded Polymeric Nanotherapeutics

  2018cites this paper
• Alpha Radionuclide Therapy Using Polymeric Nanocarriers : Solution to the Recoil Problem?

  2018cites this paper
• Smart Drug-Delivery Systems for Cancer Nanotherapy.

  2018cites this paper
• The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models

  2018cites this paper
• Application of 3D cultured multicellular spheroid tumor models in tumor‐targeted drug delivery system research

  2018cites this paper
• Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

  2017cites this paper
• Liposomes equipped with cell penetrating peptide BR2 enhances chemotherapeutic effects of cantharidin against hepatocellular carcinoma

  2017cites this paper
• Polyphenols delivery by polymeric materials: challenges in cancer treatment

  2017influential citation
• Nano‐sized drug carriers: Extravasation, intratumoral distribution, and their modeling

  2017cites this paper
• Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

  2017influential citation
• Development of a targeted liposomal delivery system for encapsulated cantharidin to treat hepatocellular carcinoma

  2017cites this paper
• HALO- AND SOLVATO-FLUOROCHROMIC POLYMER NANOASSEMBLIES FOR CANCER THERANOSTICS

  2017cites this paper
• Design and Synthesis of Self-Assembled Polymeric Nanoparticles for Cancer Drug Delivery

  2017cites this paper
• Development and applications of high-performance small-animal SPECT

  2017cites this paper
• Determinants of Nanomedicine Performance for the Treatment of Solid Tumors: Whole Tumor and Intratumoral Assessment of Liposome Distribution

  2016influential citation
• Nanomedicine and tumor heterogeneity: Concept and complex reality

  2016cites this paper
• Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide

  2016cites this paper
• Novel Antibody-Targeted Liposomes for the Treatment of Solid Tumors

  2016cites this paper
• RNA nanomedicines: the next generation drugs?

  2016cites this paper
• Functionalization of Cellulose Nanocrystals with PEG-Metal-Chelating Block Copolymers via Controlled Conjugation in Aqueous Media

  2016cites this paper
• Optimizing particle size of docetaxel-loaded micelles for enhanced treatment of oral epidermoid carcinoma.

  2016cites this paper
• A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment.

  2016cites this paper
• Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts.

  2016cites this paper
• Radiolabeled block copolymer micelles for image-guided drug delivery.

  2016cites this paper
• Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia

  2016cites this paper
• Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state.

  2016cites this paper
• NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?

  2016cites this paper
• Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro.

  2016cites this paper
• Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease.

  2015cites this paper
• Magnetic Resonance-Guided Drug Delivery.

  2015cites this paper
• Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model.

  2015cites this paper
• Improving drug delivery to solid tumors: priming the tumor microenvironment.

  2015cites this paper
• The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation.

  2015cites this paper
• 89Zr‐ and Fe‐Labeled Polymeric Micelles for Dual Modality PET and T1‐Weighted MR Imaging

  2015cites this paper
• Chemical analysis of multicellular tumour spheroids.

  2015cites this paper
• A tumor-penetrating recombinant protein anti-EGFR-iRGD enhance efficacy of paclitaxel in 3D multicellular spheroids and gastric cancer in vivo.

  2015cites this paper
• Development and preclinical validation of molecular and nanoparticulate probes for imaging of fibrin

  2014cites this paper
• Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors

  2014cites this paper
• Smart drug delivery systems: from fundamentals to the clinic.

  2014cites this paper
• Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles.

  2014cites this paper